epithelial ovarian cancer cell
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2021 ◽  
Vol 12 (14) ◽  
pp. 4277-4287
Author(s):  
Qi Li ◽  
Xiaomin Feng ◽  
Fengnan Niu ◽  
Jun Yang ◽  
Yuemei Xu ◽  
...  

2018 ◽  
Vol 2 (S1) ◽  
pp. 22-22
Author(s):  
Muhan Hu ◽  
Ekta Tiwary ◽  
Rebecca Arend ◽  
Michael Miller

OBJECTIVES/SPECIFIC AIMS: To understand the role of PGF2a and to characterize a novel cyclooxyrgenase (COX)-independent prostaglandin synthesis pathway in epithelial ovarian cancer. METHODS/STUDY POPULATION: We used high grade epithelial ovarian cancer cell line (OVCAR3) as a model to study our pathway. Our main mode of PGF2a detection is through mass spectrometry. RESULTS/ANTICIPATED RESULTS: Our current results suggest the OVCAR3 cells may synthesize PGF2a independently of COX enzymes. We anticipate this novel pathway may be dependent on the TGFb pathway. DISCUSSION/SIGNIFICANCE OF IMPACT: Understanding the role and synthesis pathway of PGF2a may allow us to uncover a novel therapeutic pathway for high grade ovarian cancer.


2018 ◽  
Vol 11 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Aline Brito de Lima ◽  
Luciana Maria Silva ◽  
Nikole Gontijo Gonçales ◽  
Maria Raquel Santos Carvalho ◽  
Agnaldo Lopes da Silva Filho ◽  
...  

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