Positive Correlation of Serum Resistin Level with Peripheral Artery Disease in Patients with Chronic Kidney Disease Stage 3 to 5

Chronic kidney disease (CKD) is associated with higher risk of cardiovascular disease-related ischemic events, which includes peripheral arterial disease (PAD). PAD is a strong predictor of future cardiovascular events, which can cause significant morbidity and mortality. Resistin has been found to be involved in pathological processes leading to CVD. Therefore, we aim to investigate whether resistin level is correlated with PAD in patients with non-dialysis CKD stage 3 to 5. There were 240 CKD patients enrolled in this study. Ankle-brachial index (ABI) values were measured using the automated oscillometric method. An ABI value < 0.9 defined the low ABI group. Serum levels of human resistin were determined using a commercially available enzyme immunoassay. Thirty CKD patients (12.5%) were included in the low ABI group. Patients in the low ABI group were older and had higher resistin levels as well as higher diabetes mellitus, hypertension and habit of smoking, and lower estimated glomerular filtration rate than patients in the normal ABI group. After the adjustment for factors that were significantly associated with PAD by multivariate logistic regression analysis, age and serum resistin level were independent predictors of PAD. A high serum resistin level is an independent predictor of PAD in non-dialysis CKD stage 3 to 5.

Serum resistin is predictive marker of development of new digital ulcers in systemic sclerosis

Systemic sclerosis (SSc) is autoimmune disease characterized by endothelial dysfunction and microvascular damage. Resistin has been implied in microvascular dysfunction. Objective of this study is to evaluate the association between baseline resistin and development of new digital ulcers (DUs) in SSc patients. At baseline, serum resistin has been assessed in 70 female SSc patients and 26 healthy controls (HC). In SSc patients, clinical assessment was performed at baseline and after a 52-weeks follow-up. Serum resistin level was increased in SSc patients compared to HC [5.89 ng/ml (2.5 ng/ml–8.1 ng/ml) vs 2.3 ng/ml (0.4 ng/ml–2.4 ng/ml), p = 0.0004)]. Resistin was lower (p = 0.005) in SSc patients with early capillaroscopic pattern than patients with active or late capillaroscopic pattern [2.49 ng/ml (0.89 ng/ml–5.81 ng/ml) vs 7.11 ng/ml (3.48 ng/ml–11.35 ng/ml) and 6.49 ng/ml (3.35 ng/ml–8.87 ng/ml), respectively]. After a 52-weeks follow-up, 34 (48.6%) patients developed new DUs. Median serum resistin was significantly higher in patients with new DUs than in patients without new DUs [6.54 ng/ml (3.35 ng/ml–11.02 ng/ml) vs 4.78 ng/ml (1.06 ng/ml–7.6 ng/ml), p = 0.019]. Kaplan–Meier curves show a significantly reduced free survival from DUs in patients with increased resistin (p = 0.002). In multivariate analysis, resistin is associated with the development of new DUs. Increased serum resistin level is a predictive marker of new DUs in SSc.

AB0415 SERUM RESISTIN LEVEL IN SYSTEMIC LUPUS ERYTHEMATOSUS: RELATION TO LUPUS NEPHRITIS AND DISEASE ACTIVITY

Background:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting different organs and systems.. Adipokines have recently been implicated as mediators of immune and inflammatory processes. Human resistin is a cytokine that induces low-grade inflammation by stimulating monocytesObjectives:The aim of this work is to assess the serum level of resistin in SLE patients and to detect its relation to lupus nephritis, and disease activityMethods:40 patients with SLE with age ranged between 18-48 years and 20 healthy age, sex and BMI matched volunteer were enrolled in this study. According to the presence or absence of lupus nephritis (LN), patients were classified into two subgroups Full history, clinical examination and laboratory investigations were performed for all patients including serum resistin levelResults:The level of serum resistin was higher in SLE patients than the controls(p=0.001).Also, serum resistin levels were higher in patients with lupus nephritis than those without nephritis(p= 0.02).Serum resistin level correlated positively with the levels of ESR(p< 0.001), CRP(p= 0.005),Anti-dsDNA(p= 0.002) and serum urea(p= 0.002).Serum resistin levels correlated negatively with hemoglobin levels(p= 0.001) and levels of C3(p< 0.001) and C4(p< 0.001).There was a significant positive correlation between serum resistin level and the presence of albumin(p= 0.001),RBCs(p= 0.003),pus cells(p= 0.001) and casts(p< 0.001) in urine and also with the levels of 24 hour urinary protein and protein/ creatinine ratio(p<0.001).Serum resistin level was found to be strongly correlated with SLEDAI(p< 0.001).No correlation was found between serum resistin levels and ISN/RPS classification of renal biopsy.Conclusion:Serum resisitin level can be used as a marker of inflammation, nephritis,disease activity in patients with SLE.Disclosure of Interests: :None declared

