scholarly journals Biomechanical Simulation of Peyronie’s Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Pavel Drlík ◽  
Vladimír Červenka ◽  
Jan Červenka
Keyword(s):  
Tunica Albuginea ◽  
Healing Process ◽  
Element Model ◽  
Peyronie’S Disease ◽  
Corpus Cavernosa ◽  
Geometrical Shape ◽  
Angular Deviation ◽  
Biomechanical Behavior ◽  
Peyronie's Disease ◽  
Initial Strains

A pathological disorder of human penile function, known as Peyronie’s disease, is characterized by the formation of plaque particles within the tunica albuginea. The plagues in the shape of rigid plate form in the scars as a result of the imperfect healing process. Due to high stiffness, plagues are the source of pain and anomalous deformations during erectile penis function. The authors simulate the biomechanical behavior of the penile structure by a 3D finite element model. The numerical model is based on the real geometrical shape and the tissue structure with consideration of large nonlinear deformations. The penile erection is modeled by the initial strains imposed on the corpus cavernosa. The stress analysis is performed in a case study of various plague locations. The Peyronie’s syndrome manifested by the penis angular deviation simulated by the analysis is compared with the clinical data. The computational simulations provide a rational explanation for the clinical observations on patients. The objective is to apply the proposed modeling approach for the development and validation of treatment methods based on the application of shock waves.

scholarly journals Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1658
Author(s):  
Yasuyoshi Miyata ◽  
Tomohiro Matsuo ◽  
Yuichiro Nakamura ◽  
Kensuke Mitsunari ◽  
Kojiro Ohba ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Tunica Albuginea ◽  
Healing Process ◽  
Treatment Strategies ◽  
Peyronie’S Disease ◽  
Pathological Mechanism ◽  
Peyronie's Disease ◽  
Phosphodiesterase Type

Erectile function is regulated by complex mechanisms centered on vascular- and nerve-related systems. Hence, dysregulation of these systems leads to erectile dysfunction (ED), which causes mental distress and decreases the quality of life of patients and their partners. At the molecular level, many factors, such as fibrosis, lipid metabolism abnormalities, the immune system, and stem cells, play crucial roles in the etiology and development of ED. Although phosphodiesterase type 5 (PDE5) inhibitors are currently the standard treatment agents for patients with ED, they are effective only in a subgroup of patients. Therefore, further insight into the pathological mechanism underlying ED is needed to discuss ED treatment strategies. In this review, we focused on the biological and pathological significance of macrophages in ED because the interaction of macrophages with ED-related mechanisms have not been well explored, despite their important roles in vasculogenic and neurogenic diseases. Furthermore, we examined the pathological significance of macrophages in Peyronie’s disease (PD), a cause of ED characterized by penile deformation (visible curvature) during erection and pain. Although microinjury and the subsequent abnormal healing process of the tunica albuginea are known to be important processes in this disease, the detailed etiology and pathophysiology of PD are not fully understood. This is the first review on the pathological role of macrophages in PD.

Initial experience in the treatment of Peyronie’s disease using testicular vaginal tunica graft

2021 ◽  
pp. 205141582110166
Author(s):  
Rico Luis ◽  
Villasante Nicolás ◽  
Blas Leandro ◽  
Bonnano Nicolás ◽  
Ameri Carlos
Keyword(s):  
Sexual Function ◽  
Tunica Albuginea ◽  
Peyronie’S Disease ◽  
Sexual Life ◽  
Rank Test ◽  
Penile Curvature ◽  
Initial Experience ◽  
Level Of Evidence ◽  
Paired Samples ◽  
Peyronie's Disease

Background: Peyronie’s disease (PD) is a progressive disorder of the connective tissue of the tunica albuginea of the penis that produces an abnormal curvature, painful erections and different degrees of erectile dysfunction (ED). The aim of this study is to evaluate our initial experience in the surgical treatment of PD using an autologous graft of testicular vaginal tunica. Materials and methods: A retrospective study of 23 patients was carried out between 2015 and 2019. The successful surgical stretching rate was defined as a functional 20 degrees of curvature or less. Postoperative sexual function and complications rate were evaluated as secondary objectives. We used the abbreviated IIEF-5 questionnaire and evaluated the sexual function before and after the surgical procedure. Wilcoxon signed-rank test for paired samples (U test) was used, considering a value of p<0.05 to be statistically significant. Results: Only one patient presented a recurrence of the penile curvature, resulting in a 95.6% success rate of functional stretching. We observed a 1.6 and 0.9 difference between pre- and postoperative total score and satisfaction ( p = 0.002 and p = 0.003 respectively) Conclusion: In this series, the use of testicular vaginal tunic was found to be safe and effective with a significant change in the quality of sexual life, especially reflected in the overall satisfaction after the procedure and a low rate of complications. Level of evidence: Not applicable for this multicentre audit.

