scholarly journals The Role of DNA Methylation and Histone Modification in Periodontal Disease: A Systematic Review

2020 ◽  
Vol 21 (17) ◽  
pp. 6217
Author(s):  
Ismael Khouly ◽  
Rosalie Salus Braun ◽  
Michelle Ordway ◽  
Bradley Eric Aouizerat ◽  
Iya Ghassib ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dna Methylation ◽  
Periodontal Disease ◽  
Histone Modification ◽  
Histone Modifications ◽  
Disease Risk ◽  
Periodontal Diseases ◽  
Epigenetic Changes ◽  
Human Adults

Despite a number of reports in the literature on the role of epigenetic mechanisms in periodontal disease, a thorough assessment of the published studies is warranted to better comprehend the evidence on the relationship between epigenetic changes and periodontal disease and its treatment. Therefore, the aim of this systematic review is to identify and synthesize the evidence for an association between DNA methylation/histone modification and periodontal disease and its treatment in human adults. A systematic search was independently conducted to identify articles meeting the inclusion criteria. DNA methylation and histone modifications associated with periodontal diseases, gene expression, epigenetic changes after periodontal therapy, and the association between epigenetics and clinical parameters were evaluated. Sixteen studies were identified. All included studies examined DNA modifications in relation to periodontitis, and none of the studies examined histone modifications. Substantial variation regarding the reporting of sample sizes and patient characteristics, statistical analyses, and methodology, was found. There was some evidence, albeit inconsistent, for an association between DNA methylation and periodontal disease. IL6, IL6R, IFNG, PTGS2, SOCS1, and TNF were identified as candidate genes that have been assessed for DNA methylation in periodontitis. While several included studies found associations between methylation levels and periodontal disease risk, there is insufficient evidence to support or refute an association between DNA methylation and periodontal disease/therapy in human adults. Further research must be conducted to identify reproducible epigenetic markers and determine the extent to which DNA methylation can be applied as a clinical biomarker.

scholarly journals The role of DNA methylation and histone modifications in blood pressure: a systematic review

2019 ◽  
Vol 33 (10) ◽  
pp. 703-715 ◽  
Author(s):  
Valentina Gonzalez-Jaramillo ◽  
Eliana Portilla-Fernandez ◽  
Marija Glisic ◽  
Trudy Voortman ◽  
Wichor Bramer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Dna Methylation ◽  
Histone Modifications

scholarly journals Targeting Epigenetic Regulators for Endometrial Cancer Therapy: Its Molecular Biology and Potential Clinical Applications

2021 ◽  
Vol 22 (5) ◽  
pp. 2305
Author(s):  
Futaba Inoue ◽  
Kenbun Sone ◽  
Yusuke Toyohara ◽  
Yu Takahashi ◽  
Asako Kukita ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Endometrial Cancer ◽  
Histone Modification ◽  
Treatment Options ◽  
Diagnostic Tools ◽  
Epigenetic Changes ◽  
Non Coding Rna ◽  
Advanced Stages ◽  
Epigenetic Regulators

Endometrial cancer is one of the most frequently diagnosed gynecological malignancies worldwide. However, its prognosis in advanced stages is poor, and there are only few available treatment options when it recurs. Epigenetic changes in gene function, such as DNA methylation, histone modification, and non-coding RNA, have been studied for the last two decades. Epigenetic dysregulation is often reported in the development and progression of various cancers. Recently, epigenetic changes in endometrial cancer have also been discussed. In this review, we give the main points of the role of DNA methylation and histone modification in endometrial cancer, the diagnostic tools to determine these modifications, and inhibitors targeting epigenetic regulators that are currently in preclinical studies and clinical trials.

scholarly journals The Role of Epigenetics in Periodontal and Systemic Diseases and Smoking: A Systematic Review

2021 ◽  
Vol 11 (11) ◽  
pp. 5269
Author(s):  
Ismael Khouly ◽  
Rosalie Salus Braun ◽  
Michelle Ordway ◽  
Iya Ghassib ◽  
Lena Larsson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dna Methylation ◽  
Web Of Science ◽  
Periodontal Diseases ◽  
Smoking Habit ◽  
Patient Characteristics ◽  
Systemic Diseases ◽  
Inclusion Criteria ◽  
Search Terms

The aims of this systematic review were to identify and synthesize the evidence for an association in DNA methylation/histone modifications between periodontal diseases and systemic diseases/smoking. Electronic database searches using relevant search terms in PubMed, Embase, MEDLINE, CINAHL, Web of Science, Scopus, and SciELO, and manual searches, were independently conducted to identify articles meeting the inclusion criteria. Nine studies of 1482 participants were included. Periodontitis was compared to metabolic disorders, rheumatoid arthritis (RA), cancer, and smokers, as well as healthy controls. Substantial variation regarding the reporting of sample sizes and patient characteristics, statistical analyses, and methodology was found. IL6 and TNF were modified similarly in RA and periodontitis. While TIMP-3 and GSTP-1 were significantly lower in periodontitis patients and controls than in cancer, SOCS-1, RMI2, CDH1, and COX2 were modified similarly in both cancer and periodontitis. While TLR4 in and CXCL8 were affected in periodontitis independent of smoking habit, smoking might change the transcription and methylation states of ECM organization-related genes, which exacerbated the periodontal condition. There was some evidence, albeit inconsistent, for an association between DNA methylation and periodontal diseases and systemic diseases or smokers compared to healthy patients or non-smokers.

scholarly journals A review of epigenetic changes in asthma: methylation and acetylation

