scholarly journals OPTICAL COHERENCE TOMOGRAPHY

2016 ◽  
Vol 23 (09) ◽  
pp. 1149-1156
Author(s):  
Faheem Ahmad ◽  
Muhmmad Hussian
Keyword(s):  
Optic Nerve ◽  
Diagnostic Accuracy ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Optic Nerve Head ◽  
Predictive Value ◽  
Structural Changes ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Cross Sectional

“Glaucoma an optic neuropathy is a caused by progressive retinal ganglion cell(RGC) loss associated with characteristic structural changes in the optic nerve and retinal nervefiber layer (RNFL).Glaucoma induced damage causes the retinal ganglion cells loss that canresult in functional loss and decrease in vision of patient . Measurement of intraocular pressureby Tonometery, characteristics of the optic nerve head changes and associated visual fieldloss are used for diagnosis of Glaucoma. Objectives: To determine the diagnostic accuracy ofOptical Coherence Tomography in detection of glaucoma taking perimetry as gold standard.Study Design: Cross sectional (validation). Period: Six months from 17-02-2014 to 16-08-2014.Material and Method: Regarding the Inclusion Criteria patients of glaucoma suspects that meetthe criteria mentioned in operational definition of either gender with age range between 35- 60years were included while patients having refractive errors, hazy media, pupil size less than4mm after dilation were not included in this study. Also patients with history diabetes mellitus,refractive or retinal surgery were also excluded. All the data was entered and analyzed by usingSPSS V-16. Results: A total of 100 patients were included in this study during the study period.Majority of the patients were between 35-45 years of age and minimum patients were 56-60 years old. Mean age of the patients was 47.10±8.02 years. Males and females were 50(50%). At OCT glaucoma was present in 71 patients while at perimetry glaucoma was presentin 69 patients .Sensitivity, specificity and diagnostic accuracy of OCT was 92.7%, 77.4%, 88.0%,respectively .Positive predictive value and negative predictive value of OCT was 90.1% and82.7%, respectively. Discussion: Regarding the pathogenesis of Glaucoma induced damageis due to result of retinal ganglion cell (RGC) death with progressive loss of axons located inthe retinal nerve fiber layer (RNFL). Many clinical studies showed that optic nerve head (ONH)damage and thinning of the RNFL occur earlier than the appearance of Glaucoma inducedvisual field defects; Conclusion: In conclusion, glaucoma suspects undergoing the OCT canbe assessed for the presence of glaucoma based purely on the results of the OCT.

scholarly journals Microvascular Density Is Associated With Retinal Ganglion Cell Axonal Volume in the Laminar Compartments of the Human Optic Nerve Head

2018 ◽  
Vol 59 (3) ◽  
pp. 1562 ◽  
Author(s):  
Min H. Kang ◽  
Mengchen Suo ◽  
Chandrakumar Balaratnasingam ◽  
Paula K. Yu ◽  
William H. Morgan ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Optic Nerve Head ◽  
Microvascular Density ◽  
Retinal Ganglion ◽  
Human Optic Nerve

scholarly journals Exosome-Mediated Delivery of the Neuroprotective Peptide PACAP38 Promotes Retinal Ganglion Cell Survival and Axon Regeneration in Rats With Traumatic Optic Neuropathy

2021 ◽  
Vol 9 ◽  
Author(s):  
Tian Wang ◽  
Yiming Li ◽  
Miao Guo ◽  
Xue Dong ◽  
Mengyu Liao ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Optic Neuropathy ◽  
Axon Regeneration ◽  
Retinal Ganglion ◽  
Traumatic Optic Neuropathy ◽  
Fiber Layer

Traumatic optic neuropathy (TON) refers to optic nerve damage caused by trauma, leading to partial or complete loss of vision. The primary treatment options, such as hormonal therapy and surgery, have limited efficacy. Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38), a functional endogenous neuroprotective peptide, has emerged as a promising therapeutic agent. In this study, we used rat retinal ganglion cell (RGC) exosomes as nanosized vesicles for the delivery of PACAP38 loaded via the exosomal anchor peptide CP05 (EXOPACAP38). EXOPACAP38 showed greater uptake efficiency in vitro and in vivo than PACAP38. The results showed that EXOPACAP38 significantly enhanced the RGC survival rate and retinal nerve fiber layer thickness in a rat TON model. Moreover, EXOPACAP38 significantly promoted axon regeneration and optic nerve function after injury. These findings indicate that EXOPACAP38 can be used as a treatment option and may have therapeutic implications for patients with TON.

