scholarly journals Quantification of Microvascular Density of the Optic Nerve Head in Diabetic Retinopathy Using Optical Coherence Tomographic Angiography

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Jianfeng Huang ◽  
Bodi Zheng ◽  
Yingyi Lu ◽  
Xiaoya Gu ◽  
Hong Dai ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Roc Curve ◽  
Mixed Model ◽  
Diabetic Patients ◽  
Optical Coherence ◽  
Binary Logistic Regression Model ◽  
Fiber Layer ◽  
Tomographic Angiography

Aims. To quantify the capillary density of the optic nerve head in healthy control eyes and different stages of diabetic retinopathy (DR) eyes and identify the parameters to detect eyes with or without DR using optical coherence tomographic angiography (OCTA). Methods. In this cross-sectional study, 211 eyes of 121 participants with type 2 diabetes with different stages of DR or without DR and 73 eyes of 38 healthy age-matched controls were imaged by OCTA. Radial peripapillary capillary (RPC) plexus density and retinal nerve fiber layer (RNFL) thickness were examined. The mixed model binary logistic regression model was used to identify the parameters to detect eyes with or without DR. The area under the receiver operating characteristic (ROC) curve was calculated. Results. RPC density decreased significantly in diabetic patients without DR compared with the healthy controls, and it was negatively correlated with the severity of DR (P<0.01). RPC density was a significant parameter to distinguish diabetic eyes with or without DR (P<0.01). The area under the ROC curve was 0.743. Conclusions. Quantification of RPC density by OCTA provides evidence of microvascular changes in the optic nerve in diabetic patients. RPC density can serve as a possible biomarker in detecting eyes with DR. Larger cohort studies need to support this statement.

Synchronous evaluation of early neurovascular changes in macula and optic nerve head in early diabetic retinopathy using combined optical coherence tomography angiography parameters

2019 ◽  
Author(s):  
Xin Wen ◽  
Zijing Li ◽  
Jiaqi Liang ◽  
Jianhui Xiao ◽  
Yichi Zhang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Optical Coherence Tomography Angiography ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Type 2 Diabetic Patients

Abstract Background This study aim to evaluate neurovascular changes in both macula and optic nerve head (ONH) in early stages of diabetic retinopathy (DR) using combined quantitative optical coherence tomography angiography (OCTA) parameters.Methods We studied 194 right eyes from 64 type 2 diabetic patients without DR (DM), 64 diabetic patients with nonproliferative diabetic retinopathy (NPDR) and 64 age-matched healthy controls. OCTA parameters were analyzed using binary logistic regression models and receiver operating characteristic (ROC) curves.Results There was significant reduction of vessel density (VD) in both macula and ONH comparing DM patients with and without NPDR to controls. The area under the curve (AUC) of the ROC curve for NPDR versus control was 0.963 ( p <0.001), with sensitivity of 93.8% and specificity of 90.6%. The ROC curves for NPDR patients versus NoDR patients (including DM and control groups) exhibited an AUC of 0.923 ( p <0.001), with sensitivity of 90.6% and specificity of 82.8%. The thickness of the retinal nerve fiber layer (RNFL) in both macula and ONH was not significantly different among these three groups.Conclusions VD in both macula and ONH was simultaneously decreased prior to RNFL thinning in DM patients through the course proceeding from preclinical DR to NPDR. Combined analysis of macula and ONH parameters was an comprehensive and accurate OCTA metric to distinguish NPDR patients from healthy controls and DM patients without DR.

Precision of Optic Nerve Head and Retinal Nerve Fiber Layer Parameter Measurements by Spectral-domain Optical Coherence Tomography

2018 ◽  
Vol 27 (5) ◽  
pp. 407-414 ◽  
Author(s):  
Laura M. Schrems-Hoesl ◽  
Wolfgang A. Schrems ◽  
Robert Laemmer ◽  
Friedrich E. Kruse ◽  
Christian Y. Mardin
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Optic Nerve Head ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Layer Parameter

scholarly journals Vascular density of optic nerve head in diabetic retinopathy using optical coherence tomography angiography

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Fariba Ghassemi ◽  
Sahar Berijani ◽  
Ramak Roohipoor ◽  
Masoumeh Mohebbi ◽  
Ameneh Babeli ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Optical Coherence Tomography Angiography ◽  
Blood Perfusion ◽  
Cross Sectional Study ◽  
Vascular Density ◽  
Optical Coherence ◽  
Cross Sectional

