scholarly journals Factors Associated with a Poor Treatment Outcome among Children Treated for Malaria in Ibadan, Southwest Nigeria

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Adesola O. Sangowawa ◽  
Olukemi K. Amodu ◽  
Subulade A. Olaniyan ◽  
Folakemi A. Amodu ◽  
Peter E. Olumese ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Neurological Complication ◽  
Age Groups ◽  
Significant Proportion ◽  
Neurological Complications ◽  
Severe Anaemia ◽  
Malarial Parasite ◽  
Factors Associated ◽  
Poor Treatment ◽  
Poor Treatment Outcome

We present data on factors associated with poor treatment outcome (death or recovery with a neurological complication) among children treated for malaria in Ibadan, Nigeria. A total of 2468 children (1532 with uncomplicated and 936 with severe malaria) were recruited from three government facilities. History was obtained from caregivers and malarial parasite test was carried out on each child. About 76.0% of caregivers had instituted home treatment. Following treatment, 2207 (89.5%) children recovered without complications, 9.1% recovered with neurological complications, and 1.4% died. The possibility of poor treatment outcome increased with decreasing child’s age (P<0.0001). A statistically significant proportion of children with pallor, jaundice, hepatomegaly, splenomegaly, respiratory distress, and severe anaemia had poor treatment outcome. Following logistic regression, child’s age < 12 months compared to older age groups (O.R = 5.99, 95% C.I = 1.15–31.15, and P=0.033) and loss of consciousness (O.R = 4.55, 95% CI = 1.72–12.08, and P=0.002) was significantly associated with poor treatment outcome. We recommend interventions to improve caregivers’ awareness on the importance of seeking medical care early. This will enhance early diagnosis and treatment and reduce the likelihood of complications that lead to poor treatment outcomes.

scholarly journals Diabetic Ketoacidosis Management and Treatment Outcome at Medical Ward of Shashemene Referral Hospital, Ethiopia: A Retrospective Study

2021 ◽  
Vol 14 ◽  
pp. 117955142110049
Author(s):  
Getu Melesie Taye ◽  
Amente Jorise Bacha ◽  
Fetene Abeje Taye ◽  
Mohammed Hussen Bule ◽  
Gosaye Mekonen Tefera
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Treatment Outcome ◽  
Hospital Mortality ◽  
Medical Ward ◽  
Inclusion Criteria ◽  
Potassium Supplementation ◽  
Poor Treatment ◽  
Poor Treatment Outcome ◽  
Concurrent Medication

Background: Diabetic Ketoacidosis (DKA) is the most common and yet potentially life-threatening acute complication of diabetes that progresses rapidly to death and requires immediate medical intervention. Objective: To assess the DKA management and treatment outcome/in-hospital mortality and its predictors among hospitalized patients with DKA at the Medical ward of Shashemene Referral Hospital (SRH). Method: A retrospective study was conducted at the Medical Ward of SRH from 01 February 2015 to 31 January 2017. A systematic random sampling technique was used to select study subjects based on the inclusion criteria. Thus, of 236 reviewed charts, only 225 patients with DKA fulfilled inclusion criteria. Treatment outcome was considered good for patients who have shown improvement at discharge, while poor for patients who left against medical advice or died in the hospital. Logistic regression analysis was done to determine independent predictors for treatment outcome/in-hospital mortality using SPSS version 20 with statistical significant at P ⩽ .05. Results: Of 225 patients with DKA, 124 (55.1%) were male. Regular insulin was prescribed to all patients and antibiotics were administered to 87 (38.7%). Potassium supplementation was given only for 28 (12.4%). Non-adherence to insulin treatment (n = 91; 40.4%) and infection (n = 66; 29.3%) were the principal DKA precipitating factors. Even though 73.8% of hospitalized patients with DKA have shown good treatment outcomes, DKA contributed 12% in-hospital mortality. The result of multivariate logistic regression analysis shown that hypoglycemia is the only independent predictor for in-hospital mortality[ P = .03]. Moreover, the independent predictors for poor DKA treatment outcome were found to be smoker [ P = .04], Urinary tract infection (UTI) relative to other co-morbid condition [ P < .001], severe hypokalemia which increase risk of poor treatment outcome by around 4 times [ P = .02], and use of Metronidazole as a concurrent medication relative to other concurrent medication [ P = .03]. Conclusion: There was a high in-hospital mortality rate due to correctable causes. This mortality is unacceptable as it was majorly related to the poor practice of potassium supplementation and hypoglycemia due to insulin. Thus, clinicians and stakeholders should have to focus on modifiable factors (hypokalemia, UTI, and hypoglycemia) to reduce poor treatment outcome/in-hospital mortality.

