High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant
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Acinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. It is characterized by a low- and high-grade component juxtaposed with one another and tends to take on a more aggressive clinical course than its low-grade counterpart, suggesting a poor clinical outcome. We, hereby, report a case of acinic cell carcinoma in a 48-year-old woman with a 6-month history of a right parotid facial swelling rapidly increasing in size. The tumor was initially resected; however, residual focal tissue subsequently revealed areas typical of low-grade acinic cell carcinoma as well as high-grade transformation/dedifferentiation via histopathology.
2016 ◽
Vol 94
(4)
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pp. 946
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2002 ◽
Vol 126
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pp. 1104-1105
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2016 ◽
Vol 121
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pp. 542-549.e1
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2016 ◽
Vol 212
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pp. 1059-1063
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2011 ◽
Vol 29
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pp. 5581-5581
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2015 ◽
Vol 10
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pp. 152-160
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2014 ◽
Vol 18
(1)
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pp. 97
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2009 ◽
Vol 33
(8)
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pp. 1137-1145
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