scholarly journals Expression of MicroRNAs in Periodontal Disease: A Systematic Review

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
María Verónica Cuevas-González ◽  
Fernando Suaste-Olmos ◽  
Alma Graciela García-Calderón ◽  
Karla Lizette Tovar-Carrillo ◽  
León Francisco Espinosa-Cristóbal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Soft Tissues ◽  
Regulation Of Gene Expression ◽  
Gingival Tissue ◽  
Main Technique ◽  
Size Type ◽  
Gingival Fluid

Introduction. Periodontal disease (PD) is a chronic inflammation of the soft tissues that support the structure of the tooth, and miRNAs are highly dynamic molecules that participate in the regulation of gene expression interfering with multiple genetic targets. The dysregulation of the expression of miRNAs has been associated with different types of pathologies; therefore, they are excellent molecules to be studied as biomarkers. Material and Methods. A search was made in the electronic databases of PubMed, Scopus, and Science Direct. The following key words were used: “microRNAs,” “miRNAs,” “periodontal disease,” “periodontitis,” and “biomarker”; employee independent search strategies with the Boolean operators “OR” and “AND”; a further search of the references of the selected studies was performed to detect potential studies that met the selection criteria. The data recollected from each article were author, country, year of publication, sample size, type of sample used to identify miRNAs, methodology used to identify miRNAs, type of periodontal disease, and miRNAs identified. Results. Of the 13 selected studies, 6 used gingival tissue as a sample for the identification of miRNAs, 3 used gingival fluid, 2 used saliva, 1 used serum, and another used periodontal tissue. Chronic periodontitis was the most studied periodontal disease in 9 of the 13 selected articles; 7 used microarrays as the main technique for the identification of miRNAs. qRT-PCR was the assay choice to validate the identified miRNAs. Conclusion. The main type of periodontal disease on which most studies are focused is chronic periodontitis, with the main miRNAs being hsa-miR-146a, hsa-miR-146b, hsa-miR-155, and hsa-miR-200. This systematic review is one of the first to carry out an analysis of the current role of miRNAs in PD as biomarkers.

scholarly journals Role of Lipids in the Onset, Progression and Treatment of Periodontal Disease. A Systematic Review of Studies in Humans

2016 ◽  
Vol 17 (8) ◽  
pp. 1202 ◽  
Author(s):  
Alfonso Varela-López ◽  
Francesca Giampieri ◽  
Pedro Bullón ◽  
Maurizio Battino ◽  
José Quiles
Keyword(s):  
Systematic Review ◽  
Periodontal Disease

scholarly journals The role of probiotic bacteria in managing periodontal disease: a systematic review

2016 ◽  
Vol 14 (7) ◽  
pp. 643-655 ◽  
Author(s):  
Victor Haruo Matsubara ◽  
H. M. H. N. Bandara ◽  
Karin Hitomi Ishikawa ◽  
Marcia Pinto Alves Mayer ◽  
Lakshman Perera Samaranayake
Keyword(s):  
Systematic Review ◽  
Periodontal Disease ◽  
Probiotic Bacteria

scholarly journals The Role of DNA Methylation and Histone Modification in Periodontal Disease: A Systematic Review

2020 ◽  
Vol 21 (17) ◽  
pp. 6217
Author(s):  
Ismael Khouly ◽  
Rosalie Salus Braun ◽  
Michelle Ordway ◽  
Bradley Eric Aouizerat ◽  
Iya Ghassib ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dna Methylation ◽  
Periodontal Disease ◽  
Histone Modification ◽  
Histone Modifications ◽  
Disease Risk ◽  
Periodontal Diseases ◽  
Epigenetic Changes ◽  
Human Adults

Despite a number of reports in the literature on the role of epigenetic mechanisms in periodontal disease, a thorough assessment of the published studies is warranted to better comprehend the evidence on the relationship between epigenetic changes and periodontal disease and its treatment. Therefore, the aim of this systematic review is to identify and synthesize the evidence for an association between DNA methylation/histone modification and periodontal disease and its treatment in human adults. A systematic search was independently conducted to identify articles meeting the inclusion criteria. DNA methylation and histone modifications associated with periodontal diseases, gene expression, epigenetic changes after periodontal therapy, and the association between epigenetics and clinical parameters were evaluated. Sixteen studies were identified. All included studies examined DNA modifications in relation to periodontitis, and none of the studies examined histone modifications. Substantial variation regarding the reporting of sample sizes and patient characteristics, statistical analyses, and methodology, was found. There was some evidence, albeit inconsistent, for an association between DNA methylation and periodontal disease. IL6, IL6R, IFNG, PTGS2, SOCS1, and TNF were identified as candidate genes that have been assessed for DNA methylation in periodontitis. While several included studies found associations between methylation levels and periodontal disease risk, there is insufficient evidence to support or refute an association between DNA methylation and periodontal disease/therapy in human adults. Further research must be conducted to identify reproducible epigenetic markers and determine the extent to which DNA methylation can be applied as a clinical biomarker.

