scholarly journals Deep Gray Matter Iron Content in Neuromyelitis Optica and Multiple Sclerosis

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Adam Pudlac ◽  
Andrea Burgetova ◽  
Petr Dusek ◽  
Petra Nytrova ◽  
Manuela Vaneckova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Magnetic Susceptibility ◽  
Substantia Nigra ◽  
Neuromyelitis Optica ◽  
Gray Matter ◽  
Iron Homeostasis ◽  
Iron Concentration ◽  
Clinical Severity ◽  
Healthy Controls ◽  
Deep Gray Matter

Background. Neuromyelitis optica (NMO) and multiple sclerosis (MS) are often presenting with overlapping symptoms. The aim of this study was to determine whether and how NMO and MS differ regarding cerebral iron deposits in deep gray matter (DGM) and the correlation between iron deposition and clinical severity as well as to regional atrophy of the DGM. Methods. We analyzed 20 patients with NMO, 40 patients with a relapsing-remitting (RR) form of MS, and 20 healthy controls with 1.5T MRI. Quantitative susceptibility mapping (QSM) was performed to estimate iron concentration in the DGM. Results. Patients with NMO have higher magnetic susceptibility values in the substantia nigra compared to healthy controls. RRMS patients have lower magnetic susceptibility values in the thalamus compared to healthy controls and NMO patients. Atrophy of the thalamus, pulvinar, and putamen is significant both in RRMS compared to NMO patients and healthy controls. A correlation was found between the disability score (EDSS) and magnetic susceptibility in the putamen in RRMS. Conclusions. This study confirms that a disturbed cerebral iron homeostasis in patients with NMO occurs in different structures than in patients with RRMS. Increased magnetic susceptibility in substantia nigra in NMO and decreased magnetic susceptibility within the thalamus in RRMS were the only significant differences in the study sample. We could confirm that iron concentration in the thalami is decreased in RRMS compared to that in the HC group. Positive association was found between putaminal iron and EDSS in RRMS.

Iron content of the pulvinar nucleus of the thalamus is increased in adolescent multiple sclerosis

2012 ◽  
Vol 19 (5) ◽  
pp. 567-576 ◽  
Author(s):  
Jesper Hagemeier ◽  
E Ann Yeh ◽  
Mari Heininen Brown ◽  
Niels Bergsland ◽  
Michael G Dwyer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Iron Content ◽  
Neurological Disorders ◽  
Normal Phase ◽  
Susceptibility Weighted Imaging ◽  
Healthy Controls ◽  
Volume Measurements ◽  
Deep Gray Matter ◽  
Age And Sex

Objective: The objective of this paper is to assess abnormal phase values, indicative of increased iron content, using susceptibility-weighted imaging (SWI)-filtered phase of the subcortical deep gray matter (SDGM) in adolescent multiple sclerosis (MS) and other neurological disorders (OND) patients, and in healthy controls (HC). Methods: Twenty adolescent MS and eight adolescent OND patients and 21 age- and sex-matched HC were scanned on a 3T GE scanner. Mean phase of abnormal phase tissue (MP-APT), MP-APT volume, normal phase tissue volume (NPTV) and normalized volume measurements were obtained for total SDGM, as well as specific structures separately. Results: Significantly increased MP-APT (28.2%, p<.001) and MP-APT volume (82.7%, p<.001), and decreased NPTV (−23.3%, p<.001) and normalized volume (−15.5%, p<.001) in the pulvinar nucleus of the thalamus was found in MS patients compared to HC. MP-APT in MS patients was also increased in total SDGM ( p=.012) and thalamus ( p=.044). Compared to OND patients, MS patients had increased MP-APT volume in the pulvinar nucleus of the thalamus ( p=.044) and caudate ( p=.045). Increased MP-APT of the SDGM structures were associated with increased T2 and T1 lesion burden and brain atrophy in MS patients. Conclusion: Adolescent MS patients showed increased iron content in the SDGM compared to OND patients and HC.

Serum iron concentration is associated with subcortical deep gray matter iron levels in multiple sclerosis patients

Neuroreport ◽  
2017 ◽  
Vol 28 (11) ◽  
pp. 645-648 ◽  
Author(s):  
Niels Bergsland ◽  
Simone Agostini ◽  
Maria M. Laganà ◽  
Roberta Mancuso ◽  
Laura Mendozzi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Serum Iron ◽  
Iron Concentration ◽  
Serum Iron Concentration ◽  
Deep Gray Matter ◽  
Multiple Sclerosis Patients

scholarly journals Assessing Abnormal Iron Content in the Deep Gray Matter of Patients with Multiple Sclerosis versus Healthy Controls

