scholarly journals Peripheral Ulcerative Keratitis Associated with HCV-Related Cryoglobulinemia

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Pedro Coelho ◽  
Carlos Menezes ◽  
Rita Gonçalves ◽  
Pedro Rodrigues ◽  
Elena Seara
Keyword(s):  
Hepatitis C ◽  
Systemic Vasculitis ◽  
Oral Prednisolone ◽  
Adjacent Area ◽  
Hepatitis C Infection ◽  
Medical Background ◽  
Peripheral Ulcerative Keratitis ◽  
History Of ◽  
Illicit Drug Abuse ◽  
Ulcerative Keratitis

Purpose. To describe a case of peripheral ulcerative keratitis associated with type II cryoglobulinemia in the context of Hepatitis C infection. Methods. Case report and literature review. Results. A 36-year-old male patient presented to our emergency department with unilateral moderate pain in his right eye, associated with redness and photophobia. Medical background elicited a history of Hepatitis C and IV illicit drug abuse. Ocular examination revealed a BCVA of 20/30 of the affected eye and slight discomfort with eye movement. Biomicroscopy revealed a ring shaped peripheral corneal ulcer, with a dense white stromal infiltrate sparing the limbus, plus an adjacent area of mild anterior diffuse nonnecrotizing scleritis. No intraocular inflammation was present. Posterior segment was normal. The patient was placed under oral prednisolone (1 mg/Kg/day) with gradual tapering. A dramatic clinical response occurred, with complete resolution of the clinical condition. Systemic analytic workup aiming at autoimmune and infectious diseases was negative, except for high HCV-viral load and the presence of type 2 cryoglobulins. Conclusion. Albeit rare, cryoglobulinemia, even in the absence of systemic vasculitis, should be considered in the differential diagnosis of PUK, when systemic workout for autoimmune diseases is negative.

The HCV National Register: towards informing the natural history of hepatitis C infection in the UK

2000 ◽  
Vol 7 (6) ◽  
pp. 420-427 ◽  
Author(s):  
H. E. Harris ◽  
M. E. Ramsay ◽  
J. Heptonstall ◽  
K. Soldan ◽  
K. P. Eldridge ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Natural History ◽  
Hepatitis C Infection ◽  
National Register ◽  
History Of ◽  
The Uk

scholarly journals Sexual behaviour and infection rates for HIV, blood-borne and sexually transmitted infections among patients attending drug treatment centres in Rio de Janeiro, Brazil

2000 ◽  
Vol 11 (6) ◽  
pp. 383-392 ◽  
Author(s):  
F I Bastos ◽  
C M Lowndes ◽  
M Derrico ◽  
L R Castello-Branco ◽  
M I Linhares-De-Carvalho ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Sexually Transmitted Infections ◽  
Odds Ratio ◽  
Rio De Janeiro ◽  
Drug Users ◽  
Hepatitis C Infection ◽  
Sexually Transmitted ◽  
History Of ◽  
Independent Risk Factors

A survey was carried out in 2 drug use treatment centres (TCs) in Rio de Janeiro, Brazil, to assess risk behaviours, HIV infection and other sexually transmitted infections/blood-borne infections (STIs/BBIs). Two hundred and twenty-five drug users (195 males and 30 females) were interviewed and clinically examined, and their blood and urine were tested for STIs/BBIs. Prevalences (%) for these infections were as follows - HIV: 0.9, hepatitis B virus (HBV): 14.7, hepatitis C virus (HCV): 5.8, syphilis: 5.3, gonorrhoea/chlamydia (CT/NG): 4.7. In bivariate analyses CT/NG infection was associated with younger age ( P =0.003); current genitourinary symptoms (odds ratio [OR]=6.2) and a mainly illegal source of income (OR= 9.1). Hepatitis C infection was associated with a history of ever having injected any drug (OR=19.6), and with each one of the injected drugs. After multiple logistic regression, lower educational level (adjusted odds ratio [AOR]=3.70) and 'ever having injected drugs' (AOR=3.69) remained as independent risk factors for hepatitis B infection. In conclusion, TCs must implement programmes directed towards the prevention of STIs/BBIs.

