scholarly journals Gastrodia elata Blume (Tianma): Hope for Brain Aging and Dementia

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Klaus Heese
Keyword(s):  
Brain Aging ◽  
Complementary Therapy ◽  
Treatment Modalities ◽  
Efficacy And Safety ◽  
Gastrodia Elata ◽  
Herbal Preparations ◽  
Gastrodia Elata Blume ◽  
Novel Approach ◽  
Potential Efficacy ◽  
Physician Scientists

Since aging-related diseases, including dementia, represent major public health threats to our society, physician-scientists must develop innovative, interdisciplinary strategies to open new avenues for development of alternative therapies. One such novel approach may lie in traditional Chinese medicine (TCM). Gastrodia elata Blume (G. elata, tianma) is a TCM frequently used for treatment of cerebrocardiovascular diseases (CCVDs). Recent studies of G. elata-based treatment modalities, which have investigated its pharmacologically relevant activity, potential efficacy, and safety, have employed G. elata in well-characterized, aging-related disease models, with a focus on models of aging-related dementia, such as Alzheimer’s disease (AD). Here, I examine results from previous studies of G. elata, as well as related herbal preparations and pure natural products, as prophylaxis and remedies for aging-related CCVDs and dementia. Concluding, data suggest that tianma treatment may be used as a promising complementary therapy for AD.

Abstract T P48: Intravenous Thrombolysis Using Low-Dose Alteplase for Nonagenarians with Acute Ischemic Stroke: The SAMURAI rtPA Registry

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Mikito Hayakawa ◽  
Masatoshi Koga ◽  
Shoichiro Sato ◽  
Shoji Arihiro ◽  
Yoshiaki Shiokawa ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Low Dose ◽  
Intravenous Thrombolysis ◽  
Functional Independence ◽  
Efficacy And Safety ◽  
Multivariate Adjustment ◽  
Potential Efficacy ◽  
Symptomatic Intracranial Hemorrhage ◽  
Baseline Characteristics

Objective: Although intravenous thrombolysis (IVT) using alteplase for octogenarians with acute ischemic stroke becomes relatively familiar, it is unclear whether IVT for nonagenarians is a futile intervention. The purpose of this study is to clarify the efficacy and safety of IVT using low-dose alteplase (0.6 mg/kg) for nonagenarians compared with octogenarians. Methods: Stroke Acute Management with Urgent Risk-factor Assessment and Improvement (SAMURAI) rtPA registry retrospectively collected 600 consecutive acute stroke patients receiving IVT from 10 Japanese stroke centers between October 2005 and July 2008. We extracted all octogenarians (O group) and nonagenarians (N group) from the registry. We compared baseline characteristics, symptomatic intracranial hemorrhage (SICH), and 3-month outcomes between the groups. 3-month outcomes include; functional independence (FI) defined as a mRS score 0-2, good outcome (GO) as a mRS score 0-2 or same as the premorbid mRS, poor outcome (PO) defined as a mRS score 5-6, and death. Results: Twenty-five nonagenarians (mean age, 93 years) and 124 octogenarians (mean age, 84 years) were included. N group was more female-predominant (76% versus 56%, p=0.06) and premorbidly dependent (44% versus 14%, p<0.001) than O group. There were no significant differences of median baseline NIHSS score (16 versus 14, p=0.95) and Alberta Stroke Program Early CT Score (9 versus 9, p=0.36) between the groups. The rate of FI tended to be lower in N group than O group (16% versus 36%, p=0.06), otherwise, the differences of the rates of GO (28% versus 37%, p=0.39), PO (40% versus 36%, p=0.73), death (20% versus 11%, p=0.23) and SICH (0% versus 2.4%, p=1.00) were not significant between the groups. In comparison with O group, N group was not associated with 3-month clinical outcomes (FI; OR 0.61; 95% CI, 0.15-2.42, GO; 0.98; 0.31-3.07, PO; 0.63; 0.15-2.70, death; 3.18; 0.62-16.3) and SICH (0.68; 0.17-2.69) after multivariate adjustment. Conclusions: IVT using low-dose alteplase for N group resulted in less frequent achievement of FI mainly because of more premorbid dependency than O group, however, showed at least a similar safety and a potential efficacy.