ELISA Evaluation of RANKL Levels in Gingival Fluid in Patients with Periodontitis and Occlusal Trauma

2018 ◽  
Vol 69 (6) ◽  
pp. 1578-1580
Author(s):  
Cosmin Gabriel Popa ◽  
Ionut Luchian ◽  
Nicoleta Ioanid ◽  
Ancuta Goriuc ◽  
Ioana Martu ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Molecular Mechanisms ◽  
Study Group ◽  
Trauma Patients ◽  
Tissue Destruction ◽  
Crevicular Fluid ◽  
Gingival Fluid ◽  
Severe Tissue

The aim of this study was to evaluate the differences in RANKL levels in crevicular fluid (GCF) in patients with chronic periodontitis, with or without chronic occlusal trauma. The study group consisted of 40 patients from whom 72 samples of crevicular fluid were collected. RANKL levels were analyzed by ELISA. We noticed significantly higher differences in RANKL levels for the study group (occlusive trauma patients) than for systemic healthy patients (p = 8.008). Research has shown that secondary occlusal trauma associated with periodontal disease is characterized by significantly higher RANKL levels in patients with chronic occlusal trauma. This partially clarifies the molecular mechanisms that underlie more severe tissue destruction in patients with occlusal trauma.

scholarly journals 4155 THE ROLE OF PERIODONTAL DISEASE IN CORONARY ARTERY DISEASE IN A HISPANIC POPULATION

2020 ◽  
Vol 4 (s1) ◽  
pp. 39-40
Author(s):  
Pablo I Altieri ◽  
Kiara Didriksen ◽  
Pablo Altieri ◽  
Hector L. Banchs ◽  
Nelson Escobales
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Periodontal Disease ◽  
Puerto Rican ◽  
Inflammatory Process ◽  
Systemic Disease ◽  
Gingival Tissue ◽  
Omega 3 ◽  
Artery Disease

OBJECTIVES/GOALS: The purpose of this report is to describe the role of Periodontal Disease (PD) in Coronary Artery Disease (CAD) in a Hispanic country. METHODS/STUDY POPULATION: Literature and Puerto Rican experience was reviewed and will be discussed. RESULTS/ANTICIPATED RESULTS: PD produces inflammatory disease by bacterial infection in the gingiva. This factor PD activates an inflammatory process affecting the CAD cascade inducing myocites, endothelial cells activation and cytokines. The incidence of gingival disease in the Puerto Rican population (P) is around 50%; of this group 80% will develop periodontal disease. Including this factor and diabetes mellitus Type 2, still the incidence of CAD is 20-30% less than the U.S.A. DISCUSSION/SIGNIFICANCE OF IMPACT : CAD is a systemic disease related to genetic factors and inflammation. PD is related to an inflammatory process, which will activate the CAD process, producing tissue infarcts. The daily use of resolving or liquid Omega 3 in the gingival tissue is useful in the prevention of gingival and periodontal disease. CONFLICT OF INTEREST DESCRIPTION: All authors have no relationship with any industry or financial associations in connection with the submitted abstract.

scholarly journals Role of melatonin in periodontal disease - A systematic review

2020 ◽  
Vol 31 (4) ◽  
pp. 593
Author(s):  
SSwarna Meenakshi ◽  
Sankari Malaiappan
Keyword(s):  
Systematic Review ◽  
Periodontal Disease

scholarly journals Brain-Derived Neurotrophic Factor in Chronic Periodontitis

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Jôice Dias Corrêa ◽  
Daniele Sirineu Pereira ◽  
Mila Fernandes Moreira Madeira ◽  
Celso Martins Queiroz-Junior ◽  
Danielle Glória Souza ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Neurotrophic Factor ◽  
Dental Pulp ◽  
Periodontal Regeneration ◽  
Disease Process ◽  
Microscopic Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Periodontal Tissues

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family. Outside the nervous system, BDNF has been shown to be expressed in various nonneural tissues, such as periodontal ligament, dental pulp, and odontoblasts. Although a role for BDNF in periodontal regeneration has been suggested, a function for BDNF in periodontal disease has not yet been studied. The aim of this study was to analyze the BDNF levels in periodontal tissues of patients with chronic periodontitis (CP) and periodontally healthy controls (HC). All subjects were genotyped for the rs4923463 and rs6265 BDNF polymorphisms. Periodontal tissues were collected for ELISA, myeloperoxidase (MPO), and microscopic analysis from 28 CP patients and 29 HC subjects. BDNF levels were increased in CP patients compared to HC subjects. A negative correlation was observed when analyzing concentration of BDNF and IL-10 in inflamed periodontium. No differences in frequencies of BDNF genotypes between CP and HC subjects were observed. However, BDNF genotype GG was associated with increased levels of BDNF, TNF-α, and CXCL10 in CP patients. In conclusion, BDNF seems to be associated with periodontal disease process, but the specific role of BDNF still needs to be clarified.

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