scholarly journals Novel Starch-PVA Polymer for Microparticle Preparation and Optimization Using Factorial Design Study

2015 ◽  
Vol 2015 ◽  
pp. 1-8
Author(s):  
Helen Chattopadhyay ◽  
Amit Kumar De ◽  
Sriparna Datta
Keyword(s):  
Polyvinyl Alcohol ◽  
Factorial Design ◽  
Microscopic Study ◽  
Targeted Delivery ◽  
Release Kinetics ◽  
Three Dimensional ◽  
Control Release ◽  
Spherical Shape ◽  
Drug Release Profile ◽  
Electron Microscopic

The aim of our present work was to optimize the ratio of a very novel polymer, starch-polyvinyl alcohol (PVA), for controlled delivery of Ornidazole. Polymer-coated drug microparticles were prepared by emulsion method. Microscopic study, scanning electron microscopic study, and atomic force microscopic study revealed that the microparticles were within 10 micrometers of size with smooth spherical shape. The Fourier transform infrared spectroscopy showed absence of drug polymer interaction. A statistical 32 full factorial design was used to study the effect of different concentration of starch and PVA on the drug release profile. The three-dimensional plots gave us an idea about the contribution of each factor on the release kinetics. Hence this novel polymer of starch and polyvinyl alcohol can be utilized for control release of the drug from a targeted delivery device.

Modeling of Spatially Controlled Biomolecules in Three-Dimensional Porous Alginate Structures

2010 ◽  
Vol 4 (4) ◽  
Author(s):  
Ibrahim T. Ozbolat ◽  
Bahattin Koc
Keyword(s):  
Computer Aided Design ◽  
Solid Freeform Fabrication ◽  
Imaging Techniques ◽  
Release Kinetics ◽  
Three Dimensional ◽  
Control Release ◽  
Stochastic Approach ◽  
Distribution Characteristics ◽  
Porous Structures ◽  
Freeform Fabrication

This paper presents a computer-aided design (CAD) of 3D porous tissue scaffolds with spatial control of encapsulated biomolecule distributions. A localized control of encapsulated biomolecule distribution over 3D structures is proposed to control release kinetics spatially for tissue engineering and drug release. Imaging techniques are applied to explore distribution of microspheres over porous structures. Using microspheres in this study represents a framework for modeling the distribution characteristics of encapsulated proteins, growth factors, cells, and drugs. A quantification study is then performed to assure microsphere variation over various structures under imaging analysis. The obtained distribution characteristics are mimicked by the developed stochastic modeling study of microsphere distribution over 3D engineered freeform structures. Based on the stochastic approach, 3D porous structures are modeled and designed in CAD. Modeling of microsphere and encapsulating biomaterial distribution in this work helps develop comprehensive modeling of biomolecule release kinetics for further research. A novel multichamber single nozzle solid freeform fabrication technique is utilized to fabricate sample structures. The presented methods are implemented and illustrative examples are presented in this paper.

The Structure of the System: Filler Rubber. An Electron-Microscopic Study

1954 ◽  
Vol 27 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Friedrich Endter
Keyword(s):  
Natural Rubber ◽  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Three Dimensional ◽  
Electron Microscopic ◽  
Rubber Mixture ◽  
Dimensional Network ◽  
Bound Rubber ◽  
Microscopic Investigations

Abstract Electron microscopic investigations of the benzene-extraction residues of filler-natural rubber mixtures which are used for the determination of bound rubber, give a pattern of a three-dimensional network consisting of filler and bound rubber. The unchanged benzene-soluble rubber is present in the interstices of the network in the untreated filler-rubber mixture.

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