scholarly journals Retracted: Modulation of Signal Proteins: A Plausible Mechanism to Explain How a Potentized Drug Secale Cor 30C Diluted beyond Avogadro’s Limit Combats Skin Papilloma in Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-1
Author(s):  
Evidence-Based Complementary and Alternative Medicine
Keyword(s):  
Skin Papilloma ◽  
Plausible Mechanism

scholarly journals Modulation of Signal Proteins: A Plausible Mechanism to Explain How a Potentized Drug Secale Cor 30C Diluted beyond Avogadro's Limit Combats Skin Papilloma in Mice

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Anisur Rahman Khuda-Bukhsh ◽  
Soumya Sundar Bhattacharyya ◽  
Saili Paul ◽  
Suman Dutta ◽  
Naoual Boujedaini ◽  
...  
Keyword(s):  
Caspase 3 ◽  
Bone Marrow Cells ◽  
Dna Damages ◽  
Skin Papilloma ◽  
Anti Cancer ◽  
Immunofluorescence Studies ◽  
Homeopathic Drug ◽  
Plausible Mechanism ◽  
Gene Regulatory ◽  
Homeopathic Drugs

In homeopathy, ability of ultra-high diluted drugs at or above potency 12C (diluted beyond Avogadro's limit) in ameliorating/curing various diseases is often questioned, particularly because the mechanism of action is not precisely known. We tested the hypothesis if suitable modulations of signal proteins could be one of the possible pathways of action of a highly diluted homeopathic drug, Secale cornutum 30C (diluted 1060times; Sec cor 30). It could successfully combat DMBA + croton oil-induced skin papilloma in mice as evidenced by histological, cytogenetical, immunofluorescence, ELISA and immunoblot findings. Critical analysis of several signal proteins like AhR, PCNA, Akt, Bcl-2, Bcl-xL, NF-κB and IL-6 and of pro-apoptotic proteins like cytochromec, Bax, Bad, Apaf, caspase-3 and -9 revealed that Sec cor 30 suitably modulated their expression levels along with amelioration of skin papilloma. FACS data also suggested an increase of cell population at S and G2 phases and decrease in sub-G1 and G1 phages in carcinogen-treated drug-unfed mice, but these were found to be near normal in the Sec cor 30-fed mice. There was reduction in genotoxic and DNA damages in bone marrow cells of Sec Cor 30-fed mice, as revealed from cytogenetic and Comet assays. Changes in histological features of skin papilloma were noted. Immunofluorescence studies of AhR and PCNA also suggested reduced expression of these proteins in Sec cor 30-fed mice, thereby showing its anti-cancer potentials against skin papilloma. Furthermore, this study also supports the hypothesis that potentized homeopathic drugs act at gene regulatory level.

New Procedure for the Highly Regioselective Aerobic Bromination of Aromatic Compounds Using Copper-based Nanocatalyst

2020 ◽  
Vol 17 (3) ◽  
pp. 234-239
Author(s):  
Jalal Albadi ◽  
Mehdi Jalali
Keyword(s):  
Aromatic Compounds ◽  
Plausible Mechanism

A new procedure for the highly regioselective aerobic bromination of aromatic compounds in the presence of copper-based nanoparticles (CuO/ZnO nanocatalyst) under reflux condition is described. Mechanistic parameters are discussed and the plausible mechanism is proposed. Recyclability of the CuO/ZnO nanocatalyst has also been explored upon aerobic bromination of aromatic compounds.

1+1 > 2: Integration of the Host-directed Traditional Chinese Medicine and the Virus-targeted Modern Medicine in Control of COVID-19

2020 ◽  
Vol 7 (2) ◽  
pp. 89-94
Author(s):  
Jianjun Sun
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Infectious Diseases ◽  
Modern Medicine ◽  
The World ◽  
Plausible Mechanism

The COVID-19 pandemic has caused millions of infections and hundreds of thousands deaths in the world. The pandemic is still ongoing and no specific antivirals have been found to control COVID-19. The integration of Traditional Chinese Medicine with supportive measures of Modern Medicine has reportedly played an important role in the control of COVID-19 in China. This review summarizes the evidence of TCM in the treatment of COVID-19 and discusses the plausible mechanism of TCM in control of COVID-19 and other viral infectious diseases.

Iodine-Mediated Sulfenylation of Imidazo[1,2-a]pyridines with Ethyl Arylsulfinates

Synlett ◽  
2021 ◽  
Author(s):  
Dong Tang ◽  
Jian Sun ◽  
Yangxiu Mu ◽  
Zafar Iqbal ◽  
Jing Hou ◽  
...  
Keyword(s):  
Reaction Process ◽  
Mild Conditions ◽  
Plausible Mechanism

AbstractA simple iodine-mediated approach is reported for the synthesis of sulfenylated imidazo[1,2-a]pyridines through the reaction of imidazo[1,2-a]pyridines with ethyl arylsulfinates under mild conditions. The reaction scope was investigated, and a plausible mechanism is proposed to elucidate the reaction process and activation mode. The results indicate that ethyl sulfinates are efficient sulfur sources for the construction of C–S bonds.

