scholarly journals Clinical Research of Combined Application of DCEUS and Dynamic Contrast-Enhanced MSCT in Preoperative cT Staging of Gastric Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Junling Wang ◽  
Xia Li ◽  
Zhijie Zhang ◽  
Chao Jing ◽  
Jie Li
Keyword(s):  
Gastric Cancer ◽  
Evaluation Method ◽  
Correct Diagnosis ◽  
Multislice Ct ◽  
Youden Index ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Diagnosis Rate ◽  
Preoperative Ct ◽  
Staging Of Gastric Cancer

Purpose. To investigate the clinical value of double contrast-enhanced ultrasound (DCEUS) combined with dynamic contrast-enhanced multislice CT (MSCT) in preoperative T staging of gastric cancer (GC). Methods. 206 patients with GC confirmed by preoperative gastroscopy from February 2019 to February 2021 were collected, all patients were examined by DCEUS and dynamic contrast-enhanced MSCT before operation, and the invasion depth (T staging) of GC was evaluated. The diagnosis results of DCEUS, dynamic contrast-enhanced MSCT, and combined diagnosis of DCEUS and MSCT methods (D&M method) were compared with the pathological staging results (gold standard). Results. The correct diagnosis rate of MSCT was 27.27% in T1 staging, 55.56% in T2 staging, 42.11% in T3 staging, 59.29% in T4 staging, and 55.34% in summation. The correct diagnosis rate of DCEUS was 90.91% in T1 staging, 88.89% in T2 staging, 78.95% in T3 staging, 82.86% in T4 staging, and 83.98% in summation. The correct diagnosis rate of the D&M method was 100.00% in T1 staging, 94.44% in T2 staging, 89.47% in T3 staging, 93.57% in T4 staging, and 93.69% in summation. The D&M method had higher correct diagnosis rate than MSCT or DCEUS alone, the correct diagnosis rate of the D&M method in T1, T2, T3, and T4 staging was significantly higher than that of MSCT ( P < 0.05 ). The correct diagnosis rate of the D&M method in T1, T3, and T4 was significantly higher than that of DCEUS ( P < 0.05 ). The Youden index of preoperative T1, T2, T3, and T4 staging of GC by the D&M method was 99.49%, 94.44%, 84.13%, and 90.54%, respectively, and the Kappa values of these were 0.954, 0.966, 0.707, and 0.881, respectively. Conclusions. Dynamic contrast-enhanced MSCT combined with DCEUS in the diagnosis of preoperative cT staging of GC has more validity, reliability, and revenue than the using of MSCT or DCEUS alone, which is an image evaluation method worthy of clinical promotion.

scholarly journals Correlation between quantitative dynamic contrast-enhanced MRI parameters and molecular typing and related immune proteins in gastric cancer

2020 ◽  
Author(s):  
Liangliang Yan ◽  
Jianbo Gao ◽  
Jinrong Qu ◽  
Hongkai Zhang ◽  
Yanan Lu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Molecular Typing ◽  
Positive Group ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced Mri ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Her 2 ◽  
Contrast Enhanced Mri ◽  
E Cadherin

Abstract Background To analyze the correlation between quantitative dynamic contrast-enhanced MRI (DCE-MRI) parameters and molecular typing and related immune proteins in gastric cancer. Methods Forty-three patients confirmed as gastric adenocarcinoma by histopathology were enrolled in this prospective study. DCE-MRI were performed before surgery, and quantitative DCE parameters (Ktrans, Kep, Ve) were measured. The specimens were stained with biomarkers EBER-ISH, MLH1, PMS2, E-Cadherin, P53 and HER-2. According to the different dyeing results, they were divided into five molecular types and four HER-2 expression grades. The quantitative DCE parameters among five molecular types was compared using the ANOVA or Kruskal-Wallis test, and pairwise comparison was performed using the LSD test. The quantitative DCE parameters between positive and negative expressions of related immune proteins were compared using the Mann-Whitney U test. The correlations between quantitative DCE parameters and HER-2 expression grades were evaluated using Spearman rank correlation test. Results Among 43 cases, 3 cases were EBV-positive groups, 9 cases were MSI groups, 2 cases were aberrant E-Cadherin groups, 23 cases were aberrant P53 groups, and 6 cases were normal P53 groups. There were significant differences of quantitative DCE parameters in Ktrans and Kep among five molecular types (P < 0.05). The Ktrans value of Aberrant P53 group was lower than that of EBV-positive group, MSI group and Normal P53 group, the Kep value of E-Cadherin group was lower than that of EBV-positive group, and the Kep value of Aberrant P53 group was lower than that of EBV-positive group and MSI group, and all differences were statistically significant (all P < 0.05). Aberrant E-Cadherin group has the lowest Ktrans value (0.28/min) and Kep value (0.26/min) in five groups, respectively. There were no significant differences in quantitative DCE parameters between positive and negative expressions of all related immune proteins (all P > 0.05). There were no significant correlation between HER-2 expression grades and Ktrans, Kep, Ve values (r=-0.08, -0.03, -0.16, P = 0.63, 0.84, 0.31, respectively). Conclusion Quantitative DCE-MRI parameters can assess some molecular types of gastric cancer in a certain extent, and not assess related immune protein expressions, and not related to HER-2 expression grades.

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