scholarly journals A Rare Presentation of Inflammatory Myofibroblastic Tumor in the Nasolabial Fold

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Hind K. Alshammari ◽  
Haya F. Alzamami ◽  
Mona Ashoor ◽  
Wasan F. Almarzouq ◽  
Haitham Kussaibi
Keyword(s):  
Inflammatory Myofibroblastic Tumor ◽  
Soft Tissues ◽  
Histopathological Examination ◽  
Benign Lesion ◽  
Neck Region ◽  
Surgical Excision ◽  
Nasolabial Fold ◽  
Rare Presentation ◽  
The Central Nervous System ◽  
Sublabial Approach

Inflammatory myofibroblastic tumor (IMT) is a benign lesion that occurs most frequently in the soft tissues and viscera. In the head and neck region, the tumor has been reported to occur in the orbit, tongue, nasopharynx, larynx, and paranasal sinuses and the central nervous system. Despite being a benign lesion, it exhibits infiltrative and destructive behaviours, making histopathological examination necessary to confirm the diagnosis. We report the case of a 38-year-old female presented with a right nasolabial fold mass, which was confirmed histologically to be an IMT. Surgical excision of the mass was achieved through a sublabial approach with an uneventful postoperative period. To the best of our knowledge, this is the first reported case of an IMT in the nasolabial fold.

scholarly journals Omental Lymphangioma in Adults—Rare Presentation Report of a Case

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
T. Narayana Rao ◽  
T. Parvathi ◽  
A. Suvarchala
Keyword(s):  
Case Report ◽  
Histopathological Examination ◽  
Benign Lesion ◽  
Surgical Excision ◽  
Histological Findings ◽  
Rare Presentation ◽  
Complete Excision ◽  
Complete Surgical Excision ◽  
Biopsy Report

Lymphangioma is an uncommon benign lesion that usually occurs during childhood. Its occurrence in adults is rare. Its presentation in the abdomen is even rare. This case report describes a case of omental lymphangioma presented as retroperitoneal lump. Subsequent imaging, operative, and histological findings revealed omental lymphangioma. Laparotomy done under general anesthesia, a 10 × 12 cm cystic swelling arising from omentum, identified complete excision of the cyst done and send the specimen for histopathological examination. Biopsy report came as omental lymphangioma. Complete surgical excision is the treatment of choice. Prognosis is excellent and recurrence rate is very low if resection is complete. During two years of followup no recurrence was detected. Omental lymphangioma is very rare presentation among abdominal lymphangiomas specifically in adults. Complete excision is the treatment of choice. Long-term followup is required to detect recurrence.

scholarly journals Melanotic Neuroectodermal Tumor of Infancy

2018 ◽  
Vol 142 (11) ◽  
pp. 1358-1363 ◽  
Author(s):  
Brian S. Soles ◽  
Allecia Wilson ◽  
David R. Lucas ◽  
Amer Heider
Keyword(s):  
Differential Diagnosis ◽  
Local Recurrence ◽  
Soft Tissues ◽  
Malignant Neoplasm ◽  
Neck Region ◽  
Neuroectodermal Tumor ◽  
Growth Potential ◽  
Incomplete Resection ◽  
The Central Nervous System ◽  
Blue Cell

Context.— Melanotic neuroectodermal tumor of infancy, albeit rare and generally regarded as benign, is an important tumor to recognize because of its rapid growth, potential for local recurrence, and small round blue cell morphology, which can lead to misdiagnosis of a malignant neoplasm. Objective.— To review its clinical presentation and immunomorphologic findings, and discuss common entities in the differential diagnosis. Data Sources.— The study involved PubMed searches, including multiple review articles, case studies, retrospective studies, selected book chapters, and University of Michigan cases. Conclusions.— Melanotic neuroectodermal tumor of infancy most commonly occurs in the bones of the head and neck region during the first year of life, but it can also present in other locations, including the central nervous system, testes, ovaries, and subcutaneous soft tissues. Histologically, it is composed of a biphasic population of cells, consisting of epithelioid melanin-producing cells and primitive neurogenic cells in a fibrocollagenous stroma. These microscopic findings, especially in small biopsies, can lead to a broad differential diagnosis that includes malignant small round blue cell tumors and malignant melanoma. Melanotic neuroectodermal tumor of infancy commonly has an infiltrative growth pattern, and anatomic constraints often lead to incomplete resection and local recurrence, requiring multiple surgical operations. Because melanotic neuroectodermal tumor of infancy can mimic a more aggressive and aggressively treated malignancy, recognition of this rare tumor is very crucial for pathologists.

