Spectral-Domain Optical Coherence Tomography of Preclinical Chloroquine Maculopathy in Egyptian Rheumatoid Arthritis Patients

Purpose. To evaluate the role of spectral-domain optical coherence tomography (SD-OCT) in early detection of Chloroquine maculopathy in rheumatoid arthritis (RA) patients.Methods. 40 left eyes of 40 female rheumatoid arthritis patients who received treatment chloroquine for more than one year were recruited in the study. All patients had no symptoms or signs of Chloroquine retinopathy. They were evaluated using SD-OCT, where the Central Foveal Thickness (CFT), parafoveal thickness and perifoveal thickness, average Retinal Nerve Fiber Layer (RNFL) thickness, and Ganglion Cell Complex (GCC) measurements were measured and compared to 40 left eyes of 40 normal females.Results. The mean CFT was found to be thinner in the Chloroquine group (238.15 µm ± 22.49) than the normal controls (248.2 µm ± 19.04), which was statistically significant (pvalue = 0.034). The mean parafoveal thickness was lesser in the Chloroquine group than the control group in all quadrants (pvalue<0.05). The perifoveal thickness in both groups showed no statistically significant difference (pvalue>0.05) in all quadrants. No significant difference was detected between the two groups regarding RNFL, GCC, or IS/OS junction.Conclusions. Preclinical Chloroquine toxicity can lead to early thinning in the central fovea as well as the parafoveal regions that is detected by SD-OCT.

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Association of Spectral-Domain Optical Coherence Tomography Findings with Visual Outcome of Macula-Off Rhegmatogenous Retinal Detachment Surgery

Ophthalmologica ◽

10.1159/000381786 ◽

2015 ◽

Vol 234 (2) ◽

pp. 83-90 ◽

Cited By ~ 16

Author(s):

Hae Min Kang ◽

Sung Chul Lee ◽

Christopher Seungkyu Lee

Keyword(s):

Optical Coherence Tomography ◽

Retinal Detachment ◽

Rhegmatogenous Retinal Detachment ◽

Subretinal Fluid ◽

Visual Outcome ◽

Spectral Domain ◽

Optical Coherence ◽

Foveal Thickness ◽

Central Foveal Thickness ◽

Sd Oct

Purpose: To identify prognostic factors for the visual outcome for patients with macula-off rhegmatogenous retinal detachment (RRD). Methods: The medical records of 27 patients (27 eyes) with macula-off RRD were retrospectively investigated. In addition to clinical characteristics, spectral-domain optical coherence tomography (SD OCT) images were analyzed. Results: The central foveal thickness at baseline was 923 ± 499.5 µm, and the mean height of the subretinal fluid was 697.8 ± 463.6 µm. Dropout of backreflection at the fovea was detected on preoperative SD OCT in 8 patients (29.6%). The external limiting membrane was disrupted in 5 patients (18.5%) as was the photoreceptor integrity in 9 patients (33.3%) at 12 months. On multiple regression analysis, backreflection integrity was the only predictive factor for postoperative visual outcome (B = 0.179, p = 0.020). Conclusions: Backreflection integrity on preoperative SD OCT seems to be helpful in predicting the postoperative visual outcome in macula-off RRD patients.

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Macular Thickness and Volume Assessed by Spectral-Domain Optical Coherence Tomography in Patients With Coronavirus Disease 2019: A Case-Control Study

10.21203/rs.3.rs-133611/v1 ◽

2020 ◽

Author(s):

Mojtaba Abrishami ◽

Fariba Tohidinezhad ◽

Zahra Emamverdian ◽

Ramin Daneshvar ◽

Neda Saeedian ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Retinal Thickness ◽

Spectral Domain ◽

Case Group ◽

Special Focus ◽

Optical Coherence ◽

Cross Sectional ◽

Significant Difference ◽

Normal Controls ◽

Sd Oct

Abstract Purpose: To quantify the retinal thickness and volume using spectral-domain optical coherence tomography (SD-OCT) analysis in the macular region of patients with Coronavirus Disease 2019 (COVID-19).Methods: In a comparative cross-sectional, observational study, patients recovered from COVID-19 were included. All included subjects had a reverse transcription-polymerase chain reaction (RT-PCR) - confirmed diagnosis of COVID-19. Macular SD-OCT was performed at least two weeks after recovery from systemic COVID-19. Inner, outer and full retinal thicknesses and volumes were measured in COVID-19 recovered patients versus age-matched normal controls.Results: Twenty-five patients (11 male) with a mean age of 36.4 ± 11 years and 60 healthy controls (31 males) with a mean age of 39.3 ± 7.7 years were enrolled in the study. There was no statistically significant difference in the retinal thickness or volume measures between the two groups. However, the thickness in the case group was minimally more than the controls. Conclusion: Retinal thickness in COVID-19 patients may be higher than healthy subjects. Comprehensive ocular examination with special focus on posterior segment manifestations should be considered in these patients.

