scholarly journals Binary Eluent Based Vortex-Assisted Matrix Solid-Phase Dispersion for the Extraction and Determination of Multicomponent from Musk by Gas Chromatography-Mass Spectrometry

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Shanshan Wang ◽  
Ye Shang ◽  
Chunxiao Liang ◽  
Tao Liu ◽  
Kunze Du ◽  
...  
Keyword(s):  
Solid Phase ◽  
Orthogonal Design ◽  
Ethyl Oleate ◽  
Correlation Coefficients ◽  
Gas Chromatography Mass Spectrometry ◽  
Ethyl Palmitate ◽  
Matrix Solid Phase Dispersion ◽  
Phase Dispersion ◽  
Target Analytes

A green, flexible, and effective strategy was proposed to quantify four target compounds (muscone, ethyl palmitate, ethyl oleate, and ethylparaben) from musk by binary eluent based vortex-assisted matrix solid-phase dispersion (MSPD) extraction coupled with GC/MS. Single-factor tests and orthogonal design were employed to optimize the MSPD parameters. In addition, the binary eluent system, methanol, and ethyl acetate 3 : 7 (v/v) were used to extract the target analytes. Finally, C18 was applied as the easily available dispersant and the sample powder was ground for 2 min. Thereafter, the mixture was rapidly extracted with the binary eluents under whirling for 3 min. Eventually, the analysis of the samples was completed within 12 min by GC/MS. All correlation coefficients (r) of four targets were more than 0.9991. The recoveries of all target compounds ranged from 92.8% to 101% while their RSDs were less than 6.94%. There was no significant matrix interference for the analysis. Thus, the combination of vortex-assisted MSPD with GC/MS was considered as a novel, rapid, and environmentally friendly quantitative approach for musk samples.

scholarly journals Simultaneous determination of 11 preservatives in cosmetics and pharmaceuticals by matrix solid-phase dispersion coupled with gas chromatography

2020 ◽  
Vol 32 (3) ◽  
pp. 203-209
Author(s):  
Yun-feng Liu ◽  
Jia-ling Zhang ◽  
Xue-fei Nie ◽  
Ping Zhang ◽  
Xiao-qing Yan ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Simultaneous Determination ◽  
Matrix Effects ◽  
Solid Phase ◽  
Correlation Coefficients ◽  
Sample Pretreatment ◽  
Matrix Solid Phase Dispersion ◽  
Phase Dispersion ◽  
Flame Ionization

A convenient method was developed for simultaneous determination of 11 preservatives in cosmetics and pharmaceuticals. Matrix solid-phase dispersion had been optimized as the sample pretreatment technology, using Florisil as a dispersant, anhydrous sodium sulfate as a dehydrant, formic acid as an additive, and n-hexane and ethyl acetate as eluents successively, and followed by gas chromatography–flame ionization detection on a TR-5 capillary column. Experimental results showed that 11 preservatives were baseline separated within 22 min. Good linearities were observed in the concentration range of 0.53–250 μg/mL for all analytes, and there were also minor differences. All correlation coefficients (r) were more than 0.995. The average recoveries at 3 levels of spiked samples ranged from 80% to 124% with 0.9–12% intra-day RSD and 1.8–12% inter-day RSD. The limits of detection were less than 0.18 μg/mL for all analytes. Besides, there was no obvious matrix effect on the analytes. The conclusion was that the developed method was simple, cheap, accurate, precise, and environment-friendly, in addition to existing little matrix effects. It could be recommended to determine 11 preservatives individually or in any their combinations to not only in liquid and gel cosmetics but also in liquid medicine and ointment.

scholarly journals Determination of Six Pesticides in the Medicinal Herb Cordia salicifolia by Matrix Solid-Phase Dispersion and Gas Chromatography/Mass Spectrometry

2009 ◽  
Vol 92 (4) ◽  
pp. 1184-1189 ◽  
Author(s):  
Pedro Henrique Viana De Carvalho ◽  
Vanessa De Menezes Prata ◽  
Pricles Barreto Alves ◽  
Sandro Navickiene
Keyword(s):  
Extraction Method ◽  
Solid Phase ◽  
Gas Chromatography Mass Spectrometry ◽  
Neutral Alumina ◽  
Appetite Suppressant ◽  
Matrix Solid Phase Dispersion ◽  
Phase Dispersion ◽  
Relative Standard ◽  
Concentration Levels

Abstract A simple and effective extraction method based on matrix solid-phase dispersion was developed for acephate, chlorpropham, pyrimicarb, bifenthrin, tetradifon, and phosalone in leaves of the medicinal plant Cordia salicifolia, whose extracts are commercialized in Brazil as diuretic, appetite suppressant, and weight loss products. The determination method was GC/MS with selectedion monitoring. Different parameters of the method were evaluated, such as type of solid phase (C18, alumina, silica gel, and Florisil) and the amount of solid phase and eluent (dichloromethane, ethyl acetate, chloroform, and cyclohexane). The best results were obtained using 0.5 g herb sample, 0.5 g neutral alumina as the dispersant sorbent, 0.5 g C18 as the cleanup sorbent, and cyclohexanedichloromethane (3 + 1, v/v) as the eluting solvent. The method was validated using herb samples fortified with pesticides at different concentration levels (0.3, 0.5, and 1.0 mg/kg). Average recoveries (seven replicates) ranged from 67.7 to 129.9, with relative standard deviations between 6.3 and 26. Detection and quantitation limits for the herb ranged from 0.10 to 0.15 and 0.15 to 0.25 mg/kg, respectively.

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