scholarly journals Long Noncoding RNA LOC441178 Reduces the Invasion and Migration of Squamous Carcinoma Cells by Targeting ROCK1

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Kai Xu ◽  
Hurong Tian ◽  
Shouyong Zhao ◽  
Daoying Yuan ◽  
Licheng Jiang ◽  
...  
Keyword(s):  
Noncoding Rna ◽  
Molecular Mechanisms ◽  
Human Cancer ◽  
Coiled Coil ◽  
Squamous Carcinoma ◽  
Prognostic Indicator ◽  
Carcinoma Cells ◽  
Invasion And Migration ◽  
Squamous Carcinoma Cells ◽  
And Migration

In recent years, long noncoding RNAs (lncRNAs) have been reported to have significant regulating effect in human cancer development. Previous studies suggested that dysregulation of lncRNA 441178 (LOC441178) is possibly associated with oral squamous cell carcinoma (OSCC). The postoperative survival time was significantly prolonged in the high-grade OSCC patients with high LOC441178 expression compared with those with low LOC441178 expression, which indicated that LOC441178 may act as a prognostic marker and as a potential tumor suppressor for OSCC. However, the biological molecular mechanisms behind these phenomena remain almost unknown. Here, our studies revealed that LOC441178 suppressed the invasion and migration of squamous carcinoma cells (SCCs). Furthermore, we found that rho-associated, coiled-coil-containing protein kinase 1 (ROCK1) is one of the functionally relevant targets of LOC441178 in squamous cells, which is negatively correlated with LOC441178 in tumor tissues from OSCC patients. In conclusion, our findings demonstrated the inhibition effect of LOC441178 on tumor in OSCC and might have potential implications for OSCC gene therapy. In conclusion, these results suggest that LOC441178 could represent a prognostic indicator for OSCC and be a new target for the diagnosis and treatment of OSCC.

scholarly journals Involvement of the Wnt-beta-catenin pathway in invasion and migration of oral squamous carcinoma cells

2011 ◽  
Vol 57 (10) ◽  
pp. 533-541 ◽  
Author(s):  
Soichi IWAI ◽  
Atsuko YONEKAWA ◽  
Chie HARADA ◽  
Masakazu HAMADA ◽  
Wataru KATAGIRI ◽  
...  
Keyword(s):  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Beta Catenin ◽  
Invasion And Migration ◽  
Squamous Carcinoma Cells ◽  
Oral Squamous Carcinoma ◽  
And Migration

The therapeutic value and molecular mechanisms of lncRNA FENDRR in human cancer

2021 ◽  
Vol 27 ◽  
Author(s):  
Wen Xu ◽  
Bei Wang ◽  
Yuxuan Cai ◽  
Jinlan Chen ◽  
Enqing Meng ◽  
...  
Keyword(s):  
Noncoding Rna ◽  
Molecular Mechanisms ◽  
Malignant Tumors ◽  
Human Cancer ◽  
Tumor Therapy ◽  
Pathophysiological Mechanism ◽  
Regulatory Processes ◽  
Carcinoma Prostate ◽  
Therapeutic Value ◽  
And Migration

Background: Long noncoding RNA (lncRNA) fetal-lethal non-coding developmental regulatory RNA (FENDRR), a newly known lncRNA, has been reported to be abnormally expressed in diverse tumors. This review is focused on clarifying the mechanism of FENDRR to regulate the biological process of tumors, affirming its value as a target for tumor therapy. Methods: The pathophysiological mechanism of FENDRR acting on tumors has been analyzed and summarized by reviewing PubMed. Results: The expression of lncRNA FENDRR is abnormally altered in clinical cancers, promoting the malignant transformation of a variety of tumors, including colon cancer, cervical cancer, hepatocellular carcinoma, prostate cancer, Malignant melanoma, lung cancer, osteosarcoma, breast cancer, etc. Cellular processions, including proliferation, invasion, apoptosis and migration affected by FENDRR, have been revealed. Conclusion: Specific evidences for the involvement of LncRNA FENDRR in cancer regulatory processes suggest that FENDRR has the potential to be a biomarker or clinical therapeutic target for malignant tumors.