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Retinal nerve fibre layer thickness in a healthy Nepalese population by spectral domain optical coherence tomography

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v6i2.11709 ◽

2014 ◽

Vol 6 (2) ◽

pp. 131-139 ◽

Cited By ~ 5

Author(s):

Madhu Thapa ◽

Safal Khanal ◽

Gulsan B Shrestha ◽

Ananda K Sharma

Keyword(s):

Optical Coherence Tomography ◽

Layer Thickness ◽

Nerve Fibre ◽

Retinal Nerve Fibre Layer ◽

Spectral Domain ◽

Optical Coherence ◽

Rnfl Thickness ◽

The Mean ◽

Nerve Fibre Layer ◽

Sd Oct

Objective: To determine the normal values for peripapillary retinal nerve fibre layer thickness (RNFL) measured by spectral domain optical coherence tomography (SD- OCT) in a healthy Nepalese population and to compare the RNFL thicknesses between the genders and among the various age groups.Material and methods: One hundred and fifty six eyes of 156 healthy Nepalese subjects (66 males and 88 females) of various age groups were enrolled in this observational, cross-sectional, hospital-based study. The peripapillary RNFL of the randomly chosen eye of each subject was imaged with a high resolution SD-OCT (Spectralis HRA+OCT, Heidelberg Engineering). The RNFL thickness was measured around the optic nerve head using 16 automatically averaged, consecutive, circular B scans with a 3.4 mm diameter and compared between the genders and among the various age groups.Results: The mean age of the subjects was 38.94 ± 17.00 years (range - 14 to 76 years). The average peripapillary RNFL was found to be 102.64 ± 9.56 μm (95 % CI 97.01 - 101.93). The mean ± SD peripapillary RNFL measurements at the superior, nasal, inferior and temporal sectors in the study population were 129.51 ± 15.09 μm, 76.55 ± 12.02 μm, 134.53 ± 17.19 μm and 70.74 ± 15.53 μm respectively. The average RNFL thickness was 99.47 ± 10.18 μm in the male whereas it was 105.09 ± 8.31 μm in the female participants. The RNFL decreased by 2.26 μm per age per decade. Conclusion: The Average RNFL thickness is 102.64 ± 9.56 μm in the Nepalese population. Gender and age related variation in the RNFL could serve as a useful guideline in the diagnosis of glaucoma in our population.DOI: http://dx.doi.org/10.3126/nepjoph.v6i2.11709Nepal J Ophthalmol 2014; 6(12): 131-139

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Comparison of Measurement of Central Corneal Thickness with Spectral Domain Optical Coherence Tomography and Standard Ultrasonic Pachymeter in Premature Infants

Journal of Ophthalmology ◽

10.1155/2015/129269 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Emre Hekimoglu ◽

Muhammet Kazım Erol ◽

Devrim Toslak ◽

Deniz Turgut Coban ◽

Berna Doğan ◽

...

Keyword(s):

Premature Infants ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Spectral Domain ◽

Optical Coherence ◽

Significant Difference ◽

The Mean ◽

Highly Correlated ◽

High Level ◽

Sd Oct

Purpose. To evaluate the repeatability of measurement of central corneal thickness (CCT) by spectral domain optical coherence (SD-OCT) in premature infants and compare it to CCT measurement by ultrasonic pachymetry (USP).Methods. Three CCT measurements of the left eyes of 50 premature infants were obtained by SD-OCT using the iVue system. 10 CCT measurements of each 28 left eyes of 28 infants were obtained by USP using the Pacscan 300P system. Bland-Altman plots were developed and the limit of agreement (LoA) was determined to compare the mean of the SD-OCT and USP measurements.Results. No statistically significant difference was found among the 3 CCT measurements by SD-OCT. Both USP and SD-OCT have been performed for only left eyes of 28 of the 50 babies. Those results have been compared with each other. A statistically significant difference was found between the mean CCT measurements by SD-OCT and USP (p<0.05). The LoA between the SD-OCT and USP measurements ranged from 11.4 to −64.1.Conclusions. CCT can be measured using the iVue SD-OCT system with a high level of repeatability. Although measurement of CCT by SD-OCT and USP is highly correlated, the 2 systems cannot be used interchangeably in premature infants.

