scholarly journals Development and Evaluation of the Wound Healing Effect of a Novel Topical Cream Formula Based on Ginkgo biloba Extract on Wounds in Diabetic Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Sana Bardaa ◽  
Khouloud Makni ◽  
Ons Boudaouara ◽  
Tarek Bardaa ◽  
Naourez Ktari ◽  
...  

Despite advances in diabetes care, impaired diabetic wound healing remains a significant clinical problem. The present study was aimed at developing a novel cream based on Ginkgo biloba extract and investigating its wound healing effect on full-thickness wounds in diabetic rats. The topical formulated oil-in-water emulsion-based cream contains Ginkgo biloba aqueous extract in an amount of about 1% to 5% as an active agent. The prepared formula was subjected to physicochemical assessment and pharmacotechnical characterization. Eighteen alloxan-induced diabetic rats completing full-thickness excisional skin wounds were randomly divided into three groups topically treated with either a normal saline (control group), the reference drug (“Cytol Centella cream®”), and cream based on the Ginkgo biloba extract. The response to treatment was assessed by macroscopic, qualitative, and quantitative histopathological analysis. The prepared formula showed good physicochemical properties. The rheological behavior of the prepared cream followed a non-Newtonian pseudoplastic pattern at different storage temperatures. The cream, which is a macroemulsion with uniform size distribution, remained stable for 6 months. Skin tolerance studies confirmed the compatibility of the cream with the skin. During the experimental trial, the cream based on the Ginkgo biloba-treated group showed significant improvements over the control and reference groups for both general wound appearance and healing dynamics. This increased rate of closure of wounds in diabetic rats was associated with increased collagen synthesis. Our findings showed that the cream could be a promising and innovative topical treatment with Ginkgo biloba extract for the management of acute diabetic wounds.

Author(s):  
Riazul Haque Tuhin ◽  
Mst. Marium Begum ◽  
Md. Sohanur Rahman ◽  
Rubaba Karim ◽  
Taslima Begum ◽  
...  

2006 ◽  
Vol 17 (6) ◽  
pp. 547-552 ◽  
Author(s):  
Dae-Hyun Roh ◽  
Seuk-Yun Kang ◽  
Jeom-Yong Kim ◽  
Young-Bae Kwon ◽  
Hae Young Kweon ◽  
...  

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Ikram Khémiri ◽  
Badiaa Essghaier Hédi ◽  
Najla Sadfi Zouaoui ◽  
Neyla Ben Gdara ◽  
Lotfi Bitri

Introduction.Opuntia ficus indica L. inermis(OFI) is used in traditional medicine pharmacopeia for its richness in natural bioactive compounds. It has been proven to be effective in the improvement of the healing of laser-induced skin burns. The aim of the present study was to investigate the wound healing effect of OFI extracted oil on full-thickness skin wound.Materials and Methods. The OFI seeds were firstly isolated from mature prickly pears, washed, dried, and then cold-pressed. The antimicrobial activities of OFI seed oil were estimatedin vitroagainst bacteria, yeast, and fungi. Minimum Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) were calculated. Skin wound healing was investigated using an excisional wound healing model in rats. The skin wounds of three experimental groups of rats were topically treated once/day with saline solution (control group), 0.15 mg/mm2of a reference drug Esth’Elle Pharma Cicaplaie cream (reference group), and 0.6 μl/mm2of OFI seed oil (OFI oil group). The healing process was monitored daily and the percentage of wound contraction was calculated. A histological study was carried on skin biopsies.Results. The extracted oil has shown an interesting antimicrobial effect onEnterobacter cloacae, antiyeast effect againstCandida parapsilosisandCandida sake, and antifungal activity against three opportunistic cutaneous molds (Penicillium, Aspergillus, and Fusarium). Moreover, OFI oil has shown a good wound healing effect. It prevents cutaneous infections and reduces the reepithelialization phase.Conclusion. OFI extracted oil hasin vitroantimicrobial/fungal properties andin vivowound healing activity. It seems to be efficient in the treatment of cutaneous infections and the promoting of the scarring process.


Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
CBS Lau ◽  
VKM Lau ◽  
CL Liu ◽  
PKK Lai ◽  
JCW Tam ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document