scholarly journals Long noncoding RNA UCA1 promotes the proliferation, invasion, and migration of nasopharyngeal carcinoma cells via modulation of miR-145

2018 ◽  
Vol Volume 11 ◽  
pp. 7483-7492 ◽  
Author(s):  
Jing Wu ◽  
Mingyu Du ◽  
Qian Zhang ◽  
Wenjun Zhang ◽  
Yanxin Fan ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Carcinoma Cells ◽  
Invasion And Migration ◽  
And Migration

Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro

2010 ◽  
Vol 88 (9) ◽  
pp. 874-879 ◽  
Author(s):  
Xueying Yang ◽  
Yang Zhang ◽  
Shumin Wang ◽  
Wenjun Shi
Keyword(s):  
Lung Carcinoma ◽  
Molecular Mechanisms ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Carcinoma Cells ◽  
Migration And Invasion ◽  
Invasion And Migration ◽  
Lung Carcinoma Cells ◽  
Rho Kinase Inhibitor ◽  
And Migration

The objective of the study was to investigate the effects of a Rho-kinase inhibitor on 95D lung carcinoma cell growth, adhesion, invasion, and migration and to explore the underlying molecular mechanisms involved in this process. After treatment of 95D lung carcinoma cells with fasudil, an inhibitor of Rho-kinase, cell biological behaviors such as growth, adhesion, invasion, and migration were observed. Matrix metalloproteinase (MMP) activity and Western blot assay were used to evaluate underlying molecular mechanisms. The IC50 of fasudil to 95D lung carcinoma cells was approximately 0.79 mg/mL (95% confidence limits 0.58–1.11 mg/mL). After treatment with 0.75 mg/mL fasudil, the ability of 95D lung carcinoma cells for growth, adhesion, migration, and invasion was decreased significantly. Total active MMP2 was decreased approximately 22.7% (p < 0.05) and total MMP9 65.9% (p < 0.01). Myosin phosphatase target subunit 1 (MYPT1) was reduced by 29.4% (p < 0.05). We conclude that the Rho-kinase inhibitor prevents the growth, adhesion, invasion, and migration of 95D lung carcinoma cells by inhibiting the Rho/Rho-kinase pathway. Changes in MMP2, MMP9, and MYPT1 may be part of its molecular mechanisms.

scholarly journals Novel Hybrids of Podophyllotoxin and Coumarin Inhibit the Growth and Migration of Human Oral Squamous Carcinoma Cells

2021 ◽  
Vol 8 ◽  
Author(s):  
Guohui Bai ◽  
Dan Zhao ◽  
Xin Ran ◽  
Lei Zhang ◽  
Degang Zhao
Keyword(s):  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Microtubule Network ◽  
Squamous Carcinoma Cells ◽  
Cycle Arrest ◽  
Carcinoma Cell Lines ◽  
Oral Squamous Carcinoma ◽  
Squamous Carcinoma Cell ◽  
And Migration ◽  
Oral Squamous Carcinoma Cell

Oral squamous cell carcinoma is the most common malignancy of oral tumor. In this study, two novel hybrids of podophyllotoxin and coumarin were designed using molecular hybridization strategy and synthesized. Pharmacological evaluation showed that the potent compound 12b inhibited the proliferation of three human oral squamous carcinoma cell lines with nanomolar IC50 values, as well as displayed less toxicity on normal cells. Mechanistic studies indicated that 12b triggered HSC-2 cell apoptosis, induced cell cycle arrest, and inhibited cell migration. Moreover, 12b could disturb the microtubule network via binding into the tubulin. It was noteworthy that induction of autophagy by 12b was associated with the upregulation of Beclin1, as well as LC3-II. Furthermore, 12b significantly stimulated the AMPK pathway and restrained the AKT/mTOR pathway in HSC-2 cells. These results indicated that compound 12b was a promising candidate for further investigation.

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