Traditional Chinese Medicine Yimucao Injection Combined with Western Medicine for Preventing Postpartum Hemorrhage after Cesarean Section: A Systematic Review and Meta-Analysis

Objective. Yimucao injection combined with several contraction uterus drugs is in use for preventing postpartum hemorrhage after cesarean section. The present study is a meta-analysis comparing the efficacy and safety of these drugs. Methods. PubMed, Cochrane Library, Embase, the China National Knowledge Infrastructure (CNKI), the Chinese Biomedical Database (CBM), VIP, and Wanfang database were searched until June 2018. We selected RCTs of Yimucao injection combined with western medicine for preventing postpartum hemorrhage and study quality was assessed using the revised Cochrane risk of bias tool. Forty-eight RCTs are comprised of 7,330 participants. Results. The overall response rate of Yimucao injection combined with western medicine as a class (OR=4.19, 95%CI=2.83, 6.20, P<0.00001) was found to be significantly improved than western medicine alone. Yimucao injection combined with western medicine group could significantly reduce blood loss in intraoperative (SMD= -1.15, 95%CI= -1.43, -0.87, P<0.00001), compared with control group. The treatment group could significantly reduce postpartum blood loss within 2 hours (SMD= -1.73, 95%CI= -2.01, -1.46, P<0.00001) and had a significantly lower blood loss within 24 hours (SMD= -1.92, 95%CI= -2.21, -1.63, P<0.00001) than control group. Additionally, in terms of the safety, Yimucao injection group reduced the risk of adverse events in the course of prevention than the western medicine group. Conclusions. This study demonstrated that Yimucao injection combined with western medicine may be more effective for preventing postpartum hemorrhage after cesarean section. However, high-quality and large multicenter randomized clinical trials will be needed to prove the consequence in the further.

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Efficacy and Safety of Modified Yunu-Jian in Patients with Periodontitis: A Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/5147439 ◽

2021 ◽

Vol 2021 ◽

pp. 1-9

Author(s):

Yuanyuan Yue ◽

Meng Gao ◽

Yanru Deng ◽

Jiemin Shao ◽

Yingguang Sun

Keyword(s):

Western Medicine ◽

Combined Therapy ◽

Meta Analysis ◽

Effective Rate ◽

Cochrane Library ◽

Efficacy And Safety ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Oral Inflammation

Background. Modified Yunu-Jian (mYJ), a Chinese medicine (CM) formula, is thought to clear heat and nourish yin. Clinically, it is often used to treat oral inflammation. However, its efficacy remains controversial. Methods. The study aims to evaluate the efficacy and safety of mYJ for treating patients with periodontitis. We searched electronic databases (PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure, Wanfang database, VIP database, and CBM) from inception to December 2020. Only randomized controlled trials investigating modified Yunu-Jian, with or without other medications, against controlled intervention in the treatment of patients diagnosed with periodontitis were included. Both Review Manager 5.3 and Stata 15.0 software were used to analyze the data. The Cochrane Collaborations risk of bias tool was used to assess the quality of the methods. Results. Thirteen clinical trials, involving 1179 participants, were included in our investigation. The results showed that the combination of mYJ with western medicine improved the total effective rate compared with western medicine alone (RR = 1.17, 95% CI (1.12, 1.23), P < 0.00001). The sensitivity analysis and Harbord’s test ( P = 0.255) both showed that the results were statistically robust. Moreover, the periodontal indexes (GI, SBI, PLI, and PD; P < 0.00001) of patients with periodontitis were also significantly improved after receiving the combined therapy. No serious adverse reactions were observed in the experimental groups. Conclusions. Evidence from the meta-analysis suggested that mYJ appeared to be effective and relatively safe for treating periodontitis. Because of the low quality of the methods used in the included RCTs, further studies with larger sample sizes and well-designed models are required to confirm our findings.

