Preventive Effects of the Chinese Herbal Medicine Prescription Tangkuei Decoction for Frigid Extremities on Sciatic Neuropathy in Streptozotocin-Induced Diabetic Rats

Ischemia and hypoxia are important physiological changes in diabetic peripheral neuropathy (DPN). Chinese herbal medicine prescription Tangkuei Decoction for Frigid Extremities (TDFE) is useful for increasing blood flow. To help determine whether TDFE could protect the peripheral nerves of diabetic patients from the degeneration caused by high blood glucose, TDFE was administered to streptozotocin-induced diabetic rats for 6 or 12 weeks. Plantar thermal stimulation reaction time thresholds, sciatic nerve conduction velocities, and the levels of HIF-1αmRNA, HIF-1αprotein, VEGF protein, and the endothelial marker vWF in sciatic nerves were measured at the end of the sixth and twelfth weeks. The thermal thresholds and sciatic nerve conduction velocities of the rats differed after 12 weeks, and the sciatic nerves of the diabetic rats that were given TDFE displayed higher levels of HIF-1αprotein, VEGF protein, and HIF-1αmRNA than those of the diabetic model rats. The results at 6 weeks differed from those at 12 weeks. These results suggest that the early preventive application of TDFE effectively delayed the development of DPN and that TDFE increased HIF-1αmRNA levels in the sciatic nerves of diabetic rats through 12 weeks of treatment.

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Protective effects of the Chinese herbal medicine prescription Zhujing pill on retina of streptozotocin-induced diabetic rats

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2017.12.071 ◽

2018 ◽

Vol 98 ◽

pp. 643-650 ◽

Cited By ~ 2

Author(s):

Xiaoqin Lei ◽

Jianyu He ◽

Cuicui Ren ◽

Yunyun Zhou ◽

Xi Chen ◽

...

Keyword(s):

Herbal Medicine ◽

Chinese Herbal Medicine ◽

Diabetic Rats ◽

Protective Effects ◽

Chinese Herbal ◽

Medicine Prescription

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Radix Astragali-Based Chinese Herbal Medicine for Oxaliplatin-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2016/2421876 ◽

2016 ◽

Vol 2016 ◽

pp. 1-14 ◽

Cited By ~ 14

Author(s):

Bo Deng ◽

Liqun Jia ◽

Zhiqiang Cheng

Keyword(s):

Peripheral Neuropathy ◽

Herbal Medicine ◽

Conduction Velocity ◽

Chinese Herbal Medicine ◽

Nerve Conduction ◽

Nerve Conduction Velocity ◽

Keyword Search ◽

Meta Analysis ◽

Radix Astragali ◽

Chinese Herbal

Background. Treatment of chemotherapy-induced peripheral neuropathy (CIPN) remains a big challenge for oncologists. The aim of this study is to evaluate the effects of Radix Astragali- (RA-) based Chinese herbal medicine in the prevention and treatment of oxaliplatin-induced peripheral neuropathy, including the incidence and grading of neurotoxicity, effective percentage, and nerve conduction velocity.Methods. All randomized controlled trials (RCTs) were found using PubMed, Cochrane, Springer, China National Knowledge Infrastructure (CNKI), and Wanfang Database of China Science Periodical Database (CSPD) by keyword search. Meta-analysis was conducted using RevMan 5.0.Results. A total of 1552 participants were included in 24 trials. Meta-analysis showed the incidence of all-grade neurotoxicity was significantly lower in experimental groups and high-grade neurotoxicity was also significantly less. Effective percentage was significantly higher and sensory nerve conduction velocity was improved significantly, but changes in motor nerve conduction velocity were not statistically significant. No adverse events associated with RA-based intervention were reported.Conclusion. RA-based intervention may be beneficial in relieving oxaliplatin-induced peripheral neuropathy. However, more double-blind, multicenter, large-scale RCTs are needed to support this theory.Trial Registration. PROSPERO International prospective register of systematic reviews has registration number CRD42015019903.

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