The Late-Gestational Triglyceride to High-Density Lipoprotein Cholesterol Ratio Is Associated with Neonatal Macrosomia in Women without Diabetes Mellitus

Objective. To investigate the associations between late-gestational dyslipidemia, expressed as the ratio between triglycerides (TGs) and high-density lipoprotein cholesterol (HDL), and the risk of macrosomia among nondiabetic pregnant women. Methods. In this case-control study, 171 pregnant women who delivered macrosomia newborns were recruited from a total of 1856 nondiabetic pregnant women who delivered a singleton, nonanomalous newborn. A total of 684 normal controls were one-to-four matched by age. Logistic regression analysis was used to analyze the association between the TG/HDL ratio and the neonatal body weight as well as the risk of macrosomia. Results. The maternal serum TG and TG/HDL levels were much higher in the macrosomia group, while the maternal serum HDL-C levels were much lower in the macrosomia group than those in the control group. However, the serum total cholesterol (TC) and LDL-C levels were not significantly different between the two groups. Furthermore, maternal TG/HDL levels were positively associated with neonatal body weight. The confounding factors including maternal age, maternal height, gestational age, maternal body mass index (BMI), FPG, SBP, and neonatal sex were adjusted. A positive association between TG/HDL and neonatal body weight was still found. Moreover, the prevalence of macrosomia increased markedly in a dose-dependent manner as with maternal TG/HDL levels increased. Conclusions. Maternal serum TG/HDL levels at late gestation are positively associated with neonatal body weight and the risk of macrosomia in women without DM. Maintaining maternal lipid levels in an appropriate range is important in the context of fetal overgrowth and primary prevention of macrosomia.

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Genetic Variation in Total Plasma and High Density Lipoprotein Cholesterol and Body Weight in Medium White Turkeys

Poultry Science ◽

10.3382/ps.0710807 ◽

1992 ◽

Vol 71 (5) ◽

pp. 807-812 ◽

Cited By ~ 1

Author(s):

EDWARD J. SMITH ◽

THOMAS F. SAVAGE

Keyword(s):

Body Weight ◽

Genetic Variation ◽

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Total Plasma

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A Biochemical Study Of High-Density Lipoprotein Cholesterol (Hdl-C) Changes In Middle Aged Common People With Different Lifestyle

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v16i2.25061 ◽

2017 ◽

Vol 16 (2) ◽

pp. 289-294

Author(s):

Suresh Kanna ◽

Premila Thamizhvanan ◽

Jaya Bharathi

Keyword(s):

Physical Activity ◽

Body Weight ◽

Young Adult ◽

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Lifestyle Factors ◽

High Density ◽

Lipoprotein Cholesterol

Background and rationale: HDL cholesterol is one of the 5 major groups of lipoproteins cholesterol, which enable lipids like cholesterol and TG to be transported within the water based blood stream. In healthy persons, about thirty percent of blood cholesterol is carried by HDL cholesterol. HDL-C is a potent predictor of coronary heart disease. Genetic as well as environmental factors including lifestyle factors play a role as determinants of its level in the blood. To examine the effects of certain lifestyle factors on serum level of high density lipoprotein cholesterol in young adult people HDL cholesterol seems to protect against CVD which increases the risk for heart disease.Subjects and methods: Three hundred and twenty five young adult subjects of both sexes aged 18-45 years asymptomatic for cardiovascular diseases were interviewed according to special questionnaire including information on lifestyle habits. Physical examination was done, height, body weight, and blood pressure measurements were performed. Blood analysis to determine the blood level of high density lipoprotein cholesterol was done after 12 hours fasting.Results and conclusion: Smoking and obesity were the most significant risk factors associated with a decreased level of high density lipoprotein cholesterol. The level of HDL-C was 50.5±11.5 mg/dl in smokers compared with 57.7±12.5 mg/dl in nonsmokers. Its level was 48.5 ±8.5 mg/dl in obese individuals compared to 57.5±11.7mg/dl in normal body weight subjects. Physical activity was not significantly associated with low level of HDL-C analysis, but it was found to be significantly associated with its level by the multiple regression analysis. High-density lipoprotein cholesterol level was a function of many factors, some of them were lifestyle related such as smoking, physical activity, and obesity. Therefore, efforts to encourage more physical activity, quitting smoking, consuming low fat diet, and keeping ideal body weight are recommended.Bangladesh Journal of Medical Science Vol.16(2) 2017 p.289-294

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Triglyceride to high density lipoprotein cholesterol ratio, total cholesterol to high density lipoprotein cholesterol ratio and low ankle brachial index in an elderly population

VASA ◽

10.1024/0301-1526/a000348 ◽

2014 ◽

Vol 43 (3) ◽

pp. 189-197 ◽

Cited By ~ 10

Author(s):

Yiqiang Zhan ◽

Jinming Yu ◽

Rongjing Ding ◽

Yihong Sun ◽

Dayi Hu

Keyword(s):

High Density Lipoprotein ◽

Total Cholesterol ◽

High Density Lipoprotein Cholesterol ◽

Ankle Brachial Index ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Lipid Lowering ◽

Cholesterol Ratio ◽

Potential Biomarker

Background: The associations of triglyceride (TG) to high-density lipoprotein cholesterol ratio (HDL‑C) and total cholesterol (TC) to HDL‑C ratio and low ankle brachial index (ABI) were seldom investigated. Patients and methods: A population based cross-sectional survey was conducted and 2982 participants 60 years and over were recruited. TG, TC, HDL‑C, and low-density lipoprotein cholesterol (LDL-C) were assessed in all participants. Low ABI was defined as ABI ≤ 0.9 in either leg. Multiple logistic regression models were applied to study the association between TG/HDL‑C ratio, TC/HDL‑C ratio and low ABI. Results: The TG/HDL‑C ratios for those with ABI > 0.9 and ABI ≤ 0.9 were 1.28 ± 1.20 and 1.48 ± 1.13 (P < 0.0001), while the TC/HDL‑C ratios were 3.96 ± 1.09 and 4.32 ± 1.15 (P < 0.0001), respectively. After adjusting for age, gender, body mass index, obesity, current drinking, physical activity, hypertension, diabetes, lipid-lowering drugs, and cardiovascular disease history, the odds ratios (ORs) with 95 % confidence intervals (CIs) of low ABI for TG/HDL‑C ratio and TC/HDL‑C ratio were 1.10 (0.96, 1.26) and 1.34 (1.14, 1.59) in non-smokers. When TC was further adjusted, the ORs (95 % CIs) were 1.40 (0.79, 2.52) and 1.53 (1.21, 1.93) for TG/HDL‑C ratio and TC/HDL‑C ratio, respectively. Non-linear relationships were detected between TG/HDL‑C ratio and TC/HDL‑C ratio and low ABI in both smokers and non-smokers. Conclusions: TC/HDL‑C ratio was significantly associated with low ABI in non-smokers and the association was independent of TC, TG, HDL‑C, and LDL-C. TC/HDL‑C might be considered as a potential biomarker for early peripheral arterial disease screening.

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