scholarly journals Association between Optic Nerve Head Microcirculation and Macular Ganglion Cell Complex Thickness in Eyes with Untreated Normal Tension Glaucoma and a Hemifield Defect

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Ayako Anraku ◽  
Kyoko Ishida ◽  
Nobuko Enomoto ◽  
Seiji Takagi ◽  
Hiroyuki Ito ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Optic Nerve Head ◽  
Structural Changes ◽  
Normal Tension Glaucoma ◽  
Cell Complex ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Ganglion Cell Complex ◽  
Fiber Layer

Purpose.We evaluated the association between optic nerve head (ONH) microcirculation and macular ganglion cell complex (mGCC) thickness in patients with untreated normal tension glaucoma (NTG) and a hemifield defect.Methods.The medical records of 47 patients with untreated NTG were retrospectively reviewed. Laser speckle flowgraphy was used to obtain mean blur rate (MBR), a relative measure of blood flow. Average total deviation (TD), mGCC, and the circumpapillary retinal nerve fiber layer (cpRNFL) thickness were also analyzed.Results.All parameters corresponding to the defective hemifield were significantly lower than those corresponding to the normal hemifield. In the defective hemifield, MBR was correlated with TD, mGCC, and cpRNFL thickness. In the normal hemifield, MBR was only correlated with mGCC thickness, and multiple regression analysis showed that mGCC thickness was a significant contributing factor of the MBR.Conclusion.MBR was well correlated with mGCC thickness in eyes with untreated NTG and a hemifield defect. In the normal hemifield, mGCC thickness was a contributing factor of the MBR indicating that ONH circulatory dysfunction may be associated with retinal structural changes in the early stages of glaucoma. A reduction in ONH microcirculation may be an early indicator of the presence and progression of glaucoma.

Differences in Optic Nerve Head, Retinal Nerve Fiber Layer, and Ganglion Cell Complex Parameters Between Caucasian and Chinese Subjects

2018 ◽  
Vol 27 (4) ◽  
pp. 350-356 ◽  
Author(s):  
Sunee Chansangpetch ◽  
Guofu Huang ◽  
Paul Coh ◽  
Catherine Oldenburg ◽  
Behzad Amoozgar ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Optic Nerve Head ◽  
Cell Complex ◽  
Ganglion Cell Complex ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Chinese Subjects

scholarly journals Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Anna Sophie Mursch-Edlmayr ◽  
Nikolaus Luft ◽  
Dominika Podkowinski ◽  
Michael Ring ◽  
Leopold Schmetterer ◽  
...  
Keyword(s):  
Pilot Study ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Normal Tension Glaucoma ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Healthy Individuals

scholarly journals Size of the Optic Nerve Head and Its Relationship with the Thickness of the Macular Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer in Patients with Primary Open Angle Glaucoma

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Nobuko Enomoto ◽  
Ayako Anraku ◽  
Kyoko Ishida ◽  
Asuka Takeyama ◽  
Fumihiko Yagi ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Nerve Fiber Layer ◽  
Optic Nerve Head ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Ganglion Cell Complex ◽  
Open Angle ◽  
Fiber Layer ◽  
Retinal Nerve Fiber

Purpose. To evaluate the relationships among the optic nerve head (ONH) area, macular ganglion cell complex (mGCC) thickness, circumpapillary retinal nerve fiber layer (cpRNFL) thickness, and visual field defects in patients with primary open angle glaucoma (POAG).Methods. This retrospective study included 90 eyes of 90 patients with POAG. The ONH area, rim area, mGCC thickness, and cpRNFL thickness were measured using optical coherence tomography. Mean deviation (MD) was measured using standard automated perimetry. The relationships among clinical factors including age, refraction, the ONH area, the rim area, the mGCC thickness, the cpRNFL thickness, and MD were evaluated using correlation coefficients and multiple regression analyses.Results. The significant correlation of the ONH area with refraction (r=0.362,P<0.001), the mGCC thickness (r=0.225,P=0.033), and the cpRNFL thickness (r=0.253,P=0.016) was found. Multiple regression analysis showed that the ONH area, rim area, and MD were selected as significant contributing factors to explain the mGCC thickness and cpRNFL thickness. No factor was selected to explain MD.Conclusions. The ONH area, in other words, the disc size itself may affect the mGCC thickness and cpRNFL thickness in POAG patients.Erratum to “Size of the Optic Nerve Head and Its Relationship with the Thickness of the Macular Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer in Patients with Primary Open Angle Glaucoma”

scholarly journals OPTICAL COHERENCE TOMOGRAPHY

2016 ◽  
Vol 23 (09) ◽  
pp. 1149-1156
Author(s):  
Faheem Ahmad ◽  
Muhmmad Hussian
Keyword(s):  
Optic Nerve ◽  
Diagnostic Accuracy ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Optic Nerve Head ◽  
Predictive Value ◽  
Structural Changes ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Cross Sectional

