scholarly journals The Relevance of Assessing the Cell Proliferation Factor Ki-67 in Squamous Cell Carcinoma of the Larynx

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
J. Vukelic ◽  
R. Dobrila-Dintinjana ◽  
A. Dekanic ◽  
B. Marijic ◽  
A. Cubranic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Treatment Outcome ◽  
Cell Carcinoma ◽  
Laryngeal Cancer ◽  
Squamous Cell ◽  
Histological Grade ◽  
Tumor Grade ◽  
Ki 67 ◽  
Index Group ◽  
Carcinoma Of The Larynx

The aim of study was to investigate the expression of the proliferation factor Ki-67 and its relationship with histological grade, cancer stage, and treatment outcome in squamous cell carcinoma of the larynx. Samples from 78 patients with laryngeal cancer were analysed retrospectively. Paraffin sections of tumors were immunohistochemically stained for Ki-67 expression. The patients were divided in two groups according to the proliferative factor values (a low Ki-67 index group - Ki-67≤34 and high Ki-67 index group-Ki-67 >34). Statistical analysis of the data shows significant correlation among histological tumor grade and the value of the Ki-67 proliferative index. There was no correlation between tumoral Ki-67 expression and diagnosis, stage of the disease, or treatment outcome. In conclusion, Ki-67 expression in laryngeal cancer is not the most reliable marker for making precise diagnosis and predicting the clinical course.

Immunoexpression of p53, Ki-67 and E-cadherin in basaloid squamous cell carcinoma of the larynx

2005 ◽  
Vol 7 (3) ◽  
pp. 110-114 ◽  
Author(s):  
María J. Rodríguez Tojo ◽  
Francisco J. García Cano ◽  
Juan C. Infante Sánchez ◽  
E. Velázquez Fernández ◽  
José M. Aguirre Urízar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basaloid Squamous Cell Carcinoma ◽  
Ki 67 ◽  
Carcinoma Of The Larynx ◽  
Basaloid Squamous ◽  
E Cadherin

Squamous Cell Carcinoma of the Larynx Metastasized to the Ampulla of Vater. Report of a Case

2003 ◽  
Vol 89 (2) ◽  
pp. 199-201 ◽  
Author(s):  
Abdullah Büyükçelik ◽  
Arzu Ensari ◽  
Mustafa Sarioğrlu ◽  
Abdurrahman Işıkdogan ◽  
Fikri İçli
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Laryngeal Cancer ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Ampulla Of Vater ◽  
Turkish Patient ◽  
Carcinoma Of The Larynx ◽  
Polypoid Tumor

Metastasis to the ampulla of Vater from squamous cell carcinoma of the larynx has not been reported previously. In a 71-year-old Turkish patient with squamous cell carcinoma of the larynx a polypoid tumor was observed in the ampulla of Vater. Histopathological examination revealed squamous cell carcinoma compatible with metastasis from laryngeal cancer.

scholarly journals Low level of interobserver concordance in assessing histological subtype and tumor grade in patients with penile cancer may impair patient care

2021 ◽  
Author(s):  
Luiza Dorofte ◽  
Diane Grélaud ◽  
Michelangelo Fiorentino ◽  
Francesca Giunchi ◽  
Costantino Ricci ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Penile Cancer ◽  
Histological Grade ◽  
Significant Risk ◽  
Tumor Grade ◽  
Patient Treatment ◽  
Histological Subtype ◽  
Penile Squamous Cell Carcinoma

