Bronchus Associated Lymphoid Tissue Lymphoma Presenting with Immunodeficiency and Multiple Pulmonary Nodules

Bronchus Associated Lymphoid Tissue Lymphoma (BALTOMA) is a rare subgroup of pulmonary non-Hodgkin’s lymphomas (NHLs) comprising less than 1% of all cases. It constitutes 3.6% of all extranodal lymphomas and only 0.5–1% of primary pulmonary malignancies. They are usually low grade B-cell lymphomas and are considered to originate from the mucosa associated lymphoid tissue (MALT) of the bronchi. Here, we represent a rare case of BALTOMA presenting with immunodeficiency and multiple pulmonary nodules.

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Eradication of Helicobacter pylori and Stability of Remissions in Low-Grade Gastric B-Cell Lymphomas of the Mucosa-Associated Lymphoid Tissue: Results of an Ongoing Multicenter Trial

Gastrointestinal Lymphoma - Recent Results in Cancer Research ◽

10.1007/978-3-642-57054-4_16 ◽

2000 ◽

pp. 125-133 ◽

Cited By ~ 45

Author(s):

C. Thiede ◽

T. Wündisch ◽

B. Neubauer ◽

B. Alpen ◽

A. Morgner ◽

...

Keyword(s):

Helicobacter Pylori ◽

B Cell ◽

Lymphoid Tissue ◽

Multicenter Trial ◽

Low Grade ◽

B Cell Lymphomas

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Most Gastric Low-Grade B-Cell Lymphomas of Mucosa-Associated Lymphoid Tissue Persist after Helicobacter pylori Eradication

Annals of Internal Medicine ◽

10.7326/0003-4819-132-10-200005160-00031 ◽

2000 ◽

Vol 132 (10) ◽

pp. 846 ◽

Cited By ~ 3

Author(s):

Graziella Pinotti ◽

Claudio Chini ◽

Carlo Capella

Keyword(s):

Helicobacter Pylori ◽

B Cell ◽

Lymphoid Tissue ◽

Low Grade ◽

B Cell Lymphomas ◽

Helicobacter Pylori Eradication

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Trisomy 3 in low-grade B-cell lymphomas of mucosa-associated lymphoid tissue

Blood ◽

10.1182/blood.v85.8.2000.bloodjournal8582000 ◽

1995 ◽

Vol 85 (8) ◽

pp. 2000-2004 ◽

Cited By ~ 210

Author(s):

AC Wotherspoon ◽

TM Finn ◽

PG Isaacson

Keyword(s):

B Cell ◽

Malt Lymphoma ◽

Lymphoid Tissue ◽

Marginal Zone ◽

B Cell Lymphoma ◽

Low Grade ◽

B Cell Lymphomas ◽

Splenic Lymphoma ◽

Trisomy 3 ◽

Primary Splenic Lymphoma

Characteristic chromosomal aberrations have been associated with subtypes of non-Hodgkin's lymphoma with distinct clinicopathologic features. Low-grade B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) form such a group and might be expected to be characterized by a specific cytogenetic abnormality. Metaphase analyses of MALT lymphoma are rare due to problems with fresh tissue collection and poor in vitro proliferation. However, the small number of published series suggests that chromosome trisomies, particularly trisomy 3, might be characteristic of these tumors. The application of interphase cytogenetic techniques to routinely processed material allows the examination of a large series of archival cases and is particularly useful for the demonstration of chromosome trisomies. We have used this technique to analyze 70 cases of low-grade MALT lymphoma from various sites and found trisomy 3 in 60%. This finding compares with 16% in low-grade nodal B-cell lymphoma and 27% in primary splenic lymphoma of marginal zone type (splenic lymphoma with villous lymphocytes). These results provide further evidence that low-grade MALT lymphomas from all sites form a single pathologic entity distinct from nodal B-cell lymphomas. Although MALT lymphoma and primary splenic lymphoma may arise from marginal zone B cells, they are genetically distinct.

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A genotypic study of low grade B-cell lymphomas, including lymphomas of mucosa associated lymphoid tissue (MALT)

The Journal of Pathology ◽

10.1002/path.1711620206 ◽

1990 ◽

Vol 162 (2) ◽

pp. 135-140 ◽

Cited By ~ 57

Author(s):

Andrew C. Wotherspoon ◽

Langxing Pan ◽

Tim C. Diss ◽

Peter G. Isaacson

Keyword(s):

B Cell ◽

Lymphoid Tissue ◽

Low Grade ◽

B Cell Lymphomas

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In situ hybridization: A diagnostic assay for low grade B-cell lymphomas of mucosa associated lymphoid tissue (MALT)

Gastroenterology ◽

10.1016/0016-5085(95)26498-1 ◽

1995 ◽

Vol 108 (4) ◽

pp. A546

Keyword(s):

In Situ Hybridization ◽

B Cell ◽

Lymphoid Tissue ◽

Low Grade ◽

Diagnostic Assay ◽

B Cell Lymphomas

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Laryngeal Lymphoma Derived from Mucosa-Associated Lymphoid Tissue

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949610500716 ◽

1996 ◽

Vol 105 (7) ◽

pp. 577-583 ◽

Cited By ~ 20

Author(s):

Hans-Peter Horny ◽

Alfio Ferlito ◽

Antonino Carbone

Keyword(s):

