scholarly journals Abdominal Wall Clear Cell Carcinoma: Case Report of a Rare Event with Potential Diagnostic Difficulties

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Maria del Mar Rivera Rolon ◽  
Dyron Allen ◽  
Gwyn Richardson ◽  
Cecilia Clement
Keyword(s):  
Cell Carcinoma ◽  
Abdominal Wall ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Rare Event ◽  
Rectus Muscle ◽  
Pubic Bone ◽  
Cystic Neoplasm ◽  
Nuclear Atypia ◽  
Diagnostic Difficulties

Clear cell carcinoma (CCC) is a well-known aggressive histological type of carcinoma, predominantly seen in ovary and endometrium. However, CCC arising in abdominal wall is a very rare event. We report a case of a 48-year-old woman with an abdominal wall mass at her cesarean section (c-section) scar, which increased in size and became painful in the last months. Radiology revealed a 7 cm mass in the right inferior rectus muscle sheath, suggestive of endometriosis. An irregular, firm mass was resected, densely adherent to the rectus muscle and pubic bone. Frozen section revealed a multicystic lesion with minimal cytologic atypia, and a benign cystic neoplasm was favored. However, permanent sections showed marked nuclear atypia, hobnail morphology, and areas of infiltrative growth within fibrous stroma. No benign endometrial glands were found, although fibrosis and hemorrhage were present. Napsin-A, racemase, and PAX-8 were positive, consistent with CCC, likely arising within a c-section endometriosis focus. Although CCC usually presents with moderate to marked nuclear atypia, it can be mild and, especially in cases with a predominant cystic pattern, create diagnostic difficulties. An endometriosis-associated malignancy should be considered in the differential with any enlarging nodule or increasing pain within an abdominal wall scar.

scholarly journals Clear Cell Carcinoma Arising in an Abdominal Wall Cesarean Section Scar: A Case Report With Description of Pathological and Molecular Features

2021 ◽  
Vol 8 ◽  
Author(s):  
Cristina Colarossi ◽  
Maria Carolina Picardo ◽  
Lorenzo Colarossi ◽  
Enrica Deiana ◽  
Costanza D'Agata ◽  
...  
Keyword(s):  
Cesarean Section ◽  
Cell Carcinoma ◽  
Abdominal Wall ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Present Report ◽  
Rare Event ◽  
Distinct Type ◽  
Molecular Features ◽  
Abdominal Lesion

Clear cell carcinoma is a clinically and biologically distinct type of carcinoma predominantly encountered in the ovary and endometrium. In the ovary, it is frequently associated with endometriosis, which is a well-known risk factor. Endometriosis has often been described in the abdominal wall of women who had a cesarean section; however, malignant transformation is a very rare event, occurring in <1% of cases. The authors report a case involving a 52-year-old woman with an abdominal wall nodule at a cesarean section scar. Radiology revealed a mass, measuring 8 cm in size, in the abdominal wall suggestive of a soft tissue tumor. After resection, histology revealed the presence of clear, eosinophilic, and hobnail cells, which, together with immunohistochemical and molecular findings, enabled the diagnosis of clear cell carcinoma of the abdominal wall. The present report describes the clinical, radiological, pathological, and molecular features of an unusual abdominal lesion that represents a rare but challenging diagnosis.

scholarly journals Clear Cell Carcinoma of the Anterior Abdominal Wall Secondary to Iatrogenic Endometriosis

2020 ◽  
Vol 27 (6) ◽  
pp. 1230-1231
Author(s):  
Sadikah Behbehani ◽  
Paul Magtibay ◽  
Longwen Chen ◽  
Megan Wasson
Keyword(s):  
Cell Carcinoma ◽  
Abdominal Wall ◽  
Clear Cell ◽  
Anterior Abdominal Wall ◽  
Clear Cell Carcinoma

scholarly journals Endometriosis-associated Clear Cell Carcinoma of the Abdominal Wall After Caesarean Section: A Case Report and Review of the Literature

In Vivo ◽  
2020 ◽  
Vol 34 (4) ◽  
pp. 2147-2152
Author(s):  
LUCA GIANNELLA ◽  
MATTEO SERRI ◽  
ELENA MACCARONI ◽  
JACOPO DI GIUSEPPE ◽  
GIOVANNI DELLI CARPINI ◽  
...  
Keyword(s):  
Case Report ◽  
Caesarean Section ◽  
Cell Carcinoma ◽  
Abdominal Wall ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Review Of The Literature

scholarly journals Malignant transformation of abdominal wall endometriosis to clear cell carcinoma: case report

2018 ◽  
Vol 136 (6) ◽  
pp. 586-590 ◽  
Author(s):  
João Kleber de Almeida Gentile ◽  
Renato Migliore ◽  
Fábio Jorge Neubaner Kistenmacker ◽  
Marcio Menezes de Oliveira ◽  
Rodrigo Biscuola Garcia ◽  
...  
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Abdominal Wall ◽  
Malignant Transformation ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Abdominal Wall Endometriosis

