scholarly journals Biomarkers and Lung Cancer Early Detection: State of the Art

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3919
Author(s):  
Elisa Dama ◽  
Tommaso Colangelo ◽  
Emanuela Fina ◽  
Marco Cremonesi ◽  
Marinos Kallikourdis ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Liquid Biopsy ◽  
Therapy Response ◽  
Multimodality Treatment ◽  
Screening Programs ◽  
Lung Cancer Diagnosis ◽  
Cancer Early Detection ◽  
Monitoring Therapy ◽  
Diagnosis Of Lung Cancer

Lung cancer burden is increasing, with 2 million deaths/year worldwide. Current limitations in early detection impede lung cancer diagnosis when the disease is still localized and thus more curable by surgery or multimodality treatment. Liquid biopsy is emerging as an important tool for lung cancer early detection and for monitoring therapy response. Here, we reviewed recent advances in liquid biopsy for early diagnosis of lung cancer. We summarized DNA- or RNA-based biomarkers, proteins, autoantibodies circulating in the blood, as well as circulating tumor cells (CTCs), and compared the most promising studies in terms of biomarkers prediction performance. While we observed an overall good performance for the proposed biomarkers, we noticed some critical aspects which may complicate the successful translation of these biomarkers into the clinical setting. We, therefore, proposed a roadmap for successful development of lung cancer biomarkers during the discovery, prioritization, and clinical validation phase. The integration of innovative minimally invasive biomarkers in screening programs is highly demanded to augment lung cancer early detection. 

scholarly journals Exo-miRNAs as a New Tool for Liquid Biopsy in Lung Cancer

Cancers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 888 ◽  
Author(s):  
Orazio Fortunato ◽  
Patrizia Gasparini ◽  
Mattia Boeri ◽  
Gabriella Sozzi
Keyword(s):  
Lung Cancer ◽  
Liquid Biopsy ◽  
Biological Fluids ◽  
Lung Cancer Screening ◽  
Cell Types ◽  
Lung Carcinogenesis ◽  
Lung Cancer Diagnosis ◽  
Diagnosis Of Lung Cancer ◽  
Exosomal Mirna ◽  
Different Cell Types

Lung cancer is the predominant cause of cancer-related deaths. The high mortality rates are mainly due to the lack of diagnosis before the cancer is at a late stage. Liquid biopsy is a promising technique that could allow early diagnosis of lung cancer and better treatment selection for patients. Cell-free microRNAs have been detected in biological fluids, such as serum and plasma, and are considered interesting biomarkers for lung cancer screening and detection. Exosomes are nanovesicles of 30–150 nm and can be released by different cell types within the tumor microenvironment. Their exosomal composition reflects that of their parental cells and could be potentially useful as a biomarker for lung cancer diagnosis. This review summarizes the state-of-the-art of circulating microRNAs (miRNAs) in lung cancer, focusing on their potential use in clinical practice. Moreover, we describe the importance of exosomal miRNA cargo in lung cancer detection and their potential role during lung carcinogenesis. Finally, we discuss our experience with the analysis of circulating exosomal miRNAs in the bioMILD screening trial.

scholarly journals Liquid biopsy for lung cancer early detection

2018 ◽  
Vol 10 (S7) ◽  
pp. S882-S897 ◽  
Author(s):  
Mariacarmela Santarpia ◽  
Alessia Liguori ◽  
Alessandro D’Aveni ◽  
Niki Karachaliou ◽  
Maria Gonzalez-Cao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Liquid Biopsy ◽  
Cancer Early Detection

scholarly journals 30PD Novel plasma circulating microRNA signature for early detection of non-small cell lung cancer in liquid biopsy

2016 ◽  
Vol 11 (4) ◽  
pp. S68
Author(s):  
T. Powrózek ◽  
P. Krawczyk ◽  
D. Kowalski ◽  
B. Kuźnar-Kamińska ◽  
K. Winiarczyk ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Liquid Biopsy ◽  
Small Cell ◽  
Circulating Microrna ◽  
Small Cell Lung

scholarly journals 191TiP Accelerating lung cancer diagnosis through liquid biopsy

2021 ◽  
Vol 16 (4) ◽  
pp. S801-S802
Author(s):  
M. García Pardo de Santayana ◽  
K. Czarnecka ◽  
T. Waddell ◽  
T. Stockley ◽  
J. Law ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Diagnosis ◽  
Liquid Biopsy ◽  
Lung Cancer Diagnosis

scholarly journals An integromic signature for lung cancer early detection

Oncotarget ◽  
2018 ◽  
Vol 9 (37) ◽  
pp. 24684-24692 ◽  
Author(s):  
Qixin Leng ◽  
Yanli Lin ◽  
Min Zhan ◽  
Feng Jiang
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Cancer Early Detection

scholarly journals P2.11-19 MicroRNAs as Liquid Biopsy Biomarkers for Early Detection in Lung Cancer.

2018 ◽  
Vol 13 (10) ◽  
pp. S785-S786 ◽  
Author(s):  
P. Reis ◽  
M. Pintilie ◽  
I. Jurisica ◽  
G. Liu ◽  
M. Tsao
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Liquid Biopsy

scholarly journals Delivering on the promise of early detection with liquid biopsies

2022 ◽  
Author(s):  
David Crosby
Keyword(s):  
Cancer Research ◽  
Cancer Therapy ◽  
Early Detection ◽  
Liquid Biopsy ◽  
Therapy Monitoring ◽  
Disease Relapse ◽  
Liquid Biopsies ◽  
Cancer Early Detection ◽  
Ideal Position

AbstractLiquid biopsy approaches are relatively well developed for cancer therapy monitoring and disease relapse, but they also have incredible potential in the cancer early detection and screening field. There are, however, several challenges to overcome before this potential can be met. Research in this area needs to be cohesive and, as a driver of research, Cancer Research UK is in an ideal position to enable this.

scholarly journals Diagnostic Value of Imaging Combined With Tumor Markers in Early Detection of Lung Cancer

2021 ◽  
Vol 8 ◽  
Author(s):  
Su-Ju Wei ◽  
Li-Ping Wang ◽  
Jun-Yan Wang ◽  
Jing-Xu Ma ◽  
Feng-Bin Chuan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Tumor Markers ◽  
Cancer Diagnosis ◽  
Diagnostic Value ◽  
Diagnostic Methods ◽  
Lung Cancer Diagnosis ◽  
Early Lung Cancer ◽  
Group A ◽  
Group B

Objective: The objective of this research is to explore the diagnostic value of imaging plus tumor markers in the early detection of lung cancer.Methods: Sixty patients with lung cancer treated in our hospital from January 2018 to January 2019 were selected as group A. They were matched with 60 patients with benign lung disease as group B and 60 healthy subjects examined in our hospital as group C. The carcino-embryonic antigen (CEA), CYFRA21-1, and neuron-specific enolase (NSE) were assessed, and the diagnostic value of tumor markers plus imaging in lung cancer diagnosis was explored.Results: The CEA, CYFRA21-1, and NSE in group A were evidently superior to those in groups B and C, and those in group B were superior to those in group C (all P < 0.001). CEA had the highest sensitivity (56.7%), and NSE had the highest specificity (93.3%). The tumor markers plus imaging had the highest sensitivity for different types of lung cancer, and the sensitivity to early lung cancer (90%) was superior to other diagnostic methods (P < 0.05).Conclusion: The tumor markers plus imaging is of great significance in early lung cancer diagnosis and provides a reference for judging the pathological classification.

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