scholarly journals Retinal Optical Coherence Tomography Angiography Findings of Acute Anterior Uveitis

2021 ◽  
Author(s):  
Gülay Yalçınkaya ◽  
Çiğdem Altan ◽  
Berna Başarır ◽  
İhsan Çakır
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Uveitis ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Control Group ◽  
Optical Coherence ◽  
Foveal Thickness ◽  
Retinal Microvasculature ◽  
Significant Difference ◽  
Capillary Plexus

Abstract Purpose: To evaluate the changes in retinal microvasculature in eyes with anterior uveitis (AU) using optical coherence tomography angiography.Methods: Foveal avascular zone (FAZ) of superficial capillary plexus (SCP) and deep capillary plexus (DCP), vessel density (VD) of SCP, DCP, and choriocapillaris, and central macular thickness (CMT) and central foveal thickness (CFT) were calculated from 34 healthy and 41 uveitic eyes. The parameters were compared between the two groups.Results: The deep FAZ was significantly lower in the eyes with AU during the attack than after recovery and the control group (p=0.001 and p=0.003, respectively). The VD in deep capillary plexus (DCP) in eyes with AU during the attack was significantly higher than the control group (p=0.048). The VD in the foveal sector of DCP in eyes with AU during the attack and after recovery was significantly higher than the control group (p=0.001 and p=0.031, respectively). There was no significant difference regarding CMT, CFT, VDs of each segment and each sector, and superficial and deep FAZ between eyes with first uveitis attack and those with recurrent uveitis during the attack and after recovery (p>0.05). Conclusion: The results of this study show that there is a reduction in the FAZ and an increase in the VD of the DCP of the retina during active AU, and these findings are reversible. Acute AU may affect the macular microvasculature, which is usually temporary, especially in the DCP.

scholarly journals Assessment of Macular Capillary Perfusion by Optical Coherence Tomography Angiography on Quiescent Unilateral Anterior Pediatric Uveitis

2021 ◽  
Author(s):  
Junyan Xiao ◽  
Yi Qu ◽  
Chan Zhao ◽  
Hang Song ◽  
Anyi Liang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Flow Density ◽  
Vascular Density ◽  
Optical Coherence ◽  
Pediatric Uveitis ◽  
Retinal Microvasculature ◽  
Capillary Plexus ◽  
Fellow Eyes

Abstract Purpose: Using spectral domain optical coherence tomography angiography (SD-OCTA) to evaluate tomographic and microvascular parameters in the macula in quiescent unilateral anterior pediatric uveitis (APU) patients.Methods: Forty-two eyes of 21 patients diagnosed with unilateral APU and 21 eyes of 21 normal controls (NC) were included in this study. 6*6 mm macular scanning mode of SD-OCTA was used for all subjects. The central macular thickness (CMT), subfoveal choroidal thickness (SFCT), vascular density (VD) of superficial capillary plexus (SCP) and the deep capillary plexus (DCP), the foveal avascular zone (FAZ) area, and choriocapillary flow density (CFD) were analyzed and compared among affected, fellow, and NC eyes. Correlation analysis were used to evaluate the potential correlating factors with CFD.Results: DCP VD and CFD were significantly lower in quiescent affected eyes as compared to fellow and NCs eyes (DCP VD both p<0.001; CDF1.0: p=0.012 and p=0.003; CDF1.5: p=0.015 and p=0.006; CDF3.0: p=0.036 and p=0.010, respectively). SCP VD, DCP VD and CMT were significantly lower in the fellow eyes as compared to NC eyes (p=0.021; p<0.001; p=0.037, respectively); CFD was negatively correlated with FAZ and CMT in affected eyes and fellow eyes. No significant differences were detected in FAZ among the 3 groups (p > .05).Conclusions: As compared to NC eyes, both retinal and choroidal microvasculature were impaired in eyes with quiescent APU; retinal microvasculature in unaffected fellow eyes of unilateral APU was also impaired. OCTA is a useful technology for detection of subclinical microvascular changes in APU and may be useful as an additional prognostic tool.

scholarly journals Macular perfusion density evaluation in constant and intermittent exotropia by means of optical coherence tomography angiography

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jing Zhai ◽  
Wei Fang ◽  
Xueting Yu ◽  
Xinjie Ye ◽  
Lijie Hou
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Cross Sectional Study ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Intermittent Exotropia ◽  
Cross Sectional ◽  
Significant Difference ◽  
Capillary Plexus ◽  
Perfusion Density