AbstractDifferentiation between penile squamous cell carcinoma patients who can benefit from limited organ-sparing surgery and those at significant risk of lymph node metastasis is based on histopathological prognostic factors including histological grade and tumor histological subtype. We examined levels of interobserver and intraobserver agreement in assessment of histological subtype and grade in 207 patients with penile squamous cell carcinoma. The cases were assessed by seven pathologists from three hospitals located in Sweden and Italy. There was poor to moderate concordance in assessing both histological subtype and grade, with Fleiss kappas of 0.25 (range: 0.02–0.48) and 0.23 (range: 0.07–0.55), respectively. When choosing HPV-associated and non-HPV-associated subtypes, interobserver concordance ranged from poor to good, with a Fleiss kappa value of 0.36 (range: 0.02–0.79). A re-review of the slides by two of the pathologists showed very good intraobserver concordance in assessing histological grade and subtype, with Cohen’s kappa values of 0.94 and 0.91 for grade and 0.95 and 0.84 for subtype. Low interobserver concordance could lead to undertreatment and overtreatment of many patients with penile cancer, and brings into question the utility of tumor histological subtype and tumor grade in determining patient treatment in pT1 tumors.

Screening and diagnosis of laryngopharyngeal reflux in patients with laryngeal cancer stage I-II (T1-2N0M0)

2020 ◽  
pp. 18-29
Author(s):  
Yaroslav V. Kizim
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Laryngeal Cancer ◽  
Squamous Cell ◽  
Laryngopharyngeal Reflux ◽  
Ph Monitoring ◽  
Stage I ◽  
Study Group ◽  
Cancer Stage ◽  
Carcinoma Of The Larynx

Topicality: The variety of manifestations of laryngopharyngeal reflux (LPR) in otolaryngological practice has made this problem relevant for the past decades. The development of LPR is associated with impaired function of the upper esophageal sphincter, which allows reflux to enter the larynx, pharynx, nasal cavity and middle ear cavity. In a number of studies, pathological reflux has been identified as one of the factors in the development of cancer of the upper respiratory and digestive tract. Aim of the study: to improve methods fors creening and diagnosis of laryngopharyngeal reflux in patients with laryngeal cancer stage I-II (T1-2N0M0). Materials and methods: The study group included 93 patients with stage I-II laryngeal cancer (T1-2N0M0). The control group was represented by 36 patients with reflux-associated benign neoplasms of the larynx. For preliminary diagnosis and objectification of complaints used the RSI test. To increase the accuracy of interpretation and objectification of laryngoscopic manifestations of LPR, the RFS scale was used. The daily pH-monitoring was carried out using an AG-1pH-M acidogastrograph with an electrode system. The severity of reflux was determined according to DeMeester criteria. According to the results of pH monitoring, clinical groups were formed. Results: When analyzing the results of the examination, the RSI index exceeded “9” in 41 (44.1%) patients. When tested on the RFS scale, the indicator “13 and higher” was recorded in 48 (51.6%) patients. All patients (41) with a positive RSI test received 24-hour pH monitoring. According to 24-hour pH-monitoring, the presence of LPR was verified in 33 (80.1%) patients with a positive RSI test. The study group consisted of 33 (80.1%) patients with squamous cell carcinoma of the larynx T1-2N0M0. After 24-hour pH-monitoring, we obtained the data: mild LPR was observed in 6 (18.2%) patients, moderate severity of LPR in 18 (54.5%) and severe LPR in 9 (27.3%). In patients with laryngeal cancer T1-2N0M0, which is associated with LPR, the DeMeester criterion exceeded 14.72. Conclusions: Comparison of pH-monitoring data and visual-analogue scales reaches 80.1% of compliance in patients with laryngeal cancer T1-2N0M0, which is associated with LPR. According to 24-hour pH-monitoring, the presence of LPR was verified in 33 (35.5%) of the examined patients with squamous cell carcinoma of the larynx. Using the modified The Reflux Symptom Index and The Reflux Finding Score scales is a highly reliable method for screening the diagnosis of laryngopharyngeal reflux in patients with laryngeal cancer.