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Mojgan Sheikhpour ◽  
Mobina Maleki ◽  
Maryam Ebrahimi Vargoorani ◽  
Vahid Amiri
Keyword(s):  
Dna Methylation ◽  
Histone Modifications ◽  
Histone Methylation ◽  
Epigenetic Changes ◽  
External Effects ◽  
The Past ◽  
Immune Pathways ◽  
Shed Light ◽  
Histone Methylation And Acetylation

AbstractSeveral studies show that childhood and adulthood asthma and its symptoms can be modulated through epigenetic modifications. Epigenetic changes are inheritable modifications that can modify the gene expression without changing the DNA sequence. The most common epigenetic alternations consist of DNA methylation and histone modifications. How these changes lead to asthmatic phenotype or promote the asthma features, in particular by immune pathways regulation, is an understudied topic. Since external effects, like exposure to tobacco smoke, air pollution, and drugs, influence both asthma development and the epigenome, elucidating the role of epigenetic changes in asthma is of great importance. This review presents available evidence on the epigenetic process that drives asthma genes and pathways, with a particular focus on DNA methylation, histone methylation, and acetylation. We gathered and assessed studies conducted in this field over the past two decades. Our study examined asthma in different aspects and also shed light on the limitations and the important factors involved in the outcomes of the studies. To date, most of the studies in this area have been carried out on DNA methylation. Therefore, the need for diagnostic and therapeutic applications through this molecular process calls for more research on the histone modifications in this disease.

scholarly journals The Role of DNA Methylation and Histone Modifications in Neurodegenerative Diseases: A Systematic Review

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0167201 ◽  
Author(s):  
Ke-xin Wen ◽  
Jelena Miliç ◽  
Bassem El-Khodor ◽  
Klodian Dhana ◽  
Jana Nano ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dna Methylation ◽  
Neurodegenerative Diseases ◽  
Histone Modifications

scholarly journals Correction to: The role of DNA methylation and histone modifications in blood pressure: a systematic review

2019 ◽  
Vol 34 (2) ◽  
pp. 193-193 ◽  
Author(s):  
Valentina Gonzalez-Jaramillo ◽  
Eliana Portilla-Fernandez ◽  
Marija Glisic ◽  
Trudy Voortman ◽  
Wichor Bramer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Dna Methylation ◽  
Histone Modifications

Periodontopathogens: a new view. Systematic review. Part 2

2020 ◽  
Vol 20 (2) ◽  
pp. 160-167
Author(s):  
E. S. Slazhneva ◽  
E. A. Tikhomirova ◽  
V. G. Atrushkevich
Keyword(s):  
Systematic Review ◽  
Periodontal Disease ◽  
Pathogenic Bacteria ◽  
Periodontal Diseases ◽  
Oral Microbiome ◽  
Controlled Trials ◽  
New Paradigm ◽  
Microbial Composition ◽  
Randomized Controlled ◽  
The Past

Relevance. The modern view of periodontitis as a dysbiotic disease that occurs as a result of changes in the microbial composition of the subgingival region is considered in a systematic review.Purpose. To study a new paradigm of development of generalized periodontitis.Materials and methods. Randomized controlled trials (RCTS) were selected for the study, including cluster RCTS, controlled (non-randomized) microbiological and clinical studies of the oral microbiome in adult patients with generalized periodontitis over the past 10 years.Results. The transition from a symbiotic microflora to a dysbiotic pathogenic community triggers the host's inflammatory response, which contributes to the development of periodontal diseases. Modern ideas about periodontal pathogenic bacteria dictate new requirements for the treatment of periodontal diseases. The second part of the review examines the microbial profiles of periodontal disease in various nosological forms, the mechanisms of the immune response and approaches to the treatment of periodontal disease from the perspective of biofilm infection.Conclusions. As follows from modern literature periodontitis is to a certain extent caused by the transition from a harmonious symbiotic bacterial community to a dysbiotic one. Recent scientific studies have shown that not single microorganism is not able to cause disease but the microbial community as a whole leads to the development of pathology.

Epigenetic Studies in Psychotherapy: A Systematic Review

2020 ◽  
Vol 16 (2) ◽  
pp. 86-92
Author(s):  
Rafael Penadés ◽  
Bárbara Arias ◽  
Mar Fatjó-Vilas ◽  
Laura González-Vallespí ◽  
Clemente García-Rizo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dna Methylation ◽  
Mental Disorders ◽  
Epigenetic Modifications ◽  
Symptom Improvement ◽  
Epigenetic Changes ◽  
Main Hypothesis ◽  
Psychological Treatments ◽  
Time Period ◽  
The Impact

Background: Epigenetic modifications appear to be dynamic and they might be affected by environmental factors. The possibility of influencing these processes through psychotherapy has been suggested. Objective: To analyse the impact of psychotherapy on epigenetics when applied to mental disorders. The main hypothesis is that psychological treatments will produce epigenetic modifications related to the improvement of treated symptoms. Methods: A computerised and systematic search was completed throughout the time period from 1990 to 2019 on the PubMed, ScienceDirect and Scopus databases. Results: In total, 11 studies were selected. The studies were evaluated for the theoretical framework, genes involved, type of psychotherapy and clinical challenges and perspectives. All studies showed detectable changes at the epigenetic level, like DNA methylation changes, associated with symptom improvement after psychotherapy. Conclusion: Methylation profiles could be moderating treatment effects of psychotherapy. Beyond the detected epigenetic changes after psychotherapy, the epigenetic status before the implementation could act as an effective predictor of response.

Sign in / Sign up

Export Citation Format

Share Document