Abstract Background To quantify and compare retinal microvascular features using optical coherence tomography angiography (OCTA) in constant (XT) and intermittent exotropia (IXT). Methods An observational cross-sectional study was conducted from September 2020 to November 2020 at the Affiliated Eye Hospital of Wenzhou Medical University. OCTA examination was performed to evaluate the macular perfusion density of the deep capillary plexus (DCP), superficial capillary plexus (SCP), and foveal avascular zone (FAZ) parameters in XT and IXT patients, and in age-matched controls. The study parameters were analyzed. Results A total of 76 participants, including 16 (21%) XT patients, 24 (32%) IXT patients, and 36 (47%) controls, were recruited. The exodeviation angle was 39.06 ± 10.38 prism degrees (PD) at near and 43.00 ± 9.74 PD at distance in the XT group, and 27.13 ± 18.28 PD at near and 31.04 ± 18.82 PD at distance in the IXT group. The macular perfusion density of the DCP in 6 × 6-mm scans and the SCP in 3 × 3-mm scans were lower in the deviating eyes than in the fixating eyes of XT patients (p < 0.001, p = 0.032, respectively). The macular perfusion density of the DCP in the deviating eyes of XT and IXT patients was significantly lower than that of the controls. There was no significant difference in the FAZ parameters among the groups. Conclusions In XT patients, OCTA revealed lower macular perfusion density in deviating eyes than in fixating eyes and control eyes. IXT patients showed no difference between the two eyes, but the macular perfusion density of the DCP was lower than that of the controls.

Wide-field swept-source optical coherence tomography angiography in the assessment of retinal microvasculature and choroidal thickness in patients with myopia

2021 ◽  
pp. bjophthalmol-2021-319540
Author(s):  
Jade Y. Moon ◽  
Itika Garg ◽  
Ying Cui ◽  
Raviv Katz ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Systemic Hypertension ◽  
Wide Field ◽  
Optical Coherence ◽  
Swept Source ◽  
Retinal Microvasculature ◽  
Capillary Plexus

Background/aimsPathological myopia (PM) is a leading cause of blindness worldwide. We aimed to evaluate microvascular and chorioretinal changes in different stages of myopia with wide-field (WF) swept-source (SS) optical coherence tomography angiography (OCTA).MethodsThis prospective cross-sectional observational study included 186 eyes of 122 patients who had undergone imaging between November 2018 and October 2020. Vessel density (VD) and vessel skeletonised density (VSD) of superficial capillary plexus, deep capillary plexus and whole retina, as well as foveal avascular zone parameters, retinal thickness (RT) and choroidal thickness (CT), were calculated.ResultsThis study evaluated 75 eyes of 48 patients with high myopia (HM), 43 eyes of 31 patients with mild to moderate myopia and 68 eyes of 53 age-matched controls. Controlling for age and the presence of systemic hypertension, we found that HM was associated with decrease in VD and VSD in all layers on 12×12 mm² scans. Furthermore, HM was associated with a VD and VSD decrease in every Early Treatment Diabetic Retinopathy Study grid, with a larger decrease temporally (βVD=−0.39, βVSD=−10.25, p<0.01). HM was associated with decreased RT and CT. Reduction in RT was outside the macular region, while reduction in CT was in the macular region.ConclusionUsing WF SS-OCTA, we identified reduction in microvasculature and structural changes associated with myopia. Decrease in VD and VSD was greater in the temporal quadrant, and reductions in RT and CT were uneven across the retina. Further work may help identify risk factors for the progression of PM and associated vision-threatening complications.

Optical coherence tomography angiography findings in young β-thalassemia patients

2020 ◽  
Vol 30 (3) ◽  
pp. 600-607
Author(s):  
Elif Güler Kazancı ◽  
Muhammet Furkan Korkmaz ◽  
Mehmet Erol Can
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Control Group ◽  
Study Group ◽  
Optical Coherence ◽  
Avascular Zone ◽  
Capillary Plexus ◽  
The Mean ◽  
Superficial Capillary Plexus