Twenty years of progress in paediatric psychopharmacology: accomplishments and unmet needs

2018 ◽  
Vol 21 (4) ◽  
pp. e10-e10 ◽  
Author(s):  
Benedetto Vitiello ◽  
Chiara Davico
Keyword(s):  
Clinical Trials ◽  
Comparative Effectiveness ◽  
Child Psychopathology ◽  
Large Population ◽  
Occupational Status ◽  
Psychosocial Interventions ◽  
Treatment Modalities ◽  
Efficacy And Safety ◽  
Usual Practice ◽  
The Impact

The systematic assessment of the efficacy and safety of psychiatric medications in children and adolescents started about 20 years ago. Since then, a considerable number of randomised clinical trials have been conducted, including also a series of publicly funded comparative effectiveness studies to evaluate the therapeutic benefit of medications relative to psychosocial interventions, alone or combined with medications. On the whole, these studies have been informative of the paediatric pharmacokinetics, efficacy and safety of the most commonly used psychotropics. As a consequence, a number of meta-analyses have been conducted that have documented both the benefits and harms of the most common medication groups, such as stimulants, antidepressants and antipsychotics. Evidence-based practice guidelines have been produced, and clinicians can now better estimate the therapeutic value and the risk of treatment, at least at the group mean level. However, most clinical trials have been conducted in research settings, and this limits the generalisability of the results. There is a need for evaluating treatment effects under usual practice conditions, through practical trials. The ongoing debate about the proper role of pharmacotherapy in child mental health can be advanced by comparative effectiveness research to assess the benefit/risk ratio of pharmacotherapy vis-à-vis alternative treatment modalities. In addition, analyses of large population databases can better inform on the impact of early treatment on important distal outcomes, such as interpersonal functioning, social and occupational status, quality of life and risk for disability or mortality. Thus far, paediatric psychopharmacology has been mostly the application to children of medications that were serendipitously discovered and developed for adults. By focusing on the neurobiological mechanisms of child psychopathology, it may be possible to identify more precise pharmacological targets and arrive at a truly developmental psychopharmacology.

scholarly journals Gastrodia elata Blume protects against stress-induced gastric mucosal lesions in mice

2007 ◽  
Author(s):  
Sang-Mi An ◽  
Chul-Hong Park ◽  
Jin-Chul Heo ◽  
Ja-Young Park ◽  
Sang-Uk Woo ◽  
...  
Keyword(s):  
Gastrodia Elata ◽  
Gastric Mucosal Lesions ◽  
Gastrodia Elata Blume ◽  
Mucosal Lesions

Treatment of Striae Alba using Fractional Radiofrequency with and without Lyophilized Growth Factors

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Marwa M. A Abdallah ◽  
Ahmed Abd Elfattah Afify ◽  
Nuha Hussain Ali Al-Rubaiay
Keyword(s):  
Patient Satisfaction ◽  
Growth Factors ◽  
Comparative Study ◽  
Collagen Synthesis ◽  
The Other ◽  
Treatment Modalities ◽  
Efficacy And Safety ◽  
Patients Satisfaction ◽  
Satisfaction Rate

Abstract Background Various treatment modalities have been applied to treat striae alba with low satisfaction rate. Fractional Microneedling radiofrequency provides deep dermal coagulation, thereby inducing collagen synthesis and tissue tightening. The addition of platelet lyophilized growth factors may add to the effect of fractional Microneedling radiofrequency. Objectives To evaluate and compare the efficacy and safety of fractional Microneedling radiofrequency alone or combined with lyophilized growth factors in the treatment of striae alba. Methods In this left-right comparative study, 25 patients suffering from striae alba on the abdomen received sessions of fractional microneedling radiofrequency with lyophilized growth factors on one side and with saline (as placebo) on the other side at 4 weeks interval. Patients‘ satisfaction was evaluated at the end of study using a questionnaire (Patients were asked the following questions: Are you satisfied with this treatment (completely satisfied, satisfied, partially satisfied, or not satisfied)?. Results There was a significant improvement in striae alba after treatment in both the lyophilized growth factors (p = &lt;0.0001) and placebo sides (p = &lt;0.0001), the lyophilized growth factors being superior (p = 0.002). Patient satisfaction was more on the LGF side (p = 0.034),where 6 versus 3 patients were completely satisfied. Erythema and hyperpigmentation were less on the lyophilized growth factors side. Conclusion The combination of fractional microneedling radiofrequency and lyophilized growth factors improves striae alba outcome.

Amycolatopsis alkalitolerans sp. nov., isolated from Gastrodia elata Blume

2019 ◽  
Vol 73 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Manik Prabhu Narsing Rao ◽  
Yan-Qiong Li ◽  
Hui Zhang ◽  
Zhou-Yan Dong ◽  
Awalagaway Dhulappa ◽  
...  
Keyword(s):  
Gastrodia Elata ◽  
Gastrodia Elata Blume
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