Expanding Contractures of the Tunica Albuginea due to Peyronie’s Disease with Temporalis Fascia Free Grafts

1991 ◽  
Vol 145 (4) ◽  
pp. 772-776 ◽  
Author(s):  
Martin K. Gelbard ◽  
Barbara Hayden
Keyword(s):  
Tunica Albuginea ◽  
Peyronie’S Disease ◽  
Temporalis Fascia ◽  
Free Grafts ◽  
Peyronie's Disease

Surgical Treatment of Peyronie’s Disease: Systematic Review of Techniques Involving or Not Tunica Albuginea Incision

2020 ◽  
Vol 8 (2) ◽  
pp. 324-332 ◽  
Author(s):  
Alan R.G. Barbosa ◽  
Lucas S. Takemura ◽  
Jonathan D. Cha ◽  
Arie Carneiro ◽  
Gustavo C. Lemos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Surgical Treatment ◽  
Tunica Albuginea ◽  
Peyronie’S Disease ◽  
Peyronie's Disease

Functional tissue engineering of autologous tunica albuginea: A possible graft for peyronie's disease surgery

2003 ◽  
Vol 2 (1) ◽  
pp. 123
Author(s):  
D. Schultheiss ◽  
R.R. Lorenz ◽  
A.I. Gabouev ◽  
N. Schlote ◽  
J. Wefer ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Tunica Albuginea ◽  
Peyronie’S Disease ◽  
Functional Tissue Engineering ◽  
Functional Tissue ◽  
Peyronie's Disease

A clinico-aetiological and ultrasonographic study of Peyronie's disease

Sexual Health ◽  
2006 ◽  
Vol 3 (2) ◽  
pp. 113 ◽  
Author(s):  
Bhushan Kumar ◽  
Tarun Narang ◽  
Somesh Gupta ◽  
Madhu Gulati
Keyword(s):  
Clinical Presentation ◽  
Clinical Symptoms ◽  
Tunica Albuginea ◽  
Connective Tissue Disorder ◽  
Peyronie’S Disease ◽  
Penile Curvature ◽  
Age Group ◽  
History Of ◽  
Peyronie's Disease ◽  
Symptoms And Signs

Background: Peyronie’s disease is a localised connective tissue disorder that involves the tunica albuginea of the penis. Although long recognised as an important clinical entity of the male genitalia, the aetiology of this disease has remained poorly understood. Methods: The epidemiology and clinical presentation of Peyronie’s disease during a 10-year period was evaluated. Results: Forty-two men with Peyronie’s disease from Chandigarh, India were reviewed retrospectively. The prevalence of Peyronie’s patients was 1.97/1000 patients. Their ages ranged from 23 to 70 years. Most of them presented during the early phase of the disease. The most common presenting complaint was penile curvature in 34 (80.95%) followed by pain on erection in 28 (66.66%). History of penile trauma was revealed by four (9.52%) patients. Among the risk factors, hypercholesterolemia (60%), hypertension (33.3%) and asymptomatic hyperuricemia (28.34%) were the most common. Twenty-two patients with Peyronie’s disease were studied by ultrasonography. Ultrasonogram was more accurate than clinical assessment in delineating the extent of lesions. In one-third of the patients, sonography demonstrated the plaques to be more extensive than had been detected by clinical examination. Conclusions: The clinical symptoms and signs in our study were, in general, similar to those found in the previous studies. Higher incidence of hypertension and diabetes in patients with Peyronie’s disease may also be to an extent due to patients being in an older age group.

Study of the Changes in Collagen of the Tunica Albuginea in Venogenic Impotence and Peyronie's Disease

1992 ◽  
Vol 21 (1) ◽  
pp. 48-51 ◽  
Author(s):  
Po-Hui Chiang ◽  
Chin-Pei Chiang ◽  
Meng-Ru Sheri ◽  
Chun-Hsiung Huang ◽  
Chii-Jye Wang ◽  
...  
Keyword(s):  
Tunica Albuginea ◽  
Peyronie’S Disease ◽  
Peyronie's Disease

119 Outcomes of Tunica Albuginea Plication for Peyronie's Disease with Limited Use of Permanent Suture

2017 ◽  
Vol 14 (2) ◽  
pp. e45
Author(s):  
D. Papagiannopoulos ◽  
J. Phelps ◽  
E. Yura ◽  
L. Levine
Keyword(s):  
Tunica Albuginea ◽  
Peyronie’S Disease ◽  
Peyronie's Disease

scholarly journals The Role of Intrinsic Pathway in Apoptosis Activation and Progression in Peyronie’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Carla Loreto ◽  
Giampiero La Rocca ◽  
Rita Anzalone ◽  
Rosario Caltabiano ◽  
Giuseppe Vespasiani ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tunica Albuginea ◽  
Fibrous Tissue ◽  
Peyronie’S Disease ◽  
Ossification Center ◽  
Apoptotic Cells ◽  
Intrinsic Pathway ◽  
Caspase 9 ◽  
Peyronie's Disease ◽  
Metaplastic Bone

Peyronie’s disease (PD) is characterized with formation of fibrous plaques which result in penile deformity, pain, and erectile dysfunction. The aim of this study was to investigate the activation of the intrinsic apoptotic pathway in plaques from PD patients. Tunica albuginea from either PD or control patients was assessed for the expression of bax, bcl-2 and caspases 9 and 3 using immunohistochemistry and by measurement of apoptotic cells using TUNEL assay. Bax overexpression was observed in metaplastic bone tissue, in fibroblasts, and in myofibroblast of plaques from PD patients. Little or no bcl-2 immunostaining was detected in samples from either patients or controls. Caspase 3 immunostaining was very strong in fibrous tissue, in metaplasic bone osteocytes, and in primary ossification center osteoblasts. Moderate caspase 9 immunostaining was seen in fibrous cells plaques and in osteocytes and osteoblasts of primary ossification centers from PD patients. Control samples were negative for caspase 9 immunostaining. In PD patients the TUNEL immunoassay showed intense immunostaining of fibroblasts and myofibroblasts, the absence of apoptotic cells in metaplasic bone tissue and on the border between fibrous and metaplastic bone tissue. Apoptosis occurs in stabilized PD plaques and is partly induced by the intrinsic pathway.

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