scholarly journals Childhood Tuberculosis Treatment Outcome and Its Association with HIV-Co infection in Ethiopia, A Systematic Review and Meta-analysis

2019 ◽  
Author(s):  
Getaneh Mulualem Belay ◽  
Chalachew Adugna Wubneh
Keyword(s):  
Systematic Review ◽  
Treatment Outcome ◽  
Successful Treatment ◽  
Meta Analysis ◽  
Tuberculosis Treatment ◽  
World Health ◽  
Successful Treatment Outcome ◽  
Poor Treatment ◽  
Poor Treatment Outcome ◽  
Tuberculosis Treatment Outcome

Abstract Introduction Globally around one million children are infected with Tuberculosis. Childhood Tuberculosis is underestimated due diagnosis challenge. HIV infection can affect the TB disease progression and treatment outcome.Objectives The aim of this systematic review and meta-analysis is to determine the pooled estimates of childhood tuberculosis treatment outcome and to analyze the impact of HIV-co infection.Methods We searched all available articles using PubMed, Google scholar and a web of science. Additionally, reference lists of included studies and Ethiopian institutional research repositories were used. Searching was limited to studies conducted in Ethiopia and published in English language. Cohort, cross-sectional and case-control studies were included. A weighted inverse variance random effects- model was used. The overall variations between studies were checked by heterogeneity test Higgins’s method (I 2 ). All included studies were assessed with the JBI quality appraisal criteria. Publication bias was checked with the funnel plot and Egger’s regression test.Result A total of 6 studies with 5,389 participants were included in this systematic review and meta-analysis. The overall pooled estimate of successful treatment outcome was found to be 79.54% (95% CI: 73.00, 86.07). Of which 72.44% were treatment completed. Moreover, this study revealed that the treatment failure, defaulter and death were 0.15%, 5.36%, and 3.54%, respectively. Poor treatment outcome was higher among children with HIV co infection with an odds ratio of 3.15 (95% CI: 1.67, 5.94) as compared to HIV negative children.Conclusion The rate of successful treatment outcome of childhood tuberculosis in Ethiopia found to be low compared to the threshold suggested by the world health organization. HIV co infection is significantly associated with poor treatment outcome. Therefore, special attention better to be given for children infected with HIV.

P-059: miRNA profiling of CD138+ plasma cells identifies miR-181a-5p overexpression as independent predictor of short-term progression and poor treatment outcome in multiple myeloma

2021 ◽  
Vol 21 ◽  
pp. S71
Author(s):  
Maria-Alexandra Papadimitriou ◽  
Aristea-Maria Papanota ◽  
Panagiotis Adamopoulos ◽  
Katerina-Marina Pilala ◽  
Christine-Ivy Liacos ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Treatment Outcome ◽  
Plasma Cells ◽  
Independent Predictor ◽  
Short Term ◽  
Mirna Profiling ◽  
Poor Treatment ◽  
Poor Treatment Outcome

scholarly journals SpecificgyrAgene mutations predict poor treatment outcome in MDR-TB

2015 ◽  
Vol 71 (2) ◽  
pp. 314-323 ◽  
Author(s):  
L. Rigouts ◽  
N. Coeck ◽  
M. Gumusboga ◽  
W. B. de Rijk ◽  
K. J. M. Aung ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Poor Treatment ◽  
Mdr Tb ◽  
Poor Treatment Outcome
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