scholarly journals Comparative Effects of Retinoic Acid or Glycolic Acid Vehiculated in Different Topical Formulations

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Patrícia Maria Berardo Gonçalves Maia Campos ◽  
Lorena Rigo Gaspar ◽  
Gisele Mara Silva Gonçalves ◽  
Lúcia Helena Terenciane Rodrigues Pereira ◽  
Marisa Semprini ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Glycolic Acid ◽  
Mechanisms Of Action ◽  
Hairless Mouse ◽  
Cell Renewal ◽  
Horny Layer ◽  
Hydroxy Acids ◽  
Topical Formulation ◽  
Hairless Mice ◽  
Regulation Of Growth

Retinoids and hydroxy acids have been widely used due to their effects in the regulation of growth and in the differentiation of epithelial cells. However, besides their similar indication, they have different mechanisms of action and thus they may have different effects on the skin; in addition, since the topical formulation efficiency depends on vehicle characteristics, the ingredients of the formulation could alter their effects. Thus the objective of this study was to compare the effects of retinoic acid (RA) and glycolic acid (GA) treatment on the hairless mouse epidermis thickness and horny layer renewal when added in gel, gel cream, or cream formulations. For this, gel, gel cream, and cream formulations (with or without 6% GA or 0.05% RA) were applied in the dorsum of hairless mice, once a day for seven days. After that, the skin was analyzed by histopathologic, morphometric, and stereologic techniques. It was observed that the effects of RA occurred independently from the vehicle, while GA had better results when added in the gel cream and cream. Retinoic acid was more effective when compared to glycolic acid, mainly in the cell renewal and the exfoliation process because it decreased the horny layer thickness.

R401 – Anti-Aging Compounds and Epidermal Effects on Mouse Skin

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P177-P177
Author(s):  
Tapan K Bhattacharyya ◽  
Natalie P Higgins ◽  
J Scott Sebastian ◽  
J Regan Thomas
Keyword(s):  
Retinoic Acid ◽  
Side Effects ◽  
Vitamin C ◽  
Glycolic Acid ◽  
Mouse Skin ◽  
Hairless Mouse ◽  
Nuclear Antigen ◽  
Proliferation Index ◽  
Cutaneous Side Effects ◽  
Significant Difference

Problem To compare topical effects of 5 anti-aging agents on epidermal histology in the non-irradiated hairless mouse. Methods Female retired breeders (SKH-1 hairless mouse) were treated topically on the dorsal skin with 5 commercially available agents as a daily treatment for 2 weeks. The agents used were retinoic acid, glycolic acid, estrogen, soy, and vitamin C. Skin sections were analyzed in the light microscope to acquire morphometric data of keratinocyte proliferation (Index of Proliferating Cell Nuclear Antigen), epidermal thickness, and nuclear volume of cells from three epidermal layers. Quantitative data were analyzed with SPSS 14.0 statistical software to detect significant difference between the means of control and 5 experimental groups. Results Epidermal stimulation was observed with all cosmeceuticals but most pronounced effects resulted from the application of glycolic acid, and estrogen, and retinoic acid to a somewhat lesser degree. Soy and vitamin C produced significant cellular changes of lesser magnitude. Conclusion Reported studies of many of these agents were conducted in the irradiated mice, and their effects on the intact animal skin have been rarely documented. These data will be useful for our contemplated studies of photo aging in the same species. Agents like retinoic acid derivatives, or glycolic acid are popular rejuvenating compounds, but have been reported to produce annoying side effects. Milder compounds like Vitamin C or soy may cause reversal of detrimental aging changes without cutaneous side effects. Significance This study may be helpful to pinpoint therapeutic advantages of popular anti-wrinkle compounds, and devise clinical strategies to combat photo aging. Support This research has been supported by the 2007 Leslie Bernstein Grant from the AAFPRS Foundation.

Molecule which changed the view on skin treatment

2021 ◽  
pp. 44-55
Author(s):  
L.Ya. Fedorich
Keyword(s):  
Retinoic Acid ◽  
Nuclear Receptors ◽  
Mechanism Of Action ◽  
Molecular Mechanisms ◽  
Local Treatment ◽  
Mechanisms Of Action ◽  
Clinical Effects ◽  
Topical Retinoids ◽  
Acne Therapy ◽  
Universal Mechanism

