scholarly journals Expression Profile of Genes Potentially Associated with Adequate Glycemic Control in Patients with Type 2 Diabetes Mellitus

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Sâmia Cruz Tfaile Corbi ◽  
Alliny Souza Bastos ◽  
Rafael Nepomuceno ◽  
Thamiris Cirelli ◽  
Raquel Alves dos Santos ◽  
...  
Keyword(s):  
Gene Expression ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Candidate Genes ◽  
Affy Package ◽  
Hla Dqa1 ◽  
The Impact

Despite increasing research in type 2 diabetes mellitus (T2D), there are few studies showing the impact of the poor glycemic control on biological processes occurring in T2D. In order to identify potential genes related to poorly/well-controlled patients with T2D, our strategy of investigation included a primary screen by microarray (Human Genome U133) in a small group of individuals followed by an independent validation in a greater group using RT-qPCR. Ninety patients were divided as follows: poorly controlled T2D (G1), well-controlled T2D (G2), and normoglycemic individuals (G3). After using affy package in R, differentially expressed genes (DEGs) were prospected as candidate genes potentially relevant for the glycemic control in T2D patients. After validation by RT-qPCR, the obtained DEGs were as follows—G1 + G2 versus G3: HLA-DQA1, SOS1, and BRCA2; G2 versus G1: ENO2, VAMP2, CCND3, CEBPD, LGALS12, AGBL5, MAP2K5, and PPAP2B; G2 versus G3: HLA-DQB1, MCM4, and SEC13; and G1 versus G3: PPIC. This demonstrated a systemic exacerbation of the gene expression related to immune response in T2D patients. Moreover, genes related to lipid metabolisms and DNA replication/repair were influenced by the glycemic control. In conclusion, this study pointed out candidate genes potentially associated with adequate glycemic control in T2D patients, contributing to the knowledge of how the glycemic control could systemically influence gene expression.

An Observational Longitudinal Study of the Impact of Sleeve Gastrectomy on Glycemic Control in Type 2 Diabetes Mellitus

2013 ◽  
Vol 15 (12) ◽  
pp. 990-995 ◽  
Author(s):  
Arundhati Dasgupta ◽  
Jasjeet Wasir ◽  
Maria Beloyartseva ◽  
Sandeep Malhotra ◽  
Ambrish Mithal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Sleeve Gastrectomy ◽  
Longitudinal Study ◽  
Glycemic Control ◽  
The Impact

The Impact of Fasting during Ramadan on the Glycemic Control of Patients with Type 2 Diabetes Mellitus

2013 ◽  
Vol 121 (09) ◽  
pp. 531-534 ◽  
Author(s):  
S. Sahin ◽  
T. Ayaz ◽  
N. Ozyurt ◽  
K. Ilkkilic ◽  
A. Kirvar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
The Impact

The impact of fasting during Ramadan on the glycemic control of patients with type 2 diabetes mellitus

2013 ◽  
Author(s):  
Serap Baydur Sahin ◽  
Teslime Ayaz ◽  
Neslihan Ozyurt ◽  
Kadir Ilkkilic ◽  
Abdulkadir Kirvar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
The Impact

scholarly journals MON-622 Rapid Improvement in Glycated Albumin Before Educational Admission Predicts Fair Glycemic Control One Year After the Discharge of Patients with Type 2 Diabetes Mellitus

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Sho Katsuragawa ◽  
Yuya Tsurutani ◽  
Tomoko Takiguchi ◽  
Jun Saito ◽  
Tetsuo Nishikawa
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Glycated Albumin ◽  
Rapid Improvement ◽  
Loading Test ◽  
One Year ◽  
The Impact

