scholarly journals A Comparison of Screening Tools for the Early Detection of Peripheral Neuropathy in Adults with and without Type 2 Diabetes

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Jennifer J. Brown ◽  
Shana L. Pribesh ◽  
Kimberly G. Baskette ◽  
Aaron I. Vinik ◽  
Sheri R. Colberg
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Early Detection ◽  
Sural Nerve ◽  
Tuning Fork ◽  
Low Cost ◽  
Screening Tools ◽  
The Right ◽  
Design And Methods

Objective. Examine the effectiveness of the 128 Hz tuning fork, two monofilaments, and Norfolk Quality of Life Diabetic Neuropathy (QOL-DN) questionnaire as tools for the early detection of diabetic peripheral neuropathy (DPN) in overweight, obese, and inactive (OOI) adults or those who have prediabetes (PD) or type 2 diabetes (T2D). Research Design and Methods. Thirty-four adults (mean age 58.4 years ± 12.1) were divided by glycemia (10 OOI normoglycemic, 13 PD, and 11 T2D). Sural nerves were tested bilaterally with the NC-stat DPNCheck to determine sural nerve amplitude potential (SNAP) and sural nerve conduction velocity (SNCV). All other testing results were compared to SNAP and SNCV. Results. Total 1 g monofilament scores significantly correlated with SNAP values and yielded the highest sensitivity and specificity combinations of tested measures. Total QOL-DN scores negatively correlated with SNAP values, as did QOL-DN symptoms. QOL-DN activities of daily living correlated with the right SNAP, and the QOL-DN small fiber subscore correlated with SNCV. Conclusions. The 1 g monofilament and total QOL-DN are effective, low-cost tools for the early detection of DPN in OOI, PD, and T2D adults. The 128 Hz tuning fork and 10 g monofilament may assist DPN screening as a tandem, but not primary, early DPN detection screening tools.

scholarly journals Risk Factors for Diabetic Peripheral Neuropathy in Adolescents and Young Adults With Type 2 Diabetes: Results From the TODAY Study

2021 ◽  
Author(s):  
Lorraine E. Levitt Katz ◽  
Neil H. White ◽  
Laure El ghormli ◽  
Christine L. Chan ◽  
Kenneth C. Copeland ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Glycemic Control ◽  
Diabetic Peripheral Neuropathy ◽  
Treatment Options ◽  
Race Ethnicity ◽  
Design And Methods ◽  
Relationship Of

<b>Objective</b>: Data related to diabetic neuropathy in youth with type 2 diabetes are limited. We examined the relationship of glycemic control, sex, race-ethnicity, BMI, and other type 2 diabetes-associated factors with the development of diabetic peripheral neuropathy (DPN) in type 2 diabetes youth enrolled in the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study. <p><b>Research Design and Methods</b>: The Michigan Neuropathy Screening Instrument (MNSI) and a 10-gram monofilament exam were performed annually. DPN was defined as a score (>2) on the MNSI-exam or combined MNSI-exam and MNSI-survey scores (exam >2 and/or survey ≥4), or monofilament (<8/10 correct responses) at 2 or more consecutive visits. Multivariable time-to-event models assessed the association of risk factors evaluated longitudinally with DPN events.</p> <p><b>Results:</b> 674 participants (35% male), with mean age 14 years and diabetes duration <2 years at study entry were evaluated annually over an average of 10.2 years. Males had a significantly higher cumulative incidence of DPN than females (38.5% vs. 27.2% via MNSI-exam, p=0.002; 14.0% vs. 5.1% via monofilament, p=0.01). Rates did not differ by race-ethnicity. Higher HbA1c and BMI were associated with higher DPN, by both MNSI and monofilament. In multivariable models, male sex, older age, and higher BMI were associated with MNSI-exam DPN risk. </p> <b>Conclusions: </b>DPN was evident early in the course of youth-onset type 2 diabetes and increased over time. It was higher in males and related to glycemic control. These findings raise concern for long-term development of neuropathy-related morbidity in youth with type 2 diabetes and the need to achieve improved glycemic control.

scholarly journals Evaluation of sural nerve automated nerve conduction study in the diagnosis of peripheral neuropathy in patients with type 2 diabetes mellitus