Objective — to study the modern classification, mechanisms of action and clinical effects of vitamin A derivatives, to analyze retinoid for local treatment of various dermatoses with a universal mechanism of action at the epidermis and dermis levels. Materials and methods. A review of the literature and an analysis of the results of international clinical trials of drugs based on the natural retinoid of the first generation — tretinoin (retinoic acid) is presented. The works of dozens of authors since 1980s to the present day are analyzed. Most sources provide detailed information on the results of topical retinoids in acne therapy, which are the base of clinical guidelines. Long-term (6 months or more) studies of retinoic acid-based preparations carried out in recent decades have discovered the unique clinical effects of tretinoin in the treatment of skin photoaging, actinic keratosis, etc. They are achieved due to the effect of tretinoid on the nuclear receptors of keratinocytes and fibroblasts. Results and discussion. The molecular mechanisms of action of retinoic acid, realizing the cellular and tissue effects of the most studied retinoid, are systematized and grouped in a single review. It has been proven that a unique feature of tretinin is its ability to activate directly all subtypes of RARs- and, indirectly, RARs-nuclear receptors of skin cells. A new modern drug for external use is presented — AltrenoТМ lotion containing micronized 0.05 % tretinoin in combination with sodium hyaluronate, soluble collagen and glycerin. This combination exhibits the expected clinical efficacy in acne therapy and prevents side effects such as dryness, redness and exfoliation. AltrenoТМ is approved for use in children of 9 years of age and older. Conclusions. Tretinoin (retinoic acid) is a modern powerful retinoid with a universal mechanism of action, recommended for the treatment of acne.

Fibroblast feeder layers inhibit differentiation of retinoic acid-treated embryonal carcinoma cells by increasing the probability of stem cell renewal

1984 ◽  
Vol 152 (2) ◽  
pp. 378-389 ◽  
Author(s):  
Maurice J. Rosenstraus ◽  
Barbara Sterman ◽  
Amanda Carr ◽  
Lori Brand
Keyword(s):  
Stem Cell ◽  
Retinoic Acid ◽  
Embryonal Carcinoma ◽  
Carcinoma Cells ◽  
Cell Renewal ◽  
Embryonal Carcinoma Cells ◽  
Stem Cell Renewal ◽  
Feeder Layers

The Effect of Alpha Hydroxy Acids ( Glycolic and Lactic acid ) on Hairless Mouse Skin

1997 ◽  
Vol 9 (4) ◽  
pp. 253 ◽  
Author(s):  
Seong Jin Kim ◽  
Jong Hyuk Park ◽  
Kun Park ◽  
Seung Chul Lee ◽  
Inn Ki Chun ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Mouse Skin ◽  
Hairless Mouse ◽  
Hydroxy Acids ◽  
Hairless Mouse Skin ◽  
Alpha Hydroxy Acids

ChemInform Abstract: Butane-2,3-diacetal-desymmetrized Glycolic Acid - A New Building Block for the Stereoselective Synthesis of Enantiopure α-Hydroxy Acids.

ChemInform ◽  
2010 ◽  
Vol 32 (47) ◽  
pp. no-no
Author(s):  
Elena Diez ◽  
Darren J. Dixon ◽  
Steven V. Ley
Keyword(s):  
Building Block ◽  
Glycolic Acid ◽  
Stereoselective Synthesis ◽  
Hydroxy Acids

Treatment with retinoic acid increases severity of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced skin lesions in hairless mice

2017 ◽  
Vol 280 ◽  
pp. S158
Author(s):  
Stanislav G. Rudyak ◽  
Mikhail A. Paltsev ◽  
Andrey A. Panteleyev
Keyword(s):  
Retinoic Acid ◽  
Skin Lesions ◽  
Hairless Mice ◽  
Tetrachlorodibenzo P Dioxin

Dermal Histology in Mouse Skin Exposed to Cosmeceuticals

2017 ◽  
Vol 33 (05) ◽  
pp. 545-550
Author(s):  
Hope Bueller ◽  
Yvonne Hsia ◽  
J. Thomas ◽  
Tapan Bhattacharyya
Keyword(s):  
Quantitative Data ◽  
Chronic Exposure ◽  
Glycolic Acid ◽  
Mouse Skin ◽  
Hairless Mouse ◽  
Dorsal Skin ◽  
Histopathological Changes ◽  
Over The Counter ◽  
Aging Populations ◽  
Skin Samples

AbstractChronic exposure to environmental ultraviolet radiation elicits deleterious photoaging changes and histopathological damage to the skin. In addition to cosmetic surgical procedures, over-the-counter products described as cosmeceuticals are widely used by a large segment of globally aging populations to partially reverse changes induced by photoaging. Many such products are rarely examined in the laboratory to examine their ameliorative properties and microscopic effects on various skin compartments. The hairless mouse is a popular animal model widely used over the last few decades by researchers to compare cosmeceuticals about their properties to combat or reverse cutaneous photoaging changes. In the present experiment, five cosmeceuticals were topically administered to the dorsal skin over 2 weeks in the nonirradiated mice, and skin samples were analyzed for dermal histopathological changes. Histomorphometric procedures were employed to generate quantitative data on skin sections prepared with immunohistochemistry and staining technics, and the data statistically examined. Among the five agents tested, glycolic acid and retinoic acid produced striking changes, while vitamin C, estrogen, and soy product resulted in less remarkable responses. These quantitative data will be useful for further photoaging studies with these cosmeceuticals.

Sign in / Sign up

Export Citation Format

Share Document