Abstract Purpose To measure optic nerve head (ONH) blood perfusion using optical coherence tomography angiography (OCTA) at various stages of diabetic retinopathy (DR). Methods One hundred seventy six eyes of 94 patients included in this retrospective single-centre cross-sectional study. The subjects were studied in normal, no diabetic retinopathy (NDR), non-proliferative diabetic retinopathy (NPDR) and proliferative retinopathy (PDR) groups. The eyes were subjected to AngioDisc ONH imaging using OCTA for papillary (Disc) and peripapillary (RPC) vascular density (VD) evaluation. Results The mean age of the participants was 56.08 ± 8.87 years and 34 (36.2 percent) were male. With increased DR severity, a statistically significant decrease in peripapillary VD was found. The study showed that only VD of the whole RPC (W-RPC) could be a valid biomarker in the staging assessment. VD of RPC, in all subsections, was considerably different from normal cases in the PDR group. Visual acuity was correlated with whole image ONH VD. The duration of DM, FBS, hyperlipidemia and DME had no effect on the ONH perfusion. Conclusions The study showed that only the W-RPC VD could be a reasonable marker in the staging assessment. VDs assessed by OCTA can be useful for assessing and tracking early ONH changes in DR patients.

A Study of Retinal Nerve Fiber Layer Thickness by using Spectral Domain Optical Coherence Tomography in Older Adults with Diabetes Mellitus

2019 ◽  
Vol 15 (1) ◽  
pp. 17-21
Author(s):  
Devendra Sharma ◽  
Arvind Chauhan ◽  
Avisha Mathur
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Diabetic Patients ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Rnfl Thickness

Introduction: Peripapillary retinal nerve fiber layer (RNFL) thinning occurs in the diabetic patients earlier than the detectable diabetic retinopathy. We conducted this study to evaluate the RNFL thickness and macular thickness in elderly diabetic patients using optical coherence tomography in comparison to healthy controls. Material and methods: One fifty study participants were divided in 3 groups (50 each): normal subjects, patients with diabetes with no detectable diabetic retinopathy (NDR) and patients with diabetic retinopathy (DR) of differing severity. The RNFL thickness and macular thickness was measured using spectral-domain optical coherence tomography (SD OCT). Results: The RNFL thickness around the optic disc differed significantly among all the 3 groups and tended to become thinner as the patient develops DR in elderly subjects. The mean, superior-temporal and upper nasal peripapillary RNFL thickness differed among all the 3 groups. We observed that, mean superior, temporal, inferior and nasal RNFL tended to be thinner as the patient develops DR. Conclusion: The RNFL thickness, macular thickness and ganglion cell complex thinning differed significantly between the healthy group and diabetic group without clinical DR. The RNFL thinning (measured by Spectral-domain OCT) is an early neurodegenerative ocular change in diabetic patients even before onset of diabetic retinopathy.

scholarly journals Optical Coherence Tomography in Patients with Chiari I Malformation

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Michele Figus ◽  
Chiara Posarelli ◽  
Francesco Nasini ◽  
Paolo Perrini ◽  
Mario Miccoli ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Chiari I Malformation ◽  
Nerve Fibers ◽  
Healthy Controls ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Chiari I

Background/Aims. To evaluate optic nerve head with spectral domain optical coherence tomography (OCT) in patients with Chiari I malformation (CMI) compared to healthy controls.Methods. Cross-sectional study. OCT of the optic nerve head of 22 patients with CMI and 22 healthy controls was quantitatively analyzed. The healthy controls were matched for age and sex with the study population. Mean retinal nerve fiber layer (RNFL) thickness was calculated for both eyes; the mean thickness value was also registered for each quadrant and for each subfield of the four quadrants.Results. CMI patients showed a reduction of the RNFL thickness in both eyes. This reduction was more statistically significant (P<0.05) for the inferior quadrant in the right eye and in each quadrant than nasal one in the left eye.Conclusion. A distress of the retinal nerve fibers could explain the observed reduction of the RNFL thickness in patients with CMI; in our series the reduction of the RNFL thickness seems lower when CMI is associated with syringomyelia.

scholarly journals Optical coherence tomography of the retina, nerve fiber layer, and optic nerve head in dogs with glaucoma

2019 ◽  
Vol 23 (1) ◽  
pp. 97-112 ◽  
Author(s):  
Kathleen L. Graham ◽  
Christina I. McCowan ◽  
Kelly Caruso ◽  
F. Mark Billson ◽  
Cameron J. G. Whittaker ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Nerve Fiber ◽  
Optic Nerve Head ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer
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