scholarly journals Intra-abdominal Solitary Myofibroma in a Child: A Rare Case Report

2021 ◽  
Author(s):  
Smita Singh ◽  
Jyoti Garg ◽  
Kusha Sharma ◽  
Kiran Agarwal
Keyword(s):  
Histopathological Examination ◽  
Smooth Muscle Actin ◽  
Iliac Fossa ◽  
Correct Diagnosis ◽  
Neck Region ◽  
Abdominal Distension ◽  
Malignant Tumours ◽  
Rare Presentation ◽  
Anaplastic Lymphoma ◽  
Abdominal Masses

Intra-abdominal masses in children are usually malignant. Benign tumours at this location are not seen frequently. It is even rarer to find solitary myofibromas intra-abdominally as these tumours are known to have predilection for the head and neck region. We present an unusual case of solitary myofibroma with abdominal localisation in a six-year-old male child who presented with abdominal distension since six months. Computed Tomography (CT) abdomen revealed a complex solid-cystic mass extending from umbilicus to right iliac fossa and measuring 9×6×4 cm. Histopathological examination revealed a tumour displaying biphasic nodular pattern with the presence of lighter staining fascicles of mature myoid cells along with darker staining and more cellular areas of smaller primitive cells. On Immunohistochemistry (IHC), tumour cells were positive for vimentin and Smooth Muscle Actin (SMA) with variable reactivity for desmin while these were negative for CD34 and Anaplastic Lymphoma Kinase 1 (ALK). Based on the histopathological and immunohistochemical findings, final diagnosis of myofibroma was made. Recognition of these lesions is extremely challenging owing to their rare presentation intra-abdominally and also because of their close morphological overlap with other spindle cell tumours commonly found at this site. This case highlights the combined role played by histopathology and IHC in making a clear distinction between different entities. It is imperative for both clinicians and histopathologists to establish the correct diagnosis as excision of the solitary myofibroma is curative in most cases and offers better clinical course than the more commonly found malignant tumours at this site.

scholarly journals The role of immunohistochemistry for diagnosing undifferentiated malignancy in the head and neck region

2019 ◽  
Vol 10 (1) ◽  
pp. 48-53
Author(s):  
Mohammad Sowkat Hossain ◽  
S M Mahbubul Alam ◽  
Sk Md Jaynul Islam ◽  
Wasim Selimul Haque ◽  
Shamoli Yasmin
Keyword(s):  
Head And Neck ◽  
Soft Tissues ◽  
Histopathological Examination ◽  
Malignant Neoplasm ◽  
Cervical Lymphadenopathy ◽  
Neck Region ◽  
Histopathological Diagnosis ◽  
Female Ratio ◽  
Head And Neck Region

