scholarly journals Sirolimus: A Successful Medical Treatment for Head and Neck Lymphatic Malformations

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Steven Curry ◽  
Andrew Logeman ◽  
Dwight Jones
Keyword(s):  
Case Report ◽  
Medical Treatment ◽  
Head And Neck ◽  
Laser Therapy ◽  
Medical Therapy ◽  
Lymphatic System ◽  
Vascular Malformations ◽  
Mammalian Target Of Rapamycin ◽  
Female Infant ◽  
Lymphatic Malformations

Lymphatic malformations are abnormalities that arise in the developing lymphatic system, most frequently presenting in the head and neck. They are typically treated with sclerotherapy, laser therapy, or surgery for localized lesions. Sirolimus, an inhibitor of the mammalian target of rapamycin, is a relatively new medical therapy for the treatment of vascular malformations. This case report presents the improvements and complications seen in a female infant who was diagnosed with a large lymphatic malformation on prenatal ultrasound and has been treated with sirolimus during the first 9 months of life.

scholarly journals Multiple vascular malformations in head and neck - Rare case report

2014 ◽  
Vol 18 (1) ◽  
pp. 137
Author(s):  
YogeshT Lakkasetty ◽  
Sangeeta Malik ◽  
Akshay Shetty ◽  
Kourosh Nakhaei
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Rare Case ◽  
Vascular Malformations ◽  
Rare Case Report

Urgent and Emergent Embolization of Lesions of the Head and Neck in Children: Indications and Results

PEDIATRICS ◽  
1987 ◽  
Vol 80 (3) ◽  
pp. 386-394
Author(s):  
Patricia E. Burrows ◽  
Pierre L. Lasjaunias ◽  
Karel G. Ter Brugge ◽  
Olaf Flodmark
Keyword(s):  
Head And Neck ◽  
Vascular Malformations ◽  
High Flow ◽  
Vein Of Galen ◽  
Respiratory Obstruction ◽  
Facial Skeleton ◽  
Lymphatic Malformations ◽  
Proliferative Phase ◽  
Interventional Neuroradiologist ◽  
Cerebral Ischemic

Indications for and results and complications of embolization of lesions of the head and neck were analyzed retrospectively. The procedures were performed since 1980 on an emergent or urgent basis in 30 infants and children by an experienced interventional neuroradiologist in Bicetre, France. Indications for embolization included hemorrhage, occular occlusion, respiratory obstruction, CNS complications or potential complications, interference with nutrition, and functional impairment related to the effect of the lesion on the developing facial skeleton and teeth. The specific lesions included seven hemangiomas (palpebral, subglottic, and nasal) and 20 vascular malformations (maxillofacial), auricular, dural, cerebral [including three vein of Galen malformations] and spinomedullary). Embolization was efficacious in 28 of 30 patients. Hemangiomas (potentially involutive tumors) responded dramatically with arrest of the proliferative phase and shrinking of the mass. Combined hemovascular lymphatic malformations (hemolymphangiomas) of the tongue demonstrated a variable decrease in size. High-flow evolutive arteriovenous malformations involving the teeth and dura were controlled but required multiple embolizations. One infant with a vein of Galen arteriovenous malformation died. Three local complications occurred in two patients. No cerebral ischemic or femoral artery complications occurred.

scholarly journals An 80 year old lingual haemangioma: a case report

2017 ◽  
Vol 3 (2) ◽  
pp. 434
Author(s):  
Marija Agius ◽  
Daniel M. Chircop ◽  
John C. Cutajar ◽  
Mario E. Said
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Vascular Malformations

<p class="abstract"><span lang="MT">Haemangiomas are benign vascular tumours which are commonly encountered in head and neck regions. They are subdivided in cavernous haemaniogma and vascular malformations. Lingual haemangiomas pose a potential airway risk because of their position. This case report is about the management of a patient with a lingual haemangioma which was asymptomatic for 80 years but which was eventually removed in view of recurrent angio-oedema</span><span lang="EN-IN">.</span></p>

scholarly journals The Role of Interventional Radiologists in the Treatment of Congenital Lymphatic Malformations

2020 ◽  
Vol 37 (03) ◽  
pp. 285-294
Author(s):  
Julie Cronan ◽  
Anne E. Gill ◽  
Jay H. Shah ◽  
C. Matthew Hawkins
Keyword(s):  
Vascular Malformations ◽  
Pediatric Population ◽  
Mammalian Target Of Rapamycin ◽  
Disease Process ◽  
Low Flow ◽  
Complication Rates ◽  
Management Options ◽  
Lymphatic Malformations ◽  
Percutaneous Sclerotherapy

AbstractLymphatic malformations are low-flow vascular malformations that are typically apparent in the pediatric population and can cause significant functional limitations and effects on quality of life. While surgical resection has historically been the mainstay of therapy, percutaneous sclerotherapy has garnered increasing popularity due to its efficacy and low complication rates. The role of interventional radiology in the multidisciplinary management of these often complex malformations requires thorough understanding of the disease process. This article will review the pathophysiology, clinical presentation, imaging workup, and management options of lymphatic malformations. Special attention will be devoted to available sclerosants, the mammalian target of rapamycin inhibitor sirolimus, and complex lymphatic anomalies.

Surgical treatment of alveolar echinococcosis: a single centre experience and systematic review of the literature

2019 ◽  
Vol 98 (4) ◽  
pp. 167-173
Keyword(s):  
Case Report ◽  
Echinococcus Multilocularis ◽  
Alveolar Echinococcosis ◽  
Lymphatic System ◽  
Surgical Intervention ◽  
Clinical Symptoms ◽  
Safety Margin ◽  
Surgical Removal ◽  
Single Centre Experience ◽  
Therapeutic Procedures

Introduction: Alveolar echinococcosis (AE) is a zoonosis caused by Echinococcus multilocularis. AE is primarily localised in the liver. Echinococcus multilocularis imitates tumour-like behaviour. It can metastasise through blood or lymphatic system to distant organs. Echinococcosis often remains asymptomatic due to its long incubation period and indistinct symptoms. Clinical symptoms are determined by the parasite’s location. Diagnosis of echinococcosis is based on medical history, clinical symptoms, laboratory tests, serology results, imaging methods and final histology findings. Surgical removal of the cyst with a safety margin, followed by chemotherapy is the therapeutic method of choice. Case report: We present a case report of alveolar echinococcosis in a thirty-year-old female patient in whom we surgically removed multiple liver foci of alveolar echinococcosis. The disease recurred after two years and required another surgical intervention. Conclusions: Alveolar echinococcosis is a disease with a high potential for a complete cure provided that it is diagnosed early and that the recommended therapeutic procedures are strictly adhered to.

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