scholarly journals Jejunojejunal Intussusception due to Metastatic Melanoma Seven Years after the Primer

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Alexander Giakoustidis ◽  
Thomas Goulopoulos ◽  
Anastasios Boutis ◽  
George Kavvadias ◽  
Aristidis Kainantidis ◽  
...  
Keyword(s):  
Small Intestine ◽  
Metastatic Melanoma ◽  
Medical Condition ◽  
Hashimoto Thyroiditis ◽  
Initial Manifestation ◽  
Intestinal Intussusception ◽  
18Fdg Pet ◽  
Loss Of Weight ◽  
Pet Ct ◽  
History Of

Intestinal intussusception in adults is a rare medical condition accounting for less than 5% of all intussusceptions. Herein we present a 45-year-old patient with a history of abdominal pain and loss of weight. CT scan revealed jejunojejunal intussusceptions. The patient was subjected to exploratory operation and small intestine resection due to a mass causing intestinal intussusception. Pathology confirmed suspected diagnosis of metastatic melanoma to small intestine secondary to melanoma, 7 years after the initial manifestation. Postoperative evaluation with 18FDG-PET/CT revealed increased uptake in the thyroid gland. Subsequent total thyroidectomy revealed severe Hashimoto thyroiditis and no signs of metastasis. The patient received adjuvant immunotherapy and is healthy with no signs of recurrence 3 years after the initial diagnosis and treatment.

scholarly journals Metastatic Melanoma Presenting as Intussusception in an 80-Year-Old Man: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Sarah Alghamdi ◽  
Yumna Omarzai
Keyword(s):  
Differential Diagnosis ◽  
Small Intestine ◽  
Gastrointestinal Tract ◽  
Metastatic Melanoma ◽  
Clinical Presentation ◽  
Gastrointestinal Symptoms ◽  
Common Site ◽  
Neoplastic Process ◽  
History Of ◽  
Uncommon Neoplasm

Malignant melanoma of the gastrointestinal tract is an uncommon neoplasm that could be primary or metastatic. Small intestine represents the most common site for the metastatic melanoma; however, it could be found anywhere in the gastrointestinal tract. Intussusception is a rare cause of intestinal obstruction in adults compared to children. In 90% of the cases, the underlying cause can be found, and in 65% of the cases, intussusception is caused by the neoplastic process. The majority of the neoplasms are benign, and about 15% are malignant. Metastatic melanoma is one of the most common metastatic malignancies to the gastrointestinal tract; however, the premortem diagnosis is rarely made. Here, we report an uncommon clinical presentation of metastatic melanoma causing intussusception in an 80-year-old man. This diagnosis should be considered in a differential diagnosis in any patient who presents with gastrointestinal symptoms and a history of melanoma.

scholarly journals MP11: COMORBID DEPRESSION OR ANXIETY IS ASSOCIATED WITH AORTIC VASCULAR INFLAMMATION AND CORONARY HEART DISEASE BEYOND TRADITIONAL CARDIOVASCULAR RISK FACTORS IN PSORIASIS

2016 ◽  
Vol 64 (3) ◽  
pp. 809.1-809
Author(s):  
T Aberra ◽  
A Joshi ◽  
J Lerman ◽  
J Rodante ◽  
J Silverman ◽  
...  
Keyword(s):  
Vascular Inflammation ◽  
Coronary Plaque ◽  
Plaque Burden ◽  
High Risk Population ◽  
Inflammatory Disorder ◽  
Comorbid Depression ◽  
18Fdg Pet ◽  
Increased Risk ◽  
Pet Ct ◽  
History Of

Purpose of StudyPsoriasis is a chronic inflammatory disorder associated with vascular inflammation (VI), measured by 18-fluorodeoxyglucose positron emission tomography/computed tomography (18-FDG PET/CT), and increased risk of MI. Patients with psoriasis are more likely to have comorbid depression and anxiety. Whether these comorbidities accelerate the development of CVD in psoriasis is unclear. We hypothesized that aortic VI and coronary plaque burden would be increased in patients with psoriasis who have depression and/or anxiety compared to those with psoriasis who do not.Methods UsedPatients were prospectively enrolled. Those who reported a history of depression and/or anxiety (n=40) on survey and age- and gender-matched patients who reported no history of psychiatric illness (n=40) were selected. Target-to-Background ratio from 18FDG PET/CT was used to assess aortic VI, and coronary CT angiography scans were analyzed for coronary plaque composition.Summary of ResultsBoth aortic VI and coronary plaque burden were higher in psoriasis patients with comorbid depression or anxiety compared to those without (table 1). After adjustment for Framingham Risk Score, body mass index, and statin use; VI (β=0.24, p=0.02), total plaque burden (β=0.13, p=0.04), and non-calcified burden (β=0.13, p=0.04) were associated with comorbid depression and/or anxiety.ConclusionsPatients with psoriasis who have comorbid depression or anxiety have increased aortic VI and coronary plaque burden, suggesting that identification of psychiatric diagnoses in psoriasis may be warranted for future CV risk reduction in this high risk population.Abstract MP11 Figure 1

scholarly journals Suture Granuloma With False-Positive Findings on FDG-PET/CT Resected via Laparoscopic Surgery