“Glaucoma an optic neuropathy is a caused by progressive retinal ganglion cell(RGC) loss associated with characteristic structural changes in the optic nerve and retinal nervefiber layer (RNFL).Glaucoma induced damage causes the retinal ganglion cells loss that canresult in functional loss and decrease in vision of patient . Measurement of intraocular pressureby Tonometery, characteristics of the optic nerve head changes and associated visual fieldloss are used for diagnosis of Glaucoma. Objectives: To determine the diagnostic accuracy ofOptical Coherence Tomography in detection of glaucoma taking perimetry as gold standard.Study Design: Cross sectional (validation). Period: Six months from 17-02-2014 to 16-08-2014.Material and Method: Regarding the Inclusion Criteria patients of glaucoma suspects that meetthe criteria mentioned in operational definition of either gender with age range between 35- 60years were included while patients having refractive errors, hazy media, pupil size less than4mm after dilation were not included in this study. Also patients with history diabetes mellitus,refractive or retinal surgery were also excluded. All the data was entered and analyzed by usingSPSS V-16. Results: A total of 100 patients were included in this study during the study period.Majority of the patients were between 35-45 years of age and minimum patients were 56-60 years old. Mean age of the patients was 47.10±8.02 years. Males and females were 50(50%). At OCT glaucoma was present in 71 patients while at perimetry glaucoma was presentin 69 patients .Sensitivity, specificity and diagnostic accuracy of OCT was 92.7%, 77.4%, 88.0%,respectively .Positive predictive value and negative predictive value of OCT was 90.1% and82.7%, respectively. Discussion: Regarding the pathogenesis of Glaucoma induced damageis due to result of retinal ganglion cell (RGC) death with progressive loss of axons located inthe retinal nerve fiber layer (RNFL). Many clinical studies showed that optic nerve head (ONH)damage and thinning of the RNFL occur earlier than the appearance of Glaucoma inducedvisual field defects; Conclusion: In conclusion, glaucoma suspects undergoing the OCT canbe assessed for the presence of glaucoma based purely on the results of the OCT.

scholarly journals Macular Retinal Ganglion Cell Complex Thickness and Its Relationship to the Optic Nerve Head Topography in Glaucomatous Eyes with Hemifield Defects

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Seiji T. Takagi ◽  
Yoshiyuki Kita ◽  
Asuka Takeyama ◽  
Goji Tomita
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Optic Nerve Head ◽  
Ganglion Cell Complex ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Optic Nerve Head Topography ◽  
Retinal Nerve Fiber

Purpose. To evaluate the relationship between the macular ganglion cell complex (mGCC) thickness, which is the sum of the retinal nerve fiber, ganglion cell, and inner plexiform layers, measured with a spectral-domain optical coherence tomograph and the optic nerve head topography measured with a confocal scanning laser ophthalmoscope in glaucomatous eyes with visual field defects localized predominantly to either hemifield.Materials and Methods. The correlation between the mGCC thickness in hemispheres corresponding to hemifields with and without defects (damaged and intact hemispheres, respectively) and the optic nerve head topography corresponding to the respective hemispheres was evaluated in 18 glaucomatous eyes.Results. The mGCC thickness was significantly correlated with the rim volume, mean retinal nerve fiber layer thickness, and cross-sectional area of the retinal nerve fiber layer in both the intact and the damaged hemispheres(P<.05).Discussion. For detecting very early glaucomatous damage of the optic nerve, changes in the thicknesses of the inner retina in the macular area and peripapillary RNFL as well as rim volume changes in the optic nerve head are target parameters that should be carefully monitored.

scholarly journals Comparison of Structural Defects between Optic Disc and Ganglion Cell Complex in Patients with Glaucoma

2019 ◽  
pp. 1-7
Author(s):  
Ilias Georgalas ◽  
Sergios Taliantzis ◽  
Maria Kazaki ◽  
Eva Papaconstantinou ◽  
Elina Panagiotopoulou ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Optic Disc ◽  
Optic Nerve Head ◽  
Cell Complex ◽  
The Other ◽  
Optic Disk ◽  
Structural Defects ◽  
Ganglion Cell Complex ◽  
Glaucomatous Damage

Purpose: To evaluate the agreement of glaucomatous structural defects of the ganglion cell complex (GCC) detected with the spectral domain optical coherence tomography (sdOCT) with the optic nerve head alterations detected with the Heidelberg retina tomography (HRT), of glaucoma patients with ocular hypertension or open angle glaucoma. Material and Methods: Ninety patients eyes with structural glaucomatous defects were enrolled. All of them underwent imaging examination of GCC with sdOCT and the optic disk with HRT. The Cohen's kappa coefficient of agreement was used. Results: The agreement between the optic disc and GCC using the parameters of the programs analysis of the HRT, the moorfields regression analysis (MRA) and glaucoma probability score (GPS) was not significant. Instead between MRA and GPS a good agreement was calculated. Significant agreements were found between MRA and GPS on one hand and GCC on the other, considering location and length of the glaucomatous damage, while non significant agreements were found between GPS and GCC for the location and the length of the glaucomatous structural defect. Conclusions: There is no significance (Please explain further if you are referring to significance in terms of the difference, similarity or agreement) between HRT and sdOCT for the detection of the glaucomatous damage between the optic nerve head and the ganglion cell complex. Instead MRA and GCC detect comparable areas and lengths of the glaucomatous damage. On the other hand GPS records larger deficits relative to MRA and has not a significant agreement with the study of GCC.

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