scholarly journals Sevoflurane Impairs Short-Term Memory by Affecting PSD-95 and AMPA Receptor in the Hippocampus of a Mouse Model

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Yuan Jiao ◽  
Hongwu Fan ◽  
Kexin Wang ◽  
Shan Lu
Keyword(s):  
Synaptic Transmission ◽  
Ampa Receptor ◽  
Ampa Receptors ◽  
Short Term Memory ◽  
Receptor Expression ◽  
Expression Level ◽  
Short Term ◽  
Term Memory ◽  
Adult Mice ◽  
T1 And T2

Objective. To explore the effects of sevoflurane on the latency and error times of the passive avoidance and levels of PSD-95 and AMPA receptors in the hippocampus. We evaluated the effects of sevoflurane on short-term memory in adult mice and explored the possible mechanism. Methods. 144 Kunming mice (2-3 months, 30-35 g) were randomly divided into two groups A (n=64) and B (n=80) and received the dark-avoidance (DA) and step-down avoidance (SA) tests, respectively. The groups DA and SA were further divided into control (inhaled 40% O2 2 h) and sevoflurane (3.3% sevoflurane and 40% O2 2 h) subgroups. Before inhalation intervention, all mice were trained to be familiar with the Morris water maze (MWM). According to the test points of behavioral indicators, 8 mice were randomly selected from each subgroup at point 12 h (T1), 24 h (T2), 48 h (T3), and 72 h (T4) after inhalation intervention. The step-through latency and error times were measured in 5 min. After the behavioral test, the mice were killed and the tissues of the hippocampus were taken for hematoxylin and eosin (H&E) staining. The expression level of PSD-95 and AMPA receptors in the hippocampus was detected by immunohistochemistry and Western Blot. The changes of synaptic transmission were measured via electrophysiology analysis of hippocampal slices. Results. The mice in the control subgroups found the platform in a shorter pathway than those in the sevoflurane subgroups during an MWM test. The step-through latency of T1 and T2 in the sevoflurane subgroup was shorter than baseline time, and the error times were increased in 5 min and higher than baseline time when compared with the control subgroup (P<0.05) in the A and B groups. Compared with the control subgroup, the expression level of PSD-95 and AMPA receptors in the hippocampus was decreased at T1 and T2 in the sevoflurane subgroup (P<0.05). The nerve cells were partially swelling. Electrophysiology analysis showed that the levels of PSD-95 and AMPA receptor expression were associated with synaptic transmission. Conclusion. Sevoflurane impaired short-term memory in adult mice by inhibiting the expression of PSD-95 and AMPA receptors in the hippocampus, which led to the decrease in synaptic transmission.

scholarly journals Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice

2011 ◽  
Vol 224 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Amy M. Taylor ◽  
Burkhard Niewoehner ◽  
Peter H. Seeburg ◽  
Rolf Sprengel ◽  
J. Nicholas P. Rawlins ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Knockout Mice ◽  
Short Term Memory ◽  
Receptor Subunit ◽  
Short Term ◽  
Term Memory ◽  
Ampa Receptor Subunit

Short-Term Flavour Memory in the Rat

1982 ◽  
Vol 34 (4b) ◽  
pp. 235-256 ◽  
Author(s):  
R. F. Westbrook ◽  
S. C. Provost ◽  
J. Homewood
Keyword(s):  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Series Of Experiments ◽  
T1 And T2

In a series of experiments, rats were exposed twice to a flavour at times T1 and T2, and the second of these exposures was followed by toxicosis. The level of the subsequent aversion was viewed as an index of whether the flavour had been recognised as familiar at T2, with a familiar flavour accruing less aversiveness than an unfamiliar one. A flavour was recognised as familiar at time T2 after a long flavour-exposure at time T1 (Experiment Ia) when moderate (3·5 h) and long (27·5 h) T1-T2 intervals were employed but was so recognised after a brief exposure at T1 (Experiment Ib) only when a moderate T1-T2 interval was employed. The memorial processes underlying flavour recognition after a brief flavour exposure were assumed, therefore, to be transient. The remaining experiments employed a brief flavour exposure at T1 and moderate T1-T2 intervals in various attempts to disrupt flavour recognition. Recognition at T2, however, was not disrupted when one (Experiment II), or three (Experiment IV) distractor flavours were interpolated between the target flavour's presentations at T1 and T2. This failure was not due to the distractor having proactively interfered with the associability of the target flavour with illness at T2 (Experiment III). Further, recognition was not disrupted when the position of the target flavour's presentation at T1 was varied across a list of distractor flavours (Experiment V), nor when the similarity of the distractor and the target flavour was varied (Experiment VI). The results indicate that the processes subserving recognition after a brief presentation of that flavour, although transient, are resistant to interference and were discussed in terms of current theories of short-term memory in animals.