2015 ◽  
Vol 100 (4) ◽  
pp. 604-607 ◽  
Author(s):  
Nobuyoshi Takeshita ◽  
Takayuki Tohma ◽  
Hideaki Miyauchi ◽  
Kazufumi Suzuki ◽  
Takanori Nishimori ◽  
...  
Keyword(s):  
Small Intestine ◽  
Laparoscopic Resection ◽  
History Of Surgery ◽  
Total Hysterectomy ◽  
Positron Emission ◽  
Pelvic Tumors ◽  
Pet Ct ◽  
History Of ◽  
Small Focus ◽  
Fdg Pet Ct

A 61-year-old woman who had undergone total hysterectomy 16 years previously exhibited a pelvic tumor on computed tomography (CT). F-18 fluorodeoxyglucose (FDG) combined positron emission tomography (PET)/CT imaging revealed a solitary small focus of increased FDG activity in the pelvis. A gastrointestinal stromal tumor originating in the small intestine or another type of tumor originating in the mesentery (desmoid, schwannoma, or foreign body granuloma) was suspected; therefore, laparoscopic resection was conducted. A white, hard tumor was found to originate from the mesentery of the sigmoid colon and adhered slightly to the small intestine. The tumor was resected with a negative margin, and the pathologic diagnosis was suture granuloma. The possibility of suture granuloma should be kept in mind in cases of tumors with positive PET findings and a history of surgery close to the lesion. However, it is difficult to preoperatively diagnose pelvic tumors using a biopsy. Therefore, considering the possibility of malignancy, it is necessary to achieve complete resection without exposing the tumor.

scholarly journals Hemichorea in a patient with ipsilateral cortical infarction: a case report

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jie Wei ◽  
Yue Zhang
Keyword(s):  
Ischemic Stroke ◽  
Frontal Lobe ◽  
Brain Lesion ◽  
Antipsychotic Treatment ◽  
Left Frontal Lobe ◽  
Cortical Infarction ◽  
18Fdg Pet ◽  
Pet Ct ◽  
History Of ◽  
The Right

Abstract Background Hemichorea is usually caused by contralateral deep structures of brain. It rarely results from acute cortical ischemic stroke and that caused by ipsilateral brain lesions is even rarer. Case presentation A 64-year-old female presented with acute obtuseness and left-sided hemichorea. She had a history of right frontal lobe surgery and radiotherapy due to brain metastasis from lung cancer 8 years ago. MRI revealed acute left frontal lobe infarction in addition to an old right frontal lobe lesion. 18FDG PET-CT showed hypometabolism in the left frontal lobe and hypermetabolism in the right basal ganglia region and central sulcus. The choreatic movement remitted after antipsychotic treatment. Conclusion The mechanism of hemichorea after ipsilateral cortical infarction is poorly understood. We assume both previous contralateral brain lesion and recent ipsilateral ischemic stroke contributed to the strange manifestation in this case.

scholarly journals 18FDG-PET/CT Specificity for the Detection of Lymphoma Recurrence in the Tonsils

OTO Open ◽  
2021 ◽  
Vol 5 (4) ◽  
pp. 2473974X2110590
Author(s):  
Jonathan D. West ◽  
Mary E. Kim ◽  
Dorian M. Lapalma ◽  
Maria Vergara-Lluri ◽  
Peter Conti ◽  
...  
Keyword(s):  
Patient Population ◽  
Medical Center ◽  
False Positive Rate ◽  
Case Series ◽  
Surgical Pathology ◽  
Specific Patient ◽  
18Fdg Pet ◽  
Standardized Uptake Values ◽  
Pet Ct ◽  
History Of

Objective In patients with a history of lymphoma who demonstrate palatine tonsil uptake on posttreatment PET/CT (positron emission tomography/computed tomography), tonsillectomy is often performed to evaluate for lymphoma recurrence. However, predictive clinical and imaging factors for true tonsil recurrence in this setting are not well established; this will be explored herein. Study Design Retrospective case series. Setting Patients treated at a tertiary medical center from January 2008 to May 2020. Methods Chart review was performed on all patients with a history of treated lymphoma in clinical remission who presented for evaluation of abnormal PET/CT imaging findings and subsequently underwent tonsillectomy. Results Among 15 patients who met inclusion criteria, 14 had benign findings on surgical pathology, yielding a false-positive rate of 93%. The patient with malignancy was identified on biopsy after inconclusive surgical pathology and is the only documented case of recurrence in this specific patient population throughout the literature. The patient presented with B symptoms, irregularly shaped tonsils, increased lymph node activity on PET/CT, and uptrending bilateral tonsil activity but with one of the lowest maximum standardized uptake values of the cohort. The singular distinguishing feature for the patient with recurrent disease was a prior tonsil biopsy suspicious for recurrence, which prompted the otolaryngology referral. Conclusion PET/CT lacks specificity in identifying lymphoma recurrence in the oropharynx. Clinical and radiographic features that were previously considered concerning for recurrence are most likely not indicative of malignancy in this patient population. Our findings call into question whether tonsillectomy should be routinely performed in this patient population.