Malignant transformation of abdominal wall endometriosis to clear cell carcinoma: case report and review of the literature

2008 ◽  
Vol 90 (4) ◽  
pp. 1197.e13-1197.e16 ◽  
Author(s):  
Anne Sophie Bats ◽  
Yaelle Zafrani ◽  
Patricia Pautier ◽  
Pierre Duvillard ◽  
Philippe Morice
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Abdominal Wall ◽  
Malignant Transformation ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Review Of The Literature ◽  
Abdominal Wall Endometriosis

scholarly journals Primary abdominal wall clear-cell carcinoma in postsurgical scar

2019 ◽  
Vol 16 (4) ◽  
Author(s):  
Ana Alberca-Páramo ◽  
Mercedes Estaire-Gómez ◽  
Bruno Menchen-Trujillo ◽  
José Luis Bertelli-Puche ◽  
Juan Alberto Sánchez-Forero ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Abdominal Wall ◽  
Clear Cell ◽  
Clear Cell Carcinoma

scholarly journals Clear Cell Carcinoma Arising from Abdominal Wall Endometriosis – A Report on Two Cases and Literature Review

2021 ◽  
Author(s):  
Vishal Bahall ◽  
Lance De Barry ◽  
Arlene Rampersad
Keyword(s):  
Cell Carcinoma ◽  
Abdominal Wall ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Case Presentation ◽  
Abdominal Wall Endometriosis ◽  
Aggressive Cancer ◽  
History Of ◽  
High Index Of Suspicion ◽  
Wall Mass

Abstract Background: Malignant transformation of abdominal wall endometriosis is extremely rare. Clear cell carcinoma and endometrioid carcinoma are the two most prevalent histological subtypes of malignant endometriosis. To date, approximately thirty cases of clear cell carcinoma arising from abdominal wall endometriosis have been described worldwide.Case Presentation: We report two cases of clear cell carcinoma developing postoperatively in the anterior abdominal wall in women with a history of extensive endometriosis. Histopathology of the resected abdominal wall tumor demonstrated benign endometriosis contiguous with features of clear cell carcinoma. These histological features satisfied Sampson’s criteria which are required for diagnosing malignant endometriosis. Both patients were successfully managed with platinum-based adjuvant chemotherapy following cytoreductive surgery. Conclusion: Clear cell carcinoma arising from abdominal wall endometriosis is a rare, highly aggressive cancer with a propensity to recur or metastasize. Due to the limited publications on this clinical entity, there are no clearly established protocols regarding adjuvant treatment, and an evaluation of prognostic factors is lacking. Clinicians must have a high index of suspicion for malignant endometriosis of the abdominal wall, particularly in patients with an abdominal wall mass, prior abdominal surgery, and long-standing endometriosis. By presenting our case, we expect to raise awareness and study of this rare endometriosis-related neoplasm.

scholarly journals Is clear cell carcinoma of abdominal wall surgery scar associated with endometriosis a poor prognosis? A case report and literature review

2021 ◽  
Author(s):  
Xuzhi Liang ◽  
Hao Zeng ◽  
Zhe Tang ◽  
Jiejie Liao ◽  
Jiangtao Fan
Keyword(s):  
Case Report ◽  
Caesarean Section ◽  
Literature Review ◽  
Cell Carcinoma ◽  
Abdominal Wall ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Specific Marker ◽  
Tumor Biopsy ◽  
Wall Mass

Abstract BackgroundClear cell carcinoma of abdominal wall surgery scar is a rare condition that can have many potential causes, and its early diagnosis is difficult after undergoing obstetrical and gynecological surgery unless performing tumor biopsy. So far, about 45 cases have been reported in the literature. This paper provides a case report and literature review of clear cell carcinoma on abdominal wall surgical scar.Case presentationWe described the case of a 47-year-old woman reporting two lumps in the scar of abdomen. Her medical history was marked by a previous Caesarean section and two excisions of benign endometriosis nodules at the scar. Physical examination found a mass of about 6×5×5 cm on the left side of the scar with mucoid on the surface and a fixed abdominal wall mass of about 10×10×8 cm in the 2 transverse fingers under the umbilicus. Histological examination proved a clear cell carcinoma result. The patient received tumor excision and first-line chemotherapy with complete remission. A review of the literature showed that 91.3% of the cases had had a Caesarean section. Besides, approximately 34.2% of women died 5–48 months after diagnosis. The average age of women was 46.5 years and the average tumor size was 10 cm.ConclusionThe abdominal wall mass of middle-aged women is closely related to the scar left by the previous Cesarean section and must be investigated in time and properly. Preoperative diagnosis is difficult and often incorrect, and there is no specific marker for malignant transformation. Treatment usually includes surgery, chemotherapy, and radiotherapy, but the prognosis is poor.

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