scholarly journals Increased Macular Pigment Optical Density and Visual Acuity following Consumption of a Buttermilk Drink Containing Lutein-Enriched Egg Yolks: A Randomized, Double-Blind, Placebo-Controlled Trial

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Sanne M. van der Made ◽  
Elton R. Kelly ◽  
Aize Kijlstra ◽  
Jogchum Plat ◽  
Tos T. J. M. Berendschot
Keyword(s):  
Visual Acuity ◽  
Optical Density ◽  
Dark Adaptation ◽  
Retinal Pigment ◽  
Elderly Subjects ◽  
Macular Pigment Optical Density ◽  
Daily Consumption ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Egg Yolks

Purpose. To study the effect of 1-year daily consumption of a dairy drink containing lutein-enriched egg yolks on macular pigment optical density (MPOD) and visual function parameters in elderly subjects with ocular drusen and/or retinal pigment abnormalities.Methods. One hundred and one subjects were recruited to participate in this randomized, double-blind, placebo-controlled parallel intervention trial. Statistical analyses were performed with 46 subjects in the lutein group and 43 in the control group. MPOD, best corrected visual acuity (BCVA, logMAR), and dark adaptation were measured at the start of the study, after 6 months and after 12 months. Plasma lutein and zeaxanthin concentrations were assessed at baseline and at the end of the study.Results. In the lutein group, plasma lutein concentrations increased significantly from 205 ng/mL at baseline to 399 ng/mL after twelve months of intervention. MPOD increased significantly from 0.45 to 0.52 and BCVA improved significantly from −0.04 to −0.09 LogMar. Differences in rod dark adaptation rate between both groups were not significant.Conclusion. Daily consumption of a dairy drink containing lutein-enriched egg yolks for one year improves visual acuity, MPOD, and plasma lutein concentration in elderly subjects with drusen and/or retinal pigment epithelial abnormalities.

Evaluation of the effects of roselle (Hibiscus sabdariffa L.) on oxidative stress and serum levels of lipids, insulin and hs-CRP in adult patients with metabolic syndrome: a double-blind placebo-controlled clinical trial

2016 ◽  
Vol 13 (2) ◽  
Author(s):  
Sedigheh Asgary ◽  
Rasool Soltani ◽  
Mohsen Zolghadr ◽  
Mahtab Keshvari ◽  
Nizal Sarrafzadegan
Keyword(s):  
Oxidative Stress ◽  
Serum Levels ◽  
Adult Patients ◽  
Controlled Clinical Trial ◽  
Hibiscus Sabdariffa ◽  
Daily Consumption ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Hs Crp ◽  
To Receive

Abstract: Roselle (: Forty adult patients with MetS were randomly assigned to receive either 500 mg of:: Daily consumption of 500 mg of

scholarly journals EFFECT OF ANTI-VEGF THERAPY ON THE STRUCTURAL STATE OF THE RETINA IN DIABETIC MACULAR EDEMA

2016 ◽  
Vol 1 (6) ◽  
pp. 24-27
Author(s):  
Бикбов ◽  
Mukharram Bikbov ◽  
Файзрахманов ◽  
Rinat Fayzrakhmanov ◽  
Зайнуллин ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Optical Density ◽  
Structural State ◽  
Central Area ◽  
Macular Pigment ◽  
Optical Coherence ◽  
Macular Pigment Optical Density ◽  
Anti Vegf

Objective: to analyze the structural state of the central area of the retina in diabetic macular edema in the background anti-VEGF therapy.Methods. The study included 38patients (40eyes) with diabetic macular edema. All patients received anti-VEGF-ranibizumab therapy at a dose of 0.05ml. The results were analyzed after three intravitreal injections with 1month interval. We assessed visual acuity, morphological and anatomical structure of the macular area, the sensitivity of the retina and macular pigment optical densityResults. Analyzing optical density of the macular pigment we revealed a significant increase of all parameters in 73% of patients after the therapy. The average value of the optical density before treatment was at 0.102±0.01du, on the background of anti-VEGF-therapy this figure went up to 0.213±0.01 (p<0.05). According to the optical coherence to-mography average retinal thickness before treatment made 404.62±15.23μm, after the treatment – 300.91±6.43μm (р<0,05). When comparing data of optical coherence tomography and macular pigment optical density we revealed more pronounced decrease in the macular pigment optical density in the area of the retinal edema and a significant increase in the basic parameters on the background of the therapy.Conclusion. Anti-VEGF-therapy significantly improves visual acuity, the recovery profile of macular edema and reduces the zone in patients with diabetic macular edema.

scholarly journals The potential retinal hazards of curing light use for dentists

2021 ◽  
Vol 2 (2) ◽  
pp. 77-84
Author(s):  
Nicole M Putnam ◽  
Sara Thomas ◽  
Grace Liao ◽  
Emily Bennett ◽  
Anne Breen ◽  
...  
Keyword(s):  
Blue Light ◽  
Optical Density ◽  
Light Exposure ◽  
Retinal Pigment Epithelial Cell ◽  
Retinal Pigment ◽  
Macular Pigment ◽  
Control Group ◽  
Macular Pigment Optical Density ◽  
Curing Light ◽  
Ocular Health

Background: Many recent studies have focused on the potential hazards of blue light exposure to ocular health. One group with a unique blue light exposure risk is dentists, who use curing lights that emit intense blue light during restorative procedures. During these procedures, dentists often experience brief ocular exposure to these lights. The purpose of the present study was to explore whether such exposures may have an effect on the vision and ocular health of dentists. Methods: A group of 12 dentists who had experienced curing light exposure over a period of 10 or more years were compared to a group of eight control subjects with no such exposure. The subjects were tested for visual acuity and contrast sensitivity. Their retinas were examined using fundus imaging and optical coherence tomography. Macular pigment optical density was measured. The likelihood that brief blue light exposure could lead to ocular effects was further explored by subjecting a retinal pigment epithelial cell (RPE) line to such exposures. Results: Although no visual defects or ocular pathologies were found in either group, the dentist group differed from the control group in having increased macular thickness (P < 0.02), a higher incidence of macular vessel tortuosity (P < 0.05), and greater variance in their macular pigment optical density values (P < 0.01). RPE cells that received blue light exposure similar to those sustained by dentists demonstrated a change in physiology. Conclusions: Retinal changes were found in dentists, which, while not pathological in themselves, are associated with some retinal pathologies. Further studies are necessary to determine whether these signs correlate with the degree of curing light exposure and to determine whether they eventually develop into pathological conditions.

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