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Comparison of Efficacy Between Steroid Therapy and Observation Therapy in the Treatment of Traumatic Optic Neuropathy-a Meta-analysis

10.21203/rs.3.rs-736728/v1 ◽

2021 ◽

Author(s):

Peipei Zhang ◽

Chao Xue ◽

Ying Chen ◽

Xuening Su

Keyword(s):

Steroid Therapy ◽

Optic Neuropathy ◽

Randomized Clinical Trials ◽

Web Of Science ◽

Meta Analysis ◽

Cochrane Library ◽

Traumatic Optic Neuropathy ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Better Than

Abstract Background: Until now, the exact pathophysiology of traumatic optic neuropathy(TON) is still unclear, its management has remained controversial. The effect of steroid in TON remains unclear. The purpose of this study is to compare the effect of steroid therapy with observation therapy in the treatment of traumatic optic neuropathy(TON). Methods: A systematic literature search was performed in data sources including CENTRAL, PubMed, EMBASE, Web of Science, Cochrane Library, MEDLINE, Chinese databases including Wanfang and China National Knowledge Infrastructure for to find relevant studies. The statistical analysis was performed by RevMan 5.3 software.Results: Eight studies including 263 eyes were enrolled in this study. The rate of improvement of VA in the steroid group was not better than that of the observation group (OR=2.17, 95%, CI=1.23-3.83, P=0.007), with no heterogeneity (I2=0,P=0.43).Conclusions: Patients with TON receiving steroid treatment may not have a better visual recovery than observation therapy. Steroid therapy is not recommend in patients with TON. Further larger randomized clinical trials are needed to evaluate the effect of steroid therapy for TON in the future.

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Effects of Sodium Valproate Monotherapy on Blood Liver Enzyme Levels in Patients with Epilepsy: A Meta-Analysis

Hormone and Metabolic Research ◽

10.1055/a-1517-6550 ◽

2021 ◽

Vol 53 (07) ◽

pp. 425-434

Author(s):

Jie Fu ◽

Tao Tao ◽

Zuoxiao Li ◽

Yangmei Chen ◽

Xiu Chen ◽

...

Keyword(s):

Sodium Valproate ◽

Early Stage ◽

Meta Analysis ◽

Group Versus ◽

Cochrane Library ◽

Control Group ◽

China National Knowledge Infrastructure ◽

Asian Patients ◽

Knowledge Infrastructure ◽

Patients With Epilepsy

AbstractWe conducted this meta-analysis to assess the effects of sodium valproate (VPA) monotherapy on blood liver enzymes in patients with epilepsy. PubMed, Web of Science, EBSCO, Cochrane Library, Wanfang, China national knowledge infrastructure databases were searched. Nine studies were included. Results showed: (1) The overall SMD for blood AST, ALT, and GGT levels of VPA monotherapy group versus control group were 0.70 (95% CI=0.31 to 1.09, Z=3.52, p=0.0004), 0.47 (95% CI=− 0.01 to 0.95, Z=1.91, p=0.06), 0.44 (95% CI=0.29 to 0.60, Z=5.55, p<0.00001), respectively. (2) In subgroup meta-analysis, increased blood AST and GGT levels were observed in epileptic minors (AST: total SMD=0.85, 95% CI=0.40 to 1.30, Z=3.69, p=0.0002; GGT: total SMD=0.46, 95% CI=0.29 to 0.63, Z=5.25, p<0.00001). Elevated blood ALT level was observed in Asian patients receiving VPA monotherapy (total SMD=0.70, 95% CI=0.51 to 0.90, Z=7.01, p<0.00001), and the early stage of VPA monotherapy (total SMD=0.93, 95% CI=0.57 to 1.29, Z=5.09, p<0.00001). Overall, our results indicated that blood AST and GGT were significantly increased in epileptic minors receiving VPA monotherapy. The elevation of blood ALT was observed in Asian patients and the early stage of VPA monotherapy. However, due to the small number of included studies, our results should be considered with caution.

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Effects of dexmedetomidine on neurocognitive disturbance after elective non-cardiac surgery in senile patients: a systematic review and meta-analysis

Journal of International Medical Research ◽

10.1177/03000605211014294 ◽

2021 ◽

Vol 49 (5) ◽

pp. 030006052110142

Author(s):

Xiaobo Bi ◽

Jingxia Wei ◽

Xia Zhang

Keyword(s):

