scholarly journals Prolonged Hypocalcemic Effect by Pulmonary Delivery of Calcitonin Loaded Poly(Methyl Vinyl Ether Maleic Acid) Bioadhesive Nanoparticles

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
J. Varshosaz ◽  
M. Minaiyan ◽  
M. Forghanian
Keyword(s):  
Physicochemical Properties ◽  
Vinyl Ether ◽  
Maleic Acid ◽  
Pulmonary Delivery ◽  
Plasma Calcium ◽  
Blood Calcium ◽  
Methyl Vinyl ◽  
Significant Difference ◽  
Hypocalcemic Effect ◽  
Methyl Vinyl Ether

The purpose of the present study was to design a pulmonary controlled release system of salmon calcitonin (sCT). Therefore, poly(methyl vinyl ether maleic acid) [P(MVEMA)] nanoparticles were prepared by ionic cross-linking method using Fe2+and Zn2+ions. Physicochemical properties of nanoparticles were studiedin vitro. The stability of sCT in the optimized nanoparticles was studied by electrophoretic gel method. Plasma calcium levels until 48 h were determined in rats as pulmonary-free sCT solution or nanoparticles (25 μg·kg−1),ivsolution of sCT (5 μg·kg−1), and pulmonary blank nanoparticles. The drug remained stable during fabrication and tests on nanoparticles. The optimized nanoparticles showed proper physicochemical properties. Normalized reduction of plasma calcium levels was at least 2.76 times higher in pulmonary sCT nanoparticles compared to free solution. The duration of hypocalcemic effect of pulmonary sCT nanoparticles was 24 h, while it was just 1 h for theivsolution. There was not any significant difference between normalized blood calcium levels reduction in pulmonary drug solution andivinjection. Pharmacological activity of nanoparticles after pulmonary delivery was 65% of theivroute. Pulmonary delivery of P(MVEMA) nanoparticles of sCT enhanced and prolonged the hypocalcemic effect of the drug significantly.

Thermal gravimetric analysis of in-situ crosslinked nanocellulose whiskers • poly(methyl vinyl ether-co-maleic acid) • polyethylene glycol

TAPPI Journal ◽  
2011 ◽  
Vol 10 (4) ◽  
pp. 29-33
Author(s):  
LEE A. GOETZ ◽  
AJI P. MATHEW ◽  
KRISTIINA OKSMAN ◽  
ARTHUR J. RAGAUSKAS
Keyword(s):  
Thermal Stability ◽  
Polyethylene Glycol ◽  
Vinyl Ether ◽  
Thermal Gravimetric Analysis ◽  
Maleic Acid ◽  
Gravimetric Analysis ◽  
Thermal Gravimetric ◽  
Methyl Vinyl ◽  
Methyl Vinyl Ether

The thermal stability and decomposition of in-situ crosslinked nanocellulose whiskers – poly(methyl vinyl ether-co-maleic acid) – polyethylene glycol formulations (PMVEMA-PEG), (25%, 50%, and 75% whiskers) – were investigated using thermal gravimetric analysis (TGA) methods. The thermal degradation behavior of the films varied according to the percent cellulose whiskers in each formulation. The presence of cellulose whiskers increased the thermal stability of the PMVEMA-PEG matrix.

scholarly journals Swelling kinetic study of poly(methyl vinyl ether-co-maleic acid) hydrogels as vehicle candidates for drug deliver

2018 ◽  
Vol 9 ◽  
Author(s):  
Rubhan Chandran ◽  
Eusni Mohd. Tohit ◽  
Mansor Ahmad ◽  
Tuan Mazlelaa Tuan Mahmood ◽  
Johnson Stanslas
Keyword(s):  
Kinetic Study ◽  
Vinyl Ether ◽  
Maleic Acid ◽  
Methyl Vinyl ◽  
Swelling Kinetic ◽  
Methyl Vinyl Ether

scholarly journals Synthesis of biotin‐targeted chitosan/poly (methyl vinyl ether‐ alt ‐maleic acid) copolymeric micelles for delivery of doxorubicin

2017 ◽  
Vol 11 (7) ◽  
pp. 843-851
Author(s):  
Jaleh Varshosaz ◽  
Ehsan Khabbazian ◽  
Farshid Hassanzadeh ◽  
Hojjat Sadeghi Aliabadi ◽  
Mahboobeh Rostami ◽  
...  
Keyword(s):  
Vinyl Ether ◽  
Maleic Acid ◽  
Methyl Vinyl ◽  
Methyl Vinyl Ether

Synthetic hydrogels formed by thiol–ene crosslinking of vinyl sulfone-functional poly(methyl vinyl ether-alt-maleic acid) with α,ω-dithio-polyethyleneglycol

Soft Matter ◽  
2018 ◽  
Vol 14 (41) ◽  
pp. 8317-8324 ◽  
Author(s):  
S. A. Stewart ◽  
M. B. Coulson ◽  
C. Zhou ◽  
N. A. D. Burke ◽  
H. D. H. Stöver
Keyword(s):  
Vinyl Ether ◽  
Maleic Acid ◽  
Vinyl Sulfone ◽  
3T3 Cells ◽  
Methyl Vinyl ◽  
Synthetic Hydrogels ◽  
Methyl Vinyl Ether

3T3 cells in hydrogel formed by thiol–ene click-crosslinking of vinyl sulfone-functional PMM-CVS with PEG-dithiols.

scholarly journals Potentiometric Titration Behavior of Maleic Acid-Methyl Vinyl Ether Copolymer

1975 ◽  
Vol 48 (1) ◽  
pp. 15-17
Author(s):  
Etsuo KOKUFUTA ◽  
Masakatsu ITO ◽  
Mitsuo HIRATA ◽  
Shinji IWAI
Keyword(s):  
Potentiometric Titration ◽  
Vinyl Ether ◽  
Maleic Acid ◽  
Methyl Vinyl ◽  
Acid Methyl ◽  
Methyl Vinyl Ether

In situ formation of multiple stimuli-responsive poly[(methyl vinyl ether)-alt-(maleic acid)]-based supramolecular hydrogels by inclusion complexation between cyclodextrin and azobenzene

RSC Advances ◽  
2016 ◽  
Vol 6 (16) ◽  
pp. 13129-13136 ◽  
Author(s):  
Xiaoe Ma ◽  
Naizhen Zhou ◽  
Tianzhu Zhang ◽  
Zhenchao Guo ◽  
Wanjun Hu ◽  
...  
Keyword(s):  
Vinyl Ether ◽  
Maleic Acid ◽  
Biomedical Applications ◽  
Inclusion Complexation ◽  
High Potential ◽  
Stimuli Responsive ◽  
Methyl Vinyl ◽  
In Situ Formation ◽  
Methyl Vinyl Ether

Stimuli-responsive poly[(methyl vinyl ether)-alt-(maleic acid)]-based supramolecular hydrogels were prepared in situ by inclusion complexation between cyclodextrin and azobenzene. They may have high potential in biomedical applications.

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