Gastrointestinal Tract ◽

B Cells ◽

B Cell ◽

Lymphoid Tissue ◽

B Cell Lymphoma ◽

Aerodigestive Tract ◽

Low Grade ◽

Upper Aerodigestive Tract ◽

Marginal Zone B Cells ◽

Hodgkin's Lymphomas

Extranodal lymphomas account for as many as 40% of non-Hodgkin's lymphomas, and most arise in the gastrointestinal tract, but other mucosal organs may be involved, especially the upper aerodigestive tract. Low-grade B-cell lymphomas arising in the gastrointestinal tract and other mucosae have been found to recapitulate the structure and cytologic features of mucosa-associated lymphoid tissue (MALT). Histologically low-grade MALT lymphomas are characterized by centrocyte-like B-cells with a phenotype similar to that of so-called marginal zone B-cells. Tumors evolving from MALT are generally rare among lymphomas of the upper aerodigestive tract, but a few cases of laryngeal lymphomas derived from MALT have been reported. Primary MALT lymphoma of the larynx should always be considered in tumors with histopathologic features of low-grade B-cell lymphoma, or so-called pseudolymphoma

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Primary Hepatic B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue

Archives of Pathology & Laboratory Medicine ◽

10.5858/1999-123-0716-phbclo ◽

1999 ◽

Vol 123 (8) ◽

pp. 716-719

Author(s):

Cheryl M. Kirk ◽

David Lewin ◽

John Lazarchick

Keyword(s):

B Cell ◽

Lymphoid Tissue ◽

Bile Ducts ◽

B Cell Lymphoma ◽

Lymphoid Cells ◽

Low Grade ◽

B Cell Lymphomas ◽

Neoplastic Cells ◽

Primary Hepatic Lymphoma ◽

Lymphoepithelial Lesions

Abstract Mucosa-associated lymphoid tissue (MALT) lymphomas are low-grade B-cell lymphomas that occur in a variety of extranodal sites but rarely as a primary hepatic lymphoma. We describe the histological findings, immunophenotype, and immunohistochemistry of one such lymphoma found incidentally in a 69-year-old woman. The lymphoid infiltrate invaded the liver in a serpiginous configuration with entrapment of nodules of normal liver. Reactive follicles were surrounded by intermediate-sized lymphoid cells with slightly irregular nuclei and pale cytoplasm. Only a few scattered lymphoepithelial lesions were identified since most of the bile ducts were destroyed. The immunophenotype determined by flow cytometry identified the lymphoid cells as being CD19, CD20 positive and exhibiting λ light chain restriction. CD5, CD10, and CD23 were negative. Immunohistochemistry showed the neoplastic cells to be positive for CD20 (L-26) and bcl-2. The reactive follicles were negative for bcl-2. CD3 showed only a few scattered T cells. Cyclin D1 did not stain the neoplastic cells. Cytokeratin (AE1/AE3) highlighted the lymphoepithelial lesions and residual bile ducts. MALT lymphomas need to be recognized and distinguished from other B-cell lymphomas, particularly mantle cell lymphomas, because of the difference in behavior and treatment.

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Immunolocalization of the ICE/Ced-3–Family Protease, CPP32 (Caspase-3), in Non-Hodgkin's Lymphomas, Chronic Lymphocytic Leukemias, and Reactive Lymph Nodes

Blood ◽

10.1182/blood.v89.10.3817.3817_3817_3825 ◽

1997 ◽

Vol 89 (10) ◽

pp. 3817-3825 ◽

Cited By ~ 2

Author(s):

Stanislaw Krajewski ◽

Randy D. Gascoyne ◽

Juan M. Zapata ◽

Maryla Krajewska ◽

Shinichi Kitada ◽

...

Keyword(s):

B Cells ◽

Lymph Nodes ◽

B Cell ◽

Germinal Center ◽

Caspase 3 ◽

Large Cell ◽

B Cell Lymphomas ◽

Mantle Zone ◽

Dynamic Regulation ◽

Hodgkin's Lymphomas

Immunohistochemical analysis of the apoptosis-effector protease CPP32 (Caspase-3) in normal lymph nodes, tonsils, and nodes affected with reactive hyperplasia (n = 22) showed strong immunoreactivity in the apoptosis-prone germinal center B-lymphocytes of secondary follicles, but little or no reactivity in the surrounding long-lived mantle zone lymphocytes. Immunoblot analysis of fluorescence-activated cell sorted germinal center and mantle zone B cells supported the immunohistochemical results. In 22 of 27 (81%) follicular small cleaved cell non-Hodgkin's B-cell lymphomas, the CPP32-immunopositive germinal center lymphocytes were replaced by CPP32-negative tumor cells. In contrast, the large cell component of follicular mixed cells (FMs) and follicular large cell lymphomas (FLCLs) was strongly CPP32 immunopositive in 12 of 17 (71%) and in 8 of 14 (57%) cases, respectively, whereas the residual small-cleaved cells were poorly stained for CPP32 in all FLCLs and in 12 of 17 (71%) FMs, suggesting that an upregulation of CPP32 immunoreactivity occurred during progression. Similarly, cytosolic immunostaining for CPP32 was present in 10 of 12 (83%) diffuse large cell lymphomas (DLCLs) and 2 of 3 diffuse mixed B-cell lymphomas (DMs). Immunopositivity for CPP32 was also found in the majority of other types of non-Hodgkin's lymphomas studied. Plasmacytomas were CPP32 immunonegative in 4 of 12 (33%) cases, in contrast to normal plasma cells, which uniformly contained intense CPP32 immunoreactivity, implying downregulation of CPP32 in a subset of these malignancies. All 12 peripheral blood B-cell chronic lymphocyte leukemia specimens examined were CPP32 immunopositive, whereas 3 of 3 small lymphocytic lymphomas were CPP32 negative, suggesting that CPP32 expression may vary depending on the tissue compartment in which these neoplastic B cells reside. The results show dynamic regulation of CPP32 expression in normal and malignant lymphocytes.

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