Urine Trefoil Factors as Prognostic Biomarkers in Chronic Kidney Disease

Introduction. Trefoil factor family (TFF) peptides are increased in serum and urine in patients with chronic kidney disease (CKD). However, whether the levels of TFF predict the progression of CKD remains to be elucidated. Methods. We determined the TFF levels using peptide-specific ELISA in spot urine samples and performed a prospective cohort study. The association between the levels of urine TFFs and other urine biomarkers as well as the renal prognosis was analyzed in 216 CKD patients (mean age: 53.7 years, 47.7% female, 56.9% with chronic glomerulonephritis, and mean eGFR: 58.5 ml/min/1.73 m2). Results. The urine TFF1 and TFF3 levels significantly increased with the progression of CKD stages, but not the urine TFF2 levels. The TFF1 and TFF3 peptide levels predicted the progression of CKD ≥ stage 3b by ROC analysis (AUC 0.750 and 0.879, resp.); however, TFF3 alone predicted CKD progression in a multivariate logistic regression analysis (odds ratio 3.854, 95% confidence interval 1.316–11.55). The Kaplan-Meier survival curves demonstrated that patients with a higher TFF1 and TFF3 alone, or in combination with macroalbuminuria, had a significantly worse renal prognosis. Conclusion. The data suggested that urine TFF peptides are associated with renal progression and the outcomes in patients with CKD.

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Total serum magnesium in cats with chronic kidney disease with nephrolithiasis

Journal of Feline Medicine and Surgery ◽

10.1177/1098612x18823588 ◽

2019 ◽

Vol 21 (12) ◽

pp. 1172-1180 ◽

Cited By ~ 1

Author(s):

Fernanda Chicharo Chacar ◽

Marcia Mery Kogika ◽

Andréa C Ferreira ◽

Khadine K Kanayama ◽

Archivaldo Reche

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Serum Magnesium ◽

Magnesium Concentration ◽

Total Serum ◽

Serum Magnesium Concentration ◽

Electrolyte Disturbances ◽

Kaplan Meier ◽

Ckd Stage ◽

Stage 1

ObjectivesMagnesium has been ‘the forgotten ion’ for many years. Over the past decade, however, the role of magnesium in essential physiological functions and several illness conditions have been elucidated. Nevertheless, the investigation of magnesium in cats with chronic kidney disease (CKD) and nephrolithiasis is yet to be determined. The purpose of this study was to investigate whether CKD cats with nephrolithiasis have changes in total serum magnesium concentrations, and whether magnesium disorders may be associated with other electrolyte disturbances, as well as with prognosis. We also aimed to evaluate whether total serum magnesium concentration differs between CKD cats with and without nephrolithiasis.MethodsTotal serum magnesium concentrations were assessed in 42 cats with CKD with stage 1–4 nephrolithiasis. The correlation between magnesium and other electrolytes, as well as Kaplan–Meier survival analysis, were performed. We also selected 14 control cats with CKD without nephrolithiasis age-matched with 14 cats with CKD with nephrolithiasis.ResultsHypermagnesemia was observed in 16/42 (38.1%) and hypomagnesemia in 6/42 (14.3%) cats. Serum magnesium abnormalities were observed in cats of all stages, and marked hypermagnesemia was noted in cats with stage 4 CKD with nephrolithiasis ( P <0.001). There was a negative correlation between total serum magnesium and ionized calcium ( r = −0.64; P <0.01), and a positive correlation between total serum magnesium and serum phosphorus ( r = 0.58, P = 0.01). Cats with CKD with nephrolithiasis and hypomagnesemia or hypermagnesemia had higher mortality than those with normal total serum magnesium concentration ( P <0.01), regardless of CKD stage. There was no difference in total serum magnesium concentration between CKD cats with and without nephrolithiasis.Conclusions and relevanceCats with CKD with nephrolithiasis have magnesium abnormalities. Hypomagnesemia and hypermagnesemia were associated with an increase in mortality, and thus total serum magnesium abnormalities may be used as prognostic factors in these cases.

