Challenges in the differential diagnosis of interdigitating dendritic cell sarcoma of intraparotid lymph node vs. metastatic malignant melanoma with unknown primary site

Background. Malignant melanoma could present with metastasis with unknown primary (MUP) and this happens in 2-3% according to the studies. Around 90% of melanomas have cutaneous origin, but still there are melanomas that could be found in visceral organs or lymph nodes with unknown primary site. Spontaneous regression of the primary site could be an explanation.Case Report. We report a 58-year-old Caucasian male who presented with a right sided swelling in the inguinal region. Surgery was performed and biopsy showed metastatic malignant melanoma. No cutaneous lesions were identified by history or physical examination. Work up could not detect the primary lesion and patient was started on radiotherapy and immunotherapy.Conclusion. We present a case of malignant melanoma of unknown primary presenting in an unusual place which is the inguinal lymph node. Theories try to explain the pathway of development of such tumors and one of the theories mentions that it could be a spontaneous regression of the primary cutaneous lesion. Another theory is that it could be from transformation of aberrant melanocyte within the lymph node. Prognosis is postulated to be better in this case than in melanoma with a known primary.

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Metastatic malignant melanoma of unknown primary site to the brain: A case report

International Journal of Surgery Case Reports ◽

10.1016/j.ijscr.2021.106311 ◽

2021 ◽

pp. 106311

Author(s):

Alex Mremi ◽

Gregory Goodluck ◽

Adnan Sadiq ◽

Jay Lodhia

Keyword(s):

Case Report ◽

Malignant Melanoma ◽

Metastatic Malignant Melanoma ◽

Primary Site ◽

Unknown Primary ◽

Unknown Primary Site ◽

The Brain

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Fatal Metastatic Malignant Melanoma in Mesentery with Unknown Primary Site

The American Journal of Gastroenterology ◽

10.14309/00000434-200910003-00762 ◽

2009 ◽

Vol 104 ◽

pp. S282

Author(s):

Jitendra Patel ◽

Gurpreet Singh ◽

Kelly Cervellione ◽

M. Del Rosario

Keyword(s):

Malignant Melanoma ◽

Metastatic Malignant Melanoma ◽

Primary Site ◽

Unknown Primary ◽

Unknown Primary Site

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Diagnostic and treatment modalities for patients with cervical lymph node metastases of unknown primary site – current status and challenges

Radiation Oncology ◽

10.1186/s13014-017-0817-9 ◽

2017 ◽

Vol 12 (1) ◽

Cited By ~ 16

Author(s):

Jens Müller von der Grün ◽

Aykut Tahtali ◽

Shahram Ghanaati ◽

Claus Rödel ◽

Panagiotis Balermpas

Keyword(s):

Lymph Node ◽

Lymph Node Metastases ◽

Cervical Lymph Node ◽

Primary Site ◽

Current Status ◽

Treatment Modalities ◽

Unknown Primary ◽

Unknown Primary Site ◽

Cervical Lymph Node Metastases ◽

Node Metastases

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Inguinal Lymph Node Squamous Cell Carcinoma of Unknown Primary Site

Cirugía Andaluza ◽

10.37351/2021323.14 ◽

2021 ◽

Vol 32 (3) ◽

pp. 411-414

Author(s):

L Pina ◽

D Sinagra ◽

ME Paradedao ◽

MA Juárez ◽

F Muñoz Pozo

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Cell Carcinoma ◽

Squamous Cell ◽

Inguinal Lymph Node ◽

Primary Site ◽

Unknown Primary ◽

Unknown Primary Site ◽

Carcinoma Of Unknown Primary

Resumen El carcinoma escamoso de piel y mucosas presenta un riesgo potencial de metástasis ganglionares, con la posibilidad de que este suceso preceda la presentación clínica del tumor primario. El objetivo del presente trabajo es describir un caso de linfadenectomía inguinal por metástasis de carcinoma escamoso de origen primario desconocido y realizar una revisión bibliográfica de los casos presentados en la literatura médica. Se describió el caso de un hombre de 84 años con una tumoración inguinal correspondiente a una neoplasia escamosa, se le realizó una evaluación multidisciplinaria con dermatología, urología y coloproctología, sin encontrar el tumor primario. Se efectuó un vaciamiento inguinal con radioterapia postoperatoria. En la base de datos de Medline informaron solo 49 casos en los últimos 10 años. Las metástasis inguinales de carcinomas escamosos representan un grupo heterogéneo de neoplasias que pueden originarse a partir de la región anogenital o de territorios cutáneos de la zona perineal, miembros inferiores o parte baja del tronco. El manejo diagnóstico y terapéutico de estas lesiones continúa siendo un desafío al que se debe enfrentar con todas las herramientas disponibles y de forma multidisciplinaria.

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