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Macular Findings Obtained by Spectral Domain Optical Coherence Tomography in Retinopathy of Prematurity

Journal of Ophthalmology ◽

10.1155/2014/468653 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 12

Author(s):

Muhammet Kazim Erol ◽

Ozdemir Ozdemir ◽

Deniz Turgut Coban ◽

Ahmet Burak Bilgin ◽

Berna Dogan ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Birth Weight ◽

Premature Infants ◽

Gestational Age ◽

Retinopathy Of Prematurity ◽

Inverse Correlation ◽

Spectral Domain ◽

Optical Coherence ◽

Foveal Thickness ◽

Sd Oct

Purpose.To examine the macular findings obtained with spectral domain optical coherence tomography (SD OCT) in infants with retinopathy of prematurity (ROP).Materials and Methods.The macular SD OCT images of 190 premature infants were analyzed. Data regarding central foveal thickness (CFT), cystoid macular edema (CME), and cyst grading were compared. The relationships of CFT with gestational age and birth weight were investigated.Results.The results were obtained from 358 eyes of 179 infants (81 females and 98 males) of a mean gestational age of30.9±2.7weeks and a mean birth weight of1609±477 g. ROP was diagnosed in 126 eyes and CME in 139 eyes. A significantly greater percentage of eyes with ROP were found to have CME (54%) compared to eyes without ROP (31%;P=0.001). The incidence of CME was 46.3% for stage 1 ROP, 57.1% for stage 2, and 87.5% for stage 3. There was a weakly inverse correlation between CFT, gestational age, and birth weight (P=0.025,r=-0.227;P=0.002,r=-0.182, resp., Spearman correlation test).Conclusions.High-quality SD OCT images can be obtained from premature infants using the iVue system. Severity and frequency of CME in premature infants increase as stage of ROP increases.

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Choroidal thickness, ganglion cell complex, and photoreceptor outer segment length evaluation in patients receiving tamoxifen therapy by spectral domain optical coherence tomography

10.21203/rs.2.10351/v2 ◽

2019 ◽

Author(s):

selim bolukbasi ◽

Ozge Kandemir Gursel ◽

Akin Cakir ◽

Burak Erden ◽

Gamze Karatas

Keyword(s):

Optical Coherence Tomography ◽

Ganglion Cell ◽

Choroidal Thickness ◽

Outer Segment ◽

Tamoxifen Therapy ◽

Spectral Domain ◽

Ganglion Cell Complex ◽

Optical Coherence ◽

Photoreceptor Outer Segment ◽

Sd Oct

Abstract Background To evaluate choroidal thickness, ganglion cell complex (GCC) and photoreceptor outer segment length were measured in patients with breast cancer undergoing tamoxifen therapy, using spectral-domain optical coherence tomography (SD-OCT); results were compared with those for normal eyes. Methods Forty-four patients with breast cancer, undergoing tamoxifen therapy, and 41 healthy controls were included in this prospective, comparative study. All participants underwent a complete ophthalmologic evaluation and SD-OCT. Subfoveal, nasal (nasal distance to fovea 500, 1000, 1500 μm), and temporal (temporal distance to fovea 500, 1000, 1500 μm) choroidal thickness measurements were performed using the enhanced depth imaging mode of SD-OCT. Using an Early Treatment Diagnostic Retinopathy Study (ETDRS) circle at the macular level, the automated retinal segmentation software was applied to determine the thickness of the GCC. The photoreceptor outer segment (PROS) length was determined manually, as the distance from the inner surface of the ellipsoid zone to the inner surface of retina pigment epithelium. Results The mean choroidal thickness was statistically greater in the tamoxifen group than controls in all quadrants ( p < 0.001 for all quadrants). Of all tamoxifen users (44 eyes of 44 patients), 33 eyes (75%) had UCP. Pachychoroid pigment epitheliopathy (PPE) was detected in five tamoxifen-group patients (11.3%). Patients with PPE in one eye had UCP in the fellow eye. Central serous chorioretinopathy findings were observed in one patient. Tamoxifen users had statistically lower GCC thickness in all inner rings of the ETDRS inlay and in the nasal outer ring only ( p = 0.027, 0.002, 0.002, 0.001, and 0.030, respectively). No statistically significant difference in mean subfoveal PROS length was found between the groups. Conclusions SD-OCT provides valuable information for identifying structural changes and evaluating ocular findings in patients receiving tamoxifen therapy. Increased choroidal thickness, PPE and thinning GCC were detected in tamoxifen users. These OCT findings may be an early indicator of retinal toxicity for patients undergoing tamoxifen therapy in the follow-up period. Keywords tamoxifen retinopathy, choroidal thickness, ganglion cell complex, PROS, spectral-domain optical coherence tomography