Background: Undifferentiated tumours in the head and neck region are not uncommon. They can arise from different sites like in mucosa as well as in salivary glands, soft tissues or lymph nodes. Histopathological examination plays a central role in the diagnosis but difficulties arise with some tumours which are poorlydifferentiated due to their high inter- and intra-observer variability. In those cases, immunohistochemistry has greatly assisted to diagnose the tumours that cannot be accurately identified using routine histopathological procedures. The correct histopathological diagnosis is essential especially in case of malignant tumourwhere subsequent specific therapy is required. The aim of this study was to determine the role of immunohistochemistry for diagnosing undifferentiated malignancy in the head and neck region. Methods: This cross-sectional study was conducted during July 2014 to June 2015. A total of 35 Bangladeshi patient’s specimens of head and neck swelling were collected from two renowned laboratories in Dhaka city.These cases were diagnosed as undifferentiated tumour in histopathological examination.Standard protocol was followed for immunohistochemistry.Then primary immunohistochemical panel which included the markers for Epithelial CK (AE1/AE3),mesenchymal marker (Vimentin) and lymphoid marker (LCA) were used.The cases which were not resolved by primary immunohistochemistry panel, the second panel was applied for further sub classification (Desmin, Chromogranin, CK20, CEA, CD20, CD30, HMB45, NSE). Based on interpretation of immunohistochemical findings final diagnoses were made.Data analysis was performed using the Statistical Package for the Social Sciences for Windows version 22.0 (SPSS, Chicago, Illinois, USA). Results: A total of 35 undifferentiated tumorsof head-neck region were studied.The mean age was 46.3±17.6 years and male to female ratio was 4.8:1. The majority 13 (37.1%) patient had cervical lymphadenopathy, 11 (31.4%) had neck mass and 4(11.4%) had in nasal/sinonasal mass.Regarding histopathologicalcell types, round cell was 21 (60.0%), spindle cell 6 (17.1%), pleomorphic cells 6(17.1%) and epithelioid cells 2(5.7%). In initial histopathological examination, majority 25(71.4%) were undifferentiated malignant neoplasm, 8(22.8%) were metastatic undifferentiated carcinoma, 1(2.9%) was pleomorphic sarcoma and the remaining 1(2.9%) had malignant adnexal tumour. By application of immunohistochemistry, most (33, 94.3%) of the cases were resolved and the two cases remained unresolved. Among the resolved cases majority (15, 45.5%) were lymphoma, 4(12.1%) were metastatic carcinoma, 3(9.1%) were Ewing’s sarcoma and malignant melanoma were found in 3(9.1%) cases. Conclusion: This study supports that the immunohistochemical technique has a fundamental role in the investigation of undifferentiated tumour origin, to determine the correct guidance for treatment and improving the prognosis for head and neck tumour patients. Birdem Med J 2020; 10(1): 48-53

scholarly journals Primitive neuroectodermal tumor of thyroid: a rare presentation

2017 ◽  
Vol 4 (1) ◽  
pp. 276
Author(s):  
Shravan S. Shetty ◽  
Dhairyasheel N. Savant ◽  
Hozefa Lokhandwala ◽  
Akanksha Chichra
Keyword(s):  
Head And Neck ◽  
Multimodal Treatment ◽  
Primitive Neuroectodermal Tumor ◽  
Soft Tissues ◽  
Neck Region ◽  
Neuroectodermal Tumor ◽  
Rare Presentation ◽  
Term Survival ◽  
Complete Surgical Excision ◽  
Response To Chemotherapy

<p>Extraskeletal Ewing’s sarcoma (EES) commonly arises in the soft tissues of trunk or extremities. EES is rare in the head and neck region; most having been documented in nasal cavity, paranasal sinuses and neck. Head and neck PNETs have an intermediate prognosis. We report the case of a 12 year old boy who presented with primitive neuroectodermal tumor of the thyroid and was treated with multimodal treatment including surgery, chemotherapy and radiotherapy. The patient is alive and fit with a functional larynx. Major drug regimens use vincristine, doxorubicin, ifosfamide or cyclophosphamide, dactinomycin and/or etoposide. Complete surgical excision is undertaken whenever possible to improve long-term survival. However, the relative radiosensitivity of tumors of the Ewing family, suggest multimodal treatment including adjuvant radiotherapy in case of positive margins or poor response to chemotherapy rather than resection with 2-3 cm margins, which would imply laryngeal sacrifice for thyroid tumors.</p>

scholarly journals Clear cell sarcoma of the nuchal region with metastasis in stomach

2011 ◽  
Vol 19 (3-4) ◽  
pp. 76-78
Author(s):  
Dragana Tegeltija ◽  
Aleksandra Lovrenski ◽  
Milana Panjkovic ◽  
Slavica Knezevic-Usaj ◽  
Zivka Eri ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Soft Tissues ◽  
Clear Cell ◽  
Neck Region ◽  
Surgical Excision ◽  
Clear Cell Sarcoma ◽  
Lower Limbs ◽  
Medical Attention ◽  
Cell Sarcoma ◽  
Complete Surgical Excision