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KETAHANAN HIDUP PASIEN GAGAL GINJAL DENGAN METODE KAPLAN MEIER (Studi Kasus di Rumah Sakit Umum Daerah dr. R. Soedjati Soemodiarjo Purwodadi)

Jurnal Gaussian ◽

10.14710/j.gauss.v7i3.26660 ◽

2018 ◽

Vol 7 (3) ◽

pp. 270-280

Author(s):

Immawati Ainun Habibah ◽

Tatik Widiharih ◽

Suparti Suparti

Keyword(s):

Chronic Kidney Disease ◽

Survival Analysis ◽

Kidney Disease ◽

Replacement Therapy ◽

Life Time ◽

Terminal Phase ◽

Type Iii ◽

Kaplan Meier ◽

Observation Process ◽

Ckd Stage

Chronic Kidney Disease (CKD) is a failure of kidney function that which get slowly and can not recover. Most of the patients CKD get death sudden becuse of cardiovascular complications (related to the heart and blood vessels) however only minor part can reach terminal phase (CKD stage 5) which need replacement therapy of Kidney. Replacement therapy of Kidney are hemodialysis, peritoneal dialysis, and Kidney transplant. Because of that, the importance to study how long the patient opportunity is life endurance analysis. Survival analysis methods to life depend from the life time and status of individual life time. Survival analysis uses Kaplan-Meier method. During the observation process, there is different observations so censor type III is choosen. Censor type III is censoring type which research is done to individual in and out for determine time, because of that estimation value of survival can be caunted using Kaplan Meier method with censor type III. This research uses medical records data from the patients with kidney failure period 1 January 2014 until 30 November 2017 in RSUD dr.R. Soedjati Soemodiarjo Purwodadi Grobogan Regency. The results of the analysis and discussion are known that if hemodialysis getting longer done, estimation value of survival. With an average estimate of survival is 776 days. Keywords: Chronic Kidney Disease, Survival Analysis, Kaplan Meier

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The features of comorbid status and its impact on the quality of life of patients with chronic kidney disease on programmed hemodialysis

Spravočnik vrača obŝej praktiki (Journal of Family Medicine) ◽

10.33920/med-10-2103-03 ◽

2021 ◽

pp. 32-40

Author(s):

Aksana Mukhamedovna Kardangusheva ◽

Rustam Khasanovich Keshokov ◽

Dzhanneta Magometovna Urusbieva ◽

Albina Anatolievna Pshukova ◽

Alina Latifovna Betuganova ◽

...

Keyword(s):

Quality Of Life ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Patient Treatment ◽

Renal Diseases ◽

Chronic Glomerulonephritis ◽

Ckd Stage ◽

Common Causes ◽

The Individual

The purpose of the research is to study the features of comorbid status in patients with chronic kidney disease (CKD) Stage 5 on programmed hemodialysis (PHD) and its impact on quality of life (QOL). Methodology: we examined 86 patients (60 men and 26 women) with CKD Stage 5 receiving PHD treatment. The average age of the patients was 55.5±13.9 years. The study protocol included an assessment of the QOL level according to the KDQOL-SF™ questionnaire, the comorbidity index according to M.E. Charlson (CCI), clinical and instrumental studies in accordance with clinical guidelines. Results: the most common causes of CKD Stage 5 in the examined patients were chronic glomerulonephritis and diabetes mellitus (26.7% each), tubulointerstitial renal diseases (23.3%) and polycystic kidney disease (13.3%). High and medium levels of CCI were found in 67.4% of the examined patients. Among the comorbidities, cardiovascular diseases rank first (51.2%). QOL of patients with CKD Stage 5 on PHD was characterized by the lowest scores on the scales of physical functioning and the burden of kidney disease. Correlation analysis revealed that comorbidities in patients with CKD Stage 5 who are on PHD negatively affect their QOL. Conclusion: the obtained results can be used in planning and organizing the provision of medical care to patients with CKD. The introduction of the used QOL and CCI assessment methods in the protocol for the management of patients with CKD Stage 5 in dialysis centers will make it possible to monitor the individual QOL indicators of patients, evaluate the effectiveness of patient treatment and correct it in a timely manner.

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Decreased Bioimpedance Phase Angle in Patients with Diabetic Chronic Kidney Disease Stage 5

Nutrients ◽

10.3390/nu11122874 ◽

2019 ◽

Vol 11 (12) ◽

pp. 2874

Author(s):

