Stromal Cell-Derived Factor-1α Promotes Melanoma Cell Invasion across Basement Membranes Involving Stimulation of Membrane-Type 1 Matrix Metalloproteinase and Rho GTPase Activities

2004 ◽  
Vol 64 (7) ◽  
pp. 2534-2543 ◽  
Author(s):  
Rubén A. Bartolomé ◽  
Beatriz G. Gálvez ◽  
Natividad Longo ◽  
Françoise Baleux ◽  
Goos N. P. van Muijen ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Melanoma Cell ◽  
Cell Invasion ◽  
Stromal Cell ◽  
Rho Gtpase ◽  
Basement Membranes ◽  
Stromal Cell Derived Factor ◽  
Membrane Type ◽  
Stimulation Of

scholarly journals Activation of Vav/Rho GTPase Signaling by CXCL12 Controls Membrane-Type Matrix Metalloproteinase–Dependent Melanoma Cell Invasion

2006 ◽  
Vol 66 (1) ◽  
pp. 248-258 ◽  
Author(s):  
Rubén A. Bartolomé ◽  
Isabel Molina-Ortiz ◽  
Rafael Samaniego ◽  
Paloma Sánchez-Mateos ◽  
Xosé R. Bustelo ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Melanoma Cell ◽  
Cell Invasion ◽  
Rho Gtpase ◽  
Membrane Type

scholarly journals Membrane-Type-3 Matrix Metalloproteinase (MT3-MMP) Functions as a Matrix Composition-Dependent Effector of Melanoma Cell Invasion

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28325 ◽  
Author(s):  
Olga Tatti ◽  
Mariliina Arjama ◽  
Annamari Ranki ◽  
Stephen J. Weiss ◽  
Jorma Keski-Oja ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Melanoma Cell ◽  
Cell Invasion ◽  
Matrix Composition ◽  
Membrane Type ◽  
Type 3

scholarly journals Noncanonical Activation of Notch1 Protein by Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Controls Melanoma Cell Proliferation

2014 ◽  
Vol 289 (12) ◽  
pp. 8442-8449 ◽  
Author(s):  
Jun Ma ◽  
Xiaoying Tang ◽  
Poki Wong ◽  
Barbara Jacobs ◽  
Ernest C. Borden ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Matrix Metalloproteinase ◽  
Melanoma Cell ◽  
Melanoma Cell Proliferation ◽  
Membrane Type

Neutrophil-derived serine proteinases enhance membrane type-1 matrix metalloproteinase–dependent tumor cell invasion

Surgery ◽  
2000 ◽  
Vol 127 (2) ◽  
pp. 142-147 ◽  
Author(s):  
Peter Shamamian ◽  
Ben J.Z. Pocock ◽  
Jess D. Schwartz ◽  
Sara Monea ◽  
Neal Chuang ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Serine Proteinases ◽  
Membrane Type

A novel celecoxib analog UTX-121 inhibits HT1080 cell invasion by modulating membrane-type 1 matrix metalloproteinase

2020 ◽  
Vol 521 (1) ◽  
pp. 137-144
Author(s):  
Hirari Yamahana ◽  
Takahisa Takino ◽  
Yoshio Endo ◽  
Hisatsugu Yamada ◽  
Takeshi Suzuki ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Cell Invasion ◽  
Ht1080 Cell ◽  
Membrane Type

scholarly journals SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) mediate trafficking of membrane type 1–matrix metalloproteinase (MT1-MMP) during invadopodium formation and tumor cell invasion

2014 ◽  
Vol 25 (13) ◽  
pp. 2061-2070 ◽  
Author(s):  
Karla C. Williams ◽  
Rachael E. McNeilly ◽  
Marc G. Coppolino
Keyword(s):  
Membrane Protein ◽  
Matrix Metalloproteinase ◽  
Cell Invasion ◽  
Cellular Invasion ◽  
Protein Receptor ◽  
Ecm Degradation ◽  
Membrane Type ◽  
Regulated Trafficking

Movement through the extracellular matrix (ECM) requires cells to degrade ECM components, primarily through the action of matrix metalloproteinases (MMPs). Membrane type 1–matrix metalloproteinase (MT1-MMP) has an essential role in matrix degradation and cell invasion and localizes to subcellular degradative structures termed invadopodia. Trafficking of MT1-MMP to invadopodia is required for the function of these structures, and here we examine the role of N-ethylmaleimide–sensitive factor–activating protein receptor (SNARE)–mediated membrane traffic in the transport of MT1-MMP to invadopodia. During invadopodium formation in MDA-MB-231 human breast cancer cells, increased association of SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) is detected by coimmunoprecipitation. Blocking the function of these SNAREs perturbs invadopodium-based ECM degradation and cell invasion. Increased level of SNAP23-Syntaxin4-VAMP7 interaction correlates with decreased Syntaxin4 phosphorylation. These results reveal an important role for SNARE-regulated trafficking of MT1-MMP to invadopodia during cellular invasion of ECM.

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