Clear cell sarcoma/malignant melanoma of soft parts is a rare malignant tumor that originates from the neural crest. It is most common in young men in the lower limbs, grows slowly in the form of deep localized nodes around the tendons, fascia, and aponeurosis. Prognosis is poor, local recurrences and metastases are common. We present a case of a 53-year-old patient who sought medical attention due to the presence of a tumefaction in the nuchal neck region, followed by pain, heightened sensitivity, and numbness in his right hand. After excision, histological examination, and application of immunohistochemical and histochemical methods, malignant melanoma of soft tissues was diagnosed. Fourteen months after the excision of the neck tumor, a metastatic stomach disease was diagnosed. Larger tumors with necrosis, expressed pleomorphisam, and increased mitotic activity give metastases before local recurrence. Diagnosis is set using immunohistochemical methods after surgical excision of the tumor and the prognosis of the disease depends on the size of tumor and complete surgical excision.

scholarly journals Treatment of Nodular Fasciitis on the Front Surface of the Neck

2020 ◽  
pp. 1-4
Author(s):  
Gagik Hakobyan ◽  
Anna Pogosyan ◽  
Gagik Hakobyan ◽  
Margarita Hovhannisyan ◽  
Martin Misakyan ◽  
...  
Keyword(s):  
Ultrasound Examination ◽  
Histopathological Examination ◽  
Benign Lesion ◽  
Front Surface ◽  
Surgical Excision ◽  
Final Diagnosis ◽  
Nodular Fasciitis ◽  
Surgery Patient ◽  
Histopathologic Evaluation ◽  
Local Injury

Nodular fasciitis (NF) is a benign reactive or inflammatory condition of mesenchymal fibroblasts. Rapid growth and histological features make nodular fasciitis a mimicker of malignancies such as sarcomas, however, nodular fasciitis is a benign lesion and does not metastasize. Although the etiology of nodular fasciitis is uncertain, histopathologically, it bears a close resemblance to organizing granulation tissue, and myofibroblastic proliferation may be initiated by a local injury or local inflammatory process, which supports a reactive proliferation theory triggered by trauma. Surgical excision is recommended for diagnosis and treatment to exclude malignancy. We are hereby reporting a case of nodular fasciitis on the front surface of the neck, 86 years old patient. Tumor grew rapidly and reached 9-10 cm., and which was clinically suspected as a malignancy located. An ultrasound examination was performed. Based on the clinical and ultrasound data, it was decided to perform an extended biopsy to establish the final diagnosis it. Tumor has been removed as a solid mass. The material was sent for histopathological examination. Based on the history, clinical picture, and histopathological examination, the lesion was diagnosed as nodular fasciitis. After surgery patient expressed satisfaction with the result of treatment. In cases of nodular fasciitis, proactive efforts are needed to perform histopathologic evaluation and treatment because nodular fasciitis tends to grow rapidly.

scholarly journals A Clinical Characters and Prognosis Analysis on 15 Cases With Malignant Melanoma in the Head and Neck

2020 ◽  
Author(s):  
Xiaodong Liu ◽  
Weixian Liu ◽  
Qiuxu Wang
Keyword(s):  
Malignant Melanoma ◽  
Parotid Gland ◽  
Head And Neck ◽  
Histopathological Examination ◽  
Maxillofacial Surgery ◽  
Neck Region ◽  
Surgical Excision ◽  
Pathological Examination ◽  
Oral And Maxillofacial Surgery ◽  
Golden Standard

