scholarly journals Suxiao JiuxinPill Induces Potent Relaxation and Inhibition on Contraction in Human Artery and the Mechanism

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Xiao-Yan Bai ◽  
Ping Zhang ◽  
Qin Yang ◽  
Xiao-Cheng Liu ◽  
Jun Wang ◽  
...  
Keyword(s):  
Internal Mammary Artery ◽  
Plasma Concentrations ◽  
Inhibitory Effect ◽  
Enos Expression ◽  
Human Artery ◽  
Full Relaxation ◽  
Potent Inhibitory Effect ◽  
Internal Mammary ◽  
Human Arteries ◽  
Main Components

Suxiao JiuxinPill, a compound Chinese traditional medicine with main components of tetramethylpyrazine and borneol, is widely used for antiangina treatment in China but its pharmacological effect on human blood vessels is unknown. We investigated the effect and possible mechanism of SJP in the human internal mammary artery (IMA,n=78) taken from patients undergoing coronary surgery. SJP caused full relaxation in KCl- (99.4±10.5%,n=6) and U46619- (99.9±5.6%,n=6) contracted IMA. Pretreatment of IMA with plasma concentrations of SJP (1 mg/mL), calculated from the plasma concentration of its major component borneol, significantly depressed the maximal contraction to KCl (from35.8±6.0 mN to12.6±5.6 mN,P=0.03) and U46619 (from19.4±2.9 mN to5.7±2.4 mN,P=0.007) while SJP at 10 mg/mL abolished the subsequent contraction. Endothelium denudation and inhibition of eNOS significantly altered the SJP-induced relaxation without changes of eNOS expression. We conclude that SJP has a potent inhibitory effect on the vasoconstriction mediated by a variety of vasoconstrictors in human arteries. The vasorelaxation involves both endothelium-dependent and -independent mechanisms. Thus, the effect of SJP on human arteries demonstrated in this study may prove to be particularly important in vasorelaxing therapy in cardiovascular disease.

Apelin has inhibitory effect of endothelium-independent relaxation in the human internal mammary artery

2019 ◽  
pp. 1
Author(s):  
Emine Kacar ◽  
Oktay Burma ◽  
Ihsan Serhatlioglu ◽  
Nazife Ulker ◽  
Ahmet Yardimci ◽  
...  
Keyword(s):  
Internal Mammary Artery ◽  
Inhibitory Effect ◽  
Internal Mammary

Inducible L-arginine/nitric oxide pathway in human internal mammary artery and saphenous vein

1995 ◽  
Vol 268 (3) ◽  
pp. H1122-H1132 ◽  
Author(s):  
N. Thorin-Trescases ◽  
C. A. Hamilton ◽  
J. L. Reid ◽  
K. L. McPherson ◽  
E. Jardine ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Internal Mammary Artery ◽  
Interleukin 1 ◽  
Inhibitory Effect ◽  
No Synthase ◽  
Interleukin 1 Beta ◽  
Contractile Responses ◽  
Saphenous Veins ◽  
Mammary Arteries ◽  
Internal Mammary

To characterize the L-arginine/nitric oxide (NO) pathway in human vascular smooth muscle (VSM), contractile responses of isolated internal mammary arteries (IMA) and saphenous veins (SV) were observed after induction of NO synthase by interleukin-1 beta (IL-1 beta) or by lipopolysaccharide (LPS). In IL-1 beta-treated endothelium-denuded rings, contractile responses to phenylephrine were reduced in SV rings only. Maximum phenylephrine-induced contraction was depressed by approximately 50%. This was not modified by the presence of indomethacin, NG-nitro-L-arginine methyl ester (L-NAME), or methylene blue (MeB). In LPS-treated vessels, contractile responses were depressed in both SV and IMA rings (40%), and this was not affected by indomethacin. In SV, L-NAME, NG-monomethyl-L-arginine, or MeB did not affect the inhibitory effect of LPS, whereas the effect was reversed in IMA by these inhibitors. In LPS-treated IMA, but not in SV, exogenous L-arginine evoked significant vasodilation (20%). We conclude that VSM of the human IMA possesses an L-arginine/NO pathway inducible by LPS. In SV, LPS or IL-1 beta treatment inhibits contraction by an unidentified system that is not dependent on NO synthase or on guanylate cyclase activities.