scholarly journals Deletion of the GluA1 AMPA receptor subunit alters the expression of short-term memory

2011 ◽  
Vol 18 (3) ◽  
pp. 128-131 ◽  
Author(s):  
D. J. Sanderson ◽  
R. Sprengel ◽  
P. H. Seeburg ◽  
D. M. Bannerman
Keyword(s):  
Ampa Receptor ◽  
Short Term Memory ◽  
Receptor Subunit ◽  
Short Term ◽  
Term Memory ◽  
Ampa Receptor Subunit

Nimodipine-Induced Hypotension but Not Nitroglycerin-Induced Hypotension Preserves Long- and Short-Term Memory in Adult Mice

2012 ◽  
Vol 114 (5) ◽  
pp. 1034-1041 ◽  
Author(s):  
Michael Haile ◽  
Samuel Galoyan ◽  
Yong-Sheng Li ◽  
Barry H. Cohen ◽  
David Quartermain ◽  
...  
Keyword(s):  
Short Term Memory ◽  
Short Term ◽  
Induced Hypotension ◽  
Term Memory ◽  
Adult Mice

scholarly journals Individual Stress Vulnerability Is Predicted by Short-Term Memory and AMPA Receptor Subunit Ratio in the Hippocampus

2010 ◽  
Vol 30 (50) ◽  
pp. 16949-16958 ◽  
Author(s):  
M. V. Schmidt ◽  
D. Trumbach ◽  
P. Weber ◽  
K. Wagner ◽  
S. H. Scharf ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Short Term Memory ◽  
Receptor Subunit ◽  
Short Term ◽  
Term Memory ◽  
Stress Vulnerability ◽  
Ampa Receptor Subunit

scholarly journals microRNA-138 controls hippocampal interneuron function and short-term memory

2021 ◽  
Author(s):  
Gerhard Schratt ◽  
Reetu Daswani ◽  
Carlotta Gilardi ◽  
Michael Soutschek ◽  
Kerstin Weiss ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Neural Circuit ◽  
Short Term Memory ◽  
Critical Role ◽  
Excitatory Neuron ◽  
Inhibitory Interneurons ◽  
Short Term ◽  
Term Memory ◽  
And Function ◽  
Neuron Function

A tightly regulated balance between excitatory and inhibitory (E/I) synaptic transmission is critical for neural circuit assembly and function. microRNAs control excitatory neuron function, but their role in inhibitory interneurons is unknown. Here, we show that miR-138-5p regulates the expression of presynaptic genes in hippocampal parvalbumin-expressing inhibitory interneurons to control short-term memory. Our finding suggests a critical role for miR-138-5p in disorders of impaired E/I balance, such as autism and schizophrenia.

scholarly journals Reduced Effect of Anticonvulsants on AMPA Receptor Palmitoylation-Deficient Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Madoka Iizumi ◽  
Akiko Oota-Ishigaki ◽  
Mariko Yamashita ◽  
Takashi Hayashi
Keyword(s):  
Synaptic Transmission ◽  
Ampa Receptor ◽  
Ampa Receptors ◽  
Receptor Expression ◽  
Mammalian Brain ◽  
Model Animal ◽  
Channel Blocking ◽  
Gabaergic Synapses ◽  
Novel Target ◽  
Basal Synaptic Transmission

AMPA receptors are responsible for fast excitatory synaptic transmission in the mammalian brain. Post-translational protein S-palmitoylation of AMPA receptor subunits GluA1-4 reversibly regulates synaptic AMPA receptor expression, resulting in long-lasting changes in excitatory synaptic strengths. Our previous studies have shown that GluA1 C-terminal palmitoylation-deficient (GluA1C811S) mice exhibited hyperexcitability in the cerebrum and elevated seizure susceptibility without affecting brain structure or basal synaptic transmission. Moreover, some inhibitory GABAergic synapses-targeting anticonvulsants, such as valproic acid, phenobarbital, and diazepam, had less effect on these AMPA receptor palmitoylation-deficient mutant mice. This work explores pharmacological effect of voltage-gated ion channel-targeted anticonvulsants, phenytoin and trimethadione, on GluA1C811S mice. Similar to GABAergic synapses-targeting anticonvulsants, anticonvulsive effects were also reduced for both sodium channel- and calcium channel-blocking anticonvulsants, which suppress excess excitation. These data strongly suggest that the GluA1C811S mice generally underlie the excessive excitability in response to seizure-inducing stimulation. AMPA receptor palmitoylation site could be a novel target to develop unprecedented type of anticonvulsants and GluA1C811S mice are suitable as a model animal for broadly evaluating pharmacological effectiveness of antiepileptic drugs.

