Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents an increasing health problem, especially in the elderly population. Drug therapies are symptomatic and inadequate to contrast disease progression and mortality. Thus, there is an urgent need to clarify the molecular mechanisms responsible for this condition in order to identify new biomarkers and therapeutic targets. Processes including oxidant/antioxidant, protease/antiprotease, and proliferative/antiproliferative balance and control of inflammatory response become dysfunctional during aging as well as in COPD. Recently it was suggested that Sirtuin 1 (SIRT1), an antiaging molecule involved in the response to oxidative stress and chronic inflammation, is implicated in both development and progression of COPD. The present review focuses on the involvement of SIRT1 in the regulation of redox state, inflammation, and premature senescence, all crucial characteristics of COPD phenotypes. Recent evidence corroborating the statement of the “aging theory for COPD” was also discussed.

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The Effect of Telerehabilitation on Quality of Life, Exercise Capacity, and Spirometry Indexes in Patients with Chronic Obstructive Pulmonary Disease in Masih Daneshvari Hospital

Journal of Iranian Medical Council ◽

10.18502/jimc.v4i3.7218 ◽

2021 ◽

Author(s):

Somayeh Ghadimi ◽

Atefeh Fakharian ◽

Mohsen Abedi ◽

Reyhaneh Zahiri ◽

Mahsan Norouz Afjeh ◽

...

Keyword(s):

Quality Of Life ◽

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Control Group ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Copd Patients ◽

And Control

Background: Chronic Obstructive Pulmonary Disease (COPD) leads to limited activity and reduced quality of life. Treatment of this disease is a long-term process that requires the cooperation of patients in monitoring and treatment. Methods: In the present study which was conducted from April 2019 to March 2021 in Masih Daneshvari Hospital, Tehran, Iran, 75 patients were randomly divided into telerehabilitation and control groups. Patients in the control group received pulmonary rehabilitation including respiratory, isometric, and aerobic exercises for 8 weeks, three times per week. In the second group, patients were given a lung rehabilitation booklet and asked to repeat the exercises three times a week for four weeks according to a specific schedule. In addition, patients installed Behzee care application on the mobile phone that recorded various indicators such as heart rate, SpO2, dyspnea, fatigue, and daily activities. This application reminded the patient of the program every day and at a specific time. Finally, the patients’ conditions were compared in the two groups after 8 weeks using CAT and mMRC questionnaires and 6-Minute Walk (6MW) exercise indices as well as spirometry tests. Results: In all four indicators (6MW, CAT, and mMRC questionnaires as well as spirometry), patients showed improvement after rehabilitation (p<0.001). This improvement was significantly higher in the telemedicine group compared to the other group (p<0.01). Conclusion: The use of telerehabilitation in COPD patients is effective in improving spirometry indices, quality of life, as well as activity and sports indices.

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Integrated System for Continuous Monitoring of COPD

Handbook of Research on Trends in the Diagnosis and Treatment of Chronic Conditions - Advances in Medical Diagnosis, Treatment, and Care ◽

10.4018/978-1-4666-8828-5.ch025 ◽

2016 ◽

pp. 536-553

Author(s):

Kostas Giokas ◽

Dimitra Iliopoulou ◽

Ioannis Makris ◽

Dimitris Koutsouris

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Risk Factor ◽

Integrated Care ◽

Pulmonary Disease ◽

Tobacco Smoke ◽

Chronic Cough ◽

The Elderly ◽

Integrated System ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease (COPD) is a progressive pulmonary disease characterized by reduction in airflow and is not fully reversible. COPD is the major cause of mortality and increased levels of disability, particularly in the elderly. Symptoms vary among individuals and include breathlessness, dyspnea, abnormal sputum and chronic cough. Exposure to tobacco smoke is by far the most important risk factor in the development of COPD and is associated with high levels of morbidity and mortality. In this chapter the authors will present a system for the integrated care of COPD focusing on prevention and intervention.

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