Tumor Necrosis Factor-α T-857C (rs1799724) Polymorphism and Risk of Cancers: A Meta-Analysis

Objectives. To investigate the potential association of tumor necrosis factor-α T-857C polymorphism with susceptibility to the five common malignant tumors. Materials and Methods. A comprehensive search of PubMed/Medline, Embase, and Web of Science databases was performed up to November 2015. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to assess the strength of the association. Subgroup analysis, heterogeneity analyses, and publication bias were also texted in the meta-analysis. Results. A total of twenty-two publications involving 5215 cases and 6755 controls were recruited. Overall, the meta-analysis revealed an increased risk between the TNF-α T-857C polymorphism and gastric cancer susceptibility in T versus C model, heterozygote genetic model, and dominant genetic model. An increased risk between the TNF-α T-857C polymorphism and hepatocellular cancer susceptibility in homozygote genetic model and recessive genetic model was also found. No significant association was found between the TNF-α T-857C polymorphism and colorectal cancer, cervical cancer, and prostate cancer. Conclusions. Our meta-analyses suggest that TNF-α T-857C polymorphism may be associated with increased risk of gastric cancer and hepatocellular cancer development. Therefore, the TNF-α T-857C polymorphism could be considered as one possible risk factor of gastric cancer and hepatocellular cancer according to our study.

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The Role of Tumor Necrosis Factor-α (TNF-α) Polymorphisms in Gastric Cancer: a Meta-Analysis

Journal of Gastrointestinal Cancer ◽

10.1007/s12029-021-00688-w ◽

2021 ◽

Author(s):

Maryam Gholamalizadeh ◽

Samaneh Mirzaei Dahka ◽

Hadi Sedigh Ebrahim-Saraie ◽

Mohammad Esmail Akbari ◽

Azam Pourtaheri ◽

...

Keyword(s):

Gastric Cancer ◽

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Meta Analysis ◽

Tnf Α ◽

Factor Α ◽

Necrosis Factor

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The correlation analysis of tumor necrosis factor-alpha-308G/A polymorphism and venous thromboembolism risk: A meta-analysis

Phlebology The Journal of Venous Disease ◽

10.1177/0268355515607405 ◽

2016 ◽

Vol 31 (9) ◽

pp. 625-631 ◽

Cited By ~ 7

Author(s):

Quangen Gao ◽

Peijin Zhang ◽

Wei Wang ◽

He Ma ◽

Yue Tong ◽

...

Keyword(s):

Venous Thromboembolism ◽

Tumor Necrosis Factor ◽

Tumor Necrosis Factor Alpha ◽

Tumor Necrosis ◽

Meta Analysis ◽

Genetic Models ◽

Necrosis Factor Alpha ◽

Increased Risk ◽

Factor Alpha ◽

Necrosis Factor

Objective Venous thromboembolism is a common complex disorder, being the resultant of gene–gene and gene–environment interactions. Tumor necrosis factor-alpha is a proinflammatory cytokine which has been implicated in venous thromboembolism risk. A promoter 308G/A polymorphism in the tumor necrosis factor-alpha gene has been suggested to modulate the risk for venous thromboembolism. However, the published findings remain inconsistent. Methods In this study, we conducted a meta-analysis of all available data regarding this issue. Eligible studies were identified through search of Pubmed, EBSCO Medline, Web of Science, and China National Knowledge Infrastructure (CNKI, Chinese) databases up to June 2014. Pooled Odd ratios (ORs) with 95% confidence intervals were applied to estimating the strength of the genetic association in the random-effects model or fixed-effects model. Results A total of 10 studies involving 1999 venous thromboembolism cases and 2166 controls were included in this meta-analysis to evaluate the association between tumor necrosis factor-alpha-308G/A polymorphism and venous thromboembolism risk. Overall, no significantly increased risk venous thromboembolism was observed in all comparison models when all studies were pooled into the meta-analysis. However, in stratified analyses by ethnicity, there was a pronounced association with venous thromboembolism risk among West Asians in three genetic models (A vs. G: OR = 1.82, 95%CI = 1.13–2.94; GA vs. GG: OR = 1.82, 95%CI = 1.08–3.06; AA/GA vs. GG: OR = 1.88, 95%CI = 1.12–3.16). When stratifying by source of controls, no significant result was detected in all genetic models. Conclusion This meta-analysis demonstrates that tumor necrosis factor-alpha 308G/A polymorphism may contribute to susceptibility to venous thromboembolism among West Asians. Studies are needed to ascertain these findings in larger samples and different racial groups.