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Macular and choroidal thicknesses in a healthy Hispanic population evaluated by high-definition spectral-domain optical coherence tomography (SD-OCT)

International Journal of Retina and Vitreous ◽

10.1186/s40942-020-00270-9 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Diana A. Cortés ◽

Daniela Roca ◽

Pedro Iván Navarro ◽

Francisco J. Rodríguez

Keyword(s):

Optical Coherence Tomography ◽

Choroidal Thickness ◽

Correlation Study ◽

Spectral Domain ◽

Optical Coherence ◽

Hispanic Population ◽

High Definition ◽

Cross Sectional ◽

Significant Difference ◽

Sd Oct

Abstract Purpose To report normal values of macular and choroidal thickness obtained from a healthy Hispanic population using Optovue (Optovue Inc, Freemont CA, USA) spectral domain optical coherence tomography (SD-OCT). Design Observational, cross-sectional, correlation study. Methods A total of 290 eyes (145 healthy subjects) were included; 69% of subjects were female. The median age was 39 ± 29 years (IQR), with a range between 18 and 89 years. The study sample was stratified into three age groups: Group 1, 18–40 years (50.3%), Group 2, 41–60 years (30.7%), and Group 3, older than 61 years (19%). Central macular, perifoveal (inner quadrants), and parafoveal (outer quadrants) thicknesses were estimated. In addition, central and peripheral choroidal thicknesses were estimated. Data analysis was performed to calculate the standardized mean difference according to the variance (Student’s t-test) and its differences with Epidat 4.1. Results Median macular central thickness was 250 ±30 µm (IQR) with Optovue. Median central choroidal thickness was 263 ± 48 µm (IQR). Median central choroidal thickness was greater than mean peripheral thickness. Macular evaluation showed a statistically significant difference in central, perifoveal, and parafoveal thicknesses, with lower values being recorded for the study sample compared with the manufacturer’s data. Conclusions SD-OCT has become a useful tool to obtain high-resolution images of the macula and choroid. This method allows precise assessment of the retinal and choroidal layers to diagnose and follow up posterior segment diseases. We are reporting normal cut-off values of macular and choroidal thicknesses in healthy Hispanic subjects evaluated with Optovue SD-OCT as new diagnostic normal parameters for research and clinical activities.

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Impact of Epiretinal Membrane on Optical Coherence Tomography Tools Used for Monitoring Glaucoma

Diagnostics ◽

10.3390/diagnostics11122203 ◽

2021 ◽

Vol 11 (12) ◽

pp. 2203

Author(s):

Marco Rocco Pastore ◽

Riccardo Merli ◽

Carmen Dell’Aquila ◽

Lorenzo Belfanti ◽

Marco Franzon ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Epiretinal Membrane ◽

Automatic Segmentation ◽

Control Group ◽

Optical Coherence ◽

Fiber Layer ◽

Significant Difference ◽

Spectralis Oct ◽

The Impact ◽

Sd Oct

Background: Retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) measurements can be influenced by many factors including the presence of concomitant retinal diseases. The aim of this study it to assess the impact of epiretinal membrane (ERM) on RNFL and GCL assessment using optical coherence tomography (OCT). Methods: GCL, peripapillary RNFL (pRNFL), and Bruch’s Membrane Opening Minimum Rim Width (BMO-MRW) thicknesses were analysed using an SD-OCT (Spectralis OCT) in eyes with idiopathic ERM and compared with a control group. Results: 161 eyes were included, 73 eyes in the control group and 88 eyes with idiopathic ERM. The pRNFL analysis revealed a statistically significant difference between the two groups in overall and temporal sector thicknesses. For GCL thickness report, the percentage of scans in which the GCL was erroneously segmented by automatic segmentation was assessed for each eye. A statistically significant difference was found in all sectors (p < 0.001), with the exception of external nasal sector. A statistically significant difference (p < 0.001) in the GCL total volume report was found in ERM group compared to the control group. For MRW at BMO analysis, there was no statistically significant difference in MRW thickness in any sector. Conclusion: In eyes with ERM, the GCL and pRNFL analysis seemed affected by the morphological retinal layers’ modification. MRW-BMO did not appear to be directly affected by the presence of ERM.

