scholarly journals Clinical Studies of Nonpharmacological Methods to Minimize Salivary Gland Damage after Radioiodine Therapy of Differentiated Thyroid Carcinoma: Systematic Review

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Andri Christou ◽  
Evridiki Papastavrou ◽  
Anastasios Merkouris ◽  
Savvas Frangos ◽  
Panayiota Tamana ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Thyroid Carcinoma ◽  
Parotid Gland ◽  
Clinical Studies ◽  
Radioiodine Therapy ◽  
Differentiated Thyroid Carcinoma ◽  
Lemon Juice ◽  
Exclusion Criteria ◽  
Limited Effect ◽  
Larger Sample

Purpose.To systematically review clinical studies examining the effectiveness of nonpharmacological methods to prevent/minimize salivary gland damage due to radioiodine treatment of differentiated thyroid carcinoma (DTC).Methods.Reports on relevant trials were identified by searching the PubMed, CINHAL, Cochrane, and Scopus electronic databases covering the period 01/2000–10/2015. Inclusion/exclusion criteria were prespecified. Search yielded eight studies that were reviewed by four of the present authors.Results.Nonpharmacological methods used in trials may reduce salivary gland damage induced by radioiodine. Sialogogues such as lemon candy, vitamin E, lemon juice, and lemon slice reduced such damage significantly (p<0.0001,p<0.05,p<0.10, andp<0.05, resp.). Parotid gland massage also reduced the salivary damage significantly (p<0.001). Additionally, vitamin C had some limited effect (p=0.37), whereas no effect was present in the case of chewing gum (p=0.99).Conclusion.The review showed that, among nonpharmacological interventions, sialogogues and parotid gland massage had the greatest impact on reducing salivary damage induced by radioiodine therapy of DTC. However, the studies retrieved were limited in number, sample size, strength of evidence, and generalizability. More randomized controlled trials of these methods with multicenter scope and larger sample sizes will provide more systematic and reliable results allowing more definitive conclusions.

Evaluation of Parotid Salivary Gland Echo Texture by Ultrasound Examinations and Correlation With Whole‐Body Scintigraphy After Radioiodine Therapy in Patients With Differentiated Thyroid Carcinoma

2020 ◽  
Vol 39 (9) ◽  
pp. 1811-1818
Author(s):  
Graziele Aparecida Simões Lima ◽  
Rossana Verónica Mendoza López ◽  
Ricardo Miguel Costa Freitas ◽  
Jose Willegaignon ◽  
Marcelo Tatit Sapienza ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Thyroid Carcinoma ◽  
Radioiodine Therapy ◽  
Differentiated Thyroid Carcinoma ◽  
Whole Body ◽  
Parotid Salivary Gland

scholarly journals Profile of salivary gland flow dysfunctions in patients with differentiated thyroid carcinoma submitted to radioiodine therapy

2013 ◽  
Vol 12 (3) ◽  
pp. 169-172
Author(s):  
Anna Clara Fontes Vieira ◽  
Aline Sampaio Lima Rodrigues ◽  
Maria Carmen Fontoura Nogueira da Cruz ◽  
Fernanda Ferreira Lopes
Keyword(s):  
Salivary Gland ◽  
Thyroid Carcinoma ◽  
Radioiodine Therapy ◽  
Differentiated Thyroid Carcinoma

Does radioiodine therapy have disadvantageous effects in non-iodine accumulating differentiated thyroid carcinoma?

2002 ◽  
Vol 57 (1) ◽  
pp. 117-124 ◽  
Author(s):  
Jeroen Schaap ◽  
Carmen F. A. Eustatia-Rutten ◽  
Marcel Stokkel ◽  
Thera P. Links ◽  
Michaela Diamant ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Radioiodine Therapy ◽  
Differentiated Thyroid Carcinoma

scholarly journals Delayed Citrus Stimulation and Prevention of Salivary Glands Damage in Patients of Thyroid Carcinoma Treated by Radioiodine Therapy

2019 ◽  
Vol 21 (2) ◽  
pp. 92-96
Author(s):  
Sharmin Reza ◽  
Sadia Sultana ◽  
Fatima Begum ◽  
Rahima Perveen ◽  
Zeenat Jabin ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Side Effects ◽  
Thyroid Carcinoma ◽  
Salivary Glands ◽  
Radioiodine Therapy ◽  
Delayed Initiation ◽  
History Of ◽  
Group A ◽  
Group B ◽  
Taste Dysfunction

Objective: It is well established that citrus stimulation has a definite role in preventing salivary gland damage after radioiodine therapy. The aim of this study was to observe how effectively this stimulation can be used to prevent salivary gland damage and whether the timing of sucking citrus substances play any role in preventing this damage more effectively. Patients and Methods: A total of 128 differentiated thyroid cancer (DTC) patients who received radioiodine treatment for thyroid carcinoma were divided into two groups- group-A and group-B. Group-A patients started citrus stimulation 1 hour after radioiodine ingestion and group-B patients started 24 hours after RAIT. Patients were followed-up at 5th day, 3rd month, and 6th month after RAIT. Follow up procedure consisted of physical examination and history of pain and swelling in salivary gland regions, taste dysfunction and dryness of mouth. Result: The incidence of different types of salivary glands side effects and abnormal scan findings were significantly high in the group of patients who were advised to start citrus stimulation 1 h after radioiodine ingestion. On the other hand, patients who started citrus stimulation 24 h after RAIT suffered less from salivary gland side effects.  Conclusion: This study showed that delayed initiation of citrus stimulation was more effective in reducing salivary gland damage after RAIT. Bangladesh J. Nuclear Med. 21(2): 92-96, July 2018

scholarly journals Recombinant Human Thyrotropin-Aided Radioiodine Therapy in Patients with Metastatic Differentiated Thyroid Carcinoma

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Ivana Zagar ◽  
Andreja A. Schwarzbartl-Pevec ◽  
Barbara Vidergar-Kralj ◽  
Rika Horvat ◽  
Nikola Besic
Keyword(s):  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Physical Condition ◽  
Radioiodine Therapy ◽  
Differentiated Thyroid Carcinoma ◽  
Therapeutic Benefit ◽  
The Poor ◽  
Radioiodine Ablation ◽  
Recombinant Human Thyrotropin ◽  
Tsh Stimulation

Our aim was to test the efficacy of 131-I therapy (RIT) using recombinant human TSH (rhTSH) in patients with differentiated thyroid carcinoma (DTC) in whom endogenous TSH stimulation was not an option due to the poor patient's physical condition or due to the disease progression during L-thyroxin withdrawal. The study comprised 18 patients, who already have undergone total or near-total thyroidectomy and radioiodine ablation and 0–12 (median 5) RITs after L-thyroxin withdrawal. Our patients received altogether 44 RITs using rhTSH while on L-thyroxin. Six to 12 months after the first rhTSH-aided RIT, PR and SD was achieved in 3/18 (17%) and 4/18 patients (22%), respectively. In most patients (n= 12; 61%) disease progressed despite rhTSH-aided RITs. As a conclusion, rhTSH-aided RIT proved to add some therapeutic benefit in 39% our patients with metastatic DTC, who otherwise could not be efficiently treated with RIT.

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