scholarly journals Acute Liver Rejection in a Multiple Myeloma Patient Treated with Lenalidomide

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Iuliana Vaxman ◽  
John Eaton ◽  
Hee Eun Lee ◽  
Morie A. Gertz
Keyword(s):  
Multiple Myeloma ◽  
Mycophenolate Mofetil ◽  
Case Report ◽  
Allograft Rejection ◽  
Acute Cellular Rejection ◽  
Primary Biliary Cholangitis ◽  
Myeloma Patient ◽  
Multiple Myeloma Patient ◽  
First Case ◽  
Cellular Rejection

Herein we present a patient that underwent a liver transplant due to primary biliary cholangitis (PBC) and after 9 years developed multiple myeloma. Following the cessation of mycophenolate mofetil and 2 weeks after lenalidomide treatment was started, the patient experienced acute cellular rejection. The patient recovered after treatment with corticosteroids, resumption of mycophenolate mofetil, and cessation of lenalidomide. Lenalidomide-associated allograft rejection has been reported in other organs. However, this is the first case report of liver rejection induced by lenalidomide.

scholarly journals Brain abscesses caused by Nocardia paucivorans in a multiple myeloma patient treated with lenalidomide and dexamethasone: a case report and review of literature.

2014 ◽  
Vol 7 ◽  
pp. e2015011 ◽  
Author(s):  
Jacopo Monticelli ◽  
Roberto Luzzati ◽  
Cristina Maurel ◽  
Chiara Rosin ◽  
Romina Valentinotti ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Adverse Effects ◽  
Infectious Complication ◽  
Chemotherapy Regimen ◽  
Review Of Literature ◽  
Myeloma Patient ◽  
Multiple Myeloma Patient ◽  
First Case ◽  
Brain Abscesses

We report the first case of multiple brain abscesses caused by Nocardia paucivorans in a patient suffering from multiple myeloma on treatment with lenalidomide and dexamethasone. Nocardia  paucivorans is a recently described species of the genus Nocardia, which is supposed to have a heightened neurotropism in cases of disseminated infection. Although nocardiosis itself is an uncommon infectious complication in multiple myeloma so far, nocardial brain abscess should be added to the spectrum of adverse effects due to this novel chemotherapy regimen.

scholarly journals Abnormal radiological features in a multiple myeloma patient: a case report and radiological review of myelomas

2011 ◽  
Vol 40 (8) ◽  
pp. 513-518 ◽  
Author(s):  
S Ghosh ◽  
P Wadhwa ◽  
A Kumar ◽  
KM Pai ◽  
S Seshadri ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Myeloma Patient ◽  
Multiple Myeloma Patient ◽  
Radiological Features

scholarly journals Case Report of a Rare Incidence of IgH Amplification Leading to Acute Kidney Injury in a Multiple Myeloma Patient

2021 ◽  
pp. 274-278
Author(s):  
Sowmya Thanikachalam ◽  
Vijay Kumar Srinivasalu ◽  
K.S. Nataraj ◽  
Sharat Damodar ◽  
Manjula Das
Keyword(s):  
Multiple Myeloma ◽  
Acute Kidney Injury ◽  
Case Report ◽  
Heavy Chain ◽  
Kidney Injury ◽  
Bone Marrow Aspiration ◽  
Structural Abnormality ◽  
Cell Transplant ◽  
Multiple Myeloma Patient ◽  
First Case

We present a case report of a 62-year-old male, treated for kappa light chain multiple myeloma with chemotherapy followed by autologous stem cell transplant (ASCT) in 2014. He has been in complete remission for 4 years. In 2018, he was evaluated for hypercreatinemia and acute kidney injury(AKI) with a suspicion of disease relapse; he underwent evaluation with bone marrow aspiration cytology which showed no evidence of relapse. However, careful cytogenetic analyses showed IgH amplification (14q32) which probably was the cause for AKI in the absence of any structural abnormality in the kidney. Heavy chain deposition leads to AKI in multiple myeloma, and its association with IgH amplification leading to AKI is reported here. Though heavy chain deposition leading to AKI is common, IgH amplification at chromosome level is the first case observed.

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