Cardiac Surgery ◽

Postoperative Delirium ◽

Meta Analysis ◽

Postoperative Cognitive Dysfunction ◽

Cochrane Library ◽

Control Group ◽

China National Knowledge Infrastructure ◽

Neurocognitive Dysfunction ◽

Knowledge Infrastructure ◽

Positive Effect

Objective Senile patients often experience neurocognitive disturbance after non-cardiac surgery. Several clinical trials have investigated if the perioperative intravenous use of dexmedetomidine has a positive effect on the prevention of neurocognitive dysfunction, but the results have been inconsistent. We performed a meta-analysis to investigate the effects of dexmedetomidine on neurocognitive disturbance after elective non-cardiac surgery in senile patients. Methods The PubMed, Cochrane Library, EMBASE and China National Knowledge Infrastructure databases were comprehensively searched for all randomized controlled trials published before 1 February 2020 that investigated the efficacy of dexmedetomidine in the prevention of postoperative delirium (POD) or postoperative cognitive dysfunction (POCD). Results Sixteen studies involving 4376 patients were included in this meta-analysis. Compared with the control (i.e., saline), the perioperative intravenous use of dexmedetomidine significantly reduced the incidence of POD and POCD. However, patients in the dexmedetomidine group were more likely to develop bradycardia and hypotension during the administration of dexmedetomidine than patients in the control group. There were no differences between the two groups in the incidence of nausea and vomiting or mortality rate. Conclusion Dexmedetomidine has a positive effect on the prevention of neurocognitive disturbance in senile patients after elective non-cardiac surgery.

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Quadratus lumborum block for postoperative analgesia after cesarean section: a meta-analysis of randomized controlled trials with trial sequential analysis

Scientific Reports ◽

10.1038/s41598-021-96546-7 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Zhigang Zhao ◽

Kaiming Xu ◽

Yanting Zhang ◽

Gang Chen ◽

Youfa Zhou

Keyword(s):

Cesarean Section ◽

Sequential Analysis ◽

Meta Analysis ◽

Analgesic Efficacy ◽

Cochrane Library ◽

Trial Sequential Analysis ◽

Sufficient Data ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Quadratus Lumborum

AbstractThe aim of this study was to assess the analgesic efficacy of QLB versus controls in women undergoing cesarean section (CS). We systematically searched Cochrane Library, PUBMED, EMBASE, VIP, WANFANG, and China National Knowledge Infrastructure. Trials were eligible if parturients received QLB during CS. GRADE system was used to assess the certainty of evidence and Trial sequential analyses (TSA) were performed to determine whether the results are supported by sufficient data. Thirteen studies involving 1269 patients were included. Compared to controls, QLB significantly reduced the cumulative postoperative intravenous opioid consumption (in milligram morphine equivalents) at 24 h (MD, − 11.51 mg; 95% CI − 17.05 to − 5.96) and 48 h (MD, − 15.87 mg; 95% CI − 26.36 to − 5.38), supported by sufficient data confirmed by TSA. The postoperative pain scores were significantly reduced by QLB at 4 h, 6 h, 12 h, 24 h, and 48 h postoperatively by QLB compared with control. Moreover, the time to first request for rescue analgesic and the incidence of PONV were also significantly reduced by QLB. The quality of evidence of most results were low and moderate assessed by GRADE.

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Quadratus lumborum block for postoperative analgesia after cesarean section: a meta-analysis of randomized controlled trials with trial sequential analysis

10.21203/rs.3.rs-283244/v1 ◽

2021 ◽

Author(s):

Zhigang Zhao ◽

Kaiming Xu ◽

Yanting Zhang ◽

Gang Chen ◽

Youfa Zhou

Keyword(s):

Cesarean Section ◽

Sequential Analysis ◽

Meta Analysis ◽

Analgesic Efficacy ◽

Cochrane Library ◽

Trial Sequential Analysis ◽

Sufficient Data ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Quadratus Lumborum

Abstract The aim of this study was to assess the analgesic efficacy of QLB versus controls in women undergoing cesarean section (CS). We systematically searched Cochrane Library, PUBMED, EMBASE, VIP, WANFANG, and China National Knowledge Infrastructure. Trials were eligible if parturients received QLB during CS. GRADE system was used to assess the certainty of evidence and Trial sequential analyses (TSA) were performed to determine whether the results are supported by sufficient data. Thirteen studies involving 1269 patients were included. Compared to controls, QLB significantly reduced the cumulative postoperative intravenous opioid consumption (in milligram morphine equivalents) at 24h (MD, -11.51 mg; 95% CI -17.05 to -5.96) and 48h (MD, -15.87 mg; 95% CI -26.36 to -5.38), supported by sufficient data confirmed by TSA. The postoperative pain scores were significantly reduced by QLB at 4h, 6h, 12h, 24h, and 48h postoperatively by QLB compared with control. Moreover, the time to first request for rescue analgesic and the incidence of PONV were also significantly reduced by QLB. The quality of evidence of most results were low and moderate assessed by GRADE.