Conceptual short-term memory (CSTM) supports core claims of Christiansen and Chater

2016 ◽  
Vol 39 ◽  
Author(s):  
Mary C. Potter
Keyword(s):  
Working Memory ◽  
Rapid Serial Visual Presentation ◽  
Language Comprehension ◽  
Short Term Memory ◽  
Visual Presentation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Use Of Knowledge

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.

Working, Declarative, and Procedural Memory in Children With Developmental Language Disorder

2020 ◽  
Vol 63 (12) ◽  
pp. 4162-4178
Author(s):  
Emily Jackson ◽  
Suze Leitão ◽  
Mary Claessen ◽  
Mark Boyes
Keyword(s):  
Working Memory ◽  
Short Term Memory ◽  
Language Disorder ◽  
Declarative Memory ◽  
Memory Systems ◽  
Procedural Memory ◽  
Typically Developing ◽  
Short Term ◽  
Term Memory ◽  
Visual Spatial

Purpose Previous research into the working, declarative, and procedural memory systems in children with developmental language disorder (DLD) has yielded inconsistent results. The purpose of this research was to profile these memory systems in children with DLD and their typically developing peers. Method One hundred four 5- to 8-year-old children participated in the study. Fifty had DLD, and 54 were typically developing. Aspects of the working memory system (verbal short-term memory, verbal working memory, and visual–spatial short-term memory) were assessed using a nonword repetition test and subtests from the Working Memory Test Battery for Children. Verbal and visual–spatial declarative memory were measured using the Children's Memory Scale, and an audiovisual serial reaction time task was used to evaluate procedural memory. Results The children with DLD demonstrated significant impairments in verbal short-term and working memory, visual–spatial short-term memory, verbal declarative memory, and procedural memory. However, verbal declarative memory and procedural memory were no longer impaired after controlling for working memory and nonverbal IQ. Declarative memory for visual–spatial information was unimpaired. Conclusions These findings indicate that children with DLD have deficits in the working memory system. While verbal declarative memory and procedural memory also appear to be impaired, these deficits could largely be accounted for by working memory skills. The results have implications for our understanding of the cognitive processes underlying language impairment in the DLD population; however, further investigation of the relationships between the memory systems is required using tasks that measure learning over long-term intervals. Supplemental Material https://doi.org/10.23641/asha.13250180

Comparison of Auditory, Language, Memory, and Attention Abilities in Children With and Without Listening Difficulties

2020 ◽  
Vol 29 (4) ◽  
pp. 710-727
Author(s):  
Beula M. Magimairaj ◽  
Naveen K. Nagaraj ◽  
Alexander V. Sergeev ◽  
Natalie J. Benafield
Keyword(s):  
Auditory Processing ◽  
Short Term Memory ◽  
Group Differences ◽  
Long Term Memory ◽  
Short Term ◽  
Significant Group ◽  
Term Memory ◽  
Memory And Attention ◽  
Speed And Accuracy

Objectives School-age children with and without parent-reported listening difficulties (LiD) were compared on auditory processing, language, memory, and attention abilities. The objective was to extend what is known so far in the literature about children with LiD by using multiple measures and selective novel measures across the above areas. Design Twenty-six children who were reported by their parents as having LiD and 26 age-matched typically developing children completed clinical tests of auditory processing and multiple measures of language, attention, and memory. All children had normal-range pure-tone hearing thresholds bilaterally. Group differences were examined. Results In addition to significantly poorer speech-perception-in-noise scores, children with LiD had reduced speed and accuracy of word retrieval from long-term memory, poorer short-term memory, sentence recall, and inferencing ability. Statistically significant group differences were of moderate effect size; however, standard test scores of children with LiD were not clinically poor. No statistically significant group differences were observed in attention, working memory capacity, vocabulary, and nonverbal IQ. Conclusions Mild signal-to-noise ratio loss, as reflected by the group mean of children with LiD, supported the children's functional listening problems. In addition, children's relative weakness in select areas of language performance, short-term memory, and long-term memory lexical retrieval speed and accuracy added to previous research on evidence-based areas that need to be evaluated in children with LiD who almost always have heterogenous profiles. Importantly, the functional difficulties faced by children with LiD in relation to their test results indicated, to some extent, that commonly used assessments may not be adequately capturing the children's listening challenges. Supplemental Material https://doi.org/10.23641/asha.12808607

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