scholarly journals A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Ekua W. Brenu ◽  
Simon Broadley ◽  
Thao Nguyen ◽  
Samantha Johnston ◽  
Sandra Ramos ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
Chronic Fatigue Syndrome ◽  
Cd8 T Cells ◽  
Preliminary Investigation ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Effector Memory ◽  
Fatigue Syndrome ◽  
The Status

Background. CD8+ T cells have putative roles in the regulation of adaptive immune responses during infection. The purpose of this paper is to compare the status of CD8+ T cells in Multiple Sclerosis (MS) and Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).Methods. This preliminary investigation comprised 23 CFS/ME patients, 11 untreated MS patients, and 30 nonfatigued controls. Whole blood samples were collected from participants, stained with monoclonal antibodies, and analysed on the flow cytometer. Using the following CD markers, CD27 and CD45RA (CD45 exon isoform 4), CD8+ T cells were divided into naïve, central memory (CM), effector memory CD45RA− (EM), and effector memory CD45RA+ (EMRA) cells.Results. Surface expressions of BTLA, CD127, and CD49/CD29 were increased on subsets of CD8+ T cells from MS patients. In the CFS/ME patients CD127 was significantly decreased on all subsets of CD8+ T cells in comparison to the nonfatigued controls. PSGL-1 was significantly reduced in the CFS/ME patients in comparison to the nonfatigued controls.Conclusions. The results suggest significant deficits in the expression of receptors and adhesion molecules on subsets of CD8+ T cells in both MS and CFS/ME patients. These deficits reported may contribute to the pathogenesis of these diseases. However, larger sample size is warranted to confirm and support these encouraging preliminary findings.

scholarly journals You + ME Registry: A Research Platform to Facilitate Clinical and Therapeutic Discoveries in ME/CFS and Related Diseases

2021 ◽  
Author(s):  
Allison Ramiller ◽  
Kathleen Mudie ◽  
Elle Seibert ◽  
Sadie Whittaker
Keyword(s):  
Multiple Sclerosis ◽  
Big Data ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Health Data ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome ◽  
Research Platform ◽  
And Control

ME/CFS (Myalgic Encephalomyelitis / Chronic Fatigue Syndrome) is a chronic, complex, heterogeneous disease that affects millions and lacks both diagnostics and treatments. Big data, or the collection of vast quantities of data that can be mined for information, has transformed the understanding of many complex illnesses like cancer (1,2) and multiple sclerosis (3,4), by dissecting heterogeneity, identifying subtypes, and enabling the development of personalized treatments. It is possible that big data can reveal the same for ME/CFS. Solve M.E. developed and launched the You + ME Registry to collect longitudinal health data from people with ME/CFS, people with Long COVID (LC) and control volunteers using rigorous protocols designed to harmonize with other groups collecting data from similar groups of people. The Registry is an invaluable resource because it integrates with a symptom tracking app, as well as a biorepository, to provide a robust and rich dataset that is available to qualified researchers. Accordingly, it facilitates collaboration that may ultimately uncover causes and help accelerate the development of therapies.

scholarly journals Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
D. Peterson ◽  
E. W. Brenu ◽  
G. Gottschalk ◽  
S. Ramos ◽  
T. Nguyen ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Chronic Fatigue Syndrome ◽  
Preliminary Investigation ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Healthy Controls ◽  
Gm Csf ◽  
Fatigue Syndrome ◽  
Human Cytokine

Objectives. Previous research has provided evidence for dysregulation in peripheral cytokines in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). To date only one study has examined cytokines in cerebrospinal fluid (CSF) samples of CFS/ME patients. The purpose of this pilot study was to examine the role of cytokines in CSF of CFS/ME patients.Methods. CSF was collected from 18 CFS/ME patients and 5 healthy controls. The CSF samples were examined for the expression of 27 cytokines (interleukin- (IL-) 1β, IL-1ra, IL-2, IL-4, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IL-13, IL-15, IL-17, basic FGF, eotaxin, G-CSF, GM-CSF, IFN-γ, IP-10, MCP-1 (MCAF), MIP-1α, MIP-1β, PDGF-BB, RANTES, TNF-α, and VEGF) using the Bio-Plex Human Cytokine 27-plex Assay.Results. Of the 27 cytokines examined, only IL-10 was significantly reduced in the CFS/ME patients in comparison to the controls.Conclusions. This preliminary investigation suggests that perturbations in inflammatory cytokines in the CSF of CFS/ME patients may contribute to the neurological discrepancies observed in CFS/ME.

scholarly journals Chronic fatigue syndrome/myalgic encephalomyelitis and the potential role of T cells

2014 ◽  
Vol 1 ◽  
pp. 25-38
Author(s):  
S. L. Hardcastle ◽  
E. W. Brenu ◽  
D.R. Staines ◽  
S. Marshall-Gradisnik
Keyword(s):  
T Cells ◽  
Chronic Fatigue Syndrome ◽  
Potential Role ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome

scholarly journals The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis

2017 ◽  
Vol 4 ◽  
Author(s):  
Eliana M Lacerda ◽  
Erinna W Bowman ◽  
Jacqueline M Cliff ◽  
Caroline C Kingdon ◽  
Elizabeth C King ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Chronic Fatigue Syndrome ◽  
Biomedical Research ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome ◽  
The Uk
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