Purpose: The purpose was to evaluate retinal vascular parameters by optical coherence tomography angiography in β-thalassemia major patients. Methods: Thirty-three patients with β-thalassemia major (study group) and 29 healthy children (control group) were enrolled in the study. All subjects underwent a complete ocular examination. The mean foveal avascular zone, non-flow area, foveal avascular zone perimeter, acircularity index of foveal avascular zone, foveal density, the superficial capillary plexus, and deep capillary plexus were scanned using 6 × 6 mm optical coherence tomography angiography scans centered on the macula. Superficial capillary plexus and deep capillary plexus were also scanned centered on the optic disk. We collected data on histories of patients, and hemoglobin and ferritin were also studied from both groups. Results: The mean age was 13.85 ± 4.69 years (range: 4–21 years) in β-thalassemia major group and 12.59 ± 3.66 years (range: 6–18 years) in the control group. The mean foveal avascular zone value was 0.265 ± 0.11 mm2 in the study group and 0.296 ± 0.12 mm2 in the control group. The mean non-flow area value was 0.468 ± 0.12 mm2 in the study group and 0.479 ± 0.14 mm2 in the control group ( p > 0.05). Differences in the mean values for foveal density and acircularity index were statistically significant between the study group and control group ( p < 0.05, p = 0.026, and p = 0.026, respectively). Superficial capillary plexus and deep capillary plexus were not a significant difference between the study and control groups in 6 × 6 mm scans on macula and 4.5 × 4.5 mm scans on optic disk area ( p > 0.05). Acircularity index was negatively correlated ( r = −0.292, p = 0.026), and foveal density was positively correlated with hemoglobin ( r = 0.292, p = 0.026). Conclusion: By using optical coherence tomography angiography, we detected foveal microvascular changes in young β-thalassemia patients before significant ocular anomalies development.

Evaluation of retinochoroidal tissues in third trimester pregnants: An optical coherence tomography angiography study

2020 ◽  
pp. 112067212096656
Author(s):  
Abdulmutalip Yildirim ◽  
Emin Kurt ◽  
Muhammed Altinisik ◽  
Yildiz Uyar
Keyword(s):  
Optical Coherence Tomography ◽  
Pregnant Women ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Control Group ◽  
Vascular Density ◽  
Optical Coherence ◽  
Third Trimester ◽  
The Third ◽  
Significant Difference

Introduction: The structural and vascular changes in the retina and choroid in women in the third trimester of pregnancy were analyzed using optical coherence tomography angiography (OCTA). Methods: Forty women in the third trimester of uncomplicated pregnancy and 40 age-matched healthy women were included. Vascular density (VD) in the superficial and deep capillary plexuses (SCP/DCP), foveal density (FD), and foveal avascular zone (FAZ) area and perimetry measured with OCTA, as well as OCT measurements of central macular thickness (CMT) and choroidal thickness (CT) were compared between the groups. Correlations between structural OCT parameters and vascular OCTA metrics were analyzed. Results: The mean gestational age was 34 (28–41) weeks. Mean age was comparable in the groups ( p = 0.732). The pregnant women had significantly higher parafoveal DCP-VD ( p = 0.015), FAZ area ( p = 0.044), and FD ( p = 0.002). Mean subfoveal CT was 21 µm higher in pregnant women but was not significant ( p = 0.472). There was no difference in CMT ( p = 0.448). FAZ metrics were positively correlated with CT in pregnants and with CMT in the control group ( p < 0.05). Parafoveal VD was negatively correlated with CT in the control group ( p < 0.05). After adjusting for CT and CMT, the significant difference in VD and FD persisted ( p < 0.05), while the difference in FAZ area lost significance ( p > 0.05). Conclusions: Considering the effects of the probable covariant factors CMT and CT, systemic changes in pregnant women in their third trimester may cause an increase in VD in the macula and parafoveal DCP.

Optical coherence tomography angiography findings of diabetic patients with and without retinopathy

2021 ◽  
pp. 112067212199056
Author(s):  
Emine Temel ◽  
Figen Batıoğlu
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Diabetic Patients ◽  
Optical Coherence ◽  
Significant Difference ◽  
Capillary Plexus ◽  
The Difference ◽  
Healthy Persons ◽  
Group 1