The natural history of hepatitis C infection acquired through injection drug use: Meta-analysis and meta-regression

2010 ◽  
Vol 53 (2) ◽  
pp. 245-251 ◽  
Author(s):  
Ava John-Baptiste ◽  
Murray Krahn ◽  
Jenny Heathcote ◽  
Audery Laporte ◽  
George Tomlinson
Keyword(s):  
Hepatitis C ◽  
Drug Use ◽  
Natural History ◽  
Injection Drug Use ◽  
Meta Analysis ◽  
Injection Drug ◽  
Hepatitis C Infection ◽  
History Of ◽  
Meta Regression

scholarly journals Updating the Signal-to-cutoff Level to Reduce Anti-hepatitis C Virus False Positivity

2021 ◽  
Vol 14 (10) ◽  
Author(s):  
Servet Oztürk ◽  
Canan Ağalar
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Area Under The Curve ◽  
Hcv Rna ◽  
Hepatitis C Infection ◽  
False Positivity ◽  
History Of ◽  
Training And Research ◽  
Polymerase Chain ◽  
The Cost

Background: Anti-hepatitis C virus (anti-HCV) is the only screening test being used in the diagnosis of hepatitis C. In this study, we examined anti-HCV positivity rates in our hospital. Objectives: The aim of administering the anti-HCV test was to distinguish patients with hepatitis C infection from false positivity in patients with reactive results. Methods: The anti-HCV tests were performed at Fatih Sultan Mehmet Training and Research Hospital in Istanbul, Turkey, between January 1, 2015 and December 31, 2019. The patients were evaluated retrospectively in terms of age, gender, anti-HCV titer, the clinic for which the examination was requested, the reason for the examination, and the history of hepatitis C. Results: In this study, 511 patients who had two negative polymerase chain reaction (PCR) results were evaluated as false positive cases and enrolled. The cut-off value was found to be 7.5 IU/ml, with the highest sensitivity of 94.4% and specificity of 94.5% (area under the curve [AUC]: 0.982). The lowest anti-HCV titer (5.2) was from patients without acute hepatitis, who were HCV-RNA positive and diagnosed with chronic hepatitis C. Conclusions: It may be more appropriate to report anti-HCV cut-off value of 0 - 5 as negative, 5 - 7.5 as borderline, and > 7.5 as positive. Working with a more acceptable cut-off level with a greater number of tests can help identify patients with asymptomatic HCV infection. Also, it can possibly reduce the cost due to a decrease in the number of PCR tests administered.

Hepatitis C infection and chemotherapy toxicity

2017 ◽  
Vol 25 (2) ◽  
pp. 474-480 ◽  
Author(s):  
Amy Ly ◽  
Heather H Cheng ◽  
Laura Alwan
Keyword(s):  
Hepatitis C ◽  
Viral Infection ◽  
Case Reports ◽  
Normal Liver ◽  
Liver Function Tests ◽  
Solid Organ ◽  
Hepatitis C Infection ◽  
Chemotherapy Toxicity ◽  
Palliative Intent ◽  
History Of

There exists little guidance on chemotherapy toxicity management in patients with a history of or active hepatitis C viral infection. We report four cases of patients with solid organ tumors and hepatitis C viral infection, who have experienced severe or unexpected toxicities with chemotherapy. Based on the four case reports, we recommend increased laboratory monitoring for toxicities, initial dose reductions for chemotherapy given with palliative intent, or pre-emptive use of growth factor support, even if the patient presents with normal liver function tests. In this patient population, we also recommend treating active hepatitis C viral infection prior to chemotherapy treatment when possible.

scholarly journals HEPATITIS C INFECTION

2015 ◽  
Vol 22 (10) ◽  
pp. 1278-1283
Author(s):  
Shabnam Naveed ◽  
Syed Masroor Ahmed ◽  
Zeeshan Ali ◽  
Romana Awan ◽  
Humaira Zakir ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Cross Sectional Study ◽  
Study Data ◽  
Diabetic Patients ◽  
Hepatitis C Virus Infection ◽  
Hepatitis C Infection ◽  
Cross Sectional ◽  
History Of ◽  
Associated Risk Factors ◽  
Insulin Use

Objectives: To determine the prevalence of Hepatitis C virus infection in Type IIDiabetes Mellitus patients and its associated risk factors in our population. Duration and Placeof Study: Study was conducted in Jinnah Post graduate Medical Centre, Karachi betweenDecember 2013 to December 2014.Study Design: It is a Cross-sectional study. Data collectionand Results: Data was collected from registered diabetic patients, 355 diagnosed Type IIdiabetes mellitus patients including 128(36.1%) males and 227(63.9%) females were selectedand their Hepatitis C screening was done by ICT method. The bio-data of the patients, history andduration of diabetes mellitus, history of blood transfusion, previous surgery, accidents, shavingfrom barber, tattooing, nose piercing, acupuncture,insulin use were recorded on a proforma.Out of the 355 diabetes mellituspatients tested, 33 were positive for anti-HCV antibodies givinga prevalence of 9.3%. Conclusion:There is increased prevalence of HCV infectionin diabeticpatients when compared with general prevalence of HCV in Pakistan.

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