Byoung-Geun Han ◽

Jun Young Lee ◽

Jae-Seok Kim ◽

Jae-Won Yang

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Nutritional Status ◽

Phase Angle ◽

Chronic Kidney Disease Stage ◽

Multivariate Logistic Regression Analysis ◽

Albumin Level ◽

Disease Stage ◽

Lean Tissue ◽

Ckd Stage

Early detection and regular monitoring of the nutritional status of patients with diabetic chronic kidney disease (DMCKD) with reliable tools are necessary. We aimed to determine the clinical significance of the phase angle (PhA) in patients with DMCKD stage 5 not undergoing dialysis. A total of 219 patients (non-diabetic CKD stage 5 [nDMCKD5], n = 84; diabetic CKD stage 5 [DMCKD5], n = 135) were analyzed. The nDMCKD5 group had a significantly higher PhA (p = 0.001), intracellular water/body weight (p = 0.001), and albumin level (p = 0.010) than the DMCKD5 group. The DMCKD5 group experienced significantly more overhydration (p < 0.001). The PhA was positively associated with the lean tissue index (LTI) (r = 0.332; p < 0.001), hemoglobin level (r = 0.223; p = 0.010), albumin level (r = 0.524; p < 0.001), and estimated glomerular filtration rate (eGFR; r = 0.204; p = 0.018) in the DMCKD5 group. Multivariate logistic regression analysis showed the eGFR (odds ratio [OR]: 0.824, 95% confidence interval [CI]: 0.698–0.974); p = 0.023), LTI (OR: 0.771, 95% CI: 0.642–0.926; p = 0.005), and albumin level (OR: 0.131, 95% CI: 0.051–0.338; p < 0.001) were significantly associated with undernutrition (PhA < 4.17°) in the DMCKD5 group. Our observations suggest that the PhA could be used as a marker to reflect the nutritional status in patients with DMCKD5.

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Positive Correlation of Serum Resistin Level with Peripheral Artery Disease in Patients with Chronic Kidney Disease Stage 3 to 5

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph182312746 ◽

2021 ◽

Vol 18 (23) ◽

pp. 12746

Author(s):

Xin-Ning Ng ◽

Chi-Chong Tang ◽

Chih-Hsien Wang ◽

Jen-Pi Tsai ◽

Bang-Gee Hsu

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Strong Predictor ◽

Chronic Kidney Disease Stage ◽

Ankle Brachial Index ◽

Multivariate Logistic Regression Analysis ◽

Disease Stage ◽

Resistin Level ◽

Ckd Stage ◽

Serum Resistin Level

Chronic kidney disease (CKD) is associated with higher risk of cardiovascular disease-related ischemic events, which includes peripheral arterial disease (PAD). PAD is a strong predictor of future cardiovascular events, which can cause significant morbidity and mortality. Resistin has been found to be involved in pathological processes leading to CVD. Therefore, we aim to investigate whether resistin level is correlated with PAD in patients with non-dialysis CKD stage 3 to 5. There were 240 CKD patients enrolled in this study. Ankle-brachial index (ABI) values were measured using the automated oscillometric method. An ABI value < 0.9 defined the low ABI group. Serum levels of human resistin were determined using a commercially available enzyme immunoassay. Thirty CKD patients (12.5%) were included in the low ABI group. Patients in the low ABI group were older and had higher resistin levels as well as higher diabetes mellitus, hypertension and habit of smoking, and lower estimated glomerular filtration rate than patients in the normal ABI group. After the adjustment for factors that were significantly associated with PAD by multivariate logistic regression analysis, age and serum resistin level were independent predictors of PAD. A high serum resistin level is an independent predictor of PAD in non-dialysis CKD stage 3 to 5.

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Analysis of profibrogenic microRNAs (miRNAs) expression in urine and serum of chronic kidney disease (CKD) stage 1–4 patients and their relationship with proteinuria and kidney function

International Urology and Nephrology ◽

10.1007/s11255-021-02928-1 ◽

2021 ◽

Author(s):

Rafał Donderski ◽

Joanna Szczepanek ◽

Natalia Naruszewicz ◽

Renata Naruszewicz ◽

Andrzej Tretyn ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Control Sample ◽