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The Effect of Letrozole Combined with Dydrogesterone for Endometriosis in China: A Meta-Analysis

BioMed Research International ◽

10.1155/2021/9946060 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Shumei Sun ◽

Hao Zhang ◽

Peicheng Zhong ◽

Zhihong Xu

Keyword(s):

Meta Analysis ◽

Carbohydrate Antigen ◽

Cochrane Library ◽

Control Group ◽

China National Knowledge Infrastructure ◽

Carbohydrate Antigen 125 ◽

Knowledge Infrastructure ◽

Significant Difference ◽

Mean Differences ◽

Endothelial Growth Factor

Purpose. To discuss the effects of dydrogesterone combined with letrozole on the effectiveness, sex hormone levels, and serological indicators in patients with endometriosis. This study is registered with PROSPERO (CRD42020213172). Methods. We searched relevant randomized controlled trials (RCTs) through PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP Database. The standardized mean differences (SMDs), the mean differences (MDs), or odds ratios (ORs) with their 95% confidence intervals (95% CIs) were computed to be outcome indicators, including total effectiveness, Vascular Endothelial Growth Factor (VEGF) level, Carbohydrate Antigen 125 (CA125) level, Follicle-Stimulating Hormone (FSH) level, Luteinizing Hormone (LH) level, estrogen (E2) level, progesterone (P) level, interleukin-6 (IL-6) level, and tumor necrosis factor-a (TNF-a) level. Results. A total of 19 RCTs involving 1,591 patients were included in this study. Our results showed that letrozole combined with dydrogesterone can significantly reduce the levels of VEGF (SMD -2.23, 95% CI -2.39 to -2.07; p < 0.00001 ), CA125 (MD -10.53, 95% CI -11.19 to -9.88; p < 0.00001 ), E2 (SMD -1.64, 95% CI -1.81 to -1.47; p < 0.00001 ), P (MD -5.11, 95% CI -6.26 to -3.96; p < 0.00001 ), IL-6 (MD -4.41, 95% CI -5.16 to -3.67; p < 0.00001 ), and TNF-a (MD -5.67, 95% CI -6.34 to -5.00; p < 0.00001 ) in patients with endometriosis compared with the control group. In addition, the results indicated that total effectiveness was significantly higher in the experiment group (OR 6.21, 95% CI 4.17 to 9.24; p < 0.00001 ) compared to the control. However, there was no significant difference between FSH and LH levels in both groups ( p > 0.05 ). Conclusion. This combination therapy can effectively decrease the levels of VEGF, CA125, E2, P, IL-6, and TNF-a and increase the total effectiveness when comparing with the control group.

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Efficacy of perioperative intravenous dexmedetomidine administration for the prevention of postoperative sore throat: a meta-analysis

Journal of International Medical Research ◽

10.1177/03000605211017686 ◽

2021 ◽

Vol 49 (5) ◽

pp. 030006052110176

Author(s):

Yuanhui Liu ◽

Dongmei Ai ◽

Xiaobin Wang

Keyword(s):

Sore Throat ◽

Meta Analysis ◽

Clinical Work ◽

Cochrane Library ◽

Control Group ◽

Postoperative Sore Throat ◽

China National Knowledge Infrastructure ◽

Related Complication ◽

Anesthetic Drugs ◽

Knowledge Infrastructure

Objective Postoperative sore throat (POST) is an undesirable intubation-related complication after surgery. Several studies have investigated the efficacy of perioperative intravenous dexmedetomidine administration for the prevention of POST, but the results have been inconsistent. We aimed to summarize all existing evidence and draw a more precise conclusion to guide future clinical work. Methods PubMed, Cochrane Library, EMBASE and China National Knowledge Infrastructure databases were comprehensively searched for all randomized controlled trials published before 1 February 2021 that investigated the efficacy of dexmedetomidine for the prevention of POST. Results Nine studies involving 400 patients were included in our meta-analysis. Compared with the control groups (i.e., saline and anesthetic drugs), perioperative intravenous use of dexmedetomidine significantly reduced the incidence of POST [risk ratio (RR): 0.56; 95% confidence interval (CI): 0.40–0.77; I2 = 0%) and coughing on the tube during extubation (RR: 0.58; 95% CI: 0.41–0.82; I2 = 0%). Additionally, patients in the dexmedetomidine group were more likely to develop bradycardia (RR: 2.46; 95% CI: 1.28–4.71; I2 = 0%) and hypotension (RR: 3.26; 95% CI: 1.14–9.33; I2 = 0%) during the administration of dexmedetomidine than those in the control group. Conclusion Perioperative intravenous administration of dexmedetomidine has a positive effect on the prevention of POST.