scholarly journals Retinal Ganglion Cell Layer Thinning Followed By Retinal Nerve Fiber Layer Thinning In Patients with Uveitis

2016 ◽  
Vol 1 (2) ◽  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Ganglion Cell ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Ganglion Cell Layer

In the model of experimentally induced ischemia- reperfusion injury, retinal ganglion cells (RGC) expressing the gene AP-1 result apoptosis. The inflammation mediators, such as TNF-α, IL-1β, etc. lead RGC to apoptosis, that may lead the thinning of the retinal ganglion cell layer (RGCL) followed by the optic nerve fiber layer (RNFL) thinning. In his study we observed retinal ganglion cell and optic nerve fiber layer thinning in patients with various uveitis, that the pathological features appear obliterative vasculitis, using the optical coherence tomography (OCT) imaging analyses. Subjects were 182 eyes of 91 uveitis patients without glaucoma. Comparison were patients with normal tension glaucoma (NTG). Image analyses were conducted with 3D OCT-2000. As a result average RGCL thickness values in the patients with uveitis were significantly(p<0.01) thinner than those in healthies. Cycle scan findings of RNFL around the optic disc in the patients with uveitis showed significant thinning especially at nasal side. The retinal ganglion cell layer thinning followed by the retinal nerve fiber thinning in the patients with various uveitis was observed, and the thinning was similar to that in patients with glaucoma. The observation of RGCL and RNFL thickness may be useful for the diagnosis and the follow-up of uveitis.

scholarly journals Comparison of Retinal Nerve Fiber Layer Thinning and Retinal Ganglion Cell Loss After Optic Nerve Transection in Adult Albino Rats

2015 ◽  
Vol 56 (8) ◽  
pp. 4487 ◽  
Author(s):  
Giuseppe Rovere ◽  
Francisco M. Nadal-Nicolás ◽  
Marta Agudo-Barriuso ◽  
Paloma Sobrado-Calvo ◽  
Leticia Nieto-López ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Ganglion Cell ◽  
Retinal Nerve Fiber Layer ◽  
Cell Loss ◽  
Albino Rats ◽  
Retinal Ganglion ◽  
Nerve Transection ◽  
Fiber Layer

Glaucoma Diagnostic Accuracy of Ganglion Cell–Inner Plexiform Layer Thickness: Comparison with Nerve Fiber Layer and Optic Nerve Head

Ophthalmology ◽  
2012 ◽  
Vol 119 (6) ◽  
pp. 1151-1158 ◽  
Author(s):  
Jean-Claude Mwanza ◽  
Mary K. Durbin ◽  
Donald L. Budenz ◽  
Fouad E. Sayyad ◽  
Robert T. Chang ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Diagnostic Accuracy ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Optic Nerve Head ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer

scholarly journals Association between Optic Nerve Head Microcirculation and Macular Ganglion Cell Complex Thickness in Eyes with Untreated Normal Tension Glaucoma and a Hemifield Defect

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Ayako Anraku ◽  
Kyoko Ishida ◽  
Nobuko Enomoto ◽  
Seiji Takagi ◽  
Hiroyuki Ito ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Optic Nerve Head ◽  
Structural Changes ◽  
Normal Tension Glaucoma ◽  
Cell Complex ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Ganglion Cell Complex ◽  
Fiber Layer

Purpose.We evaluated the association between optic nerve head (ONH) microcirculation and macular ganglion cell complex (mGCC) thickness in patients with untreated normal tension glaucoma (NTG) and a hemifield defect.Methods.The medical records of 47 patients with untreated NTG were retrospectively reviewed. Laser speckle flowgraphy was used to obtain mean blur rate (MBR), a relative measure of blood flow. Average total deviation (TD), mGCC, and the circumpapillary retinal nerve fiber layer (cpRNFL) thickness were also analyzed.Results.All parameters corresponding to the defective hemifield were significantly lower than those corresponding to the normal hemifield. In the defective hemifield, MBR was correlated with TD, mGCC, and cpRNFL thickness. In the normal hemifield, MBR was only correlated with mGCC thickness, and multiple regression analysis showed that mGCC thickness was a significant contributing factor of the MBR.Conclusion.MBR was well correlated with mGCC thickness in eyes with untreated NTG and a hemifield defect. In the normal hemifield, mGCC thickness was a contributing factor of the MBR indicating that ONH circulatory dysfunction may be associated with retinal structural changes in the early stages of glaucoma. A reduction in ONH microcirculation may be an early indicator of the presence and progression of glaucoma.

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