scholarly journals Cancer Cells Regulate Lymphocyte Recruitment and Leukocyte-Endothelium Interactions in the Tumor-Draining Lymph Node

2005 ◽  
Vol 65 (24) ◽  
pp. 11639-11648 ◽  
Author(s):  
Virginie Carrière ◽  
Renaud Colisson ◽  
Carine Jiguet-Jiglaire ◽  
Elisabeth Bellard ◽  
Gérard Bouche ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cancer Cells ◽  
Draining Lymph Node ◽  
Tumor Draining Lymph Node

Targeting the Tumor-Draining Lymph Node With Adjuvant Nanoparticles for Cancer Immunotherapy

2013 ◽  
Author(s):  
Susan N. Thomas
Keyword(s):  
Drug Delivery ◽  
Lymph Node ◽  
Cancer Immunotherapy ◽  
Cancer Progression ◽  
Targeted Delivery ◽  
Immune Escape ◽  
Material Design ◽  
Draining Lymph Node ◽  
Clinical Interest ◽  
Tumor Draining Lymph Node

Immunotherapy-based approaches for cancer treatment are of increasing clinical interest. Principles of drug delivery and the emerging field of material design for immunomodulation might hold significant promise for novel approaches in cancer immunotherapy since biomaterials engineering strategies enable enhanced delivery of immune modulatory agents to tissues and cells of the immune system1. One tissue of significant clinical interest in a cancer setting is the tumor-draining lymph node (TDLN), which participates in cancer progression by enabling both metastatic dissemination as well as tumor-induced immune escape. Hence, the TDLN represents a novel target for drug delivery schemes for cancer immunotherapy. We hypothesize that targeted delivery of adjuvants (Adjs) to the TDLN using a biomaterials-based approach might promote antitumor immunity and hinder tumor growth.

Effect of Interleukin-l?? on the In Vitro Activation of Tumor-Draining Lymph Node Cells for Adoptive Immunotherapy

1994 ◽  
Vol 16 (1) ◽  
pp. 1-12
Author(s):  
James M. Hammel ◽  
Melissa K. Tuck ◽  
Jon M. Hain ◽  
Alfred E. Chang ◽  
Vernon K. Sondak
Keyword(s):  
Lymph Node ◽  
Adoptive Immunotherapy ◽  
In Vitro Activation ◽  
Lymph Node Cells ◽  
Draining Lymph Node ◽  
Tumor Draining Lymph Node

Activation by anti-CD3 of tumor-draining lymph node cells for specific adoptive immunotherapy

1991 ◽  
Vol 134 (2) ◽  
pp. 473-479 ◽  
Author(s):  
Hirohisa Yoshizawa ◽  
Keisuke Sakai ◽  
Alfred E. Chang ◽  
Suyu Shu
Keyword(s):  
Lymph Node ◽  
Adoptive Immunotherapy ◽  
Lymph Node Cells ◽  
Draining Lymph Node ◽  
Tumor Draining Lymph Node

Abstract 526: Tumor-draining lymph node irradiation reduces tumor-infiltrating stem-like CD8+T-cells and abrogates the abscopal effect

2019 ◽  
Author(s):  
Zachary S. Buchwald ◽  
Tahseen H. Nasti ◽  
Christiane S. Eberhardt ◽  
Andreas Wieland ◽  
David Lawson ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Node ◽  
Cd8 T Cells ◽  
Abscopal Effect ◽  
Draining Lymph Node ◽  
Tumor Draining Lymph Node ◽  
Lymph Node Irradiation

scholarly journals Administration of low-dose combination anti-CTLA4, anti-CD137, and anti-OX40 into murine tumor or proximal to the tumor draining lymph node induces systemic tumor regression

2017 ◽  
Vol 67 (1) ◽  
pp. 47-60 ◽  
Author(s):  
Jonathan P. O. Hebb ◽  
Adriane R. Mosley ◽  
Felipe Vences-Catalán ◽  
Narendiran Rajasekaran ◽  
Anna Rosén ◽  
...  
Keyword(s):  
Lymph Node ◽  
Low Dose ◽  
Tumor Regression ◽  
Murine Tumor ◽  
Dose Combination ◽  
Draining Lymph Node ◽  
Tumor Draining Lymph Node
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