2016 ◽  
Vol 2 ◽  
pp. 390-393 ◽  
Author(s):  
Georgia Chatzikosma ◽  
Kalliopi Pafili ◽  
Maria Demetriou ◽  
Dimitrios Papazoglou ◽  
Konstantinos Vadikolias ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Nerve Conduction Study ◽  
Nerve Conduction ◽  
Sural Nerve

scholarly journals Risk Factors for Diabetic Peripheral Neuropathy in Adolescents and Young Adults With Type 2 Diabetes: Results From the TODAY Study

2021 ◽  
Author(s):  
Lorraine E. Levitt Katz ◽  
Neil H. White ◽  
Laure El ghormli ◽  
Christine L. Chan ◽  
Kenneth C. Copeland ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Glycemic Control ◽  
Diabetic Peripheral Neuropathy ◽  
Treatment Options ◽  
Race Ethnicity ◽  
Design And Methods ◽  
Relationship Of

<b>Objective</b>: Data related to diabetic neuropathy in youth with type 2 diabetes are limited. We examined the relationship of glycemic control, sex, race-ethnicity, BMI, and other type 2 diabetes-associated factors with the development of diabetic peripheral neuropathy (DPN) in type 2 diabetes youth enrolled in the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study. <p><b>Research Design and Methods</b>: The Michigan Neuropathy Screening Instrument (MNSI) and a 10-gram monofilament exam were performed annually. DPN was defined as a score (>2) on the MNSI-exam or combined MNSI-exam and MNSI-survey scores (exam >2 and/or survey ≥4), or monofilament (<8/10 correct responses) at 2 or more consecutive visits. Multivariable time-to-event models assessed the association of risk factors evaluated longitudinally with DPN events.</p> <p><b>Results:</b> 674 participants (35% male), with mean age 14 years and diabetes duration <2 years at study entry were evaluated annually over an average of 10.2 years. Males had a significantly higher cumulative incidence of DPN than females (38.5% vs. 27.2% via MNSI-exam, p=0.002; 14.0% vs. 5.1% via monofilament, p=0.01). Rates did not differ by race-ethnicity. Higher HbA1c and BMI were associated with higher DPN, by both MNSI and monofilament. In multivariable models, male sex, older age, and higher BMI were associated with MNSI-exam DPN risk. </p> <b>Conclusions: </b>DPN was evident early in the course of youth-onset type 2 diabetes and increased over time. It was higher in males and related to glycemic control. These findings raise concern for long-term development of neuropathy-related morbidity in youth with type 2 diabetes and the need to achieve improved glycemic control.

STUDY OF RADIATION CHARACTERISTICS THE RENAL FUNCTION IN PATIENTS WITH TYPE 2 DIABETES

2014 ◽  
pp. 73-77
Author(s):  
Van Chuong Nguyen ◽  
Thi Kim Anh Nguyen
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Disease Duration ◽  
Left Kidney ◽  
Cross Sectional ◽  
The Right

Background: A Research glomerular filtration rate (GFR) of 61 patients with type 2 diabetes mellitus with renal scanning 99mTc-DTPA glomerular filtration rate at the hospital 175. Objective: (1) To study characteristics of imaging of renal function. (2) Understanding the relationship between GFR with blood sugar, HbA1c, blood pressure and albuminuria in patients with type 2 diabetes. Methods: Descriptive, prospective, cross-sectional study. Clinical examination, Clinical tests and 99mTc-DTPA GFR gamma - camera renography for patients. Result: GFR of the study group was 75,4 ± 22,3 ml/phut/1,73m2, the left kidney was 35,0 ± 13,0 is lower than the right kidney and 39,8 ± 11,9; p <0,01. There is no correlation between GFR with blood glucose and HbA1c, the risk of reduced GFR in hypertensive group associated is OR = 6,5 with p<0,01; albuminuria (+) is OR = 4,2 with p <0,01; and disease duration > 10 years is OR = 3,5 with p <0.01. Conclusion: GFR of the left kidneys is lower than the right kidney; correlation decreased GFR associated with hypertension, albuminuria and disease duration. Keywords: GFR, diabetes, albuminuria

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