P0785POSITIVE CORRELATION OF SERUM RESISTIN LEVEL WITH PERIPHERAL ARTERY OCCLUSIVE DISEASE IN PATIENTS WITH CHRONIC KIDNEY DISEASE STAGE 3 TO 5

Background and Aims Resistin named for its ability to resist insulin action has an important link between obesity, insulin resistance and diabetes. Moreover, additional reports suggest that resistin has a pathogenic role in the development and progression of atherosclerosis and coronary artery disease. Chronic kidney disease (CKD) accelerates atherosclerosis via augmentation of inflammation and perturbation of lipid metabolism. Peripheral arterial occlusive disease (PAOD) is associated with an increased risk of death in CKD patients. The aim of this study was to evaluate the relationship between serum resistin level and PAOD by ankle-brachial index (ABI) in CKD patients. Method Fasting blood samples and baseline characteristics were obtained from 240 patients with CKD (stage 3-5). ABI values were measured using the automated oscillometric method (VaSera VS-1000). ABI values that were &lt; 0.9 were included in the low ABI group. Concentrations of human serum resistin were determined using a commercially available enzyme immunoassay kit. Results Among the 240 CKD patients, 30 of them (12.5%) were in the low ABI group. Compared with patients in the control group, the patients in the low ABI group had higher prevalence of diabetes (p = 0.033), hypertension (p = 0.023), current smoking (p = 0.013), older age (p &lt; 0.001), higher systolic blood pressure (p = 0.013), glucose (p = 0.022) level and resistin (p &lt; 0.001) levels. In addition, the multivariable logistic regression analysis showed that serum resistin levels (Odds ratio [OR]: 1.140, 95% confidence interval [CI]: 1.054-1.234, p = 0.001) and age (OR: 1.102, 95% CI: 1.051-1.156, p &lt; 0.001) were the independently associated with PAOD in CKD patients. The area under the receiver-operating characteristic (ROC) curve predicting PAOD by serum resistin level in CKD patients was 0.699 (95% CI: 0.636-0.756, p = 0.0001). Conclusion In this study, serum resistin level was found to be associated with PAOD in non-dialysis CKD stage 3-5 patients.

Effects of Aerobic Training With No Caloric Restriction on Serum Resistin and Lipid Profile in Inactive Overweight Women

Introduction: Obesity is a major risk factor for inflammation and cardiovascular diseases. We tried to assess whether 12 weeks of aerobic exercises affect serum resistin level and lipid profile in overweight females or not. Methods: For this purpose, 32 non-trained adult females with the mean age of 38 ± 7 years old and body mass index (BMI) of 32 ± 3 kg/m2 were randomly assigned to aerobic exercise (n=16) and control (n=16) groups. Twelve weeks of aerobic exercise program including 3 sessions weekly at 60-75% of maximum heart rate was considered. Fasting serum resistin level, lipid profile (total cholesterol [TC], low-density lipoprotein [LDL] and high-density lipoprotein [HDL] cholesterol, and triglyceride [TG]), and anthropometric indexes were measured and compared between the two groups before and after training. Results: Serum resistin, lipid profile markers, and anthropometrical indexes were not significantly different at baseline between the two groups (P>0.05). TG, TC, LDL, and serum resistin did not change significantly after the intervention in the exercise group (P>0.05). However, a significant increase in HDL (exercise: 46.3 ± 9.6 vs. 51.4 ± 8.5, P=0.011; control: 45.8 ± 7.9 vs. 46.8 ± 6.9 P=0.326) and a significant decrease in LDL/HDL ratio (exercise: 2.94 ± 0.12 vs. 2.47 ± 0.19, P=0.019; control: 3.14 ± 0.23 vs. 3.18 ± 0.63, P=0.265) were observed after the intervention. Other variables in the control group remained unchanged. Conclusion: Aerobic exercises had no impacts on the inflammatory profile but could improve lipid profile with an emphasis on HDL in adult obese women.

The Association Between Serum Resistin Level with the Degree of Coronary Artery Stenosis

.