scholarly journals Pleural effusion as the initial manifestation of metastatic melanoma: a case report and literature review

2020 ◽  
Author(s):  
LiHua Yu ◽  
Duoduo Quan ◽  
Zhangwei Qiu ◽  
Hui Xu ◽  
Jianbo He ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Metastatic Melanoma ◽  
Poor Prognosis ◽  
Clinical Manifestations ◽  
Parietal Pleura ◽  
Mediastinal Lymph Nodes ◽  
Initial Manifestation ◽  
Pleural Thickening ◽  
History Of ◽  
Thoracoscopic Biopsy

Abstract Background: Malignant melanoma (MM) is a highly invasive form of skin cancer with poor prognosis. Pleural metastatic melanoma is rare, with only a few reported cases.Case presentation: A 47-year-old woman with a medical history of right heel melanoma was diagnosed with left-sided pleural effusion, with pleural thickening and calcified mediastinal lymph nodes, using chest computed tomography (CT). A video-assisted thoracoscopic biopsy was performed which revealed numerous pink lumps arising from the parietal pleura and viscera along the diaphragmatic surface. The pathological diagnosis was pleural metastatic melanoma and the tumor cells were immunocytochemically positive for S100, SOX10, and Melan-A.Conclusions: The clinical manifestations of metastatic pleural melanoma are nonspecific. Pleural effusion cytology combined with thoracoscopy is an effective diagnostic method. The presence of melanocytes has improved the diagnosis of this condition.

Diagnostic approach to causes of spinal pain

2018 ◽  
pp. 66-70
Author(s):  
F. D. Nasirova
Keyword(s):  
Spinal Pain ◽  
Rapid Loss ◽  
Loss Of Weight ◽  
History Of ◽  
Radiologic Investigation ◽  
Males And Females ◽  
Serious Disease ◽  
Pain At Rest ◽  
Oncologic Diseases ◽  
Selection Of

Causes of spinal pain are extremely varying. Sex composition of patients referring with spinal pain at the age of 16 to 35 was 35% and 65% for males and females, respectively. Peak number of complaints was observed in 30-40 years age group of highest work ability. The followings should be considered as precautions in spinal pain: onset of pain at the age of 20 and after 50, family history of oncologic diseases, walking disorders or dysfunctions of sphincters, numbness in extremities, general malaise and rapid loss of weight, pain at rest and primarily at night, as these conditions may be a warning of underlying serious disease. Selection of algorithm for radiologic investigation is decided by the treating physician.

STEREOTACTIC HYPO-FRACTIONAL RADIOTHERAPY OF PATIENTS WITH LUNG CANCER I-IIA CLINICAL STAGE: THE ROLE OF SUVMAX ASSESSMENT IN 18F-FDG PET/CT FOR MONITORING TREATMENT OUTCOMES

2017 ◽  
Vol 63 (4) ◽  
pp. 632-638
Author(s):  
Tatyana Borisova ◽  
Arif Allakhverdiev ◽  
Yuriy Gerasimov ◽  
Nadezhda Meshcheryakova ◽  
Mikhail Dolgushin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Treatment Effectiveness ◽  
Clinical Stage ◽  
First Year ◽  
Pet Ct ◽  
History Of ◽  
Single Factor Analysis ◽  
Fdg Pet Ct ◽  
Second Tumor ◽  
Monitoring Treatment

Material and methods: Since 2014, 33 patients with lung cancer of clinical stage I-IIa (cT1N0M0 - 12 patients, with T2N0M0 - 21 patients) have undergone SRT. Verification of tumor process was obtained in 30 patients. A third of patients (n = 10) had a history of metachronic primary-multiple tumors and 31 patients had peripheral lung cancer. The used variants of SRT fractionation were as followed: 10Gr x 5 fractions (n = 22) and 7Gr x 8 fractions (n = 11) - BED 100Gy. Results: With a median follow-up of 21 months (range 3-37 months), 4 patients (12 %) within the first year had a loco-regional and distant progression, of which two died. During the year one patient died from complications of treatment, one - from the progression of the second tumor. One- and two-year local control was 94 %. Overall and disease-free 2-year survival was 84 % (95 % CI, 70 - 99) and 83.2 % (95 % CI, 70.5 - 99), respectively. Single-factor analysis revealed a significant effect on the overall survival of the fractionation regimen (p = 0.04). The effect of the baseline SUVmax tended to be reliable (p = 0.07). Conclusions: In order to implement the principles of risk-adaptive radiation therapy it is necessary to consider the initial SUVmax of tumor as one of potential predictive and predicative markers of treatment effectiveness.

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