2011 ◽  
Vol 33 (2) ◽  
pp. 252-258 ◽  
Author(s):  
C.A. Habib ◽  
M. Liu ◽  
N. Bawany ◽  
J. Garbern ◽  
I. Krumbein ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Iron Content ◽  
Healthy Controls ◽  
Deep Gray Matter

scholarly journals Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain

2018 ◽  
Vol 18 ◽  
pp. 1007-1016 ◽  
Author(s):  
Jesper Hagemeier ◽  
Robert Zivadinov ◽  
Michael G. Dwyer ◽  
Paul Polak ◽  
Niels Bergsland ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Magnetic Susceptibility ◽  
Gray Matter ◽  
Control Brain ◽  
Healthy Control ◽  
Deep Gray Matter

scholarly journals Diffusion tensor imaging of the normal-appearing deep gray matter in primary and secondary progressive multiple sclerosis

2019 ◽  
Vol 61 (1) ◽  
pp. 85-92
Author(s):  
Ramona Woitek ◽  
Fritz Leutmezer ◽  
Assunta Dal-Bianco ◽  
Julia Furtner ◽  
Gregor Kasprian ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Diffusion Tensor Imaging ◽  
Substantia Nigra ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Progressive Multiple Sclerosis ◽  
Secondary Progressive Multiple Sclerosis ◽  
Secondary Progressive ◽  
Deep Gray Matter

Background Despite strongly overlapping patterns of clinical and histopathologic findings in primary and secondary progressive multiple sclerosis, differences concerning motor symptoms, central nervous system inflammation, atrophy, and demyelination that cannot be accounted for by lesion load alone remain to be elucidated. Purpose To evaluate the normal-appearing deep gray matter in patients with primary and secondary progressive multiple sclerosis, diffusion tensor imaging was used in this study. Material and Methods In 14 multiple sclerosis patients with primary and secondary progressive multiple sclerosis, axial echo-planar single-shot diffusion tensor imaging sequences with 32 diffusion-encoding directions and axial FLAIR sequences were acquired on a 3T system using an eight-channel SENSE head coil. FLAIR hyperintense multiple sclerosis lesions were outlined semi-automatically and normal-appearing deep gray matter was outlined manually (caudate nucleus, globus pallidus, putamen, thalamus, substantia nigra, and red nucleus). Fractional anisotropy and mean diffusivity values within the normal-appearing deep gray matter for the two groups were compared. Results Interhemispheric differences in mean diffusivity values (but not in fractional anisotropy), were significantly higher in primary progressive multiple sclerosis than in secondary progressive multiple sclerosis for the substantia nigra ( P = 0.04) and the putamen ( P = 0.021). Volumes, mean diffusivity, or fractional anisotropy of the remaining normal-appearing deep gray matter did not differ significantly. Conclusion This study showed a higher interhemispheric difference in the mean diffusivity in the substantia nigra and putamen in patients with primary progressive multiple sclerosis than in those with secondary progressive multiple sclerosis. These changes may represent edema, as well as axonal and myelin loss that can affect the normal-appearing deep gray matter of the two hemispheres differently and may point to differences in the laterality of motor symptoms.

Comparison of deep gray matter lesions on magnetic resonance imaging among adults with acute disseminated encephalomyelitis, multiple sclerosis, and neuromyelitis optica

2013 ◽  
Vol 20 (4) ◽  
pp. 418-423 ◽  
Author(s):  
Lei Zhang ◽  
Aimin Wu ◽  
Bingjun Zhang ◽  
Suqin Chen ◽  
Xuejiao Men ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Neuromyelitis Optica ◽  
Gray Matter ◽  
Acute Disseminated Encephalomyelitis ◽  
Morphological Features ◽  
Adult Patients ◽  
Resonance Imaging ◽  
Deep Gray Matter

Background: Deep gray matter lesions have been reported in patients with acute disseminated encephalomyelitis (ADEM), multiple sclerosis (MS), and neuromyelitis optica (NMO). Objectives: The purpose of this study was to compare the features of deep gray matter lesions on magnetic resonance imaging (MRI) among adult patients with ADEM, MS, and NMO. Methods: Ninety-five adult patients with ADEM ( n=12), MS ( n=60), and NMO ( n=23) who had deep gray matter lesions on MRI were enrolled. Morphological features of deep gray matter lesions among these patients were assessed. Results: Putamen involvement was more common in patients with ADEM than in patients with MS and NMO. Differing from children, thalamus involvement might not be helpful in differentiating ADEM from MS in adults. Hypothalamus involvement was more common in patients with NMO than in patients with ADEM and MS. More importantly, bilateral hypothalamus involvement was more helpful in differentiating NMO from MS. The diameter of the thalamus lesions in patients with ADEM was larger than that in patients with NMO. Conclusions: Morphological features of deep gray matter lesions vary among adult patients with ADEM, MS, and NMO, and may be helpful in distinguishing these diseases.

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