Expression Level ◽

Chronic Glomerulonephritis ◽

Relative Expression ◽

Micro Rnas ◽

Ckd Stage ◽

Stage 1 ◽

Urine And Serum

Abstract Purpose Besides conventional kidney diseases diagnostics, micro RNAs (miRNAs) assessment in urine and serum is considered to be a promising non-invasive method of diagnostics of renal parenchymal diseases and valuable therapeutic target also. The purpose of the study was to investigate the role of several miRNAs as a markers of kidney damage. Methods Assessment of 45 chronic kidney disease (CKD) patients stage 1–4 and 17 healthy control. Sample of urine and blood was taken from each participant for molecular analysis using Real Time PCR method to identify such micro-RNAs as: hsa-miR-155-5p, hsa-miR-214-3p, hsa-miR-200a-5p, hsa-miR-29a-5p, hsa-miR-21-5p, hsa-miR-93-5p, and hsa-miR-196a-5p. Basic biochemical test was done. Analysis was performed in CKD patients group and subgroup with chronic glomerulonephritis (CGN) confirmed by kidney biopsy. Moreover, analysis was performed in subgroup with different estimated glomerular filtration rate (eGFR) (according to CKD–EPI equation: eGFR < 60 ml/min, eGFR > 60 ml/min) and different daily protein excretion (DPE): (DPE < 3.5 g; DPE > 3.5 g). Results Increased relative expression of hsa-miR-29-5p, hsa-miR-21-5p, and hsa-miR-196a-5p and decreased expression of hsa-miR-155-5p, hsa-miR-214-5p, hsa-miR-200a-5p, and hsa-miR-93-5p was demonstrated in urine of analyzed CKD patients. In subpopulation of chronic glomerulonephritis (CGN) patients, there was higher level of expression in urine of hsa-miR-155-5p, hsa-miR 214-3p, hsa-miR-93-5p, and hsa-miR-196a-5p in CGN with DPE < 3.5 g. CGN patients with eGFR < 60 ml/min showed higher expression level of miRNAs such as hsa-miR-214-3p, hsa-miR-29-5p, hsa-miR-93-5p, and hsa-miR-196-5p in urine. There was increase in hsa-miR 155-5p, hsa-miR-214-3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR-21-5p, and hsa-miR-93-5p expression. Increased level of expression of hsa-miR-155-5p; hsa-miR-214-3p, hsa-miR-200a-5p, and hsa-miR-29-5p was found in CGN patients with eGFR > 60 ml/min. Conclusion Increased relative expression of profibrogenic miRNAs in urine or serum of CKD patients with eGFR > 60 ml/min and DPE < 3.5 g may indicate higher degree of fibrosis at early CKD stages.

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Vascular access and its complications in patients with chronic kidney disease on haemodialysis: a retrospective analysis

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20200756 ◽

2020 ◽

Vol 8 (3) ◽

pp. 927

Author(s):

Kamal Goplani ◽

Jigar Shrimali ◽

Amitkumar Prajapati ◽

Bhavin Desai

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Vascular Access ◽

Jugular Vein ◽

Femoral Vein ◽

Venous Hypertension ◽

Chronic Glomerulonephritis ◽

Ckd Stage ◽

Haemoglobin Type ◽

Lumen Catheter

Background: Inadequate vascular access in patients on haemodialysis is a major cause of hospitalization leading to life threatening complications. This study evaluated the types of vascular access, location and associated complications in patients with chronic kidney disease (CKD) on haemodialysis.Methods: Patients with CKD stage V on haemodialysis were included in the study. The data was retrospectively collected including demographic details, comorbidities, serum creatinine, haemoglobin, type and site of access and associated complications.Results: A total of 82 patients with mean (SD) age of 56.6(13.9) years were included with 50 (60.9%) patients on arteriovenous fistula (AVF) access and remaining 32 (39.1%) on dual-lumen catheter (DLC). Hypertension (42.6%) was the most common comorbidity reported followed by diabetes (24.3%) and chronic glomerulonephritis (13.4%). In AVF access, 25 (50.0%) had wrist as site of access, 10 (20.0%) had forearm, 11(22.0%) had brachiocephalic and four (8.0%) brachiobasilic. Of 32 DLC access, 27(84.4%) had jugular vein and four (12.5%) femoral vein. One patient with AVF access reported venous hypertension; however, the complications reported in patients with DLC access were infection (n=6, 18.8%) and hematoma and venous hypertension (n=1, 3.7%, each).Conclusions: This study with limited sample size showed that the most common access site for AVF and DLC was wrist and jugular vein, respectively. Infection was the most common complication in patients with DLC. AVF is comparatively safe option for haemodialysis; however, DLC should be used only as a temporary option.

