scholarly journals Endoscopic Diagnostic System Using Autofluorescence

1999 ◽  
Vol 5 (2) ◽  
pp. 59-63 ◽  
Author(s):  
S. Takehana ◽  
M. Kaneko ◽  
H. Mizuno

A fluorescence imaging system (Xillix LIFE – Lung Fluorescence Endoscopy system) using fluorescence for the accurate diagnosis and early detection of lesions through an endosocope has been developed. This system has applied an optical diagnostic technology to functionally diagnose lesions which have been difficult to morphologically recognize or are occult with conventional endoscope. The benefit of this system in the diagnosis of lung cancer has already been confirmed in the US and Japan, and feasibility of the system in the gastric intestinal field has also been evaluated.

2017 ◽  
Vol 66 (2) ◽  
pp. 307-312
Author(s):  
Manar Ahmed Abdel Rahman ◽  
Nadia Abdel Moneim Nada ◽  
Khaled Refaat Zalata ◽  
Mohammad Khairy El Badrawy ◽  
Iman Mohammed El Salkh ◽  
...  

Thorax ◽  
2018 ◽  
Vol 73 (12) ◽  
pp. 1097-1098 ◽  
Author(s):  
Michael D Peake ◽  
Neal Navani ◽  
David R Baldwin

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3919
Author(s):  
Elisa Dama ◽  
Tommaso Colangelo ◽  
Emanuela Fina ◽  
Marco Cremonesi ◽  
Marinos Kallikourdis ◽  
...  

Lung cancer burden is increasing, with 2 million deaths/year worldwide. Current limitations in early detection impede lung cancer diagnosis when the disease is still localized and thus more curable by surgery or multimodality treatment. Liquid biopsy is emerging as an important tool for lung cancer early detection and for monitoring therapy response. Here, we reviewed recent advances in liquid biopsy for early diagnosis of lung cancer. We summarized DNA- or RNA-based biomarkers, proteins, autoantibodies circulating in the blood, as well as circulating tumor cells (CTCs), and compared the most promising studies in terms of biomarkers prediction performance. While we observed an overall good performance for the proposed biomarkers, we noticed some critical aspects which may complicate the successful translation of these biomarkers into the clinical setting. We, therefore, proposed a roadmap for successful development of lung cancer biomarkers during the discovery, prioritization, and clinical validation phase. The integration of innovative minimally invasive biomarkers in screening programs is highly demanded to augment lung cancer early detection. 


2004 ◽  
Vol 20 (2) ◽  
pp. 71-85 ◽  
Author(s):  
Jason S. Vourlekis ◽  
Eva Szabo

The unacceptably high morbidity and mortality associated with the diagnosis of lung cancer mandates new approaches toward the early detection and treatment of this disease. Enhanced understanding of the molecular biology of the carcinogenic process is identifying many potential markers of risk of lung cancer occurrence as well as of poor prognosis. Identification of high risk populations who are at greatest risk of being diagnosed with and dying from lung cancer would allow delivery of more intensive screening and interventions to the individuals who are most likely to benefit from such strategies. This review examines the current status of markers of lung cancer risk, early detection, and prognosis, and their applicability to current standards of clinical care.


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