A Case of Histiocytic Sarcoma Arising from Mycosis Fungoides

Histiocytic sarcoma (HS) is an uncommon malignant neoplasm arising from mature histiocytes and most commonly characterized by the immunophenotypic expression of CD68, CD163, or lysozyme. Although rare, HS arising as a second primary malignancy following hematolymphoid neoplasms has been reported. To our knowledge, this is the first reported case of HS occurring as a second primary malignancy in a patient with mycosis fungoides (MF), with the retained immunophenotype markers CD30 and CD4.

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Metachronous Multiple Primary Malignant Neoplasms of the Stomach and the Breast: Report of Two Cases With Review of Literature

International Surgery ◽

10.9738/intsurg-d-13-00056.1 ◽

2014 ◽

Vol 99 (1) ◽

pp. 52-55 ◽

Cited By ~ 4

Author(s):

Vilvapathy Senguttuvan Karthikeyan ◽

Sarath Chandra Sistla ◽

Ramachandran Srinivasan ◽

Debdatta Basu ◽

Lakshmi C. Panicker ◽

...

Keyword(s):

Malignant Neoplasm ◽

Second Primary ◽

Malignant Neoplasms ◽

Rare Occurrence ◽

Review Of Literature ◽

Second Primary Malignancy ◽

Carcinoma Of The Breast ◽

Primary Malignancy ◽

Multiple Primary ◽

Second Primary Malignancies

Abstract Multiple primary malignant neoplasm is the occurrence of a second primary malignancy in the same patient within 6 months of the detection of first primary (synchronous), or 6 months or more after primary detection (metachronous). Multiple primary malignant neoplasms are not very frequently encountered in clinical practice. The relative risk for a second primary malignancy increases by 1.111-fold every month from the detection of the first primary malignancy in any individual. We present 2 patients treated for carcinoma of the breast who developed a metachronous primary malignancy in the stomach to highlight the rare occurrence of multiple primary malignant neoplasms. These tumors were histologically dissimilar, with distinct immunohistochemical parameters. The importance lies in carefully identifying the second primary malignancies, not dismissing them as metastases, and treating them accordingly.

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Occurrence of second primary malignancy in medullary thyroid cancer (MTC) patients

Endocrine Abstracts ◽

10.1530/endoabs.67.o2 ◽

2019 ◽

Author(s):

George Simeakis ◽

Katerina Saltiki ◽

Evangelia Zapanti ◽

Evanthia Kassis ◽

Maria Alevizaki

Keyword(s):

Thyroid Cancer ◽

Medullary Thyroid Cancer ◽

Second Primary ◽

Second Primary Malignancy ◽

Primary Malignancy ◽

Medullary Thyroid

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Mutation associated with Fanconi anemia pathway may increase patients’ second primary malignancy risk: Results from somatic and germline testing of clear cell papillary renal cell carcinoma

European Urology ◽

10.1016/s0302-2838(21)01088-5 ◽

2021 ◽

Vol 79 ◽

pp. S980

Author(s):

X. Tian ◽

A. Aihetaimujiang ◽

Y.Y. Qu ◽

H.L. Zhang ◽

D.W. Ye

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Fanconi Anemia ◽

Renal Cell ◽

Clear Cell ◽

Papillary Renal Cell Carcinoma ◽

Second Primary ◽

Second Primary Malignancy ◽

Primary Malignancy ◽

Germline Testing

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Second primary malignancy of the aerodigestive tract in patients treated for cancer of the oral cavity and larynx

Head & Neck ◽

10.1002/hed.20272 ◽

2005 ◽

Vol 27 (12) ◽

pp. 1042-1048 ◽

Cited By ~ 73

Author(s):

Karen Lin ◽

Snehal G. Patel ◽

Pen Yuan Chu ◽

Jeannette M. S. Matsuo ◽

Bhuvanesh Singh ◽

...

Keyword(s):

Oral Cavity ◽

Aerodigestive Tract ◽

Second Primary ◽

Second Primary Malignancy ◽

Primary Malignancy

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Clinical Course Of Patients with Small Cell Lung Cancer As Second Primary Malignancy

The Chinese-German Journal of Clinical Oncology ◽

10.1007/s10330-004-0325-x ◽

2005 ◽

Vol 4 (5) ◽

pp. 297-300 ◽

Cited By ~ 3

Author(s):

Xiuwen WANG ◽

Lian LIU ◽

Yawei WANG ◽

Robert Siegel

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Clinical Course ◽

Small Cell ◽

Second Primary ◽

Small Cell Lung ◽

Second Primary Malignancy ◽

Primary Malignancy

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The risk and prognosis of secondary primary malignancy in lung cancer: a population-based study

Future Oncology ◽

10.2217/fon-2021-0045 ◽

2021 ◽

Author(s):

Jia Hong ◽

Rongrong Wei ◽

Chuang Nie ◽

Anastasiia Leonteva ◽

Xu Han ◽

...

Keyword(s):

Lung Cancer ◽

Overall Survival ◽

Cox Regression ◽

Population Based ◽

Second Primary ◽

Second Primary Malignancy ◽

Risk Models ◽

Primary Malignancy ◽

Population Based Study ◽

Competing Risk Models

Aim: To assess and predict risk and prognosis of lung cancer (LC) patients with second primary malignancy (SPM). Methods: LC patients diagnosed from 1992 to 2016 were obtained through the Surveillance, Epidemiology, and End Results database. Standardized incidence ratios were calculated to evaluate SPM risk. Cox regression and competing risk models were applied to assess the factors associated with overall survival, SPM development and LC-specific survival. Nomograms were built to predict SPM probability and overall survival. Results & conclusion: LC patients remain at higher risk of SPM even though the incidence declines. Patients with SPM have a better prognosis than patients without SPM. The consistency indexes for nomograms of SPM probability and overall survival are 0.605 (95% CI: 0.598–0.611) and 0.644 (95% CI: 0.638–0.650), respectively.

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