Abstract Objective: We analyze the pathogenesis, clinical characteristics, diagnosis, treatment and histological feature of Malignant Melanoma in the head and neck. To improve the understanding and help the early diagnosis and treatment of the disease. As a result, improve the treatment and prognosis of Malignant Melanoma in head and neck.Method: We collect 15 cases of Malignant Melanoma in the head and neck region treated in the Department of Oral and Maxillofacial Surgery in Shengjing Hospital of China Medical University. All data were obtained from patient’s medical records which including the pathogenesis, clinical and histological features, diagnosis, treatment and prognosis.Result: This study included 15 cases, there are 9 male and 6 female patients. The average age is 62.9 years lid, the oldest one is 75 years old and the youngest one is 40 years old. 2 cases occurred in the lip, 2 cases occurred in the tongue, 2 cases occurred in the submandibular area, 1 cases occurred in the parotid gland, 1 case occurred in the neck, other 7 cases occurred in the gingiva. The cases occurred in the lip, gingiva, tongue, parotid gland and submandibular area are primary tumor, cases occurred in neck were metastasis. 6 cases were treated by surgical excision. 1 cases occurred in gingiva was treated by surgical excision combine with chemotherapy. 5 years followed up has been taken. 10 cases were dead because of recurrence and metastasis in 5 years after the operation. 5 patients do not have a relapse and still alive.Conclusion: Malignant Melanoma in the head and neck are mostly affected the old people. In this study gingiva is the most commonly primary site, neck is the most commonly transferring site. The diagnosis of malignant Melanoma is mainly relying on the clinical manifestation and pathological examination. Histopathological examination is considered the golden standard for diagnosis. Surgical excision combined with chemotherapy is the main treatment modality for Malignant Melanoma. Cryotherapy and immunotherapy also have been used in the treatment. The prognosis of Malignant Melanoma is poor. So early detection and early treatment is important in the treatment.

scholarly journals Adenoid cystic carcinoma of arytenoid: a rare tumor at a rare site

2020 ◽  
Vol 6 (7) ◽  
pp. 1380
Author(s):  
B. D. Krishnappa ◽  
B. K. Akshay
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Histopathological Examination ◽  
Benign Lesion ◽  
Malignant Neoplasm ◽  
Surgical Excision ◽  
Adenoid Cystic ◽  
Body Sensation ◽  
History Of ◽  
Rare Site ◽  
Pedunculated Polyp

<p>Pedunculated primary adenoid cystic carcinoma of larynx is an uncommon form of malignant neoplasm. This case is an extremely rare entity and hence reported. Until today this type of carcinoma is not reported in medical literature. A 55 year old female patient came with 6 months history of dyspnoea and foreign body sensation in throat and occasional change of voice. Micro laryngeal surgical excision of the pedunculated polyp was done under general anaesthesia using diathermy cautery and specimen was sent for histopathological examination, perineural spread of the tumour is highlighted. The pedunculated polyp from the arytenoid looked like a benign lesion and histopathological examination showed the lesion to be adenoid cystic carcinoma. </p>

Rare presentation of rectal duplication cyst as perineal hernia in an adult

2021 ◽  
Vol 14 (4) ◽  
pp. e239879
Author(s):  
Rahul Bhat ◽  
Rajat Ravindrakumar Choudhari ◽  
Shivananda Prabhu ◽  
Poornachandra Thejeswi
Keyword(s):  
Histopathological Examination ◽  
Surgical Excision ◽  
Duplication Cyst ◽  
Perineal Hernia ◽  
Sacrococcygeal Teratoma ◽  
Rare Presentation ◽  
Natal Cleft ◽  
Surgical Exploration ◽  
Sacral Region ◽  
Rectal Duplication

Rectal duplication cysts are rare congenital anomalies of the gastrointestinal tract. They can present with pain, gastrointestinal bleeding, infection or compressive symptoms on the rectum and urinary bladder. A 79-year-old man presented with a 8×5 cm swelling in the sacral region above the natal cleft with a positive cough impulse. During surgical exploration, there were two cysts with the posterior one presenting as the hernia. The cyst was excised and histopathological examination confirmed a diagnosis of rectal duplication cyst. Rectal duplications can lie anterior or more commonly posterior to the rectum. Differential diagnoses include dermoid cyst, diverticular cyst, sacrococcygeal teratoma or meningocele and endoscopic ultrasound is imaging of choice for diagnosis. Surgical excision is the treatment of choice. This is a rare presentation of a rectal duplication cyst as a perineal hernia with only a handful of cases in literature.

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