Immunohistochemical Expression of TGF-β3 in Oral Squamous Cell Carcinoma

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Asmaa Ali Hussein
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Transforming Growth Factor ◽  
Tumor Grade ◽  
Tumor Stage ◽  
High Rate ◽  
Female Ratio ◽  
Positive Expression

Squamous cell carcinoma characterized by poor prognosis due to aggressive tumor growth and dissemination high rate of tumor cell . age ranged of patient case included in the study 40-62 years and mean age 55±99. The sex distribution male/female ratio 1:1. Male case 15 and female 15 of the present study The results of clinical forums showed in the current study was endophytic 10(33.3%) in the same time Exophytic were presented in 20 cases (76.7%). Regarding distribution of the tumors site, the preponderance of them 19 cases 73.3% were located alveolar mucosa, followed by in the tongue 11 cases(36.7%) Tumor stage was analyzed and recorded in Oral squamous cell carcinoma included cases, the preponderance of them were Stage II 11 cases 36.7% followed by stage III 10 cases 33.3% , 9 cases 30.0% were stage I. While Concerning tumor grade, majority of them 15 cases 50% had grade II moderately differentiated SCC, while 11 cases 36.7% had grade III poorly differentiated SCC and 4 cases 13.3% had grade I well differentiated SCC Positive TGF-β3 immunostaining was detected as cell with staining brown color, all tissues sections included show Positive expression based on IHC teqnique. Positive Transforming Growth Factor TGF-β3 Immuno staining was found in all case results and display that 4 samples with percentage 13.3% expressed strong positive 87.67 ± 1.45 expression , 11cases 36.7% showed 51.33 ±0.88 positive expression moderate at the same time 15 samples 50.0% showed positive weak expression.

scholarly journals Primary squamous cell carcinoma of the pancreas with a large pseudocyst of the pancreas as the first manifestation: a rare case report and literature review

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xia Qiu ◽  
Yajie Meng ◽  
Meiqin Lu ◽  
Chuan Tian ◽  
Min Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Mass ◽  
Elevated Serum ◽  
Abdominal Distension ◽  
Needle Aspiration ◽  
Pancreatic Pseudocysts ◽  
Primary Squamous Cell Carcinoma ◽  
Ki 67

Abstract Background Primary squamous cell carcinoma (SCC) of the pancreas with pseudocysts, especially diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), is extremely rare. Case presentation A 64-year-old man was admitted to our department for abdominal distension. Two months ago, he experienced abdominal pain for 1 day and was diagnosed with acute pancreatitis in another hospital. After admission, laboratory tests showed the following: amylase 400 U/L, lipase 403 U/L, and carbohydrate antigen 19–9 (CA19-9) 347 U/mL. Abdominal computed tomography (CT) revealed pancreatitis with a pseudocyst with a diameter measuring 7 cm. During linear EUS, a large pseudocyst (5.4 × 5.2 cm) was observed in the pancreatic body. EUS-FNA was performed. We obtained specimens for histopathology and placed a plastic stent through the pancreas and stomach to drain the pseudocyst. Puncture fluid examination revealed the following: CA19-9 > 12,000 U/mL carcinoembryonic antigen (CEA) 7097.42 ng/ml, amylase 27,145.3 U/L, and lipase > 6000 U/L. Cytopathology revealed an abnormal cell mass, and cancer was suspected. Furthermore, with the result of immunohistochemistry on cell mass (CK ( +), P40 ( +), p63 ( +), CK7 (−) and Ki-67 (30%)), the patient was examined as squamous cell carcinoma (SCC). However, the patient refused surgery, radiotherapy and chemotherapy. After drainage, the cyst shrank, but the patient died 3 months after diagnosis due to liver metastasis and multiple organ failure. Conclusion For patients with primary pancreatic pseudocysts with elevated serum CEA and CA19-9 levels, we should not rule out pancreatic cancer, which may also be a manifestation of primary pancreatic SCC. EUS-FNA is helpful for obtaining histopathology and cytology and thus improving diagnostic accuracy.

scholarly journals Prognostic value of p27Kip1expression in Basaloid Squamous Cell Carcinoma of the larynx

BMC Cancer ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Grazia Salerno ◽  
Dolores Di Vizio ◽  
Stefania Staibano ◽  
Giampiero Mottola ◽  
Giuseppe Quaremba ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Basaloid Squamous Cell Carcinoma ◽  
Carcinoma Of The Larynx ◽  
Basaloid Squamous
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