Inactivation of Nuclear Factor κB by Soy Isoflavone Genistein Contributes to Increased Apoptosis Induced by Chemotherapeutic Agents in Human Cancer Cells

2005 ◽  
Vol 65 (15) ◽  
pp. 6934-6942 ◽  
Author(s):  
Yiwei Li ◽  
Fakhara Ahmed ◽  
Shadan Ali ◽  
Philip A. Philip ◽  
Omer Kucuk ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Nuclear Factor Κb ◽  
Chemotherapeutic Agents ◽  
Nuclear Factor ◽  
Soy Isoflavone ◽  
Human Cancer Cells

scholarly journals Constituents and Anti-Multidrug Resistance Activity of Taiwanofungus camphoratus on Human Cervical Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3730 ◽  
Author(s):  
Hsin-Yi Hung ◽  
Chin-Chuan Hung ◽  
Jun-Weil Liang ◽  
Chin-Fu Chen ◽  
Hung-Yi Chen ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Cells ◽  
Human Cancer ◽  
Chemical Constituents ◽  
Nutritional Supplement ◽  
Chemotherapeutic Agents ◽  
High Morbidity ◽  
Human Cancer Cells ◽  
Cervical Cancer Cells ◽  
Taiwanofungus Camphoratus

Resistance to anti-cancer drugs is one of the main factors of treatment failure resulting in high morbidity. Among the reasons of resistance, overexpression of efflux pumps leading to multidrug resistance is an important issue that needs to be solved. Taiwanofungus camphoratus has been used as a nutritional supplement to treat various cancers. However, its effects on the resistance to chemotherapeutic agents are still unknown. In this study, we report four new chemical constituents of T. camphoratus isolated from an ether extract: camphoratins K (1) and N (2) and benzocamphorins G (3) and I (4). Furthermore, we evaluated zhankuic acids A–C for their P-glycoprotein (P-gp) inhibitory effects. The results showed that zhankuic acid A was the most potent P-gp inhibitor compound and (at 20 μM) could reverse drug resistance in human cancer cells, restoring an IC50 of 78.5 nM for doxorubicin, of 48.5 nM for paclitaxel, and of 321.5 nM for vincristine, indicating a reversal fold of 48, 38, and 45 times, respectively. This study provides support for the use of T. camphoratus in the further development of cancer therapy.

The Effect of Chemotherapeutic Agents upon the Metabolism of Intact Human Cancer Cells

1963 ◽  
Vol 9 (5) ◽  
pp. 511-529 ◽  
Author(s):  
Bernard J Katchman ◽  
Robert E Zipf ◽  
James P F Murphy
Keyword(s):  
Lactic Acid ◽  
Cancer Cells ◽  
Acid Production ◽  
Nitrogen Mustard ◽  
Human Cancer ◽  
Lactic Acid Production ◽  
Chemotherapeutic Agents ◽  
Cell Sensitivity ◽  
Human Cancer Cells ◽  
Stimulation Of

Abstract The effect of certain chemotherapeutic agents upon the metabolism of human ascites and leukemic leukocytes was investigated. Human leukemic blast cells show 2-3 times the respiratory activity of "chronic" cells. From a study of the effects of eight chemotherapeutic drugs upon the respiration of human leukemic leukocytes and human ascites cells, relative index of cell sensitivity was obtained. The alkaloid, vinblastine sulfate, and the alkylating agents, triethylenethiophosphoramide and nitrogen mustard, were found to be more toxic to human cancer cells than the antimetabolites, 6-mercaptopurine, 8-azaguanine, aminopterin, diazouracil, or prednisone. Stimulation of aerobic glycolysis was found for all chemicals except aminopterin (no effect) and nitrogen mustard (inhibition). No correlation between stimulation of lactic acid production and inhibition of respiration was found. Stimulation of lactic acid production could be produced under conditions where respiration was unchanged. Only nitrogen mustard differed in that inhibition of respiration always accompanied inhibition of lactic acid production. Most chemotherapeutic agents tested are Pasteur effect inhibitors. An unusual stimulation of glucose disappearance to products unknown as yet was caused by 6-mercaptopurine in all cells tested. The potential usefulness of a cell sensitivity test in clinical chemotherapy is discussed.

Indirubin derivatives inhibit SFKs/Stat signaling associated with apoptosis in human cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
S Nam ◽  
R Buettner ◽  
X Liu ◽  
J Turkson ◽  
D Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Stat Signaling
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