Purpose: To emphasize the importance of optical coherence tomography angiography (OCTA) in the diagnosis and follow-up of diabetic individuals with and without retinopathy. Methods: Retrospective, cross-sectional, observational study of healthy persons and diabetic individuals with and without retinopathy. Area of the foveal avascular zone (FAZ) (mm²), non-perfused areas in the superficial capillary plexus (SCP), mean vessel density (VD) in the SCP, and deep capillary plexus (DCP) were calculated. In eyes with diabetic retinopathy (DR), measurements at baseline, 3rd, 6th, 9th, and 12th months were evaluated. Results: This study conducted on 39 eyes of 23 patients with DR (group 1), 59 eyes of 30 diabetic individuals without DR (group 2), and 51 eyes of 27 healthy persons (group 3). When the mean area of the FAZ at baseline was compared between groups, the difference among groups 1 and 3 ( p < 0.001) and the difference among groups 2 and 3 ( p = 0.001) were statistically significant. There was no significant difference among the measurements of mean area of the FAZ, mean non-perfused area in the SCP, mean VD in SCP, and DCP at baseline, 3rd, 6th, 9th, and 12th months in group 1. Conclusion: OCTA is a developing technology that can detect early microvascular changes in diabetic patients.

Intra- and Interdevice Deviation of Optical Coherence Tomography Angiography

2019 ◽  
Vol 236 (04) ◽  
pp. 551-554 ◽  
Author(s):  
Stefan Trachsler ◽  
Arthur Baston ◽  
Marcel Menke
Keyword(s):  
Optical Coherence Tomography ◽  
Healthy Subjects ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Swept Source ◽  
Significant Difference ◽  
Capillary Plexus ◽  
Swept Source Oct ◽  
Scan Modes

Abstract Purpose To compare 4 optical coherence tomography-angiography (OCT-A) devices for foveal avascular zone (FAZ) measurements in healthy subjects. Methods The central retinas of 24 eyes of 12 healthy subjects were scanned with 4 different OCT-A devices (Optovue RTVue-XR, Zeiss Cirrus 5000-HD-OCT, a prototype Spectralis OCT2, Heidelberg Engineering, and Topcon DRI-OCT Triton Swept-source OCT). For the Topcon, Zeiss, and Optovue devices, 3-mm and 6-mm scans were performed. The Heidelberg device only provided 4-mm scans. En-face OCT-A images of the superficial and deep capillary plexus of the macular area were generated. The FAZ areas were measured and compared. Results Twenty-four healthy eyes were included. OCT-A devices showed significant differences in FAZ measurements. The Zeiss OCT-A device measured the smallest values for foveal avascular area (mean 218.7 mm2), followed by the Optovue device (229.6 mm2), the Topcon device (239.3 mm2), and the Heidelberg device (250.4 mm2). Differences were statistically significant for following devices: Heidelberg versus Optovue (p < 0.001), Heidelberg versus Zeiss (p < 0.001), Topcon versus Zeiss (p < 0.001), and Optovue versus Zeiss (p = 0.046). For the Optovue device, FAZ measurements were significantly different between 3 mm (mean 220 mm2) and 6 mm (mean 239.3 mm2, p = 0.007) scans. All other devices showed no significant difference within scan modes. Conclusion Current OCT-A devices provide images that allow such measurements, but values showed significant differences between devices and, for the Optovue instrument, even within scan modes. The data for OCTA measurements cannot be transferred interchangeably between the devices. Therefore, a patient should always be measured with the same device.

scholarly journals Retinal and Choriocapillaris Vascular Changes in Patients Affected by Different Clinical Phenotypes of β-Thalassemia: An Optical Coherence Tomography Angiography Study

Biology ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 276
Author(s):  
Gilda Cennamo ◽  
Daniela Montorio ◽  
Giuliano Mazzella ◽  
Paolo Ricchi ◽  
Silvia Costantini ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Clinical Phenotypes ◽  
Thalassemia Minor ◽  
Significant Difference ◽  
Avascular Zone ◽  
Capillary Plexus

In this cross-sectional study we assessed the vascular alterations in retinal and choriocapillaris perfusion in patients affected by β-thalassemia, by means of optical coherence tomography angiography (OCTA). A total of 124 eyes of 62 patients (mean age 44.74 ± 5.79 years old) affected by β-thalassemia (transfusion dependent thalassemia (TDT), non-transfusion dependent thalassemia (NTDT) and minor) were compared to 40 eyes of twenty healthy subjects. We evaluated the vessel density (VD) in superficial capillary plexus, deep capillary plexus, radial peripapillary capillary, choriocapillaris and the foveal avascular zone area. The TDT group showed a statistically significant reduction in retinal and choriocapillaris VD respect to controls and the other groups (p < 0.05). No statistically significant difference was found in OCTA parameters between β-thalassemia minor and controls. The NTDT group showed a significant reduction in VD in deep capillary plexus respect to controls and β-thalassemia minor. Significant negative correlations were shown in TDT group between foveal avascular zone and hemoglobin (r = −0.437, p = 0.044) and between ferritin levels and VD of choriocapillaris (r = −0.431, p = 0.038). The OCTA parameters provided a deeper understanding on retinal and choriocapillaris vascular impairment affected by tissue hypoxia levels and the oxidative stress in different clinical phenotypes of the β-thalassemia.