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The Diagnostic Value of Pulsar Perimetry, Optical Coherence Tomography, and Optical Coherence Tomography Angiography in Pre-Perimetric and Perimetric Glaucoma

Journal of Clinical Medicine ◽

10.3390/jcm10245825 ◽

2021 ◽

Vol 10 (24) ◽

pp. 5825

Author(s):

Hung-Chih Chen ◽

Michael Chia-Yen Chou ◽

Ming-Tsung Lee ◽

Chia-Yi Lee ◽

Che-Ning Yang ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Ganglion Cell ◽

Optical Coherence Tomography Angiography ◽

Diagnostic Value ◽

Vessel Density ◽

Control Group ◽

Ganglion Cell Complex ◽

Optical Coherence ◽

The Mean ◽

Sensitive Parameters

The purpose of this article is to investigate the diagnostic value of Pulsar perimetry (PP), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA) in pre-perimetric glaucoma (PPG) and perimetric glaucoma (PG). This retrospective cross-sectional study included 202 eyes (145 eyes in the control group, 40 eyes in the PPG group, and 17 eyes in the PG group) from 105 subjects. The results were analyzed by paired t-tests and Wilcoxon signed-rank test. The area under the curve (AUC), sensitivity, and specificity were used to evaluate the diagnostic accuracy. Pearson correlation was used to investigate the relationships of each parameter. The most sensitive parameters for differentiating the control group from the PPG group by using Pulsar, OCT, and OCTA were square loss variance of PP (AUC = 0.673, p < 0.001), superior ganglion cell complex thickness (AUC = 0.860, p < 0.001), and superior-hemi retina thickness (AUC = 0.817, p < 0.001). In the PG group, the most sensitive parameters were mean defect of PP (AUC = 0.885, p < 0.001), whole image of ganglion cell complex thickness (AUC = 0.847, p < 0.001), and perifoveal retina thickness (AUC = 0.833, p < 0.001). The mean defect of PP was significantly correlated with vascular parameters (radial peripapillary capillary (RPC), p = 0.008; vessel density of macular superficial vascular complex (VDms), p = 0.001; vessel density of macular deep vascular complex (VDmd), p = 0.002). In conclusion, structural measurements using OCT were more sensitive than vascular measurements of OCTA and functional measurements of PP for PPG, while PP was more sensitive than the structural and vascular measurements for PG. The mean defect of PP was also shown to be highly correlated with the reduction of vessel density.

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Retinal Optical Coherence Tomography Angiography Findings of Acute Anterior Uveitis

10.21203/rs.3.rs-576509/v1 ◽

2021 ◽

Author(s):

Gülay Yalçınkaya ◽

Çiğdem Altan ◽

Berna Başarır ◽

İhsan Çakır

Keyword(s):

Optical Coherence Tomography ◽

Anterior Uveitis ◽

Optical Coherence Tomography Angiography ◽

Foveal Avascular Zone ◽

Control Group ◽

Optical Coherence ◽

Foveal Thickness ◽

Retinal Microvasculature ◽

Significant Difference ◽

Capillary Plexus

Abstract Purpose: To evaluate the changes in retinal microvasculature in eyes with anterior uveitis (AU) using optical coherence tomography angiography.Methods: Foveal avascular zone (FAZ) of superficial capillary plexus (SCP) and deep capillary plexus (DCP), vessel density (VD) of SCP, DCP, and choriocapillaris, and central macular thickness (CMT) and central foveal thickness (CFT) were calculated from 34 healthy and 41 uveitic eyes. The parameters were compared between the two groups.Results: The deep FAZ was significantly lower in the eyes with AU during the attack than after recovery and the control group (p=0.001 and p=0.003, respectively). The VD in deep capillary plexus (DCP) in eyes with AU during the attack was significantly higher than the control group (p=0.048). The VD in the foveal sector of DCP in eyes with AU during the attack and after recovery was significantly higher than the control group (p=0.001 and p=0.031, respectively). There was no significant difference regarding CMT, CFT, VDs of each segment and each sector, and superficial and deep FAZ between eyes with first uveitis attack and those with recurrent uveitis during the attack and after recovery (p>0.05). Conclusion: The results of this study show that there is a reduction in the FAZ and an increase in the VD of the DCP of the retina during active AU, and these findings are reversible. Acute AU may affect the macular microvasculature, which is usually temporary, especially in the DCP.

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