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Evaluation of the efficacy and safety of different class III anti-arrhythmic drugs for treating patients with atrial fibrillation: a network meta-analysis

10.21203/rs.2.17803/v1 ◽

2019 ◽

Author(s):

Chuang Yang ◽

Zhibo Li ◽

Xin Xue ◽

yu fei

Keyword(s):

Atrial Fibrillation ◽

Adverse Reactions ◽

Meta Analysis ◽

Heart Rhythm ◽

Cochrane Library ◽

Control Group ◽

Class Iii ◽

China National Knowledge Infrastructure ◽

Significant Treatment ◽

Knowledge Infrastructure

Abstract Background Class III anti-arrhythmic drugs (AADs) are used to control heart rhythm or rate in the management of atrial fibrillation (AF). In this study, we evaluated the most effective and safe class III AADs used to treat patients with AF. Methods We searched the PubMed, Cochrane Library, Web of Science, Embase, WanFang databases, as well as the China National Knowledge Infrastructure from 2014 to 2019 to identify studies that reported the use of class III ADDs to treat AF. Results We identified 31 articles (24 Chinese and 7 English), that included 2,894 AF patients (treatment group = 1,498, control group = 1,396) for our analysis. Several class III AADs showed significant treatment effects in AF patients compared to conventional treatment. The ADDs were ranked in terms of efficacy from good to bad as follows: vernakalant (relative risk (RR) =2.7, 95% confidence interval (CI):1.9-3.7), ibutilide (RR=2.0, 95% CI:1.7-2.4), nifekalant (RR=1.5, 95% CI:1.2-2.0), and amiodarone (RR=1.4,95% CI:1.3-1.5). There were no significant differences in the incidence of adverse reactions among the different class III AADs. These ADDs were ranked from least to most adverse reactions as follows: vernakalant(RR=0.46, 95% CI:0.20-1.0), sotalol (RR=0.52, 95% CI:0.25-1.0), ibutilide (RR=0.64, 95% CI:0.33-1.2), amiodarone (RR=0.79, 95% CI:0.58-1.1), and nifekalant (RR=1.0, 95% CI:0.44-2.5). Conclusion Our network meta-analysis shows that different class III AADs can be used to treat patients with AF both safely and effectively. Vernakalant appears to offer optimal therapeutic effect with minimal adverse reactions.

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Combined Therapy of Diabetic Peripheral Neuropathy with Breviscapine and Mecobalamin: A Systematic Review and a Meta-Analysis of Chinese Studies

BioMed Research International ◽

10.1155/2015/680756 ◽

2015 ◽

Vol 2015 ◽

pp. 1-11 ◽

Cited By ~ 10

Author(s):

Chanjiao Zheng ◽

Weilin Ou ◽

Huanyu Shen ◽

Zhiheng Zhou ◽

Jiaji Wang

Keyword(s):

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Combined Therapy ◽

Meta Analysis ◽

Cochrane Library ◽

Control Group ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Chinese Studies ◽

Better Than

Objective. A meta-analysis on combined therapy of diabetic peripheral neuropathy (DPN) with breviscapine and mecobalamin was performed to evaluate the efficacy of this therapy.Methods. Six English databases (Medline, Cochrane Library, PubMed, EMBASE, Web of Science, and CINAHL) and four Chinese databases (China National Knowledge Infrastructure, VIP Journals Database, CBM, and Wanfang database) were searched for studies on the clinical trials in which DPN was treated with breviscapine and mecobalamin, and RevMan 5.1 package was employed for analyzing pooled trials and publication bias.Results. A total of 17 articles including 1398 DPN patients were identified. Homogeneity was observed among different studies (P=0.74). The efficacy of combined therapy with breviscapine and mecobalamin was significantly better than that in control group [P<0.0001(OR=5.01, 95% CI: 3.70–6.78)].Conclusion. Available findings suggest that the therapeutic efficacy of breviscapine combining mecobalamin is superior to mecobalamin alone, and this strategy is required to be popularized in clinical practice.

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