scholarly journals Retinal microvascular alterations after phacoemulsification in patients with diabetes evaluated using optical coherence tomography angiography

2019 ◽  
Author(s):  
Le Feng ◽  
Guliqiwaer Azhati ◽  
Tingting Li ◽  
Fang Liu
Keyword(s):  
Optical Coherence Tomography ◽  
Cataract Surgery ◽  
Optical Coherence Tomography Angiography ◽  
Macular Thickness ◽  
Diabetic Group ◽  
Foveal Avascular Zone ◽  
Diabetic Patients ◽  
Optical Coherence ◽  
Retinal Microvasculature ◽  
Significant Difference

Abstract Purpose: To quantify changes in retinal microvasculature in diabetic patients after phacoemulsificatio by using optical coherence tomography angiography (OCTA). Methods: Macular thickness(MT), superficial capillary plexus (SCP), deep capillary plexuses (DCP) and foveal avascular zone (FAZ) measurements of the 3×3 mm macular images were obtained by OCTA at baseline, 1 day,1 week, 1 month, and 3 months after cataract surgery in diabetic and non- diabetic patients. Results: There was a significant increase in MT at 1 month and 3 months after surgery in both groups (all P<0.05), but no significant difference between the two groups (p= 0.217). At 3 months postoperatively, the SCP increase was significantly higher compared with baseline in diabetic group (P<0.05). The MT and SCP was negatively correlated with logMAR best corrected visual acuity(BCVA), while the FAZ area and perimeter were positively correlated with logMAR BCVA in diabetic group. Conclusions: Cataract surgery can increase macular thickness in both diabetic and non- diabetic patients, and also increase the SCP in diabetic patients. Whether these changes will persist a longer period still needs to be followed up.

Evaluation of Lamellar Macular Hole With Optical Coherence Tomography Angiography and Comparison Between Degenerative and Tractional Subtypes

2021 ◽  
Author(s):  
Burcu Polat Gültekin
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Hole ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Control Group ◽  
Vascular Density ◽  
Lamellar Macular Hole ◽  
Optical Coherence ◽  
Macular Holes ◽  
Significant Difference

Abstract Aim To evaluate the optical coherence tomography angiography (OCTA) findings in cases with degenerative and tractional-subtype lamellar macular hole (LMH). Methods Two sub-types of LMH cases were included. Thirty-seven patients had degenerative-subtype, whereas 35 patients had tractional-subtype LMH. Thirty healthy cases were enrolled as control group. Foveal avascular zone (FAZ), retinal vascular densities in superficial, deep capillary and choriocapillaris plexuses were analyzed and compared with fellow eyes and healthy controls using OCTA. Results Mean FAZ area was wider in the degenerative-subtype (0.33±0.14 mm²) than the tractional-subtype (0.24±0.10 mm²) (p=0.04) and control eyes (0.26±0.10 mm2) (p=0.02). Compared with the tractional group, foveal vessel density in the superficial layer was lower in the degenerative group (29.1±6.9% vs.21.9±9.2%, p=0.01). Choriocapillaris vascular density in the parafoveal area was also lower in the degenerative-subtype lamellar macular holes ( 61.8±4.7% vs. 63.2±4.2 %) (p=0.03). The vascular densities in the DCP did not disclose any significant difference between two sub-types (p>0.05). Compared with control eyes, the vascular densities in the superficial, deep and choriocapillaris layers were significantly lower in the LMH subtypes (p<0.05). Conclusion These OCTA changes may indicate a primary or secondary chronic degenerative process affecting the retinal microvascular plexuses in degenerative and tractional lamellar macular holes. The distinction of the pathogenesis is also demonstrated by OCTA and supports the recent change in classification and terminology of this macular pathology.

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