Impact of Preparation Quality during Skeletonized Internal Mammary Artery Harvesting on Sternal Microcirculation

2020 ◽  
Author(s):  
L. Saemann ◽  
A. Zubarevich ◽  
F. Wenzel ◽  
S. Korkmaz-Icöz ◽  
M. Karck ◽  
...  
Keyword(s):  
Internal Mammary Artery ◽  
Internal Mammary

Mitral Valve Replacement via Anterolateral Right Thoracotomy without Cross-Clamping in a Patient with Fungal Infective Endocarditis and Functioning Internal Mammary Artery after Previous Coronary Artery Bypass Grafting and Mitral Valve Repair

2016 ◽  
Vol 19 (1) ◽  
pp. 033
Author(s):  
Takahiro Taguchi ◽  
Jeswant Dillon ◽  
Mohd Azhari Yakub
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Mitral Valve ◽  
Coronary Artery Bypass ◽  
Internal Mammary Artery ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Valve Repair ◽  
Artery Bypass Grafting ◽  
Internal Mammary

A 55-year-old man developed severe mitral regurgitation with persistent fungal infective endocarditis 8 months after coronary artery bypass grafting with a left internal mammary artery and 2 saphenous veins, as well as mitral valve repair with a prosthetic ring. Echocardiography demonstrated severe mitral regurgitation and a valvular vegetation. Computed tomography coronary arteriography indicated that all grafts were patent and located intimately close to the sternum. Median resternotomy was not attempted due to the risk of injury to the bypass grafts, and therefore, a right anterolateral thoracotomy approach was utilized. Mitral valve replacement was performed with the patient under deep hypothermia and ventricular fibrillation without aortic cross-clamping. The patient`s postoperative course was uneventful. Thus, right anterolateral thoracotomy may be a superior approach to mitral valve surgery in patients who have undergone prior coronary artery bypass grafting.

Internal Mammary Artery Bypass Grafting in Left Main Stenosis

Cardiology ◽  
1993 ◽  
Vol 82 (5) ◽  
pp. 343-346
Author(s):  
Reinhard Höltgen ◽  
Ruud Krijne ◽  
Karl-Wilhelm Heinrich ◽  
Hermann Sons ◽  
Arno Krian
Keyword(s):  
Internal Mammary Artery ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Left Main ◽  
Artery Bypass Grafting ◽  
Left Main Stenosis ◽  
Internal Mammary

scholarly journals Aquatic Toxicity of Photocatalyst Nanoparticles to Green Microalgae Chlorella vulgaris

Water ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 77
Author(s):  
Cristina Adochite ◽  
Luminita Andronic
Keyword(s):  
Chlorella Vulgaris ◽  
Advanced Oxidation Process ◽  
Growth Parameters ◽  
Aquatic Toxicity ◽  
Basal Medium ◽  
Inhibitory Effect ◽  
Synthesis Methods ◽  
Potent Inhibitory Effect ◽  
Density Surface ◽  
The Impact

In the last years, nanoparticles such as TiO2, ZnO, NiO, CuO and Fe2O3 were mainly used in wastewater applications. In addition to the positive aspects concerning using nanoparticles in the advanced oxidation process of wastewater containing pollutants, the impact of these nanoparticles on the environment must also be investigated. The toxicity of nanoparticles is generally investigated by the nanomaterials’ effect on green algae, especially on Chlorella vulgaris. In this review, several aspects are reviewed: the Chlorella vulgaris culture monitoring and growth parameters, the effect of different nanoparticles on Chlorella vulgaris, the toxicity of photocatalyst nanoparticles, and the mechanism of photocatalyst during oxidative stress on the photosynthetic mechanism of Chlorella vulgaris. The Bold basal medium (BBM) is generally recognized as an excellent standard cultivation medium for Chlorella vulgaris in the known environmental conditions such as temperature in the range 20–30 °C and light intensity of around 150 μE·m2·s−1 under a 16/8 h light/dark cycle. The nanoparticles synthesis methods influence the particle size, morphology, density, surface area to generate growth inhibition and further algal deaths at the nanoparticle-dependent concentration. Moreover, the results revealed that nanoparticles caused a more potent inhibitory effect on microalgal growth and severely disrupted algal cells’ membranes.

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