Abstract Background and Aim: Glycated albumin (GA) reflects a short-term glycemic control (about 2 weeks) in comparison to glycated hemoglobin (HbA1c) which reflects a long-term glycemic control. Thus, if the dietary, exercise, or medication therapy before the educational admission is effective, a rapid improvement in GA can be observed. However, the impact of the improvement in GA on the subsequent glycemic control is not well understood. This retrospective study analyzed the association between the change of GA before educational admission and glycemic control one year after the discharge of patients with type 2 diabetes mellitus (T2DM). Method: We analyzed data from 114 T2DM patients who were admitted to our hospital from 2011 to 2016. The GA data within 30 days before admission and on the day of admission were available for all patients. The change of GA per day (ΔGA/day) was calculated as [(GA on admission) - (GA before admission)/number of days between the two measurements of GA]. Patients with renal dysfunction (eGFR < 30 mL/min/1.73 m2) or insulin deficiency [fasting C-peptide (CPR) < 0.5 ng/mL or two-hour postprandial CPR < 1.0 ng/mL] were excluded. Patients achieving an HbA1c of < 7.0 % at one year after discharge were defined as achievers, and the rest were defined as non-achievers. Multiple baseline factors including the ΔGA/day between the two groups were compared. Results: Of the 114 patients, 68 were achievers and 46 were non-achievers. GA significantly declined during before and just after the admission to hospital (median [interquartile range]: 26.0 [22.2 - 32.7] to 25.0 [21.4 - 29.8] %, p < 0.001). The range of the ΔGA/day was between -1.14 and 0.28, with a median value of -0.08 [-0.26 - 0.002]. The age, body mass index, and HbA1c levels at admission were not significantly different between the two groups. The increase in CPR after the glucagon loading test was higher in the achievers than in the non-achievers (1.85 [1.32 - 2.87] vs 1.21 [0.53 - 1.92] ng/ml, p = 0.004). The ΔGA/day was lower in the achievers than in the non-achievers (-0.14 [-0.39 - -0.006] vs -0.04 [-0.13 - 0.03], p = 0.002). A logistic regression analysis demonstrated that the ΔGA/day was the factor associated with achieving an HbA1c of < 7.0% at one year after discharge (Odds ratio: 0.037, 95 % confidence interval: 0.004 - 0.267, p < 0.001). In the receiver operating characteristic curve analysis, the ΔGA/day had an area under the curve of 0.67 in the achievement group and the cutoff value was set as -0.146 for predicting the achievement, with a sensitivity of 0.50 and a specificity of 0.85. Conclusion: Our results suggest that the change in GA before the educational admission can predict the glycemic control one year after the discharge of T2DM patients.

The impact of pioglitazone on glycemic control and atherogenic dyslipidemia in patients with type 2 diabetes mellitus

2001 ◽  
Vol 12 (5) ◽  
pp. 413-423 ◽  
Author(s):  
Sidney Rosenblatt ◽  
Barry Miskin ◽  
N. Bradly Glazer ◽  
Melvin J. Prince ◽  
Kenneth E. Robertson
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Atherogenic Dyslipidemia ◽  
The Impact

Hatha Yoga Practice for Type 2 Diabetes Mellitus Patients: A Pilot Study

2013 ◽  
Vol 23 (2) ◽  
pp. 59-65 ◽  
Author(s):  
Maricarmen Vizcaino
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Perceived Stress ◽  
Physiological Stress ◽  
Self Care ◽  
Hatha Yoga ◽  
The Impact

Objective: This study was conducted to examine the impact of Hatha yoga on glycemic control, psychological and physiological stress, and self-care for individuals with type 2 diabetes mellitus (T2DM). Methods: Ten sedentary individuals with T2DM who were non-insulin dependent, free of diabetes-related complications, and had no previous yoga experience completed therapeutic yoga classes for 6 weeks, 3 times per week . Glycemic control measures included fasting blood glucose, glycated hemoglobin, and fasting insulin. The State-Trait Anxiety Inventory, Perceived Stress Scale, and salivary cortisol were used to assess levels of stress, and the Summary of Diabetes Self-care Activities questionnaire was used to assess regimen adherence. Results: No significant changes in glucose control or physiological stress were found; however, significant changes in perceived stress, state anxiety, and self-care behaviors were detected. Conclusions: Preliminary findings support further investigation of the benefits of Hatha yoga as a complementary therapy for those with T2DM.

Impact of COVID 19 Lockdown on Glycemic Control in Patients with Type 2 Diabetes Mellitus in Dubai

2021 ◽  
Vol 18 ◽  
Author(s):  
Ibtehal Makki ◽  
Nouf Alnoon ◽  
Najma Rahmani ◽  
Jawaher Almulla ◽  
Asma Alamiri ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
P Value ◽  
Before And After ◽  
The Mean ◽  
Design And Methods ◽  
The Impact

Objective: The objective of this study is to evaluate the impact of the COVID-19 lockdown on glycemic control and accompanying laboratory parameters in patients with type 2 Diabetes Mellitus. Research design and methods: This study is a retrospective cohort study that was done on a multicenter level. It was conducted during the lockdown in 341 individuals. HbA1c was tested to measure glycemic control immediately before and after the lockdown period that lasted for 13 weeks. Results: The primary outcome was the improvement of mean HbA1C after 13 weeks of lockdown compared to the pre-lockdown HbA1C. It was found that the mean HbA1C improved from 7.5±1.5 to 7.3±1.5 with a p-value of 0.001. Conclusion: Our study showed that patients with type 2 diabetes mellitus exhibited an improvement in their glycemic control after the period of lockdown.

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