Digital imaging of the oil permeation mechanism in an oleophobic textile

2021 ◽  
pp. 004051752110069
Author(s):  
Gannian Zhang ◽  
Qinfa Zhang
Keyword(s):  
Pore Size ◽  
Digital Imaging ◽  
Chemical Warfare ◽  
Linear Variation ◽  
Contact Lines ◽  
High Definition ◽  
Effective Protection ◽  
Silicon Oil ◽  
Plausible Mechanism ◽  
Three Stages

Resistance of military clothing to oil permeation is important for effective protection against chemical warfare. In this paper, while a military textile is rendered oleophobic (oil contact angle ≈ 120°) through plasma-assisted deposition of perfluorodecyl acrylate (PFAC8), permeation of the textile by silicon oil is observed. Using high-definition digital imaging, we study the oil permeation dynamics, rationalize the permeation with a plausible mechanism and identify the threshold textile pore size for prevention of the permeation. We find that oil permeates defects of PFAC8 textiles. Our data suggests a linear variation for oil permeation volume ΔV with time t and implies a gravity-driving permeation mechanism. The mechanism comprises three stages involving merging and propagation of oil–yarn contact lines. The threshold pore size dm scales with σ/ P, where σ is the oil surface tension and P is the hydrostatic head exerted by the oil drop. The paper indicates the importance of an undamaged textile structure to ‘robust’ oil resistance.

scholarly journals Be different to be better: the effect of personality on optimal foraging with incomplete knowledge

2021 ◽  
Author(s):  
Poppy M. Jeffries ◽  
Samantha C. Patrick ◽  
Jonathan R. Potts
Keyword(s):  
Optimal Foraging ◽  
Optimal Foraging Theory ◽  
Foraging Strategy ◽  
Foraging Strategies ◽  
Partial Knowledge ◽  
Marginal Value ◽  
Animal Populations ◽  
Plausible Mechanism ◽  
Insight Into ◽  
Modelling Approach

AbstractMany animal populations include a diversity of personalities, and these personalities are often linked to foraging strategy. However, it is not always clear why populations should evolve to have this diversity. Indeed, optimal foraging theory typically seeks out a single optimal strategy for individuals in a population. So why do we, in fact, see a variety of strategies existing in a single population? Here, we aim to provide insight into this conundrum by modelling the particular case of foraging seabirds, that forage on patchy prey. These seabirds have only partial knowledge of their environment: they do not know exactly where the next patch will emerge, but they may have some understanding of which locations are more likely to lead to patch emergence than others. Many existing optimal foraging studies assume either complete knowledge (e.g. Marginal Value Theorem) or no knowledge (e.g. Lévy Flight Hypothesis), but here we construct a new modelling approach which incorporates partial knowledge. In our model, different foraging strategies are favoured by different birds along the bold-shy personality continuum, so we can assess the optimality of a personality type. We show that it is optimal to be shy (resp. bold) when living in a population of bold (resp. shy) birds. This observation gives a plausible mechanism behind the emergence of diverse personalities. We also show that environmental degradation is likely to favour shyer birds and cause a decrease in diversity of personality over time.

An Elegant Synthetic Route to 3-Cyano-5,6-dihydro-2-ethoxy-4-phenyl-pyrido[2,3-a]carbazoles

2004 ◽  
Vol 59 (1) ◽  
pp. 106-108 ◽  
Author(s):  
Isravel A. Danish ◽  
Karnam J. R. Prasad
Keyword(s):  
Elemental Analysis ◽  
Spectral Methods ◽  
Title Compound ◽  
Sodium Hydride ◽  
Synthetic Route ◽  
Mass Spectral ◽  
Plausible Mechanism

Abstract 2-Benzylidene-1-oxo-1,2,3,4-tetrahydrocarbazoles (1a - e) obtained from the corresponding 1- oxo-1,2,3,4-tetrahydrocarbazoles on reaction with malononitrile in dry benzene with sodium hydride afforded 3-cyano-5,6-dihydro-2-ethoxy-4-phenyl-pyrido[2,3-a]carbazoles (2a - e) in good yields. A plausible mechanism for the formation of the title compound has been proposed and all the compounds were characterised by IR, NMR, mass spectral methods and elemental analysis.

Cu2+-Selectivity gated photochromism in Schiff-modified diarylethenes with a star-shaped structure

2017 ◽  
Vol 5 (2) ◽  
pp. 282-289 ◽  
Author(s):  
Shangshang Wang ◽  
Xin Li ◽  
Wandong Zhao ◽  
Xuanying Chen ◽  
Junji Zhang ◽  
...  
Keyword(s):  
Photochromic Behavior ◽  
Plausible Mechanism

A Cu2+-gated photochromic behavior of a star-shaped diarylethene derivative and its plausible mechanism are discussed.

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