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MO064CORRELATION BETWEEN SODIUM IN SPOT URINE AND 24-HOUR URINE COLLECTION - EFFECTS OF CHRONIC KIDNEY DISEASE (CKD) STAGE AND USE OF DIURETICS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfx125.mo064 ◽

2017 ◽

Vol 32 (suppl_3) ◽

pp. iii72-iii73

Author(s):

Johanna Kurzhagen ◽

Stephanie Titze ◽

Beatrix Büschges-Seraphin ◽

Markus Schneider ◽

Kai-Uwe Eckardt ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Urine Collection ◽

Spot Urine ◽

Ckd Stage

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Study on haematological abnormalities in various stages of chronic kidney disease: stage 3-5

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20201112 ◽

2020 ◽

Vol 7 (4) ◽

pp. 626

Author(s):

Pattu Swarnalatha ◽

T. Vinotha

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Chronic Kidney Disease Stage ◽

Disease Stage ◽

Total Count ◽

Differential Count ◽

Chronic Glomerulonephritis ◽

College Hospital ◽

Ckd Stage ◽

Wbc Count

Background: Chronic kidney disease is one of the major health problems worldwide and a major cause of morbidity and mortality. CKD is diagnosed on the basis of the presence of markers of kidney damage and kidney function. Aim of the study to assess the prevalence of hematological abnormalities in CKD (stage 3-5) and to assess their correlation among various etiologies of CKD (diabetes, chronic glomerulonephritis, hypertension.Methods: The study was done in 150 cases diagnosed as CKD in the Department of Nephrology, IMCU, and in the medical ward at Tirunelveli Medical College Hospital. The diagnosis was based on an estimated GFR level <60ml/mt/1.73M2. Total count, differential count, Hb, MCV, MCH, MCHC, WBC count, platelet count, and peripheral smear examination, coagulation profile were done on all the patients and results were compared and correlated with each other.Results: In 150 patients, 90 males and 60 females were included. Among 90 males 43 were in stage 3 CKD, 11 in stage 4, 36 in stage 5. Among 60 females 7 were in stage 3, 39 in stage four, 14 were in stage 5. 63 patients had both hypertension and diabetes, 30 patients had only diabetes. There was a decrease in RBC, Total count platelet value with respect to increase in stages of CKD. There was a prolongation in BT, CT, PT, APTT and INR value in respect to increase in stages of CKD.Conclusions: Chronic kidney disease patients have lower haematological indices and the degree of changes depends on the severity of kidney disease.

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Associations Between Arterial Stiffness Indices and Chronic Kidney Disease Categories in Essential Hypertensive Patients

American Journal of Hypertension ◽

10.1093/ajh/hpaa163 ◽

2020 ◽

Author(s):

Hiroshi Kusunoki ◽

Yoshio Iwashima ◽

Yuhei Kawano ◽

Yuko Ohta ◽

Shin-ichiro Hayashi ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Arterial Stiffness ◽

Multivariate Logistic Regression Analysis ◽

Resistive Index ◽

Renal Resistive Index ◽

Risk Category ◽

Hypertensive Patients ◽

Ckd Stage ◽

Risk Categories

Abstract BACKGROUND This study investigated the association between arterial stiffness indices and asymptomatic chronic kidney disease (CKD) risk categories in hypertensive patients. METHODS Arterial stiffness indices, including 24-hour brachial and aortic systolic blood pressure (SBP) and pulse wave velocity (PWV), were measured by an oscillometric Mobil-O-Graph device, brachial-ankle PWV (baPWV) by a volume-plethysmographic method, and renal resistive index (RI) by ultrasonography, in 184 essential hypertensive patients (66.0 ± 17.1 years, 47.3% male). CKD was categorized into 3 stages based on the Kidney Disease Improving Global Outcomes (KDIGO) criteria, using a combination of estimated glomerular filtration and albuminuria. RESULTS The 24-hour aortic PWV (aPWV), baPWV, and RI increased with worsening severity of CKD risk category (all P < 0.01 for trend). Multivariate logistic regression analysis found that a 1 SD increase of nighttime aortic SBP (odds ratio [OR] 1.52), PWV (OR 4.80), or RI (OR 1.75) was an independent predictor of high or very-high CKD stage (all P < 0.05). After adjustment for potential confounders, day-to-night change in brachial SBP as well as in aPWV differed among groups (P < 0.05, respectively). In a multivariate regression model, day-to-night changes in aortic SBP and PWV, and RI were independently associated with day-to-night brachial SBP change. CONCLUSIONS In hypertension, circadian hemodynamics in high CKD stage are characterized by higher nighttime values of aortic SBP and PWV and disturbed intrarenal hemodynamics. Further, the blunted nocturnal BP reduction in these patients might be mediated via disturbed intrarenal hemodynamics and circadian hemodynamic variation in aortic SBP and arterial stiffness.

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