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Polymorphisms of tumor necrosis factor-alpha are associated with increased susceptibility to gastric cancer: a meta-analysis

Journal of Human Genetics ◽

10.1007/s10038-008-0273-3 ◽

2008 ◽

Vol 53 (6) ◽

pp. 479-489 ◽

Cited By ~ 40

Author(s):

Jiyuan Zhang ◽

Chao Dou ◽

Yuting Song ◽

Chaoneng Ji ◽

Shaohua Gu ◽

...

Keyword(s):

Gastric Cancer ◽

Tumor Necrosis Factor ◽

Tumor Necrosis Factor Alpha ◽

Tumor Necrosis ◽

Meta Analysis ◽

Necrosis Factor Alpha ◽

Factor Alpha ◽

Necrosis Factor ◽

Increased Susceptibility

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Association between tumor necrosis factor-alpha 857C/T polymorphism and gastric cancer: a meta-analysis

Tumor Biology ◽

10.1007/s13277-013-0910-0 ◽

2013 ◽

Vol 34 (6) ◽

pp. 3383-3388 ◽

Cited By ~ 8

Author(s):

Gang Cen ◽

Weidong Wu

Keyword(s):

Gastric Cancer ◽

Tumor Necrosis Factor ◽

Tumor Necrosis Factor Alpha ◽

Tumor Necrosis ◽

Meta Analysis ◽

Necrosis Factor Alpha ◽

Factor Alpha ◽

Necrosis Factor

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A meta-analysis of tumor necrosis factor-α-308 G>A polymorphism in gastric cancer

Asian Biomedicine ◽

10.1515/abm-2020-0014 ◽

2020 ◽

Vol 14 (3) ◽

pp. 91-96

Author(s):

Xin Jiang ◽

Niyaz Ahmad Naikoo ◽

Shuowei Gao

Keyword(s):

Gastric Cancer ◽

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

English Language ◽

Meta Analysis ◽

Recessive Model ◽

Case Control Studies ◽

Tnf Α ◽

Factor Α ◽

Necrosis Factor

AbstractBackgroundGastric cancer (GC) is the common cause of cancer-related deaths worldwide and inflammation represents the early phases in the GC.ObjectiveTo review the tumor necrosis factor (TNF)-α-308 G>A (GG, GA, and AA) in GC by meta-analysis studies for any differences in TNF-α-308 G>A gene polymorphisms.MethodsCase–control studies published from 2003 to 2017 were identified by searching PubMed, EMASE, and the Internet with the English language. The analysis published on TNF-α-308 G>A polymorphism was analyzed and a limited number of articles were included in the present study. TNF-α-308 G>A from 4,157 patients and 5,185 healthy controls was evaluated. Studies were evaluated using Cochrane Q-test and publication bias was evaluated by constructing funnel plots.ResultsOverall, TNF-α-308 GA genotype showed significant association [P < 0.0001, odds ratio (OR), 95% confidence interval (CI) = 0.82 (0.74–0.91)]. However, meta-analysis of TNF-α-308 genotypes (GG, GA, AA, and GA + AA) between GC patients and controls showed nonsignificant association with GC [P > 0.05, recessive model: OR = 1.38, 95% CI: 1.15–1.66; dominant model: OR = 1.23, 95% CI: 1.09–1.39; (G/A) vs. (G/G): OR = 1.15, 95% CI: 1.02–1.28; (A/A) vs. (G/G): OR = 1.44, 95% CI: 1.19–1.73]. Analysis stratified by ethnicity showed same results in Asian and Caucasian populations.ConclusionsResults revealed nonsignificant association of TNF-α-308 genotypes (GG, GA, AA, and GA + AA) and GC. TNF-α-308GA genotype showed significant association whereas homozygous genotype AA did not show association with GC risk.

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